Rich, creamy, nutritious and now cancer fighting. New research reveals that molecules derived from avocados could be effective in treating a form of cancer. Professor Paul Spagnuolo from the University of Waterloo has discovered a lipid in avocados that combats acute myeloid leukemia (AML) by targeting the root of the disease – leukemia stem cells. Worldwide, there are few drug treatments available to patients that target leukemia stem cells.... Read more »
Lee, E., Angka, L., Rota, S., Hanlon, T., Mitchell, A., Hurren, R., Wang, X., Gronda, M., Boyaci, E., Bojko, B.... (2015) Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death. Cancer Research, 75(12), 2478-2488. DOI: 10.1158/0008-5472.CAN-14-2676
The brown antechinus may look like a mouse - but that is where the similarities end. Photo by Glen Fergus at Wikimedia.Although most animal species breed multiple times throughout their lives, a few oddballs put everything they've got into a single reproductive season, after which they promptly die. This is a rare strategy (for obvious reasons), especially in mammals. One Australian mammal, the brown antechinus, is just odd enough to pull it off.The brown antechinus is a small insectivorous mous........ Read more »
Fisher, D., & Cockburn, A. (2005) The large-male advantage in brown antechinuses: female choice, male dominance, and delayed male death. Behavioral Ecology, 17(2), 164-171. DOI: 10.1093/beheco/arj012
by Anne-Lise Routier-Kierzkowska in the Node
Quantifying shape, growth and gene expression at the cellular level are key to understanding morphogenesis, i.e. how organs are shaped. Many image processing tools have been developed towards this goal that operate on either 2D or 3D images. 2D tools are fast, easy to use, and typically involve datasets of modest size. However organs and […]... Read more »
Barbier de Reuille, P., Routier-Kierzkowska, A., Kierzkowski, D., Bassel, G., Schüpbach, T., Tauriello, G., Bajpai, N., Strauss, S., Weber, A., Kiss, A.... (2015) MorphoGraphX: A platform for quantifying morphogenesis in 4D. eLife. DOI: 10.7554/eLife.05864
Kierzkowski, D., Nakayama, N., Routier-Kierzkowska, A., Weber, A., Bayer, E., Schorderet, M., Reinhardt, D., Kuhlemeier, C., & Smith, R. (2012) Elastic Domains Regulate Growth and Organogenesis in the Plant Shoot Apical Meristem. Science, 335(6072), 1096-1099. DOI: 10.1126/science.1213100
Aegerter-Wilmsen, T., Heimlicher, M., Smith, A., de Reuille, P., Smith, R., Aegerter, C., & Basler, K. (2012) Integrating force-sensing and signaling pathways in a model for the regulation of wing imaginal disc size. Development, 139(17), 3221-3231. DOI: 10.1242/dev.082800
Vlad, D., Kierzkowski, D., Rast, M., Vuolo, F., Dello Ioio, R., Galinha, C., Gan, X., Hajheidari, M., Hay, A., Smith, R.... (2014) Leaf Shape Evolution Through Duplication, Regulatory Diversification, and Loss of a Homeobox Gene. Science, 343(6172), 780-783. DOI: 10.1126/science.1248384
Montenegro-Johnson, T., Stamm, P., Strauss, S., Topham, A., Tsagris, M., Wood, A., Smith, R., & Bassel, G. (2015) Digital Single-Cell Analysis of Plant Organ Development Using 3DCellAtlas. The Plant Cell, 27(4), 1018-1033. DOI: 10.1105/tpc.15.00175
Santuari, L., Scacchi, E., Rodriguez-Villalon, A., Salinas, P., Dohmann, E., Brunoud, G., Vernoux, T., Smith, R., & Hardtke, C. (2011) Positional Information by Differential Endocytosis Splits Auxin Response to Drive Arabidopsis Root Meristem Growth. Current Biology, 21(22), 1918-1923. DOI: 10.1016/j.cub.2011.10.002
Yoshida, S., Barbier de Reuille, P., Lane, B., Bassel, G., Prusinkiewicz, P., Smith, R., & Weijers, D. (2014) Genetic Control of Plant Development by Overriding a Geometric Division Rule. Developmental Cell, 29(1), 75-87. DOI: 10.1016/j.devcel.2014.02.002
Bassel, G., Stamm, P., Mosca, G., Barbier de Reuille, P., Gibbs, D., Winter, R., Janka, A., Holdsworth, M., & Smith, R. (2014) Mechanical constraints imposed by 3D cellular geometry and arrangement modulate growth patterns in the Arabidopsis embryo. Proceedings of the National Academy of Sciences, 111(23), 8685-8690. DOI: 10.1073/pnas.1404616111
MedicalResearch.com Interview with: Cécile Gaujoux-Viala, MD, PhD Université Montpellier I Chef de Service de Rhumatologie CHU de Nîmes Carémeau France Medical Research: What is the background for this study? Response: Chronic inflammatory rheumatic diseases – such as rheumatoid arthritis (RA), … Continue reading →
The post Biologics in Rheumatic Disease Reduce Missed Workdays appeared first on MedicalResearch.com Medical Research Interviews and News.
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Cécile Gaujoux-Viala, MD, PhD, Université Montpellier I, Chef de Service de Rhumatologie, CHU de Nîmes Carémeau, & France. (2015) Biologics Reduce Missed Workdays in Rheumatic Disease. MedicalResearch.com. info:/
I was catching up on some of the journal articles I’ve accumulated to read over the last year and I one caught my eye: “Transformational and transactional presidents,” by Joseph Nye, Jr. In the article, Nye makes the case that … Continue reading →... Read more »
One of the participants in an upsetting series of new interviews says she once stared into the mirror for eleven hours straight. She was looking, searching, trying to find a perspective where she felt good enough about herself to be able to go outside.The woman in question, Louise, has Body Dysmorphic Disorder (BDD), which is defined by psychiatrists as a disabling and distressing preoccupation with what she sees as her perceived physical flaw or flaws.For their study, Joanna Silver and Jacqui F........ Read more »
Silver, J., & Farrants, J. (2015) 'I Once Stared at Myself in the Mirror for Eleven Hours.' Exploring mirror gazing in participants with body dysmorphic disorder. Journal of Health Psychology. DOI: 10.1177/1359105315581516
by Rita Handrich in The Jury Room
At least that’s what the headlines say. But the quieter truth of what the research says is enough for me: the intervention reduced implicit bias and the results held when re-measured one week later. Wow. This is pretty amazing stuff that needs to be used for good and not evil. Can you imagine? This means […]
Biased hearts, biased cameras and biased verdicts
Jury Selection: Art? Science? Or just a ‘gut’ feeling?
How ‘myside bias’ is related to your intelligence
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Preclinical problems are solved as CIVO simultaneously injects eight drugs.... Read more »
Klinghoffer, R., Bahrami, S., Hatton, B., Frazier, J., Moreno-Gonzalez, A., Strand, A., Kerwin, W., Casalini, J., Thirstrup, D., You, S.... (2015) A technology platform to assess multiple cancer agents simultaneously within a patient's tumor. Science Translational Medicine, 7(284), 284-284. DOI: 10.1126/scitranslmed.aaa7489
I was rather interested in the findings reported by Kimberly Aldinger and colleagues  (open-access here) recently and an intriguing attempt to find out whether "there are predictive patterns of medical conditions that co-occur with ASD [autism spectrum disorder], which could inform medical evaluation and treatment in ASD, as well as potentially identify etiologically meaningful subgroups."Comorbidity (if I can still call it that) is of great interest to this blog and the idea that a........ Read more »
Aldinger KA, Lane CJ, Veenstra-VanderWeele J, & Levitt P. (2015) Patterns of Risk for Multiple Co-Occurring Medical Conditions Replicate Across Distinct Cohorts of Children with Autism Spectrum Disorder. Autism research : official journal of the International Society for Autism Research. PMID: 26011086
In their book Make It Stick, authors Peter Brown, Henry Roediger III, and Mark McDaniel have this to say as an introduction to the study we'll look at in this post (along with a few other studies about the benefits of generating solutions [emphasis mine]):... Read more »
Richland, L., Kornell, N., & Kao, L. (2009) The pretesting effect: Do unsuccessful retrieval attempts enhance learning?. Journal of Experimental Psychology: Applied, 15(3), 243-257. DOI: 10.1037/a0016496
Imagine you’re a fly buzzing through the forest looking for something to eat, and you happen upon a sweet fruit that tastes bitter. What’s a fly to do? A sweet fruit is a nutritious meal, but the bitter taste implies toxins. In a recent paper by French et al. in the Journal of Neuroscience, researchers […]... Read more »
French AS, Sellier MJ, Moutaz AA, Guigue A, Chabaud MA, Reeb PD, Mitra A, Grau Y, Soustelle L, & Marion-Poll F. (2015) Dual mechanism for bitter avoidance in Drosophila. The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(9), 3990-4004. PMID: 25740527
More than 60,000 Australians are estimated to have reduced or discontinued their use of prescribed cholesterol-lowering statin medications following the airing of a two-part series critical of statins by ABC TV’s science program, Catalyst, a University of Sydney study reveals. The analysis of the Pharmaceutical Benefits Scheme medication records of 191,000 people revealed that there was an immediate impact after Catalyst was aired in October 2013, with 14,000 fewer people dispensed statins per........ Read more »
Schaffer, A., Buckley, N., Dobbins, T., Banks, E., & Pearson, S. (2015) The crux of the matter: Did the ABC's Catalyst program change statin use in Australia?. The Medical Journal of Australia, 202(11), 591-594. DOI: 10.5694/mja15.00103
MedicalResearch.com Interview with: Wei Zheng, MD, PhD, Professor of Medicine Anne Potter Wilson Chair in Medicine Director, Vanderbilt Epidemiology Center and Danxia Yu, PhD Research Fellow Vanderbilt Epidemiology Center Vanderbilt University School of Medicine Nashville, TN, 37203 Medical Research: What … Continue reading →
The post Healthy Diet May Reduce Mortality In Low Income Populations appeared first on MedicalResearch.com Medical Research Interviews and News.
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MedicalResearch.com Interview with: Wei Zheng, MD, PhD, Professor of Medicine, Anne Potter Wilson Chair in Medicine, Director, Vanderbilt Epidemiology Center and, Danxia Yu, PhD Research Fellow Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, & Nashville, TN, 37203. (2015) Healthy Diet May Reduce Mortality In Low Income Populations. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Neetika Garg, MD Fellow in Nephrology Beth Israel Deaconess Medical Center Division of Nephrology, Department of Medicine Boston, MA 02215 MedicalResearch: What is the background for this study? What are the main findings? Dr. Garg: One in … Continue reading →
The post Your Smartphone May Help You Control Your Blood Pressure appeared first on MedicalResearch.com Medical Research Interviews and News.
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Neetika Garg, MD, Fellow in Nephrology, Beth Israel Deaconess Medical Center, Division of Nephrology, Department of Medicine, & Boston, MA 02215. (2015) Your Smartphone May Help You Control Your Blood Pressure. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Kimberly Allen PhD, RN Assistant Professor Center for Narcolepsy, Sleep and Health Research Department Women Children and Family Health Science Chicago, IL 60612 Medical Research: What is the background for this study? Dr. Allen: Pediatric traumatic brain … Continue reading →
The post Children With Traumatic Brain Injuries Can Have Poor Sleep Quality appeared first on MedicalResearch.com Medical Research Interviews and News.
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Kimberly Allen PhD, RN Assistant Professor, Center dr-kimberly-allenfor Narcolepsy, Sleep and Health Research, Department Women Children and Family Health Science, & Chicago, IL 60612. (2015) Children With Traumatic Brain Injuries Can Have Poor Sleep Quality . MedicalResearch.com. info:/
A description of the formation of the solar system and how we think it got to be how it is today, with a focus on Pluto and Kuiper belt.... Read more »
Thayne Currie, Carey M. Lisse, Marc J. Kuchner, Nikku Madhusudhan, Scott J. Kenyon, Christian Thalmann, Joseph Carson, & John H. Debes. (2015) Direct Imaging and Spectroscopy of a Young Extrasolar Kuiper Belt in the Nearest OB Association. Astrophysical Journal Letters. arXiv: 1505.06734v1
Konstantin Batygin, & Gregory Laughlin. (2015) Jupiter's Decisive Role in the Inner Solar System's Early Evolution. Proceedings of the National Academy of Sciences. arXiv: 1503.06945v2
A new large-scale study of over 12,000 participants shows that higher income is associated with less daily sadness but not more daily happiness... Read more »
Kushlev, K., Dunn, E., & Lucas, R. (2015) Higher Income Is Associated With Less Daily Sadness but not More Daily Happiness. Social Psychological and Personality Science, 6(5), 483-489. DOI: 10.1177/1948550614568161
We’ve all been there: We eat an entire sleeve of fat-free, low-calorie cookies and we’re stuffing ourselves with more food 15 minutes later. One theory to explain this phenomenon is that artificial sweeteners don’t contain the calories or energy that evolution has trained the brain to expect from sweet-tasting foods, so they don’t fool the brain […]... Read more »
Monica Dus et al. (2015) Nutrient Sensor in the Brain Directs the Action of the Brain-Gut Axis in Drosophila. Neuron. info:/10.1016/j.neuron.2015.05.032
Sure, you praise your kids. And they look at you with beaming little faces. Such a warm feeling, if only for a moment. But, is that all there is to praise? What’s simmering in the brain behind those sparkling eyes? It may well depend on the precise nature of the praise you gave. There are […]
Check out In Praise of (the Right Kind of) Praise, an original post on Thinker Academy.
... Read more »
Gunderson, E., Gripshover, S., Romero, C., Dweck, C., Goldin-Meadow, S., & Levine, S. (2013) Parent Praise to 1- to 3-Year-Olds Predicts Children's Motivational Frameworks 5 Years Later. Child Development. DOI: 10.1111/cdev.12064
MedicalResearch.com Medical Research Interviews and News
MedicalResearch.com Interview with: Frank C. Brosius, MD Professor, Internal Medicine and Physiology Chief, Division of Nephrology University of Michigan Ann Arbor, MI Dr. Matthias Kretzler MD Professor, Internal Medicine Research Professor, Computational Medicine and Biology University of Michigan Ann Arbor, MI … Continue reading →
The post JAK1-2 inhibitor Baricitinib May Limit Progression of Diabetic Kidney Disease appeared........ Read more »
MedicalResearch.com Interview with: Frank C. Brosius, MD Professor, Internal Medicine and Physiology, Chief, Division of Nephrology, & University of Michigan Ann Arbor, MI. (2015) JAK1-2 inhibitor Baricitinib May Limit Progression of Diabetic Kidney Disease. MedicalResearch.com. info:/
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