It’s no secret for anyone who follows me that I am a Marine veteran. It’s also no secret for anyone who follows me that I’ve had my own ups and downs in life because of my experiences. PTSD is a nightmare, one that you can’t quite shake no matter how hard you try. Then again, not everyone reacts the same way to the trauma that typically causes PTSD, not everyone walks away from war with it. The big question that scientists set out to answer was, why? And now they might just have an answe........ Read more »
Nikolaos P. Daskalakis, Hagit Cohen, Guiqing Caia, Joseph D. Buxbaum, & Rachel Yehuda. (2014) Expression profiling associates blood and brain glucocorticoid receptor signaling with trauma-related individual differences in both sexes. Proceedings of the National Academy of Sciences of the United States of America, 111(32). info:/10.1073/pnas.1401660111
Do you remember on Who Wants to Be a Millionaire—apparently this show is still on, but I’ll assume no one else has seen it this decade—how after contestants picked an answer, Regis Philbin sometimes asked, “How sure are you?” They’d pull a number seemingly out of the air: “Oh, eighty-five percent.” This trick of estimating our […]The post Even Kindergarteners Can Rate Their Own Confidence appeared first on Inkfish.... Read more »
Vo, V., Li, R., Kornell, N., Pouget, A., & Cantlon, J. (2014) Young Children Bet on Their Numerical Skills: Metacognition in the Numerical Domain. Psychological Science. DOI: 10.1177/0956797614538458
For the past two months, I have been busy preparing my dissertation data for analysis. This means that I am taking the paper versions of my data from books, monographs, […]... Read more »
C. Cave, & M. Oxenham. (2014) Identification of the Archaeological ‘Invisible Elderly’: An Approach Illustrated with an Anglo-Saxon Example. International Journal of Osteoarchaeology. info:/
credit: Gray's Anatomy/WikipediaRemembering and imagining appear to be very different functions, one recovering true information from the past, the other considering the unreal or exploring the future. And yet many patients with damage to the hippocampus (a structure in the temporal lobes) - and resultant memory impairment - struggle in imagining the future. Moreover, neuroimaging data show the hippocampus is involved in both tasks. Taken together, this evidence suggests that memory for the past........ Read more »
Kirwan CB, Ashby SR, & Nash MI. (2014) Remembering and imagining differentially engage the hippocampus: A multivariate fMRI investigation. Cognitive neuroscience, 1-9. PMID: 24967816
The findings from Chang-Ching Wei and colleagues  suggesting an over-representation of the diagnosis of attention-deficit hyperactivity disorder (ADHD) following a history of neonatal jaundice provides fodder for today's brief post. Based in Taiwan, one of the most impressive countries when it comes to the use and analysis of 'big data' (see here), researchers were able to identify some 25,000 participants diagnosed with neonatal jaundice and compare them with almost 70,000 non-jaundiced........ Read more »
Wei CC, Chang CH, Lin CL, Chang SN, Li TC, & Kao CH. (2014) Neonatal jaundice and increased risk of attention-deficit hyperactivity disorder: a population-based cohort study. Journal of child psychology and psychiatry, and allied disciplines. PMID: 25056274
Autoimmune diseases are on the rise. Since I have a history of over sharing, my Uncle suffered from a form of lupus. It caused him intense and — in my opinion — unbearable pain although he shouldered it like the incredible man he was and never complained. My sister unfortunately is suffering from a rare disease that has yet to be diagnosed, which in my opinion has autoimmune dysfunction as the root cause. If you or anyone you know suffers in a similar fashion then you know that the treatment........ Read more »
Chhabra S, Chang SC, Nguyen HM, Huq R, Tanner MR, Londono LM, Estrada R, Dhawan V, Chauhan S, Upadhyay SK.... (2014) Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. PMID: 24891519
Those of you familiar with a certain misanthropic maverick MD will no doubt be familiar with the phrase “it’s never lupus”. Unfortunately, in the real world, it IS sometimes lupus – but what is lupus and how does it arise?
... Read more »
Absher DM, Li X, Waite LL, Gibson A, Roberts K, Edberg J, Chatham WW, & Kimberly RP. (2013) Genome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent hypomethylation of interferon genes and compositional changes to CD4 T-cell populations. PLoS genetics, 9(8). PMID: 23950730
Tiffin N, Adeyemo A, & Okpechi I. (2013) A diverse array of genetic factors contribute to the pathogenesis of systemic lupus erythematosus. Orphanet journal of rare diseases, 2. PMID: 23289717
Several drug classes hold promise for reduction in pathological gambling behavior.However, there are very few published randomized and controlled clinical drug trials in gambling subjects.Searching clinical trials and gambling on PubMed yields only one small open-label proof of concept trial for the drug tolcapone within the last year.This study found evidence that this COMT inhibitor drug reduced gambling symptoms and was accompanied by fronto-parietal activation on fMRI imaging.However, on sea........ Read more »
Grant JE, Odlaug BL, Chamberlain SR, Hampshire A, Schreiber LR, & Kim SW. (2013) A proof of concept study of tolcapone for pathological gambling: relationships with COMT genotype and brain activation. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 23(11), 1587-96. PMID: 23953269
Global surface air temperatures have risen less rapidly over the past 15 years than the previous few decades. The causes of this ‘hiatus’ have been much debated. However, just considering surface temperatures does not tell the whole story – a … Continue reading →... Read more »
Allan, R., Liu, C., Loeb, N., Palmer, M., Roberts, M., Smith, D., & Vidale, P. (2014) Changes in global net radiative imbalance 1985-2012. Geophysical Research Letters. DOI: 10.1002/2014GL060962
We spend much of our lives attempting to figure out the opposite sex in the hopes that it will lead to increased opportunities to attract a mate. But even when in a relationship, looking back to see how it all kicked off can still leave you scratching your head for answers. Understanding attraction and the rules (or lack of them) that govern it are complicated, but there is no shortage of purported help out there to be found in books, cinema and online. Midst the cloud of confusion, we sometime........ Read more »
Puechmaille SJ, Borissov IM, Zsebok S, Allegrini B, Hizem M, Kuenzel S, Schuchmann M, Teeling EC, & Siemers BM. (2014) Female Mate Choice Can Drive the Evolution of High Frequency Echolocation in Bats: A Case Study with Rhinolophus mehelyi. PloS one, 9(7). PMID: 25075972
Recent studies investigating Lithium, a drug commonly used for the treatment of mood disorders in humans, found its robust neurotrophic and neuroprotective effects which can help us exploring new novel, exciting, and promising targets. The molecular mechanism underlying lithium’s mood stabilizing effect is not yet unraveled. Suggested hypotheses include inositol-depletion via inhibition of inositol- monophosphatase and neuroprotection, via inhibition of GSK-3. Chronic lithium treatment inc........ Read more »
Chen G, Rajkowska G, Du F, Seraji-Bozorgzad N, & Manji HK. (2000) Enhancement of hippocampal neurogenesis by lithium. Journal of neurochemistry, 75(4), 1729-34. PMID: 10987856
O'Brien WT, Harper AD, Jové F, Woodgett JR, Maretto S, Piccolo S, & Klein PS. (2004) Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium. The Journal of neuroscience : the official journal of the Society for Neuroscience, 24(30), 6791-8. PMID: 15282284
Berggren U, Tallstedt L, Ahlenius S, & Engel J. (1978) The effect of lithium on amphetamine-induced locomotor stimulation. Psychopharmacology, 59(1), 41-5. PMID: 100811
Wexler EM, Geschwind DH, & Palmer TD. (2008) Lithium regulates adult hippocampal progenitor development through canonical Wnt pathway activation. Molecular psychiatry, 13(3), 285-92. PMID: 17968353
Agam G, Bersudsky Y, Berry GT, Moechars D, Lavi-Avnon Y, & Belmaker RH. (2009) Knockout mice in understanding the mechanism of action of lithium. Biochemical Society transactions, 37(Pt 5), 1121-5. PMID: 19754464
Bessa JM, Ferreira D, Melo I, Marques F, Cerqueira JJ, Palha JA, Almeida OF, & Sousa N. (2009) The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling. Molecular psychiatry, 14(8), 764. PMID: 18982002
Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, Yang TH, Kim HM, Drake D, Liu XS.... (2014) REST and stress resistance in ageing and Alzheimer's disease. Nature, 507(7493), 448-54. PMID: 24670762
Last winter was horrible, and this summer has been mild – so global warming must not be real. This is the thought process for many people, but it points out the confusion between climate and weather. Climate is the average weather for a place over a given period, while weather is what you get day to day. New research is showing that climate change is causing more intense hurricanes - but is the number changing? Recent studies land on both sides of the issue.... Read more »
Bender MA, Knutson TR, Tuleya RE, Sirutis JJ, Vecchi GA, Garner ST, & Held IM. (2010) Modeled impact of anthropogenic warming on the frequency of intense Atlantic hurricanes. Science (New York, N.Y.), 327(5964), 454-8. PMID: 20093471
Knutson, T., Sirutis, J., Garner, S., Vecchi, G., & Held, I. (2008) Simulated reduction in Atlantic hurricane frequency under twenty-first-century warming conditions. Nature Geoscience, 1(6), 359-364. DOI: 10.1038/ngeo202
On what makes our fingers wrinkle in water... Read more »
Haseleu J, Omerbašić D, Frenzel H, Gross M, & Lewin GR. (2014) Water-induced finger wrinkles do not affect touch acuity or dexterity in handling wet objects. PloS one, 9(1). PMID: 24416318
Kareklas K, Nettle D, & Smulders TV. (2013) Water-induced finger wrinkles improve handling of wet objects. Biology letters, 9(2), 20120999. PMID: 23302867
Dummies (known as pacifiers in the US) can calm a crying baby in seconds, so their appeal is obvious. However, a new study warns there could be a price to pay. Magdalena Rychlowska and her colleagues claim that because dummies obscure babies' faces, they interfere with the way that adults respond to babies' emotions.The researchers used electrodes to record the facial muscles of 29 women (average age 21; two of them were mothers) while they looked at photographs of two young babies expressing ha........ Read more »
Rychlowska, M., Korb, S., Brauer, M., Droit-Volet, S., Augustinova, M., Zinner, L., & Niedenthal, P. (2014) Pacifiers Disrupt Adults’ Responses to Infants’ Emotions. Basic and Applied Social Psychology, 36(4), 299-308. DOI: 10.1080/01973533.2014.915217
by Rita Handrich in The Jury Room
We’ve written a number of times about bias against Muslims. But here’s a nice article with an easy to incorporate finding on how to reduce bias against your female client who wears a Muslim head-covering. (In case you have forgotten, we’ve already written about head-coverings for the Muslim man.) The graphic illustrating this post shows […]
Simple Jury Persuasion: Tilt your head. (no kidding)
Simple Jury Persuasion: In the face of ambiguity, we just make stuff up!
S........ Read more »
Everett, J., Schellhaas, F., Earp, B., Ando, V., Memarzia, J., Parise, C., Fell, B., & Hewstone, M. (2014) Covered in stigma? The impact of differing levels of Islamic head-covering on explicit and implicit biases toward Muslim women. Journal of Applied Social Psychology. DOI: 10.1111/jasp.12278
Taste is one of our five basic senses, and every child is taught that you use the tongue to taste things. But science is proving that many other tissues can taste what you ingest.... Read more »
Depoortere I. (2014) Taste receptors of the gut: emerging roles in health and disease. Gut, 63(1), 179-90. PMID: 24131638
Liggett SB. (2013) Bitter taste receptors on airway smooth muscle as targets for novel bronchodilators. Expert opinion on therapeutic targets, 17(6), 721-31. PMID: 23577615
Lee RJ, & Cohen NA. (2013) The emerging role of the bitter taste receptor T2R38 in upper respiratory infection and chronic rhinosinusitis. American journal of rhinology , 27(4), 283-6. PMID: 23883809
Deshpande DA, Wang WC, McIlmoyle EL, Robinett KS, Schillinger RM, An SS, Sham JS, & Liggett SB. (2010) Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction. Nature medicine, 16(11), 1299-304. PMID: 20972434
Mosinger B, Redding KM, Parker MR, Yevshayeva V, Yee KK, Dyomina K, Li Y, & Margolskee RF. (2013) Genetic loss or pharmacological blockade of testes-expressed taste genes causes male sterility. Proceedings of the National Academy of Sciences of the United States of America, 110(30), 12319-24. PMID: 23818598
"This is the first study to identify an increased risk for neurodevelopmental disorders in patients with hypospadias, as well as an increased risk for ASD [autism spectrum disorders] in their brothers, suggesting a common familial (genetic and/or environmental) liability".Rainy days and Mondays... @ Wikipedia That was the conclusion reached in the study by Agnieszka Butwicka and colleagues  looking at various neurodevelopmental outcomes associated with a diagnosis of ........ Read more »
Butwicka A, Lichtenstein P, Landén M, Nordenvall AS, Nordenström A, Nordenskjöld A, & Frisén L. (2014) Hypospadias and increased risk for neurodevelopmental disorders. Journal of child psychology and psychiatry, and allied disciplines. PMID: 25048198
Take Home Message: Sports-related injuries among teenagers accounts for over 430,000 emergency room visits in the United States in 2008 and represent a significant financial burden to the healthcare system.
Sports-related injuries in teenagers result in a significant number of emergency room visits, which can result in relatively large direct costs. However, little is known about national estimates of how many emergency room visits actually occur as well as the direct costs affiliated ........ Read more »
Nalliah RP, Anderson IM, Lee MK, Rampa S, Allareddy V, & Allareddy V. (2014) Epidemiology of Hospital-Based Emergency Department Visits Due to Sports Injuries. Pediatric Emergency Care, 30(8), 511-515. PMID: 25062295
One of the problems with an aspirational and non-prescriptive definition of recovery is that it is hard to measure. The definitions most commonly featured in the literature share some elements including wellbeing or health, abstinence and citizenship. Clearly if you can’t define it precisely, then it’s hard to commission services to deliver on it. In [...]
The post “You’re all going to hate the word ‘recovery’” appeared first on Recovery Review.
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Neale, J., Tompkins, C., Wheeler, C., Finch, E., Marsden, J., Mitcheson, L., Rose, D., Wykes, T., & Strang, J. (2014) “You’re all going to hate the word ‘recovery’ by the end of this”: Service users’ views of measuring addiction recovery. Drugs: Education, Prevention, and Policy, 1-9. DOI: 10.3109/09687637.2014.947564
My wife likes to sanitize everything with bleach. I don’t really approve, but I bite my tongue because it makes her feel better. Germs are everywhere and honestly there is […]... Read more »
Pycke BF, Geer LA, Dalloul M, Abulafia O, Jenck AM, & Halden RU. (2014) Human biomonitoring of prenatal exposure to triclosan and triclocarban in a multiethnic urban population from Brooklyn, New York. Environmental Science , 8831-8838. info:/10.1021/es501100w
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