"Further RCTs [randomised-controlled trials] should be conducted on study populations with diagnosed or clinically significant depression of adequate duration using EPA [eicosapentaenoic acid] -predominant omega-3 HUFA [highly unsaturated fatty acids] formulations."So went the conclusions of the review article published by Brian Hallahan and colleagues  who searched the peer-reviewed science literature for clinical trials "evaluating efficacy of omega-3 high........ Read more »
Hallahan B, Ryan T, Hibbeln JR, Murray IT, Glynn S, Ramsden CE, SanGiovanni JP, & Davis JM. (2016) Efficacy of omega-3 highly unsaturated fatty acids in the treatment of depression. The British journal of psychiatry : the journal of mental science. PMID: 27103682
Humans are a migratory species. Although in modern society the dominant imagery we have created about ourselves is that it...... Read more »
Piller, I. (2016) Language and migration. Language and migration, 1-20. info:/
Zika Virus (ZIKV) is an emerging flavivirus that was first isolated in 1947 from a sentinel monkey in Uganda as part of study that aimed to identify novel pathogens and despite sporadic local outbreaks in countries such as Gabon, Nigeria, Cambodia, Malaysia and Indonesia followed by the first major outbreak in Yap/Federal States of Micronesia 2007 only caused mild disease in humans with up to 80% of asymptomatic cases. Here the repurposing of drugs for treating Zika as well as the effect of re........ Read more »
Bonaldo MC, Ribeiro IP, Lima NS, Dos Santos AA, Menezes LS, da Cruz SO, de Mello IS, Furtado ND, de Moura EE, Damasceno L.... (2016) Isolation of Infective Zika Virus from Urine and Saliva of Patients in Brazil. PLoS neglected tropical diseases, 10(6). PMID: 27341420
Campos Rde M, Cirne-Santos C, Meira GL, Santos LL, de Meneses MD, Friedrich J, Jansen S, Ribeiro MS, da Cruz IC, Schmidt-Chanasit J.... (2016) Prolonged detection of Zika virus RNA in urine samples during the ongoing Zika virus epidemic in Brazil. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 69-70. PMID: 26921737
Chatel-Chaix L, Cortese M, Romero-Brey I, Bender S, Neufeldt CJ, Fischl W, Scaturro P, Schieber N, Schwab Y, Fischer B.... (2016) Dengue Virus Perturbs Mitochondrial Morphodynamics to Dampen Innate Immune Responses. Cell host , 20(3), 342-56. PMID: 27545046
Costa F, Sarno M, Khouri R, de Paula Freitas B, Siqueira I, Ribeiro GS, Ribeiro HC, Campos GS, Alcântara LC, Reis MG.... (2016) Emergence of Congenital Zika Syndrome: Viewpoint From the Front Lines. Annals of internal medicine, 164(10), 689-91. PMID: 26914810
Cugola FR, Fernandes IR, Russo FB, Freitas BC, Dias JL, Guimarães KP, Benazzato C, Almeida N, Pignatari GC, Romero S.... (2016) The Brazilian Zika virus strain causes birth defects in experimental models. Nature, 534(7606), 267-71. PMID: 27279226
DICK GW. (1953) Epidemiological notes on some viruses isolated in Uganda; Yellow fever, Rift Valley fever, Bwamba fever, West Nile, Mengo, Semliki forest, Bunyamwera, Ntaya, Uganda S and Zika viruses. Transactions of the Royal Society of Tropical Medicine and Hygiene, 47(1), 13-48. PMID: 13077697
DICK GW. (1952) Zika virus. II. Pathogenicity and physical properties. Transactions of the Royal Society of Tropical Medicine and Hygiene, 46(5), 521-34. PMID: 12995441
DICK GW, KITCHEN SF, & HADDOW AJ. (1952) Zika virus. I. Isolations and serological specificity. Transactions of the Royal Society of Tropical Medicine and Hygiene, 46(5), 509-20. PMID: 12995440
Garcez PP, Loiola EC, Madeiro da Costa R, Higa LM, Trindade P, Delvecchio R, Nascimento JM, Brindeiro R, Tanuri A, & Rehen SK. (2016) Zika virus impairs growth in human neurospheres and brain organoids. Science (New York, N.Y.), 352(6287), 816-8. PMID: 27064148
Hanners NW, Eitson JL, Usui N, Richardson RB, Wexler EM, Konopka G, & Schoggins JW. (2016) Western Zika Virus in Human Fetal Neural Progenitors Persists Long Term with Partial Cytopathic and Limited Immunogenic Effects. Cell reports, 15(11), 2315-22. PMID: 27268504
Jurado KA, Simoni MK, Tang Z, Uraki R, Hwang J, Householder S, Wu M, Lindenbach BD, Abrahams VM, Guller S.... (2016) Zika virus productively infects primary human placenta-specific macrophages. JCI insight, 1(13). PMID: 27595140
Li H, Saucedo-Cuevas L, Regla-Nava JA, Chai G, Sheets N, Tang W, Terskikh AV, Shresta S, & Gleeson JG. (2016) Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation. Cell stem cell. PMID: 27545505
Miner JJ, & Diamond MS. (2016) Understanding How Zika Virus Enters and Infects Neural Target Cells. Cell stem cell, 18(5), 559-60. PMID: 27152436
Miner JJ, Sene A, Richner JM, Smith AM, Santeford A, Ban N, Weger-Lucarelli J, Manzella F, Rückert C, Govero J.... (2016) Zika Virus Infection in Mice Causes Panuveitis with Shedding of Virus in Tears. Cell reports, 16(12), 3208-18. PMID: 27612415
Nowakowski TJ, Pollen AA, Di Lullo E, Sandoval-Espinosa C, Bershteyn M, & Kriegstein AR. (2016) Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells. Cell stem cell, 18(5), 591-6. PMID: 27038591
Oehler E, Watrin L, Larre P, Leparc-Goffart I, Lastere S, Valour F, Baudouin L, Mallet H, Musso D, & Ghawche F. (2014) Zika virus infection complicated by Guillain-Barre syndrome--case report, French Polynesia, December 2013. Euro surveillance : bulletin Europeen sur les maladies transmissibles , 19(9). PMID: 24626205
Onorati M, Li Z, Liu F, Sousa AM, Nakagawa N, Li M, Dell'Anno MT, Gulden FO, Pochareddy S, Tebbenkamp AT.... (2016) Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia. Cell reports, 16(10), 2576-92. PMID: 27568284
Qian X, Nguyen HN, Song MM, Hadiono C, Ogden SC, Hammack C, Yao B, Hamersky GR, Jacob F, Zhong C.... (2016) Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure. Cell, 165(5), 1238-54. PMID: 27118425
Ribeiro LS, Marques RE, Jesus AM, Almeida RP, & Teixeira MM. (2016) Zika crisis in Brazil: challenges in research and development. Current opinion in virology, 76-81. PMID: 27179929
Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, Yao B, Shin J, Zhang F, Lee EM.... (2016) Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell stem cell, 18(5), 587-90. PMID: 26952870
Weaver SC, Costa F, Garcia-Blanco MA, Ko AI, Ribeiro GS, Saade G, Shi PY, & Vasilakis N. (2016) Zika virus: History, emergence, biology, and prospects for control. Antiviral research, 69-80. PMID: 26996139
Wu KY, Zuo GL, Li XF, Ye Q, Deng YQ, Huang XY, Cao WC, Qin CF, & Luo ZG. (2016) Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice. Cell research, 26(6), 645-54. PMID: 27174054
Xu, M., Lee, E., Wen, Z., Cheng, Y., Huang, W., Qian, X., TCW, J., Kouznetsova, J., Ogden, S., Hammack, C.... (2016) Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen. Nature Medicine. DOI: 10.1038/nm.4184
Zhang F, Hammack C, Ogden SC, Cheng Y, Lee EM, Wen Z, Qian X, Nguyen HN, Li Y, Yao B.... (2016) Molecular signatures associated with ZIKV exposure in human cortical neural progenitors. Nucleic acids research. PMID: 27580721
Rohn TT, Wirawan E, Brown RJ, Harris JR, Masliah E, & Vandenabeele P. (2011) Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain. Neurobiology of disease, 43(1), 68-78. PMID: 21081164
Wirawan E, Vande Walle L, Kersse K, Cornelis S, Claerhout S, Vanoverberghe I, Roelandt R, De Rycke R, Verspurten J, Declercq W.... (2010) Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria. Cell death . PMID: 21364619
Zhou A, Li S, Khan FA, & Zhang S. (2016) Autophagy postpones apoptotic cell death in PRRSV infection through Bad-Beclin1 interaction. Virulence, 7(2), 98-109. PMID: 26670824
Zhu Y, Zhao L, Liu L, Gao P, Tian W, Wang X, Jin H, Xu H, & Chen Q. (2010) Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis. Protein , 1(5), 468-77. PMID: 21203962
Dalrymple, N., Cimica, V., & Mackow, E. (2015) Dengue Virus NS Proteins Inhibit RIG-I/MAVS Signaling by Blocking TBK1/IRF3 Phosphorylation: Dengue Virus Serotype 1 NS4A Is a Unique Interferon-Regulating Virulence Determinant. mBio, 6(3). DOI: 10.1128/mBio.00553-15
Phoolcharoen W, & Smith DR. (2004) Internalization of the dengue virus is cell cycle modulated in HepG2, but not Vero cells. Journal of medical virology, 74(3), 434-41. PMID: 15368519
Thepparit C, & Smith DR. (2004) Serotype-specific entry of dengue virus into liver cells: identification of the 37-kilodalton/67-kilodalton high-affinity laminin receptor as a dengue virus serotype 1 receptor. Journal of virology, 78(22), 12647-56. PMID: 15507651
Chattopadhyay S, Marques JT, Yamashita M, Peters KL, Smith K, Desai A, Williams BR, & Sen GC. (2010) Viral apoptosis is induced by IRF-3-mediated activation of Bax. The EMBO journal, 29(10), 1762-73. PMID: 20360684
Sharif-Askari E, Nakhaei P, Oliere S, Tumilasci V, Hernandez E, Wilkinson P, Lin R, Bell J, & Hiscott J. (2007) Bax-dependent mitochondrial membrane permeabilization enhances IRF3-mediated innate immune response during VSV infection. Virology, 365(1), 20-33. PMID: 17451770
Pillai, S., Nguyen, J., Johnson, J., Haura, E., Coppola, D., & Chellappan, S. (2015) Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis. Nature Communications, 10072. DOI: 10.1038/ncomms10072
Richter B, Sliter DA, Herhaus L, Stolz A, Wang C, Beli P, Zaffagnini G, Wild P, Martens S, Wagner SA.... (2016) Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria. Proceedings of the National Academy of Sciences of the United States of America, 113(15), 4039-44. PMID: 27035970
Thurston, T., Ryzhakov, G., Bloor, S., von Muhlinen, N., & Randow, F. (2009) The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria. Nature Immunology, 10(11), 1215-1221. DOI: 10.1038/ni.1800
Saving up excess solar and wind energy for times when the sun is down or the air is still requires a storage device. Batteries get the most attention as a promising solution although pumped hydroelectric storage is currently used most often. Now researchers are advancing another potential approach using sugar alcohols—an abundant waste product of the food industry—mixed with carbon nanotubes.
... Read more »
Zhang, H., Rindt, C., Smeulders, D., & Nedea, S. (2016) Nanoscale Heat Transfer in Carbon Nanotubes - Sugar Alcohol Composite as Heat Storage Materials. The Journal of Physical Chemistry C. DOI: 10.1021/acs.jpcc.6b05466
A recent study highlights pet rabbit management practices. Although some owners take extra steps to protect their rabbit, many do not.Guest post by James Oxley (Independent Researcher, UK; Twitter) and Clare Ellis (Moulton College, UK; Twitter; Web).Rabbits sometimes get labelled as an easy pet to keep, and some owners may not consider that common pet care practices used for dogs and cats may also be beneficial for rabbits. In fact, a recent study by Oxley et al. has highlighted h........ Read more »
Oxley, J., Previti, A., Alibrandi, A., Briefer, E., & Passantino, A. (2015) A Preliminary internet survey of pet rabbit owners’ characteristics. World Rabbit Science, 23(4), 289. DOI: 10.4995/wrs.2015.3771
DNA methylation and hydroxymethylation are well-established key players in gene regulation. Although many would agree that 5hmC also plays a critical role, there is still some debate over whether it serves a functional role, or is merely an artifact of DNA de-methylation. Even still, other intermediates of de-methylation are actively being investigated. In a recent paper by Iuilaro et al. 2016, a group of scientists argue that 5-formlycytosine (5fC), an intermediate of DNA de-methylation, is a s........ Read more »
Iurlaro M, McInroy GR, Burgess HE, Dean W, Raiber EA, Bachman M, Beraldi D, Balasubramanian S, & Reik W. (2016) In vivo genome-wide profiling reveals a tissue-specific role for 5-formylcytosine. Genome biology, 17(1), 141. PMID: 27356509
Stabilization exercises are better than general exercises for people with chronic non-specific low back pain and possibly as effective as manual therapy.... Read more »
Neto, M., Lopes, J., Conceição, C., Araujo, A., Brasileiro, A., Sousa, C., Carvalho, V., & Arcanjo, F. (2016) Stabilization exercise compared to general exercises or manual therapy for the management of low back pain: A systematic review and meta-analysis. Physical Therapy in Sport. DOI: 10.1016/j.ptsp.2016.08.004
The paper by Enzo Grossi and colleagues  (open-access) is definitely worthy of a post today and the suggestion that the "appropriate use of probiotics" might be something to consider for at least some diagnosed as being on the autism spectrum.Accepting that I'm slightly curious as to what would be considered 'inappropriate use of probiotics', the Grossi paper describes the clinical journey of a boy aged 12 diagnosed with an autism spectrum disorder (ASD) accompanied by learning (intellectual)........ Read more »
Grossi, E., Melli, S., Dunca, D., & Terruzzi, V. (2016) Unexpected improvement in core autism spectrum disorder symptoms after long-term treatment with probiotics. SAGE Open Medical Case Reports. DOI: 10.1177/2050313X16666231
Entitlement--a personality trait driven by exaggerated feelings of deservingness and superiority--may lead to chronic disappointment, unmet expectations and a habitual, self-reinforcing cycle of behavior with dire psychological and social costs, according to new research. In a new theoretical model, researchers have mapped how entitled personality traits may lead to a perpetual loop of distress.
... Read more »
Grubbs, J., & Exline, J. (2016) Trait Entitlement: A Cognitive-Personality Source of Vulnerability to Psychological Distress. Psychological Bulletin. DOI: 10.1037/bul0000063
To what extent does brain structure correlate with different psychological traits? An interesting new paper from Massachusetts General Hospital researchers Mert R. Sabuncu and colleagues uses a new method to examine what the authors call the 'morphometricity' of various behaviours and mental disorders.
Sabuncu et al. define morphometricity as "the proportion of phenotypic variation that can be explained by macroscopic brain morphology" - in other words, the degree to which people with sim... Read more »
Sabuncu MR, Ge T, Holmes AJ, Smoller JW, Buckner RL, Fischl B, & Alzheimer's Disease Neuroimaging Initiative. (2016) Morphometricity as a measure of the neuroanatomical signature of a trait. Proceedings of the National Academy of Sciences of the United States of America. PMID: 27613854
Type II and type III bursts are generated, via the plasma emission mechanism, when beams of suprathermal electrons interact with the ambient plasma generating radio emissions at the plasma frequency fp (the fundamental emission) or at its second harmonic 2fp (the harmonic emission) [see also previous CESRA highlights here and [...]... Read more »
V. Krupar et al. (2016) An Analysis of Interplanetary Solar Radio Emissions Associated with a Coronal Mass Ejection. Astrophys. J. Lett., 823, L5. info:/
Here’s a round-up of articles that could be “all about voir dire” or simply interesting things to ponder as you go about your daily tasks. You may not think of Lemony Snicket as an expert on voir dire but he may have a point with the quote illustrating this post when it comes to voir […]
Should political orientation matter in voir dire?
Voir Dire Fundamentals: Look for trouble, not for friends
Voir Dire Strategy: Who’s the authoritarian?
... Read more »
Bavishi, A., Slade, M., & Levy, B. (2016) A chapter a day: Association of book reading with longevity. Social Science , 44-48. DOI: 10.1016/j.socscimed.2016.07.014
Williams, M., Gruenfeld, D., & Guillory, L. (2016) Sexual Aggression When Power Is New: Effects of Acute High Power on Chronically Low-Power Individuals. Journal of Personality and Social Psychology. DOI: 10.1037/pspi0000068
Today I'm (belatedly) talking about the paper by Robert Naviaux and colleagues  (open-access) and some further peer-reviewed discussion concerning the metabolomics of chronic fatigue syndrome (CFS). Suggesting that "targeted, broad-spectrum metabolomics of plasma not only revealed a characteristic chemical signature but also revealed an unexpected underlying biology" when it comes to CFS, it is not surprising that this work has attracted some media interest (indeed, quite a lot of m........ Read more »
Training the brain to treat itself is a promising therapy for traumatic stress. The training uses an auditory or visual signal that corresponds to the activity of a particular brain region, called neurofeedback, which can guide people to regulate their own brain activity. However, treating stress-related disorders requires accessing the brain's emotional hub, the amygdala, which is located deep in the brain and difficult to reach with typical neurofeedback methods.
... Read more »
Keynan, J., Meir-Hasson, Y., Gilam, G., Cohen, A., Jackont, G., Kinreich, S., Ikar, L., Or-Borichev, A., Etkin, A., Gyurak, A.... (2016) Limbic Activity Modulation Guided by Functional Magnetic Resonance Imaging–Inspired Electroencephalography Improves Implicit Emotion Regulation. Biological Psychiatry, 80(6), 490-496. DOI: 10.1016/j.biopsych.2015.12.024
Molecular model of the drug buprenorphineThe U.S. Surgeon General recently sent a letter to all physicians about the danger of prescription opioids, particularly when used in combination with benzodiazepines (i.e. Valium, Xanax). This combination greatly increases the risk of overdose death.Clinicians can successfully assist those with opioid use disorders. Marc Schuckit, M.D. recently published a nice summary review of entitled "Treatment of Opioid-Use Disorder" in the New England Journal........ Read more »
This post describes the concept behind combination therapies for cancer. Why are they needed? Why can they fail...?... Read more »
"Tablet and phone games could help diagnose autism, study suggests" went the BBC headline covering the paper by Anna Anzulewicz and colleagues  (open-access). The idea being that the way that touch screens are used on tablet and smart phones could potentially 'separate out' those with autism from those with not-autism.Based on a small participant number of "37 children 3–6 years old with autism and 45 age- and gender-matched children developing typically" researchers set about examinin........ Read more »
Anzulewicz A, Sobota K, & Delafield-Butt JT. (2016) Toward the Autism Motor Signature: Gesture patterns during smart tablet gameplay identify children with autism. Scientific reports, 31107. PMID: 27553971
Three minutes of acupressure was effective in decreasing pain in athletes that sustained an acute musculoskeletal injury; however, it failed to help decrease anxiety levels.... Read more »
Mącznik, A., Schneiders, A., Athens, J., & Sullivan, S. (2016) Does Acupressure Hit the Mark? A Three-Arm Randomized Placebo-Controlled Trial of Acupressure for Pain and Anxiety Relief in Athletes With Acute Musculoskeletal Sports Injuries. Clinical Journal of Sport Medicine, 1. DOI: 10.1097/JSM.0000000000000378
Recent research published in the Journal of Diversity in Higher Education shows that older women are “ideal learners”... Read more »
Rubin, M., Scevak, J., Southgate, E., Macqueen, S., Williams, P., & Douglas, H. (2016) Older women, deeper learning, and greater satisfaction at university: Age and gender predict university students’ learning approach and degree satisfaction. Journal of Diversity in Higher Education. DOI: 10.1037/dhe0000042
A tiny RNA appears to play a role in producing major depression, the mental disorder that affects as many as 250 million people a year worldwide. Major depression, formally known as major depressive disorder, or MDD, brings increased risk of suicide and is reported to cause the second-most years of disability after low-back pain.
... Read more »
Roy, B., Dunbar, M., Shelton, R., & Dwivedi, Y. (2016) Identification of microRNA-124-3p as a Putative Epigenetic Signature of Major Depressive Disorder. Neuropsychopharmacology. DOI: 10.1038/npp.2016.175
Do you write about peer-reviewed research in your blog? Use ResearchBlogging.org to make it easy for your readers — and others from around the world — to find your serious posts about academic research.
If you don't have a blog, you can still use our site to learn about fascinating developments in cutting-edge research from around the world.
Research Blogging is powered by SMG Technology.
To learn more, visit seedmediagroup.com.