Post List

  • October 31, 2014
  • 04:05 PM
  • 12 views

New Genetic Editing Technique Offers Novel Treatment of Defects

by Gabriel in Lunatic Laboratories

The promises of genetic modifications are endless, longer life, better health, cures for genetic based diseases that would otherwise cause an unimaginable amount of suffering all wiped out. We’ve come a long way in genetic alteration thanks, in part, to the ever faster moving pace of science. While genetic modification is the thing of horror movies, it also can change the world in ways we cannot even imagine — unfortunately getting genome-editing proteins into cells, where they need to be t........ Read more »

  • October 31, 2014
  • 12:05 PM
  • 24 views

I Need How Many Calories? Caloric Needs in Bulimia Nervosa Patients

by Tetyana in Science of Eating Disorders


In the 1980s, a few studies came out suggesting that patients with bulimia nervosa (BN) require fewer calories for weight maintenance than anorexia nervosa patients (e.g., Newman, Halmi, & Marchi, 1987) and healthy female controls (e.g., Gwirtsman et al., 1989).
Gwirtsman et al. (1989), after finding that patients with bulimia nervosa required few calories for weight maintenance than healthy volunteers, had these suggestions for clinicians:
When bulimic patient........ Read more »

de Zwaan, M., Aslam, Z., & Mitchell, J.E. (2002) Research on energy expenditure in individuals with eating disorders: a review. International Journal of Eating Disorders, 31(4), 361-9. PMID: 11948641  

Gwirtsman, H.E., Kaye, W.H., Obarzanek, E., George, D.T., Jimerson, D.C., & Ebert, M.H. (1989) Decreased caloric intake in normal-weight patients with bulimia: comparison with female volunteers. American Journal of Clinical Nutrition, 49(1), 86-92. PMID: 2912015  

  • October 31, 2014
  • 11:48 AM
  • 21 views

Halloween Special: The Drosophila Halloween Genes

by Bethany Christmann in Fly on the Wall

In the movies, spooks and phantoms are often undead humans with unfinished business. But would you be afraid of a ghostly fruit fly? In 1995, fruit fly researchers Christiane Nüsslein-Volhard and Eric Wieschaus were awarded a Nobel Prize for their research on development. They were interested in understanding how a fertilized egg develops into a complex […]... Read more »

  • October 31, 2014
  • 11:44 AM
  • 18 views

Tissue-specific genome editing in Ciona embryos by CRISPR/Cas9

by Shashank Gandhi in the Node

Researchers have always been interested in tissue-specific loss of function to probe the role of specific genes in embryonic development, cell physiology and disease conditions. Migration of lateral plate primordial germ cells in zebrafish, border cell migration during oogenesis in drosophila, interaction of T-cells with their target, and numerous other cases have continued to give […]... Read more »

Stolfi, A., Gandhi, S., Salek, F., & Christiaen, L. (2014) Tissue-specific genome editing in Ciona embryos by CRISPR/Cas9. Development, 141(21), 4115-4120. DOI: 10.1242/dev.114488  

  • October 31, 2014
  • 11:15 AM
  • 21 views

Canonical circuits in neuroscience

by neuroecology in Neuroecology

Gary Marcus, Adam Marblestone, and Thomas Dean have a nice perspective piece in Science this week on the atoms of neural computation (gated): One hypothesis is that cortical neurons form a single, massively repeated “canonical” circuit, characterized as a kind of a … Continue reading →... Read more »

  • October 31, 2014
  • 11:14 AM
  • 21 views

NS1: It’s all about location, location, location

by Clay Clark in Biochem Blogs

  Viruses are minimalists when it comes to genomic data. This light packing of genetic information requires that every protein the virus codes for needs to be as versatile as possible. The flavivirus genus is no exception to this; its genome encodes for three structural proteins (capsid, membrane, and envelope) and seven nonstructural proteins (NS1, […]... Read more »

  • October 31, 2014
  • 06:37 AM
  • 23 views

Mind Blowing Brain Cases: The Man With A Hole In His Head

by Elisabeth Buhl Thubron in United Academics

In this series neuroscientist Elisabeth Buhl Thubron takes a closer look at intriguing brain cases that revolutionised the field. Part I: The Man With A Whole In His Head... Read more »

Harlow JM. (1999) Passage of an iron rod through the head. 1848. The Journal of neuropsychiatry and clinical neurosciences, 11(2), 281-3. PMID: 10334003  

Ratiu P, Talos IF, Haker S, Lieberman D, & Everett P. (2004) The tale of Phineas Gage, digitally remastered. Journal of neurotrauma, 21(5), 637-43. PMID: 15165371  

Van Horn JD, Irimia A, Torgerson CM, Chambers MC, Kikinis R, & Toga AW. (2012) Mapping connectivity damage in the case of Phineas Gage. PloS one, 7(5). PMID: 22616011  

  • October 31, 2014
  • 06:22 AM
  • 18 views

TSC1 is required for iNKT cell maturation and function

by Lizzie Perdeaux in BHD Research Blog

Invariant Natural Killer T (iNKT) cell development is highly regulated, starting at stage 0, where DP thermocytes become committed to the iNKT cell lineage, and ending as fully mature stage 3 iNKT cells, which are capable of illiciting an immune … Continue reading →... Read more »

Wu J, Yang J, Yang K, Wang H, Gorentla B, Shin J, Qiu Y, Que LG, Foster WM, Xia Z.... (2014) iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions. The Journal of clinical investigation, 124(4), 1685-98. PMID: 24614103  

  • October 31, 2014
  • 05:06 AM
  • 25 views

Caesarean section births and autism risk?

by Paul Whiteley in Questioning Answers

It was a familiar story. Big media headlines such as: Caesarean sections 'may increase risk of autism' appearing all over, but when it came to finding the study behind the headlines, the publishing journal seemed to be trailing a little way behind. We've been in a similar situation before."As the flames rose to her Roman nose"Anyhow, the paper by Eileen Curran and colleagues [1] (open-access) has finally made it to the research table and hence is fodder for today's ramblings with the sugges........ Read more »

  • October 30, 2014
  • 03:45 PM
  • 40 views

Zombies: Science Fiction vs. Fact

by Gabriel in Lunatic Laboratories

Well in the spirit of Halloween I thought I would make a nice little zombie post. Zombies, those brain loving little guys, [and girls] are everywhere. From shows like The Walking […]... Read more »

Lafferty KD. (2006) Can the common brain parasite, Toxoplasma gondii, influence human culture?. Proceedings. Biological sciences / The Royal Society, 273(1602), 2749-55. PMID: 17015323  

Vyas A, Kim SK, Giacomini N, Boothroyd JC, & Sapolsky RM. (2007) Behavioral changes induced by Toxoplasma infection of rodents are highly specific to aversion of cat odors. Proceedings of the National Academy of Sciences of the United States of America, 104(15), 6442-7. PMID: 17404235  

Thomas, F., Schmidt-Rhaesa, A., Martin, G., Manu, C., Durand, P., & Renaud, F. (2002) Do hairworms (Nematomorpha) manipulate the water seeking behaviour of their terrestrial hosts?. Journal of Evolutionary Biology, 15(3), 356-361. DOI: 10.1046/j.1420-9101.2002.00410.x  

W. Wesołowska T. Wesołowski. (2014) Do Leucochloridium sporocysts manipulate the behaviour of their snail hosts?. Journal of Zoology , 292(3), 151-155. info:/10.1111/jzo.12094

  • October 30, 2014
  • 11:20 AM
  • 34 views

Alcoholism as a Reward System Dysfunction

by William Yates, M.D. in Brain Posts

Alcoholism and other addictive behaviors often occur together within individual patients.For example, individuals with alcoholism commonly also are smokers and meet criteria for a diagnosis of nicotine dependence.This co-occurrence suggests multiple types of addiction may share genetic and environmental risk factors. Additionally, there might be a common neurobiological mechanism in play for many addictions.Kenneth Blum and other leading alcoholism researchers recently published a review that pr........ Read more »

  • October 30, 2014
  • 09:57 AM
  • 31 views

Resourceful Crustaceans Turn Invasive Seaweed into Homes

by Elizabeth Preston in Inkfish

When a new developer comes to town and starts aggressively building up the empty property around your home, you can get mad—or you can move in. That’s what tiny crustaceans in the Georgia mudflats have done. Facing an invasive Japanese seaweed, they’ve discovered that it makes excellent shelter, protecting them from all kinds of threats. […]The post Resourceful Crustaceans Turn Invasive Seaweed into Homes appeared first on Inkfish.... Read more »

  • October 30, 2014
  • 07:59 AM
  • 48 views

Fright Week: The Stranger in the Mirror

by The Neurocritic in The Neurocritic

In the mirror we see our physical selves as we truly are, even though the image might not live up to what we want, or what we once were. But we recognize the image as “self”. In rare instances, however, this reality breaks down.In Black Swan, Natalie Portman plays Nina Sayers, a ballerina who auditions for the lead in Swan Lake. The role requires her to dance the part of the innocent White Swan (for which she is well-suited), as well as her evil twin the Black Swan — which is initially out........ Read more »

Barnier AJ, Cox RE, Connors M, Langdon R, & Coltheart M. (2011) A stranger in the looking glass: developing and challenging a hypnotic mirrored-self misidentification delusion. The International journal of clinical and experimental hypnosis, 59(1), 1-26. PMID: 21104482  

Chandra SR, & Issac TG. (2014) Mirror image agnosia. Indian journal of psychological medicine, 36(4), 400-3. PMID: 25336773  

Mendez MF, Martin RJ, Smyth KA, & Whitehouse PJ. (1992) Disturbances of person identification in Alzheimer's disease. A retrospective study. The Journal of nervous and mental disease, 180(2), 94-6. PMID: 1737981  

  • October 30, 2014
  • 04:44 AM
  • 37 views

Pain and adolescent Chronic Fatigue Syndrome

by Paul Whiteley in Questioning Answers

"We found a higher prevalence of severe pain among adolescents with CFS [Chronic Fatigue Syndrome] and lowered pain thresholds compared with HCs [healthy controls]".That was the headline generated by the study from Anette Winger and colleagues [1] (open-access) looking to describe several parameters tied into experience of pain in the context of CFS. Further: "The total sum of bodily symptoms represented a heavy burden with great functional consequences".Your hokey pokey drag........ Read more »

  • October 30, 2014
  • 02:30 AM
  • 20 views

Horror paradox

by Donders in Donders Wonders

Halloween is een feest dat in Nederland steeds populairder lijkt te worden. Deze tijd van het jaar komen er altijd veel horrorfilms uit waar we ons graag bang door laten maken. Maar is dat niet een beetje gek? Bang zijn is toch helemaal niet leuk? Wat vertelt de wetenschap ons over deze paradox? Afbeelding door […]... Read more »

Linda de Voogd. (2014) Horror paradox. Donders Wonders. info:other/

  • October 29, 2014
  • 05:40 PM
  • 42 views

Electron Paramagnetic Resonance of hair!

by mrsitandspin in Sit and Spin

I wanted to switch gears a bit and do a paper on Electron Paramagnetic Resonance (EPR), also know as Electron Spin Resonance (ESR). The paper for this weeks is

Electron spin resonance (ESR/EPR) of free radicals observed in human red hair: a new, simple empirical method of determination of pheomelanin/eumelanin ratio in hair.

by

Chikvaidze EN, Partskhaladze TM and Gogoladze TV... Read more »

  • October 29, 2014
  • 03:19 PM
  • 51 views

More Genetic Links Behind Autism

by Gabriel in Lunatic Laboratories

Vaccines do NOT cause autism. One more time, vaccines DO NOT cause autism. So what does cause autism, that problem has been plaguing scientists for awhile now. Thankfully two major genetic studies of autism and involving more than 50 laboratories worldwide, have newly implicated dozens of genes in the disorder. The research shows that rare mutations in these genes affect communication networks in the brain and compromise fundamental biological mechanisms that govern whether, when, and how genes ........ Read more »

Iossifov, I., O’Roak, B., Sanders, S., Ronemus, M., Krumm, N., Levy, D., Stessman, H., Witherspoon, K., Vives, L., Patterson, K.... (2014) The contribution of de novo coding mutations to autism spectrum disorder. Nature. DOI: 10.1038/nature13908  

De Rubeis, S., He, X., Goldberg, A., Poultney, C., Samocha, K., Ercument Cicek, A., Kou, Y., Liu, L., Fromer, M., Walker, S.... (2014) Synaptic, transcriptional and chromatin genes disrupted in autism. Nature. DOI: 10.1038/nature13772  

  • October 29, 2014
  • 01:45 PM
  • 49 views

This Month in Blastocystis Research (OCT 2014) - Trick or Treat Edition

by Christen Rune Stensvold in Blastocystis Parasite Blog

October was mostly about conferences and funding. And why is no one studying endosymbiosis in Blastocystis?... Read more »

Fletcher S, Caprarelli G, Merif J, Andresen D, Hal SV, Stark D, & Ellis J. (2014) Epidemiology and geographical distribution of enteric protozoan infections in sydney, australia. Journal of public health research, 3(2), 298. PMID: 25343139  

Nowack EC, & Melkonian M. (2010) Endosymbiotic associations within protists. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 365(1541), 699-712. PMID: 20124339  

Prodeus TV, Zelia OP, Khlebnikova TA, & Pikul' DA. (2014) [Extraenteric infection caused by Blastocystis spp. in a female patient with liver abscess]. Meditsinskaia parazitologiia i parazitarnye bolezni, 6-9. PMID: 25296418  

  • October 29, 2014
  • 12:59 PM
  • 42 views

October 28, 2014

by Erin Campbell in HighMag Blog

If you’ve ever tried to get your kids to share a donut, you understand the importance to dividing things equally (and learning crucial lessons…just buy more donuts next time...I mean, seriously!). Cell division is no different—chromosomes and organelles must all get divided equally. Today’s images are from a paper showing how mitochondria are positioned during cell division in order to allow equal segregation.Many years of research have focused on the equal segregation of chromosomes d........ Read more »

  • October 29, 2014
  • 09:46 AM
  • 43 views

Video Tip of the Week: PaleoBioDB, for your paleobiology searches

by Mary in OpenHelix

Yeah, I know, it’s not genomics–but it’s the history of life on this planet–right?  The Paleobiology Database has been keeping records of this ancient biology for a while now, and they have some really nice tools to explore the fossil records and resources that have become available. It’s also interesting to me to see the […]... Read more »

Varela Sara, González-Hernández Javier, Sgarbi Luciano, Marshall Charles, Uhen Mark, Peters Shanan, & McClennen Michael. (2014) paleobioDB: an R package for downloading, visualizing and processing data from the Paleobiology Database. Ecography. DOI: 10.1111/ecog.01154  

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