by Mike Levin in the Node
My lab works on developmental bioelectricity, studying how cells communicate via endogenous gradients of plasma membrane resting potential (Vmem) in order to coordinate their activity during pattern regulation (Levin, 2013; Levin, 2014b; Tseng and Levin, 2013). It is well-known that resting potential is an important regulatory parameter for individual cells’ proliferation, differentiation, and oncogenic potential[...]
The post Gap junctions: versatile mediators of long-range de........ Read more »
Pai, V., Lemire, J., Pare, J., Lin, G., Chen, Y., & Levin, M. (2015) Endogenous Gradients of Resting Potential Instructively Pattern Embryonic Neural Tissue via Notch Signaling and Regulation of Proliferation. Journal of Neuroscience, 35(10), 4366-4385. DOI: 10.1523/JNEUROSCI.1877-14.2015
Sorting through the confusing array of allergy medications by learning how they work.... Read more »
Ariano R, Berto P, Tracci D, Incorvaia C, & Frati F. (2006) Pharmacoeconomics of allergen immunotherapy compared with symptomatic drug treatment in patients with allergic rhinitis and asthma. Allergy and asthma proceedings : the official journal of regional and state allergy societies, 27(2), 159-63. PMID: 16724637
Nasser S, Vestenbaek U, Beriot-Mathiot A, & Poulsen PB. (2008) Cost-effectiveness of specific immunotherapy with Grazax in allergic rhinitis co-existing with asthma. Allergy, 63(12), 1624-9. PMID: 19032235
Wallace DV, Dykewicz MS, Bernstein DI, Blessing-Moore J, Cox L, Khan DA, Lang DM, Nicklas RA, Oppenheimer J, Portnoy JM.... (2008) The diagnosis and management of rhinitis: an updated practice parameter. The Journal of allergy and clinical immunology, 122(2 Suppl). PMID: 18662584
Derendorf H, & Meltzer EO. (2008) Molecular and clinical pharmacology of intranasal corticosteroids: clinical and therapeutic implications. Allergy, 63(10), 1292-300. PMID: 18782107
OK, a few choice words to start: the National Health Insurance Research Database (NHIRD), nationwide cohort study, large participant numbers.That's right. Yet again Taiwan continues to give when it comes to research based on that very useful national health insurance program. Regular readers will already know that I'm a fan of this resource. This time around the results come in the form of the paper published by Yao-Tung Lee and colleagues  (open-access) who suggested that: "Clinicians s........ Read more »
Lee YT, Hu LY, Shen CC, Huang MW, Tsai SJ, Yang AC, Hu CK, Perng CL, Huang YS, & Hung JH. (2015) Risk of Psychiatric Disorders following Irritable Bowel Syndrome: A Nationwide Population-Based Cohort Study. PloS one, 10(7). PMID: 26222511
MedicalResearch.com Interview with: Meera Sheffrin MD Geriatrics Fellow Division of Geriatrics | Department of Medicine San Francisco VA Medical Center University of California, San Francisco Medical Research: What is the background for this study? What are the main findings? Dr. … Continue reading →
The post Dementia Patients on Cholinesterase Inhibitors Risk Substantial Weight Loss appeared first on MedicalResearch.com Medical Research Interviews and News.
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Meera Sheffrin MD. (2015) Dementia Patients on Cholinesterase Inhibitors Risk Substantial Weight Loss. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Misha A. Rosenbach, MD Assistant Professor of Dermatology at the Hospital of the University of Pennsylvania Assistant Professor of Dermatology in Medicine Medical Research: What is the background for this study? What are the main findings? Dr. … Continue reading →
The post Penn Developed Sarcoidosis Score Reliably Measures Disease Activity appeared first on MedicalResearch.com Medical Research Interviews and News.
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Misha A. Rosenbach, MD. (2015) Penn Developed Sarcoidosis Score Reliably Measures Disease Activity. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Scott A. Adler, Ph.D. Associate Professor Coordinator Developmental Science Graduate Program Dept. of Psychology & Centre for Vision Research Visual and Cognitive Development Project York University Toronto, Ontario Canada Medical Research: What is the background for … Continue reading →
The post C- Section May Raise Attention Deficit Risk in Neonates appeared first on MedicalResearch.com Medical Research Interviews and News.
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Scott A. Adler, Ph.D. (2015) C- Section May Raise Attention Deficit Risk in Neonates. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Bradley C. Clark, MD Pediatric Cardiology Fellow – 3rd Year Division of Cardiology Children’s National Health System Washington, DC 20010 Medical Research: What is the background for this study? What are the main findings? Dr. Clark: After consulting on … Continue reading →
The post Synthetic Cannabinoids Put Teenagers at Cardiac Risk appeared first on MedicalResearch.com Medical Research Interviews and News.
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Bradley C. Clark, MD. (2015) Synthetic Cannabinoids Put Teenagers at Cardiac Risk. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Prof. Hanns-Ulrich Marschall Professor of clinical hepatology Wallenberg Laboratory Sahlgrenska Academy Göteborg, Sweden Medical Research: What is the background for this study? Dr. Marschall: Intrahepatic cholestasis of pregnancy, or ICP, is the most common liver disease during … Continue reading →
The post Liver Inflammation During Pregnancy Linked To Later Life Cancer, Cardiac and Autoimmune Disease appeared first on MedicalResearch.com Medical........ Read more »
Prof. Hanns-Ulrich Marschall. (2015) Liver Inflammation During Pregnancy Linked To Later Life Cancer, Cardiac and Autoimmune Disease. MedicalResearch.com. info:/
Although now obsolete, the use of crudely processed hunks of flesh cut out of dead animals in the treatment of various diseases was widespread in the past. These fleshy parts, usually glands or organs, contain hormones and vitamins necessary for good health that at the time had either not yet been isolated or were difficult/expensive to isolate and use as drugs. They were prepared and administered in several ways: pulverized and snorted, purified somewhat and injected, or cooked up and eaten. Un........ Read more »
Mahon, W., Scott, D., Ansell, G., Manson, G., & Fraser, R. (1967) Hypersensitivity to pituitary snuff with miliary shadowing in the lungs. Thorax, 22(1), 13-20. DOI: 10.1136/thx.22.1.13
Decision making in an enormous range of tasks involves the accumulation of evidence in support of different hypotheses. One of the enduring models of evidence accumulation is the Markov random walk (MRW) theory, which assigns a probability to each hypothesis. In an MRW model of decision making, when deciding between two hypotheses, the cumulative evidence for and against each hypothesis reaches different levels at different times, moving particle-like from state to state and only occupying a sin........ Read more »
Kvam, P., Pleskac, T., Yu, S., & Busemeyer, J. (2015) Interference effects of choice on confidence: Quantum characteristics of evidence accumulation. Proceedings of the National Academy of Sciences, 201500688. DOI: 10.1073/pnas.1500688112
The ClinicalTrials.gov initiative was created with the purpose to establish a platform for recording information on clinical trials conducted by public organizations (research institutes and government agencies) and private (pharmaceutical companies). A recent study published in the New England Journal of Medicine, however, shows a worrying scenario. Despite the requirement to register clinical trials in a publicly accessible base, a small fraction of them are published in scientific journals, c........ Read more »
Anderson, M., Chiswell, K., Peterson, E., Tasneem, A., Topping, J., & Califf, R. (2015) Compliance with Results Reporting at ClinicalTrials.gov. New England Journal of Medicine, 372(11), 1031-1039. DOI: 10.1056/NEJMsa1409364
This week’s tip is not our usual short video. We’ll connect you to our newest tutorial suite, our World Tour of Genomics Resources, part II. Our previous tour was really popular–because as much as bench researchers know about the tools they currently use–everyone realizes there are more tools out there. And many of them don’t […]... Read more »
Williams, J., Mangan, M., Perreault-Micale, C., Lathe, S., Sirohi, N., & Lathe, W. (2010) OpenHelix: bioinformatics education outside of a different box. Briefings in Bioinformatics, 11(6), 598-609. DOI: 10.1093/bib/bbq026
And that toys are important in photographs of adoptable cats.We all assume that internet photos and adverts play an important role in pet adoption these days, and now it’s possible to put a figure on it, at least for cats. 82.5% of people who adopted a cat from a shelter in Western New York said Petfinder strongly or moderately influenced their adoption. The length of time cats waited for adoption varied from 1 to 126 days. Cats whose Petfinder profiles were clicked more than once a day were t........ Read more »
Lampe, R., & Witte, T. (2014) Speed of Dog Adoption: Impact of Online Photo Traits. Journal of Applied Animal Welfare Science, 1-12. DOI: 10.1080/10888705.2014.982796
Siettou, C., Fraser, I., & Fraser, R. (2014) Investigating Some of the Factors That Influence “Consumer” Choice When Adopting a Shelter Dog in the United Kingdom. Journal of Applied Animal Welfare Science, 17(2), 136-147. DOI: 10.1080/10888705.2014.883924
Workman, M., & Hoffman, C. (2015) An Evaluation of the Role the Internet Site Petfinder Plays in Cat Adoptions. Journal of Applied Animal Welfare Science, 1-10. DOI: 10.1080/10888705.2015.1043366
The things that can happen to twins in the womb before they can be born are bizarre. Some get absorbed by their sibling and some just vanish. Two conjoined twins might grow differently and one may becomes a parasite – one boy just had a second face coming out of his chest that could smile, blink and cry. Even scarier - many of you are harboring a twin right now.... Read more »
Navaei AA, Habibi Z, Moradi E, & Nejat F. (2015) Parasitic rachipagus twins; report of two cases. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 31(6), 1001-3. PMID: 25715843
Daga, B., Chaudhary, V., Ingle, A., Dhamangaokar, V., Jadhav, D., & Kulkarni, P. (2009) Double fetus-in-fetu: CT scan diagnosis in an adult. Indian Journal of Radiology and Imaging, 19(3), 216. DOI: 10.4103/0971-3026.54890
Zahed, L., Oreibi, G., Darwiche, N., & Mitri, F. (2004) Potential trisomy 21 misdiagnosis by amniocentesis due to a resorbed twin. Prenatal Diagnosis, 24(12), 1013-1013. DOI: 10.1002/pd.918
MedicalResearch.com Interview with:
Sharon-Marie Weldon, MSc, RN Department of Surgery and Cancer Imperial College London, UK Dr. Terhi Korkiakangas, PhD, MSc, BSc UCL Institute of Education University College London, UK MedicalResearch: What is the background for this study? Response: Our … Continue reading →
The post Music Can Affect Efficiency in Surgical Operating Rooms appeared first on MedicalResearch.com Medical Research Interviews and News.
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Sharon-Marie Weldon,Terhi Korkiakangas. (2015) Music Can Affect Efficiency in Surgical Operating Rooms. MedicalResearch.com. info:/
Experts often exhibit "overclaiming" –believing they know things that they don't.If you consider yourself a science buff, see if any of these terms seem familiar: meta-toxin, bio-sexual, retroplex. Ringing any bells? If so, you may be surprised to hear that these terms are entirely made-up. They are “trap items” invented to study overclaiming, the claiming of knowledge you could not possibly possess. If you overclaimed, you’re not alone; one early study showed as many as one in five........ Read more »
Atir, S., Rosenzweig, E., & Dunning, D. (2015) When Knowledge Knows No Bounds: Self-Perceived Expertise Predicts Claims of Impossible Knowledge. Psychological Science, 26(8), 1295-1303. DOI: 10.1177/0956797615588195
I'll freely admit that the paper by Lieve Thienpont and colleagues  (open-access available here) made me feel rather uncomfortable. With the objective of identifying "patterns in euthanasia requests and practices relating to psychiatric patients", authors detailed the experiences of 100 Belgian patients requesting euthanasia - 'the act of deliberately ending a person's life to relieve suffering' - through a retrospective case note review. Euthanasia is legal in Belgium under certain........ Read more »
Thienpont L, Verhofstadt M, Van Loon T, Distelmans W, Audenaert K, & De Deyn PP. (2015) Euthanasia requests, procedures and outcomes for 100 Belgian patients suffering from psychiatric disorders: a retrospective, descriptive study. BMJ open, 5(7). PMID: 26216150
Two years after anterior cruciate ligament (ACL) reconstruction, a patient who was treated with patellar tendon grafts was less likely to sustain reinjury than a patient who received a hamstring graft. Further, a younger patient (27 years old or younger) was more likely to have an adverse event than an older patient.... Read more »
Mohtadi, N., Chan, D., Barber, R., & Paolucci, E. (2015) Reruptures, Reinjuries, and Revisions at a Minimum 2-Year Follow-up. Clinical Journal of Sport Medicine, 1. DOI: 10.1097/JSM.0000000000000209
MedicalResearch.com Interview with: Prof. Der-Cherng Tarng, MD, PhD Division of Nephrology Taipei Veterans General Hospital, and National Yang-Ming University, Taiwan MedicalResearch: What is the background for this study? What are the main findings? Prof. Tarng: Metformin is generally recommended as … Continue reading →
The post Metformin Linked With Increased Mortality In Diabetic Kidney Disease Patients appeared first on MedicalResearch.com Medical Research Interviews and News.
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Prof. Der-Cherng Tarng, MD, Ph. (2015) Metformin Linked With Increased Mortality In Diabetic Kidney Disease Patients. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Alain H. Rook, M.D. Professor of Dermatology University of Pennsylvania Philadelphia, PA 19104 and Rachael A. Clark, M.D., Ph.D. Department of Dermatology Brigham and Women’s Hospital Boston, MA 02115 Researchers’ summary: In this paper, Dr. Rachael Clark … Continue reading →
The post Treated and Untreated CTCL Lesions Resolved With Topical Resiquimod appeared first on MedicalResearch.com Medical Research Interviews and News.
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Alain H. Rook, M.D. (2015) Treated and Untreated CTCL Lesions Resolved With Topical Resiquimod. MedicalResearch.com. info:/
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