Microbial communities are fierce battlegrounds between bacteria and other microbes competing for limited resources. One method some bacteria use to kill their competitors is the production of bacteriocins...... Read more »
Nedialkova LP, Sidstedt M, Koeppel MB, Spriewald S, Ring D, Gerlach RG, Bossi L, & Stecher B. (2015) Temperate phages promote colicin-dependent fitness of Salmonella enterica serovar Typhimurium. Environmental microbiology. PMID: 26439675
Human Cytomegalovirus (HCMV), the prototype member of the herpesvirus subfamily Betaherpesvirinae, is the major cause of birth defects caused by viral infections, pose a serious problem for immunocompromised patients and has more recently also been associated with the onset of artherosclerosis. Upon birth, between 0.5 and 2.5% of all newborns are infected with HCMV with up to 5% being symptomatic, i.e. presenting themselves with symptoms ranging from microcephaly, motor disabilities to chorioret........ Read more »
Shintani T, & Klionsky DJ. (2004) Autophagy in health and disease: a double-edged sword. Science (New York, N.Y.), 306(5698), 990-5. PMID: 15528435
Decuypere JP, Parys JB, & Bultynck G. (2012) Regulation of the autophagic bcl-2/beclin 1 interaction. Cells, 1(3), 284-312. PMID: 24710477
Espert L, Codogno P, & Biard-Piechaczyk M. (2007) Involvement of autophagy in viral infections: antiviral function and subversion by viruses. Journal of molecular medicine (Berlin, Germany), 85(8), 811-23. PMID: 17340132
Hyttinen JM, Niittykoski M, Salminen A, & Kaarniranta K. (2013) Maturation of autophagosomes and endosomes: a key role for Rab7. Biochimica et biophysica acta, 1833(3), 503-10. PMID: 23220125
Sarkar S, Davies JE, Huang Z, Tunnacliffe A, & Rubinsztein DC. (2007) Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. The Journal of biological chemistry, 282(8), 5641-52. PMID: 17182613
Beale R, Wise H, Stuart A, Ravenhill BJ, Digard P, & Randow F. (2014) A LC3-interacting motif in the influenza A virus M2 protein is required to subvert autophagy and maintain virion stability. Cell host , 15(2), 239-47. PMID: 24528869
Sun Y, Yu S, Ding N, Meng C, Meng S, Zhang S, Zhan Y, Qiu X, Tan L, Chen H.... (2014) Autophagy benefits the replication of Newcastle disease virus in chicken cells and tissues. Journal of virology, 88(1), 525-37. PMID: 24173218
Shrivastava S, Devhare P, Sujijantarat N, Steele R, Kwon YC, Ray R, & Ray RB. (2015) Knockdown of Autophagy Inhibits Infectious Hepatitis C Virus Release by the Exosomal Pathway. Journal of virology, 90(3), 1387-96. PMID: 26581990
Geiser V, Rose S, & Jones C. (2008) Bovine herpesvirus type 1 induces cell death by a cell-type-dependent fashion. Microbial pathogenesis, 44(6), 459-66. PMID: 18222625
da Silva, L., Gaudreault, N., & Jones, C. (2011) Cytoplasmic localized infected cell protein 0 (bICP0) encoded by bovine herpesvirus 1 inhibits β interferon promoter activity and reduces IRF3 (interferon response factor 3) protein levels. Virus Research, 160(1-2), 143-149. DOI: 10.1016/j.virusres.2011.06.003
Montagnaro, S., Ciarcia, R., Pagnini, F., De Martino, L., Puzio, M., Granato, G., Avino, F., Pagnini, U., Iovane, G., & Giordano, A. (2013) Bovine herpesvirus type 4 infection modulates autophagy in a permissive cell line. Journal of Cellular Biochemistry, 114(7), 1529-1535. DOI: 10.1002/jcb.24494
Park S, Buck MD, Desai C, Zhang X, Loginicheva E, Martinez J, Freeman ML, Saitoh T, Akira S, Guan JL.... (2016) Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation. Cell host , 19(1), 91-101. PMID: 26764599
O'Connor S, Taylor C, Campbell LA, Epstein S, & Libby P. (2001) Potential infectious etiologies of atherosclerosis: a multifactorial perspective. Emerging infectious diseases, 7(5), 780-8. PMID: 11747688
Lunardi C, Dolcino M, Peterlana D, Bason C, Navone R, Tamassia N, Tinazzi E, Beri R, Corrocher R, & Puccetti A. (2007) Endothelial cells' activation and apoptosis induced by a subset of antibodies against human cytomegalovirus: relevance to the pathogenesis of atherosclerosis. PloS one, 2(5). PMID: 17534423
Orvedahl A, Alexander D, Tallóczy Z, Sun Q, Wei Y, Zhang W, Burns D, Leib DA, & Levine B. (2007) HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein. Cell host , 1(1), 23-35. PMID: 18005679
Mocarski ES Jr. (2002) Immunomodulation by cytomegaloviruses: manipulative strategies beyond evasion. Trends in microbiology, 10(7), 332-9. PMID: 12110212
Terhune S, Torigoi E, Moorman N, Silva M, Qian Z, Shenk T, & Yu D. (2007) Human cytomegalovirus UL38 protein blocks apoptosis. Journal of virology, 81(7), 3109-23. PMID: 17202209
Iwahori S, Hakki M, Chou S, & Kalejta RF. (2015) Molecular Determinants for the Inactivation of the Retinoblastoma Tumor Suppressor by the Viral Cyclin-dependent Kinase UL97. The Journal of biological chemistry, 290(32), 19666-80. PMID: 26100623
Smith JD, & de Harven E. (1978) Herpes simplex virus and human cytomegalovirus replication in WI-38 cells. III. Cytochemical localization of lysosomal enzymes in infected cells. Journal of virology, 26(1), 102-9. PMID: 206717
McFarlane S, Aitken J, Sutherland JS, Nicholl MJ, Preston VG, & Preston CM. (2011) Early induction of autophagy in human fibroblasts after infection with human cytomegalovirus or herpes simplex virus 1. Journal of virology, 85(9), 4212-21. PMID: 21325419
Chaumorcel M, Lussignol M, Mouna L, Cavignac Y, Fahie K, Cotte-Laffitte J, Geballe A, Brune W, Beau I, Codogno P.... (2012) The human cytomegalovirus protein TRS1 inhibits autophagy via its interaction with Beclin 1. Journal of virology, 86(5), 2571-84. PMID: 22205736
Kudchodkar SB, Yu Y, Maguire TG, & Alwine JC. (2004) Human cytomegalovirus infection induces rapamycin-insensitive phosphorylation of downstream effectors of mTOR kinase. Journal of virology, 78(20), 11030-9. PMID: 15452223
Datan E, Shirazian A, Benjamin S, Matassov D, Tinari A, Malorni W, Lockshin RA, Garcia-Sastre A, & Zakeri Z. (2014) mTOR/p70S6K signaling distinguishes routine, maintenance-level autophagy from autophagic cell death during influenza A infection. Virology, 175-90. PMID: 24606695
Matsuo J, Tsukumo Y, Sakurai J, Tsukahara S, Park HR, Shin-ya K, Watanabe T, Tsuruo T, & Tomida A. (2009) Preventing the unfolded protein response via aberrant activation of 4E-binding protein 1 by versipelostatin. Cancer science, 100(2), 327-33. PMID: 19068091
Matsuo J, Tsukumo Y, Saito S, Tsukahara S, Sakurai J, Sato S, Kondo H, Ushijima M, Matsuura M, Watanabe T.... (2012) Hyperactivation of 4E-binding protein 1 as a mediator of biguanide-induced cytotoxicity during glucose deprivation. Molecular cancer therapeutics, 11(5), 1082-91. PMID: 22402126
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Clippinger AJ, & Alwine JC. (2012) Dynein mediates the localization and activation of mTOR in normal and human cytomegalovirus-infected cells. Genes , 26(18), 2015-26. PMID: 22987636
Zhao J, Li Z, Wang M, Zhang Z, Ma H, Chang J, Gao D, & Wang S. (2013) Manipulation of autophagy by HCMV infection is involved in mTOR and influences the replication of virus. Acta biochimica et biophysica Sinica, 45(11), 979-81. PMID: 24108761
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Belzile JP, Sabalza M, Craig M, Clark E, Morello CS, & Spector DH. (2015) Trehalose, an mTOR-Independent Inducer of Autophagy, Inhibits Human Cytomegalovirus Infection in Multiple Cell Types. Journal of virology, 90(3), 1259-77. PMID: 26559848
Mouna L, Hernandez E, Bonte D, Brost R, Amazit L, Delgui LR, Brune W, Geballe AP, Beau I, & Esclatine A. (2015) Analysis of the role of autophagy inhibition by two complementary human cytomegalovirus BECN1/Beclin 1-binding proteins. Autophagy. PMID: 26654401
Marschall M, Feichtinger S, & Milbradt J. (2011) Regulatory roles of protein kinases in cytomegalovirus replication. Advances in virus research, 69-101. PMID: 21762822
Matsunaga K, Saitoh T, Tabata K, Omori H, Satoh T, Kurotori N, Maejima I, Shirahama-Noda K, Ichimura T, Isobe T.... (2009) Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nature cell biology, 11(4), 385-96. PMID: 19270696
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Bu XF, Wang MB, Zhang ZJ, Zhao YH, Li M, & Yan YL. (2015) Autophagy is involved in recombinant Newcastle disease virus (rL-RVG)-induced cell death of stomach adenocarcinoma cells in vitro. International journal of oncology, 47(2), 679-89. PMID: 26058483
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Carpal tunnel syndrome is a very common pain disorder associated with compression of the median nerve at the carpal tunnel. Approximately 139 women and 67 males per 100,000 people will report this problem over the course of one year, although this depends on the definition used. The problem with CTS is not only that it is common, but also that it affects function - it is really difficult to carry out normal daily life with a numb or tingly hand, poor grip strength (particularly in the fingertips........ Read more »
Fernández-Muñoz, J., Palacios-Ceña, M., Cigarán-Méndez, M., Ortega-Santiago, R., de-la-Llave-Rincón, A., Salom-Moreno, J., & Fernández-de-las-Peñas, C. (2016) Pain is Associated to Clinical, Psychological, Physical, and Neurophysiological Variables in Women With Carpal Tunnel Syndrome. The Clinical Journal of Pain, 32(2), 122-129. DOI: 10.1097/AJP.0000000000000241
One of the most common genetic disorders is a condition called neurofibromatosis, which causes brown spots on the skin and benign tumors on the brain, spinal cord and other parts of the nervous system. Neurofibromatosis is one of at least 60 genetic diseases called neurocutaneous disorders that involve the skin, central nervous system, and/or peripheral nervous system.
... Read more »
Figueiredo, A., Mata-Machado, N., McCoyd, M., & Biller, J. (2016) Neurocutaneous Disorders for the Practicing Neurologist: a Focused Review. Current Neurology and Neuroscience Reports, 16(2). DOI: 10.1007/s11910-015-0612-7
MedicalResearch.com Interview with: Ephraim L. Tsalik, MD MHS PhD Assistant Professor of Medicine Division of Infectious Diseases Center for Applied Genomics & Precision Medicine Duke University Medical Center Emergency Department Service Line Durham VA Medical Center Medical Research: What … Continue reading →
The post Genes Identified That May Predispose Some Individuals to Getting Sick appeared first on MedicalResearch.com.
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Dr. Ephraim L. Tsalik. (2016) Genes Identified That May Predispose Some Individual to Getting Sick. MedicalResearch.com. info:/
Snowstorms like the one that hit the east coast of North America this weekend are sometimes used by climate sceptics to argue that global warming is a hoax. “Surely we wouldn’t have seen 2 feet of snow if the temperature...... Read more »
O’Gorman, P. (2014) Contrasting responses of mean and extreme snowfall to climate change. Nature, 512(7515), 416-418. DOI: 10.1038/nature13625
Seager, R., Kushnir, Y., Nakamura, J., Ting, M., & Naik, N. (2010) Northern Hemisphere winter snow anomalies: ENSO, NAO and the winter of 2009/10. Geophysical Research Letters, 37(14). DOI: 10.1029/2010GL043830
More on Heart Disease on MedicalResearch.com MedicalResearch.com Interview with: Professor Ian C K Wong Fellow of Royal Pharmaceutical Society Fellow of Royal College of Paediatrics and Child Health (Honorary) Fellow of the Higher Education Academy Chair in Pharmacy Practice Head … Continue reading →
The post Increased Short Term Risk of Adverse Cardiac Effects With Antibiotic Clarithromycin appeared first on MedicalResearch.com.
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Prof. Ian CK Wong. (2016) Increased Short Term Risk of Adverse Cardiac Effects With Antibiotic Clarithromycin. MedicalResearch.com. info:/
Dangerous activities of a person can be increased with the use of safety equipments as, for example, “wearing a bicycle helmet can increase risk taking and sensation seeking in adults.”
In a study, researchers from the University of Bath’s department of psychology have reported that humans develop their risk-taking behavior on the basis of the use of safety equipments.
They worked with some people ........ Read more »
Gamble, T., & Walker, I. (2016) Wearing a Bicycle Helmet Can Increase Risk Taking and Sensation Seeking in Adults. Psychological Science. DOI: 10.1177/0956797615620784
MedicalResearch.com Interview with: Dr. Chirag Patil, MD American Board Certified Neurosurgeon Brain & Spine Tumor Program Lead Investigator, Precision Medicine Initiative Against Brain Cancer Program Director, Neurosurgical Residence training program Director, Center for Neurosurgical Outcomes Research Cedars-Sinai Medical Center, Los … Continue reading →
The post Virtual Tumor Model Allows Precision Treatment of Glioblastomas appeared first on MedicalResearch.com.
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Dr. Chirag Patil, MD. (2016) Virtual Tumor Model Allows Precision Treatment of Glioblastomas. MedicalResearch.com. info:/
More on Cancer Research on MedicalResearch.com MedicalResearch.com Interview with: Firas Abdollah, M.D., F.E.B.U. (Fellow of European Board of Urology) Urology Fellow with the Center for Outcomes Research, Analytics and Evaluation Vattikuti Urology Institute at Henry Ford Hospital in Detroit MedicalResearch: … Continue reading →
The post Nearly 1/3 of Elderly Receive Non-Recommended Cancer Screening Tests appeared first on MedicalResearch.com.
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Firas Abdollah, M.D., F.E.B.U. (2016) Nearly 1/3 of Elderly Receive Non-Recommended Cancer Screening Tests. MedicalResearch.com. info:/
A musician takes up his/her violin and starts to play, but rather than gripping the strings, the fingers seize up--and this happens every time he/she takes up the instrument. Such a movement disorder--the so-called focal dystonia-- is a dramatic disease for those affected, which has thus far barely been studied.
... Read more »
Rozanski VE, Rehfuess E, Bötzel K, Nowak D. (2015) Task-specific dystonia in professional musicians—a systematic review of the importance of intensive playing as a risk factor. Dtsch Arztebl Int. info:/10.3238/arztebl.2015.0871
MedicalResearch.com Interview with: Frank J. Rybicki, MD, PhD Professor, Chair and Chief, Department of Radiology The University of Ottawa, Faculty of Medicine and The Ottawa Hospital Editor-in-Chief, 3D Printing in Medicine Medical Research: What is the background for this document? Dr. … Continue reading →
The post Cardiac Groups Outline Appropriate Imaging For Chest Pain in ER appeared first on MedicalResearch.com.
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Frank J. Rybicki, MD, PhD. (2016) Cardiac Groups Outline Appropriate Imaging For Chest Pain in ER. MedicalResearch.com. info:/
22q11.2 deletion syndrome has turned out to be something of real interest to this blog. Not only because of the reported connection to the presentation of autism (see here) including some suggestion of a role for the immune system (see here) but also because of the idea that certain somatic comorbidity linked to the gastrointestinal (GI) tract might also figure as part of the presentation of at least some cases of Del22 (see here). Said GI issues have also cropped up across quite a few other lab........ Read more »
Vangkilde, A., Olsen, L., Hoeffding, L., Pedersen, C., Mortensen, P., Werge, T., & Trabjerg, B. (2016) Schizophrenia Spectrum Disorders in a Danish 22q11.2 Deletion Syndrome Cohort Compared to the Total Danish Population—A Nationwide Register Study. Schizophrenia Bulletin. DOI: 10.1093/schbul/sbv195
Overfishing, global warming, waste and contamination, and ocean acidification are at the forefront of scientists concerns.... Read more »
Boonstra, W., Ottosen, K., Ferreira, A., Richter, A., Rogers, L., Pedersen, M., Kokkalis, A., Bardarson, H., Bonanomi, S., Butler, W.... (2015) What are the major global threats and impacts in marine environments? Investigating the contours of a shared perception among marine scientists from the bottom-up. Marine Policy, 197-201. DOI: 10.1016/j.marpol.2015.06.007
MedicalResearch.com Interview with: Carolyn Ee, MBBS Department of General Practice University of Melbourne Carlton, Victoria, Australia Medical Research: What is the background for this study? What are the main findings? Response: Hot flushes affect up to 90% of women during the … Continue reading →
The post Acupuncture No Better Than Placebo For Hot Flashes appeared first on MedicalResearch.com.
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Dr. Carolyn Cheng-Ling Fe. (2016) Acupuncture No Better Than Placebo For Hot Flashes. MedicalResearch.com. info:/
More on Ovarian Cancer on MedicalResearch.com MedicalResearch.com Interview with: Dirk Timmerman, MD PhD Department of Development and Regeneration Department of Obstetrics and Gynecology University Hospitals Leuven Leuven, Belgium Medical Research: What is the background for this study? What are the … Continue reading →
The post Proposed Model Clarifies Ovarian Risk Assessment By Ultrasound appeared first on MedicalResearch.com.
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Dirk Timmerman, MD PhD. (2016) Proposed Model Clarifies Ovarian Risk Assessment By Ultrasound. MedicalResearch.com. info:/
More on Depression on MedicalResearch.com MedicalResearch.com Interview with: Prof. Steven LoBello, Professor of Psychology Auburn University at Montgomery Study co-authors: Megan Traffanstedt (graduate student) and Dr. Sheila Mehta Medical Research: What is the background for this study? What are the main … Continue reading →
The post SAD? No Relationship Between Sunlight and Depression appeared first on MedicalResearch.com.
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Prof. Steven LoBello, Professor of Psychology. (2016) SAD? No Relationship Between Sunlight and Depression. MedicalResearch.com. info:/
The immune system exercises constant vigilance to protect the body from external threats–including what we eat and drink. A careful balancing act plays out as digested food travels through the intestine. Immune cells must remain alert to protect against harmful pathogens like Salmonella, but their activity also needs to be tempered since an overreaction can lead to too much inflammation and permanent tissue damage.
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Gabanyi, I., Muller, P., Feighery, L., Oliveira, T., Costa-Pinto, F., & Mucida, D. (2016) Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages. Cell. DOI: 10.1016/j.cell.2015.12.023
MedicalResearch.com Interview with: Dr. Refaat Hegazi, MD, PhD MS MPH Abbott medical director and study author MedicalResearch: What is the background for this study? What are the main findings? Dr. Hegazi: The NOURISH study that was recently published in Clinical … Continue reading →
The post Reduced Mortality With Specialized Oral Nutrition In Malnourished Older Adults appeared first on MedicalResearch.com.
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Dr. Refaat Hegazi, MD, PhD MS MPH. (2016) Reduced Mortality and Readmissions With Specialized Oral Nutrition In Malnourished Older Adults. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Marita Teng, MD Associate Professor of Otolaryngology Head and Neck Institute Icahn School of Medicine at Mount Sinai MedicalResearch.com Editor’s note: January is Thyroid Awareness Month. In recognition, Dr. Teng discusses the thyroid gland’s important role in the … Continue reading →
The post Thyroid Gland’s Importance Recognized During Thyroid Awareness Month appeared first on MedicalResearch.com.
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Marita Teng, MD. (2016) Thyroid Gland's Importance Recognized During Thyroid Awareness Month. MedicalResearch.com. info:/
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