Post List

  • June 18, 2015
  • 04:43 AM
  • 135 views

Atypical enterovirus encephalitis and 'autism-like' (again)

by Paul Whiteley in Questioning Answers

"The autism spectrum disorder or autism-like clinical symptoms are extremely rare, but they may be a clear manifestations of enterovirus encephalitis."That was the finding reported in a poster by Akcakaya and colleagues [1] submitted as part of the 11th European Paediatric Neurology Society Congress 2015. In it, they detail a case report of an adolescent young woman "who developed behavioural changes and autistic features such as impairment of communication, mutism and lack of eye contact" ........ Read more »

  • June 17, 2015
  • 01:54 PM
  • 76 views

Emergency Planning Is For Pets Too

by CAPB in Companion Animal Psychology Blog

Failure to include pets in emergency planning puts human lives at risk.“There is no other factor contributing as much to human evacuation failure in disasters that is under the control of emergency management when a threat is imminent as pet ownership.” So say Sebastian Heath(FEMA) and Robert Linnabary(University of Tennessee) in a review of the ways in which pets should be included in emergency planning. Emergency management has five stages: planning, preparedness, mitigation, ........ Read more »

  • June 17, 2015
  • 01:33 PM
  • 64 views

Living Kidney Donors Experience 37 Heart Changes After Donation

by Cristy at Living Donor 101 in Living Donors Are People Too

You’ve heard me harp on this before. How a 10% reduction in kidney function significantly increases the risk of cardiovacular disease and death. How most people who are diagnosed in with early stage CKD (chronic kidney disease), GFR 60-80, will die of a cardiovascular event before progressing to kidney failure. How 26% of kidney failure …
Continue reading »
The post Living Kidney Donors Experience 37 Heart Changes After Donation appeared first on Living Donors Are People Too.
... Read more »

Moody, W., Ferro, C., Edwards, N., Chue, C., Lin, E., Cockwell, P., Steeds, R., Townend, J., & Taylor, R. (2015) 37 Cardiovascular Effects of Unilateral Nephrectomy in Human Kidney Donors. Heart, 101(Suppl 4). DOI: 10.1136/heartjnl-2015-308066.37  

  • June 17, 2015
  • 11:11 AM
  • 103 views

Using bacteria to look for oil and gas

by Rosin Cerate in Rosin Cerate

In 1938, a Russian scientist by the name of Mogilewskii published a paper describing the use of methane-oxidizing bacteria as a means of prospecting for natural gas fields. Several patents were subsequently issued to oil companies in the 1940s based on this paper and others by American researchers.The idea is that smaller gaseous hydrocarbons (e.g. methane, propane, butane) tend to escape in small amounts from underground oil and gas deposits and rise to the surface. The continuous seepage of th........ Read more »

Rasheed, M., Hasan, S., Rao, P., Boruah, A., Sudarshan, V., Kumar, B., & Harinarayana, T. (2014) Application of geo-microbial prospecting method for finding oil and gas reservoirs. Frontiers of Earth Science, 9(1), 40-50. DOI: 10.1007/s11707-014-0448-5  

  • June 17, 2015
  • 09:38 AM
  • 15 views

Video Tip of the Week: ZBrowse for GWAS viewing and exploration

by Mary in OpenHelix

Maybe you’ve heard of the others. ABrowse. BBrowse. CBrowse. [you get the idea] GBrowse has been widely adopted. JBrowse is picking up steam. Into the orderly arrangement we now throw ZBrowse: a new way to look at genome-wide association study data. Sharing and chatter about ZBrowse for viewing GWAS was abundant when the paper was […]... Read more »

  • June 17, 2015
  • 07:02 AM
  • 20 views

Did Caitlyn Jenner feel “morally tainted”? 

by Rita Handrich in The Jury Room

Caitlyn Jenner has been in the headlines pretty continuously since the publication of her Vanity Fair cover photo. And many of us have heard the voiceover quote from her about the number of years she has been in hiding, protecting secrets, and feeling imprisoned. “Bruce always had to tell a lie. He was always living […]

Related posts:
Got morals?
I’m disgusted (until I wash my hands and feel purified)
What’s a moral issue for us these days?


... Read more »

  • June 17, 2015
  • 05:02 AM
  • 118 views

Antipsychotic drugs as epigenetic modifiers?

by Paul Whiteley in Questioning Answers

The paper by Blaga Rukova and colleagues [1] (open-access available here) published last year (2014) caught my eye recently and their observations of: "major differences in methylation profiles between male schizophrenia patients in complete remission before and after treatment and healthy controls" as potential evidence that: "antipsychotic drugs may play a role in epigenetic modifications."The process of methylation, as in DNA methylation where methyl groups are added to specific segments........ Read more »

Rukova B, Staneva R, Hadjidekova S, Stamenov G, Milanova V, & Toncheva D. (2014) Whole genome methylation analyses of schizophrenia patients before and after treatment. Biotechnology, biotechnological equipment, 28(3), 518-524. PMID: 26019538  

  • June 16, 2015
  • 10:23 PM
  • 95 views

Know your brain: Default mode network

by neurosci in Neuroscientifically Challenged

Where is the default mode network?The default mode network (sometimes called simply the default network) refers to an interconnected group of brain structures that are hypothesized to be part of a functional system. The default network is a relatively recent concept, and because of this there is not yet a complete consensus on which brain regions should be included in a definition of it. Regardless, some structures that are generally included are the medial prefrontal cortex, posterior cingulate........ Read more »

Buckner RL, Andrews-Hanna JR, & Schacter DL. (2008) The brain's default network: anatomy, function, and relevance to disease. Annals of the New York Academy of Sciences, 1-38. PMID: 18400922  

  • June 16, 2015
  • 08:58 AM
  • 82 views

Understanding images: microRNAs contribute to hair loss and follicle regression

by Guest Contributor in PLOS Biologue

In a piece reflecting on this month’s PLOS Genetics issue image, author Zhengquan Yu discusses the research behind Yuan et al. Author: Zhengquan Yu, State Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China Competing interests: … Continue reading »... Read more »

  • June 16, 2015
  • 04:54 AM
  • 0 views

Data Duplication in 25% of Cancer Biology Papers?

by Neuroskeptic in Neuroskeptic_Discover

25% of papers published in cancer biology journals contain signs of 'data duplication', which can be a sign of scientific errors or even misconduct.

That's according to a remarkable paper just published in Science and Engineering Ethics by a Norwegian cancer researcher, Morten P. Oksvold.



Oksvold writes that he randomly selected 40 recent original data papers from three cancer journals, for a total of 120 articles. The journals were chosen to represent one low, one middle, and high imp... Read more »

  • June 16, 2015
  • 04:46 AM
  • 119 views

Gut bacteria and toddler temperament

by Paul Whiteley in Questioning Answers

The 'terrible twos'. Y'know, that special time in a child's development when the words 'mine' and 'no' are much more than a daily occurrence and visions of supermarket / restaurant meltdowns complete with scathing looks from strangers still linger in the rose-tinted memories of parenting.There's still quite a bit of debate about the hows and whys of the terrible twos but new research by Lisa Christian and colleagues [1] implicates a hitherto unappreciated system potentially at work: our gut........ Read more »

Christian LM, Galley JD, Hade EM, Schoppe-Sullivan S, Kamp Dush C, & Bailey MT. (2015) Gut microbiome composition is associated with temperament during early childhood. Brain, behavior, and immunity, 118-27. PMID: 25449582  

  • June 16, 2015
  • 04:46 AM
  • 96 views

Gut bacteria and toddler temperament

by Paul Whiteley in Questioning Answers

The 'terrible twos'. Y'know, that special time in a child's development when the words 'mine' and 'no' are much more than a daily occurrence and visions of supermarket / restaurant meltdowns complete with scathing looks from strangers still linger in the rose-tinted memories of parenting.There's still quite a bit of debate about the hows and whys of the terrible twos but new research by Lisa Christian and colleagues [1] implicates a hitherto unappreciated system potentially at work: our gut........ Read more »

Christian LM, Galley JD, Hade EM, Schoppe-Sullivan S, Kamp Dush C, & Bailey MT. (2015) Gut microbiome composition is associated with temperament during early childhood. Brain, behavior, and immunity, 118-27. PMID: 25449582  

  • June 16, 2015
  • 03:08 AM
  • 31 views

Topic Pages: a bridge between academia and Wikipedia

by Christophe Dessimoz in Open Reading Frame

We have published our latest review, on methods to infer horizontal gene transfer, in Wikipedia. It was peer-reviewed and it simultaneously appeared in PLOS Computational Biology. After our review on approximate Bayesian computations published two years ago, this is our second contribution using an exciting new format called “Topic Page”. In this post, I reflect on our motivation and experience as Topic Page authors.

The difficult relationship between academia and Wikipedia

Academi........ Read more »

Ravenhall M, Škunca N, Lassalle F, & Dessimoz C. (2015) Inferring horizontal gene transfer. PLoS computational biology, 11(5). PMID: 26020646  

Sunnåker M, Busetto AG, Numminen E, Corander J, Foll M, & Dessimoz C. (2013) Approximate Bayesian computation. PLoS computational biology, 9(1). PMID: 23341757  

  • June 15, 2015
  • 02:23 PM
  • 3 views

Dramatic Increase In Young Children Accidentally Exposed To Pot

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Dr. Gary Smith MD, DrPH Center for Injury Research and Policy Nationwide Children’s Hospital Columbus, Ohio Medical Research: What is the background for this study? What are the main findings? Dr. Smith: As of January 2015, 23 … Continue reading →
The post Dramatic Increase In Young Children Accidentally Exposed To Pot appeared first on MedicalResearch.com Medical Research Interviews and News.
... Read more »

Dr. Gary Smith MD, DrPH, Center for Injury Research and Policy, Nationwide Children's Hospital, & Columbus, Ohio. (2015) Dramatic Increase In Young Children Accidentally Exposed To Pot. MedicalResearch.com. info:/

  • June 15, 2015
  • 02:05 PM
  • 3 views

Parkinson’s Disease Can Be Stratified Into Three Distinct Groups

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Ron Postuma, MD, MSc Associate Professor Department of Neurology Montreal General Hospital Montreal, Quebec Medical Research: What is the background for this study? What are the main findings? Dr. Postuma: The background is that we often think … Continue reading →
The post Parkinson’s Disease Can Be Stratified Into Three Distinct Groups appeared first on MedicalResearch.com Medical Research Interviews and News.
... Read more »

Ron Postuma, MD, MSc, Associate Professor, Department of Neurology, Montreal General Hospital, & Montreal, Quebec. (2015) Parkinson’s Disease Can Be Stratified Into Three Distinct Groups. MedicalResearch.com. info:/

  • June 15, 2015
  • 01:16 PM
  • 4 views

Bone Marrow Receptor Opens Door To New Therapy For a Pediatric Leukemia

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Susan Schwab, PhD Assistant professor at NYU Langone Skirball Institute of Biomolecular Medicine Medical Research: What is the background for this study? What are the main findings? Dr. Schwab:  T cell acute lymphoblastic leukemia (T-ALL) remains a … Continue reading →
The post Bone Marrow Receptor Opens Door To New Therapy For a Pediatric Leukemia appeared first on MedicalResearch.com Medical Research Interviews and News.
... Read more »

Susan Schwab, PhD, Assistant professor at NYU Langone, & Skirball Institute of Biomolecular Medicine. (2015) Bone Marrow Receptor Opens Door To New Therapy For a Pediatric Leukemia. MedicalResearch.com. info:/

  • June 15, 2015
  • 01:13 PM
  • 87 views

Avocados may hold the answer to beating leukemia

by Dr. Jekyll in Lunatic Laboratories

Rich, creamy, nutritious and now cancer fighting. New research reveals that molecules derived from avocados could be effective in treating a form of cancer. Professor Paul Spagnuolo from the University of Waterloo has discovered a lipid in avocados that combats acute myeloid leukemia (AML) by targeting the root of the disease – leukemia stem cells. Worldwide, there are few drug treatments available to patients that target leukemia stem cells.... Read more »

Lee, E., Angka, L., Rota, S., Hanlon, T., Mitchell, A., Hurren, R., Wang, X., Gronda, M., Boyaci, E., Bojko, B.... (2015) Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death. Cancer Research, 75(12), 2478-2488. DOI: 10.1158/0008-5472.CAN-14-2676  

  • June 15, 2015
  • 12:50 PM
  • 92 views

Loving to Death

by Miss Behavior in The Scorpion and the Frog

The brown antechinus may look like a mouse - but that is where the similarities end. Photo by Glen Fergus at Wikimedia.Although most animal species breed multiple times throughout their lives, a few oddballs put everything they've got into a single reproductive season, after which they promptly die. This is a rare strategy (for obvious reasons), especially in mammals. One Australian mammal, the brown antechinus, is just odd enough to pull it off.The brown antechinus is a small insectivorous mous........ Read more »

  • June 15, 2015
  • 08:59 AM
  • 73 views

MorphoGraphX: A platform for quantifying morphogenesis in 4D

by Anne-Lise Routier-Kierzkowska in the Node

Quantifying shape, growth and gene expression at the cellular level are key to understanding morphogenesis, i.e. how organs are shaped. Many image processing tools have been developed towards this goal that operate on either 2D or 3D images. 2D tools are fast, easy to use, and typically involve datasets of modest size. However organs and […]... Read more »

Barbier de Reuille, P., Routier-Kierzkowska, A., Kierzkowski, D., Bassel, G., Schüpbach, T., Tauriello, G., Bajpai, N., Strauss, S., Weber, A., Kiss, A.... (2015) MorphoGraphX: A platform for quantifying morphogenesis in 4D. eLife. DOI: 10.7554/eLife.05864  

Kierzkowski, D., Nakayama, N., Routier-Kierzkowska, A., Weber, A., Bayer, E., Schorderet, M., Reinhardt, D., Kuhlemeier, C., & Smith, R. (2012) Elastic Domains Regulate Growth and Organogenesis in the Plant Shoot Apical Meristem. Science, 335(6072), 1096-1099. DOI: 10.1126/science.1213100  

Aegerter-Wilmsen, T., Heimlicher, M., Smith, A., de Reuille, P., Smith, R., Aegerter, C., & Basler, K. (2012) Integrating force-sensing and signaling pathways in a model for the regulation of wing imaginal disc size. Development, 139(17), 3221-3231. DOI: 10.1242/dev.082800  

Vlad, D., Kierzkowski, D., Rast, M., Vuolo, F., Dello Ioio, R., Galinha, C., Gan, X., Hajheidari, M., Hay, A., Smith, R.... (2014) Leaf Shape Evolution Through Duplication, Regulatory Diversification, and Loss of a Homeobox Gene. Science, 343(6172), 780-783. DOI: 10.1126/science.1248384  

Montenegro-Johnson, T., Stamm, P., Strauss, S., Topham, A., Tsagris, M., Wood, A., Smith, R., & Bassel, G. (2015) Digital Single-Cell Analysis of Plant Organ Development Using 3DCellAtlas. The Plant Cell, 27(4), 1018-1033. DOI: 10.1105/tpc.15.00175  

Santuari, L., Scacchi, E., Rodriguez-Villalon, A., Salinas, P., Dohmann, E., Brunoud, G., Vernoux, T., Smith, R., & Hardtke, C. (2011) Positional Information by Differential Endocytosis Splits Auxin Response to Drive Arabidopsis Root Meristem Growth. Current Biology, 21(22), 1918-1923. DOI: 10.1016/j.cub.2011.10.002  

Yoshida, S., Barbier de Reuille, P., Lane, B., Bassel, G., Prusinkiewicz, P., Smith, R., & Weijers, D. (2014) Genetic Control of Plant Development by Overriding a Geometric Division Rule. Developmental Cell, 29(1), 75-87. DOI: 10.1016/j.devcel.2014.02.002  

Bassel, G., Stamm, P., Mosca, G., Barbier de Reuille, P., Gibbs, D., Winter, R., Janka, A., Holdsworth, M., & Smith, R. (2014) Mechanical constraints imposed by 3D cellular geometry and arrangement modulate growth patterns in the Arabidopsis embryo. Proceedings of the National Academy of Sciences, 111(23), 8685-8690. DOI: 10.1073/pnas.1404616111  

  • June 15, 2015
  • 07:45 AM
  • 3 views

Biologics in Rheumatic Disease Reduce Missed Workdays

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Cécile Gaujoux-Viala, MD, PhD Université Montpellier I Chef de Service de Rhumatologie CHU de Nîmes Carémeau France Medical Research: What is the background for this study? Response: Chronic inflammatory rheumatic diseases – such as rheumatoid arthritis (RA), … Continue reading →
The post Biologics in Rheumatic Disease Reduce Missed Workdays appeared first on MedicalResearch.com Medical Research Interviews and News.
... Read more »

Cécile Gaujoux-Viala, MD, PhD, Université Montpellier I, Chef de Service de Rhumatologie, CHU de Nîmes Carémeau, & France. (2015) Biologics Reduce Missed Workdays in Rheumatic Disease. MedicalResearch.com. info:/

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