Post List

  • November 30, 1999
  • 12:00 AM

HIV vaccine research heading towards success,so near but so far, latest research and development towards developing HIV vaccine

by B V Waghmare in HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets

There are few cases observed where some people are tested HIV positive long ago but have not developed AIDS symptoms or the AIDS disease in their entire life and are called by researchers for finding out what is the key difference in them and the other peoples which is imparting capability for not developing HIV infection in to disease AIDS in such individuals.

Researchers have observed that there is a key difference in the genetic constitution of such peoples and they are termed as controlle........ Read more »

B V Waghmare. (2010) Information on HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets . info:/DOI/arXiv/bvwaghmare

  • November 30, 1999
  • 12:00 AM

in indirect support of the hygiene hypothesis

by Ragamuffin in How We Are Hungry

A recent study out of the University of Michigan Medical School suggests that the stomach bacterium Helicobacter pylori protects against inflammation caused by Salmonella in a mouse model of Inflammatory Bowel Disease (IBD).... Read more »

  • November 30, 1999
  • 12:00 AM

Diversity: It Matters! (for plants & algae)

by jebyrnes in I'm a chordata, urochordata!

Geological time has witnessed 5 extinction crises. Now we're in the middle of the 6th - this time driven by man. What's unprecedented, however, is the rate we are driving species extinct. For many taxa, it's faster than we've seen in geological time (see here for discussion).

So? Will vast reductions in the diversity of species on earth matter? I mean, heck, maybe we only need two or three of each taxa, and we’re all good. Or maybe not…

This question has ........ Read more »

Cardinale, B., Matulich, K., Hooper, D., Byrnes, J., Duffy, E., Gamfeldt, L., Balvanera, P., O'Connor, M., & Gonzalez, A. (2011) The functional role of producer diversity in ecosystems. American Journal of Botany, 98(3), 572-592. DOI: 10.3732/ajb.1000364  

  • November 30, 1999
  • 12:00 AM

Interactive software tool for optimal sequence alignments with dynamic programming.

by suji george in Research Software and Book

Dynamic programming (DP) is an optimizing strategy commonly used in various discipline in science. It is widely used in biology to calculate optimal alignment between pairs of protein or DNA sequences. DP is so important, that it is core of many software applications available today for sequence analysis. DP algorithm is essential topic in many undergraduate and graduate bioinformatics course. Although simple in formulation, DP is not that easy for students to learn.

S........ Read more »

  • November 30, 1999
  • 12:00 AM

Approaching Happiness: The Importance of Social Goals

by Amie in Psych Your Mind

The last time you went on a date or hung out with a new friend, what thoughts were going through your mind as you got ready? Were you thinking things like “I hope I have a great time tonight!” and “I hope we have a really good connection,” or were your thoughts more along the lines of “I hope I don’t make a fool out of myself” and “I hope we aren’t bored with each other”? ... Read more »

  • November 30, 1999
  • 12:00 AM

Chasing Earthquakes

by Tara Tai in Student Voices

A survey on earthquakes and their effects on causing future quakes.... Read more »

  • November 30, 1999
  • 12:00 AM

Crystal structure solved by protein folding game players

by Olexandr Isayev in

Following the failure of a wide range of attempts to solve the crystal structure of M-PMV retroviral protease by molecular replacement, authors challenged players of the protein folding game Foldit to produce accurate models of the protein. Remarkably, Foldit players were able to generate models of sufficient quality for successful molecular replacement and subsequent structure determination.... Read more »

Khatib, F., DiMaio, F., Cooper, S., Kazmierczyk, M., Gilski, M., Krzywda, S., Zabranska, H., Pichova, I., Thompson, J., Popović, Z.... (2011) Crystal structure of a monomeric retroviral protease solved by protein folding game players. Nature Structural . DOI: 10.1038/nsmb.2119  

  • November 30, 1999
  • 12:00 AM

Do OTC Head Louse Treatments Work? Part 2: Questionable treatments

by Joe Ballenger in Cheshire

Many treatments for head lice on the market claim to be effective, but this is not backed up by evidence. Many head louse treatment manufacturers make claims of efficacy which go above and beyond the evidence behind their products.... Read more »

Burgess, I. (2009) Current treatments for pediculosis capitis. Current Opinion in Infectious Diseases, 22(2), 131-136. DOI: 10.1097/QCO.0b013e328322a019  

Canyon, D., & Speare, R. (2007) Do head lice spread in swimming pools?. International Journal of Dermatology, 46(11), 1211-1213. DOI: 10.1111/j.1365-4632.2007.03011.x  

  • November 30, 1999
  • 12:00 AM

Tipping points and abrupt warming in the arctic

by brettcherry in Institute of Hazard, Risk and Resilience Blog

Researchers argue that tipping elements — ‘large-scale components of the Earth system that can exhibit a tipping point’ — not only exist, but are interconnected, increasing the risk of extreme weather events... Read more »

Duarte, C., Lenton, T., Wadhams, P., & Wassmann, P. (2012) Abrupt climate change in the Arctic. Nature Climate Change, 2(2), 60-62. DOI: 10.1038/nclimate1386  

  • November 30, 1999
  • 12:00 AM

Genes Dealt Made Asians Svelte

by nooffensebut in The Unsilenced Science

Early genome-wide association studies suggest a genetic propensity to thinness in Asians. I review how these kinds of studies might be able reveal genetic racial differences in obesity and intelligence, and I address a few of the challenges to doing so.... Read more »

Belsky DW, Moffitt TE, Houts R, Bennett GG, Biddle AK, Blumenthal JA, Evans JP, Harrington H, Sugden K, Williams B.... (2012) Polygenic risk, rapid childhood growth, and the development of obesity: evidence from a 4-decade longitudinal study. Archives of pediatrics , 166(6), 515-21. PMID: 22665028  

Hsu FC, Lenchik L, Nicklas BJ, Lohman K, Register TC, Mychaleckyj J, Langefeld CD, Freedman BI, Bowden DW, & Carr JJ. (2005) Heritability of body composition measured by DXA in the diabetes heart study. Obesity research, 13(2), 312-9. PMID: 15800289  

Kilpeläinen TO, Zillikens MC, Stančákova A, Finucane FM, Ried JS, Langenberg C, Zhang W, Beckmann JS, Luan J, Vandenput L.... (2011) Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nature genetics, 43(8), 753-60. PMID: 21706003  

Lohmueller KE, Indap AR, Schmidt S, Boyko AR, Hernandez RD, Hubisz MJ, Sninsky JJ, White TJ, Sunyaev SR, Nielsen R.... (2008) Proportionally more deleterious genetic variation in European than in African populations. Nature, 451(7181), 994-7. PMID: 18288194  

MacArthur DG, Balasubramanian S, Frankish A, Huang N, Morris J, Walter K, Jostins L, Habegger L, Pickrell JK, Montgomery SB.... (2012) A systematic survey of loss-of-function variants in human protein-coding genes. Science (New York, N.Y.), 335(6070), 823-8. PMID: 22344438  

Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Lango Allen H, Lindgren CM, Luan J, Mägi R.... (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nature genetics, 42(11), 937-48. PMID: 20935630  

Tennessen JA, Bigham AW, O'Connor TD, Fu W, Kenny EE, Gravel S, McGee S, Do R, Liu X, Jun G.... (2012) Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science (New York, N.Y.), 337(6090), 64-9. PMID: 22604720  

Zuk O, Hechter E, Sunyaev SR, & Lander ES. (2012) The mystery of missing heritability: Genetic interactions create phantom heritability. Proceedings of the National Academy of Sciences of the United States of America, 109(4), 1193-8. PMID: 22223662  

  • November 30, 1999
  • 12:00 AM

Evidence that financial analysis is biased

by Adriana Wilner in Academic Radar

According to a recent study, investment analysts in US were less optimistic in their recommendations after the banks they work for were sanctioned. However, clients did not gain anything with that change.... Read more »

  • November 30, 1999
  • 12:00 AM

Methylomes in Lethal Prostate Cancer Support Personalized Medicine

by Nicole Kelesoglu in E3 Engaging Epigenetics Experts

Description of new Science Translational Medicine pub out of Johns Hopkins. Epigenetic profiling of metastatic prostate cancer reveals that epigenetic biomarkers are worth the search.... Read more »

  • November 30, 1999
  • 12:00 AM

Drinking is Healthy

by Anton Power in BioMed Weekly

Response to absurd assertion that alcoholic beverages are simply vices.... Read more »

Frozza, R., Bernardi, A., Hoppe, J., Meneghetti, A., Matté, A., Battastini, A., Pohlmann, A., Guterres, S., & Salbego, C. (2013) Neuroprotective Effects of Resveratrol Against Aβ Administration in Rats are Improved by Lipid-Core Nanocapsules. Molecular Neurobiology. DOI: 10.1007/s12035-013-8401-2  

  • November 30, 1999
  • 12:00 AM

Do Women Want Nice Guys?

by Annemarie van Oosten in United Academics

It’s a familiar story: women who say they are looking to date a kind, sensitive and emotionally expressive guy often end up dating a macho man or a jerk. This leaves many ‘nice guys’ feeling they always finish last. For many decades, researchers have tried to get a grip on this so called ‘nice guy paradox’.... Read more »

Urbaniak, G.C., . (2003) Physical Attractiveness and the “Nice Guy Paradox”: Do Nice Guys Really Finish Last? . Sex Roles, 413-426. info:/

  • November 30, 1999
  • 12:00 AM

Not all E.coli strains are created equal

by Dave Dilyx in Protein Solubility Blog

BL21 (DE3) strain of E.coli and its derivatives have the ability to support expression from the strong T7 promoter, traditionally used for expression vectors. However, transcription from this promoter is “leaky”, e.g. there is some level of expression even in the absence of induction. If the protein is toxic - and if you have protein aggregation this is often the case - this creates selective pressure to get rid of the protein by accumulating mutations in the vector. That’s ........ Read more »

  • November 30, 1999
  • 12:00 AM

The case of the missing genitalia: copulation costs for male spiders

by Chris Buddle in Arthropod Ecology

Male spiders can be missing their organs (pedipalps) and this is clearly quite a cost for their fitness! This post explores this topic, with some original data, and with some discussion of past literature on the topic.... Read more »

  • November 30, 1999
  • 12:00 AM

Bubbles and Bite: Why Fizzy Drinks Taste So Good

by Dyani Lewis in United Academics

Why do we choose to drink the beverages that we do? When we reach for a cup of coffee, perhaps it’s the caffeine we’re after; in a glass of wine, the social lubricating effects of alcohol may have lured us. But for carbonated drinks, the subtle zing of effervescence often combined with sugary sweetness, creates a sensory delight that can be irresistible.... Read more »

  • November 30, 1999
  • 12:00 AM

What You Can't Expect When You're Expecting

by Doctor Spurt in Common Currencies

An account of LA Paul's paper of the same title. Paul, L. (2015). What You Can't Expect When You're Expecting Res Philosophica, 92 (2).... Read more »

  • November 30, 1999
  • 12:00 AM

‘Hotspots’ for DNA breakage in neurons may promote brain genetic diversity, disease

by Tom Ulrich in Vector, a Boston Children's Hospital blog

As organs go, the brain seems to harbor an abundance of somatic mutations — genetic variants that arise after conception and affect only some of our neurons. In one recent study, researchers found about 1,500 variants in each of neurons they sampled.

New research revealing the propensity of DNA to break in certain spots backs up the idea of a genetically diverse brain. Reported in Cell last month, it also suggests a new avenue for thinking about brain development, brain tumors and neuro........ Read more »

  • November 30, 1999
  • 12:00 AM

DHM attenuates obesity-induced slow-twitch-fiber decrease via FLCN/FNIP1/AMPK pathway

by Joana Guedes in BHD Research Blog

Obesity is often associated with decreases in the proportion of skeletal muscle slow-twitch fibers and insulin sensitivity. Slow-twitch fibers are rich in mitochondria and utilize fatty acid oxidative phosphorylation for energy production. In their new study, Zhou et al. (2017) explore the role of the FLCN/FNIP1/AMPK signalling pathway in obesity-induced reductions in slow-twitch fibers and insulin sensitivity in skeletal muscle using high-fat-diet-induced (HFD) obese mice, ob/ob mutant mice, an........ Read more »

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