Post List

  • November 30, 1999
  • 12:00 AM

Rethinking Circadian Clock Machinery

by Allison in Dormivigilia

Chronobiologists at Cambridge have discovered circadian rhythms in peroxide oxidation in HUMAN blood cells. That sounds cool, right? But what if I told you that this research will forever make us rethink the innerworkings of the circadian clock because this is the first documentation of non-transcriptionally driven circadian rhythms... Read more »

O'Neill JS, & Reddy AB. (2011) Circadian clocks in human red blood cells. Nature, 469(7331), 498-503. PMID: 21270888  

  • November 30, 1999
  • 12:00 AM

Only Science Can Save Us, but Science Alone Can’t Save Us

by Paul Statt in Paul Statt Communications

Chris Mooney, writing about the recently un-raptured believers, climate change skeptics, and Moms who refuse to vaccinate, in Mother Jones (“Rapture Ready: The Science of Self Delusion,” May/June 2011) comes to the melancholy conclusion that science has proven that science seldom changes anyone’s mind.... Read more »

  • November 30, 1999
  • 12:00 AM

Minding As and P: Can Arsenic Substitute for Phosphorus or Not?

by Sara Klink in Promega Connections

Back in December 2010, there was a press conference held by NASA to announce the discovery of a bacterium found in a high salt, high pH lake with high concentrations of arsenic that seemed to have substituted arsenic for phosphorus in the bacterium’s biomolecules. This set off a wave of response in the blogosphere regarding what Felisa Wolfe-Simon and her team did nor did not do to confirm arsenic was incorporated into DNA molecules. Controversy ranged from the ability of arsenic to form a sta........ Read more »

Wolfe-Simon, F., Blum, J., Kulp, T., Gordon, G., Hoeft, S., Pett-Ridge, J., Stolz, J., Webb, S., Weber, P., Davies, P.... (2011) Response to Comments on "A Bacterium That Can Grow Using Arsenic Instead of Phosphorus". Science. DOI: 10.1126/science.1202098  

  • November 30, 1999
  • 12:00 AM

STSE Education Research

by Jack Hassard in The Art of Teaching Science

Review of research on Science, Technology, Society, Environmental Education research... Read more »

  • November 30, 1999
  • 12:00 AM

Simpler LCP-based crystallization

by Peter Nollert in Protein Crystallization Blog

For all those that are interested in simplifying membrane protein crystallization trials, you may want to check out this paper on the topic of 'simplifying LCP-based crystallization':

Wallace E, Dranow D, Laible PD, Christensen J, & Nollert P (2011). Monoolein lipid phases as incorporation and enrichment materials for membrane protein crystallization. PloS one, 6 (8) PMID: 21909395... Read more »

  • November 30, 1999
  • 12:00 AM

Communication as a network problem

by Becky in It Takes 30

I recently gave a short talk to a group of post-docs who had organized their own mini-symposium and workshop as a way of bringing the Harvard post-doc community in systems biology together. Those of you who haven’t worked in the Boston area may be surprised that we need special events to bring together a community that is separated by only ~4 miles, but in fact the trip from Harvard’s main campus in Cambridge to Harvard Medical School in Boston is a frustrating and lengthy one. Mu........ Read more »

  • November 30, 1999
  • 12:00 AM

Cannabis law has no effect on cannabis use

by Neurobonkers in Neurobonkers

European Monitoring Centre for Drugs and Drug Addiction confirms that prohibition does not appear to effect levels of cannabis use in any way... Read more »

The european monitoring centre for drugs and drug addiction. (2011) The state of the drugs problem in Europe . Annual Report. info:/

  • November 30, 1999
  • 12:00 AM


by xxx in Anole Annals

xxx... Read more »

Kirsten E. Nicholson and Paul M. Richards. (2011) Home-range size and overlap within an introduced population of the Cuban Knight Anole, Anolis equestris (Squamata: Iguanidae). Phyllomedusa, 10(1), 65-73. info:/

  • November 30, 1999
  • 12:00 AM

Poppies: You’re getting sleepy…very sleepy…

by aewills in A Bouquet From Mendel

An intro to the lovely California poppy, Eschscholzia californica, its useful alkaloids, and molecular approaches to maximize their biosynthetic yield.... Read more »

  • November 30, 1999
  • 12:00 AM

Many Vegetarians Consume Animal-Derived Products in Medicines

by United Academics in United Academics

What should vegetarians do when medicines contain animal products? The answer seems an easy one: to refuse them or to act according to their conscience. But what if the consumers are not appropriately informed about the medicine components, or the doctors not even know that it contains animal products?... Read more »

  • November 30, 1999
  • 12:00 AM

Robot Reveals the Inner Workings of Brain Cells

by Jason Carr in Wired Cosmos

Gaining access to the inner workings of a neuron in the living brain offers a wealth of useful information: its patterns of electrical activity, its shape, even a profile of which genes are turned on at a given moment. However, achieving this entry is such a painstaking task that it is considered an art form; it is so difficult to learn that only a small number of labs in the world practice it.... Read more »

Kodandaramaiah, S., Franzesi, G., Chow, B., Boyden, E., & Forest, C. (2012) Automated whole-cell patch-clamp electrophysiology of neurons in vivo. Nature Methods. DOI: 10.1038/nmeth.1993  

  • November 30, 1999
  • 12:00 AM

Fossil ears and ancient primate locomotion

by W. Andrew Barr in W. Andrew Barr's Paleoecology Blog

Discussion of a recent study on anthropoid primate locomotion as indicated by the semi-circular canal. ... Read more »

  • November 30, 1999
  • 12:00 AM

Working Late in Pregnancy May Be as Bad for the Baby as Smoking: Research

by United Academics in United Academics

Researchers at the University of Essex, in the UK, have found that babies born to women who kept working during their eighth month of pregnancy tend to weight 230g less than those born to mothers who stopped working. The harm was bigger when the women had lower levels of education, while there was no harm at all when they were younger than 24.... Read more »

  • November 30, 1999
  • 12:00 AM

Three Top Redox-Reagents for preventing protein oxidation

by Vicky Doronina in Protein Solubility Blog

Intact cells contain enzymatic and non-enzymatic systems, which counteract amino acid oxidation by reactive oxygen species from the air and chemical reactions and return them into unmodified state. However, after you break the cells, the anti-oxidation systems are gone and you have to supply excess of external antioxidants. In general, the concentration of the reducing agent should be more than your protein concentration. The good old dithiothreitol (DTT) or β-mercaptoethanol (BME) are no........ Read more »

  • November 30, 1999
  • 12:00 AM

Spontaneous Alternation for T Maze, Y Maze

by Adam Maze Engineers in Maze Engineers

Spontaneous alternation behavior (SAB) is a fancy, sciency way of describing the natural tendency of animals (specifically mice/rats/rodents) to alternate which arms of a maze they choose to check out. Unlike the tests for reference and working memory that we discussed last week, when studying spatial memory through observation of spontaneous alternation behavior, the arms of the mazes do not contain any reward. Mice are simply put into the maze, allowed to explore, and their sequence of choices........ Read more »

  • November 30, 1999
  • 12:00 AM

2014: The Year in Science

by Viputheshwar Sitaraman in Draw Science

The year in review: innovative discoveries and progress in all different fields of science. [Infographic]... Read more »

Qiu, X., Wong, G., Audet, J., Bello, A., Fernando, L., Alimonti, J., Fausther-Bovendo, H., Wei, H., Aviles, J., Hiatt, E.... (2014) Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp. Nature, 514(7520), 47-53. DOI: 10.1038/nature13777  

Obokata, H., Wakayama, T., Sasai, Y., Kojima, K., Vacanti, M., Niwa, H., Yamato, M., & Vacanti, C. (2014) Stimulus-triggered fate conversion of somatic cells into pluripotency. Nature, 505(7485), 641-647. DOI: 10.1038/nature12968  

Quintana, E., Barclay, T., Raymond, S., Rowe, J., Bolmont, E., Caldwell, D., Howell, S., Kane, S., Huber, D., Crepp, J.... (2014) An Earth-Sized Planet in the Habitable Zone of a Cool Star. Science, 344(6181), 277-280. DOI: 10.1126/science.1249403  

A.K. Geim, & K. S. Novoselov. (2010) The rise and rise of graphene. Nature Nanotechnology, 5(11), 755-755. DOI: 10.1038/nnano.2010.224  

  • November 30, 1999
  • 12:00 AM

Tit for tet: Tet3 regulates neuron activity through epigenetic changes

by Betty Zou in Eat, Read, Science

Tet3 regulates neuronal activity through epigenetic changes in the cells' DNA. It alters the speed and ease with which neurons communicate by altering the number of receptors at the synapse.... Read more »

Yu H, Su Y, Shin J, Zhong C, Guo JU, Weng YL, Gao F, Geschwind DH, Coppola G, Ming GL.... (2015) Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair. Nature neuroscience, 18(6), 836-43. PMID: 25915473  

  • November 30, 1999
  • 12:00 AM

Is Your Tech Working for You? Accuracy of Activity Trackers

by Rodney Steadman in Gravity's Pull

Two studies that investigate the effectiveness of activity trackers.... Read more »

  • November 30, 1999
  • 12:00 AM

Appearances Can Be Deceiving

by Paco Jariego in Mind the Post

Social behaviours are often contagious, but why do some behaviours spread like wildfire while others remain mostly unseen? The configuration of initial adopters on a social network can systematically skew the observations people make of their friends’ behaviour. This can create the illusion that something is much more popular than it actually is, thus creating conditions for its spread.... Read more »

Kristina Lerman, Xiaoran Yan, & Xin-Zeng Wu. (2015) The Majority Illusion in Social Networks. arxiv. arXiv: 1506.03022v1

  • November 30, 1999
  • 12:00 AM

Autonomous, soft robots

by vitul in Think, Ask and Resolve

A Harvard University team of researchers with expertise in various fields recently came together to develop the first entirely soft robots. ... Read more »

Wehner M, Truby RL, Fitzgerald DJ, Mosadegh B, Whitesides GM, Lewis JA, & Wood RJ. (2016) An integrated design and fabrication strategy for entirely soft, autonomous robots. Nature, 536(7617), 451-5. PMID: 27558065  

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