Post List

  • April 29, 2016
  • 07:02 AM
  • 194 views

Phubbing, more FOMO, blonde jokes, and what holds our  attention?

by Rita Handrich in The Jury Room

It’s time to run down some articles that are curious, but not substantial enough to justify a full blog post. Once again, we have kept a few pearls in our virtual filing cabinet, and have combined them here for your curiosity and possibly entertainment. This is one of those combination posts that will offer you […]

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Does this mean we need to pay no attention to 1 in  10 research f........ Read more »

  • April 29, 2016
  • 05:41 AM
  • 180 views

Review, Refine, Redesign

by AG McCluskey in Zongo's Cancer Diaries

Drug Discovery, Part III

How is a an Initial Hit optimised and turned into a Lead Compound?... Read more »

Hughes, J., Rees, S., Kalindjian, S., & Philpott, K. (2011) Principles of early drug discovery. British Journal of Pharmacology, 162(6), 1239-1249. DOI: 10.1111/j.1476-5381.2010.01127.x  

AG McCluskey. (2016) Review, Refine, Redesign. Zongo's Cancer Diaries. info:/

  • April 29, 2016
  • 04:54 AM
  • 75 views

Looking back on your past can make you less likely to suffer depression in the future

by BPS Research Digest in BPS Research Digest

Is spending time looking back on our lives good for our mental health? A lot of research suggests it is, but these studies have been cross-sectional, making it hard to form a clear causal story – for example, perhaps being happier makes it more likely that people will reminisce. On the other hand, there are therapeutic trials that show purposeful reminiscence can bring about clinically meaningful decreases in depression. Now, a longitudinal investigation in Applied Cognitive Psychology provide........ Read more »

  • April 29, 2016
  • 04:34 AM
  • 207 views

Why organisations should encourage their staff to become friends

by BPS Research Digest in BPS Research Digest

They say you should never mix business and pleasure but in reality many of us find that we become friends with the people who we work with. No wonder, when you consider the hours spent together and the deep bonds formed through collaboration and sharing the highs and lows of the job.A new study in Personnel Psychology is among the first to examine the effects on job performance of having more "multiplex relationships" – colleagues you work with directly who are also your friends outside of wor........ Read more »

  • April 29, 2016
  • 02:33 AM
  • 211 views

Organophosphate exposure and ADHD?

by Paul Whiteley in Questioning Answers

"Children with higher urinary DMP [dimethylphosphate] concentrations may have a twofold to threefold increased risk of being diagnosed with ADHD [attention-deficit hyperactivity disorder]."So said the results presented in the paper by Yu and colleagues [1] who looking at "97 doctor-diagnosed ADHD cases and 110 non-ADHD controls who were 4-15 years of age" examined urine and blood samples for various factors including "biomarkers of OP [organophosphate] pesticide exposure." Th........ Read more »

  • April 28, 2016
  • 05:33 PM
  • 197 views

MERS-CoV and antiviral singling: role of orf4b and M protein

by thelonevirologist in Virology Tidbits

Coronaviruses (CoV) are positive sense RNA viruses with a genome size of 29-32 kb with four genera (Alpha-, Beta-, Gamma- and Delta CoV) belonging to the family of the Coronaviridae within the order of Nidovirales, with the Betacoronaviruses further divided into four lineages (A-D).

Most CoV identified until now are causing severe disease only in animals including agricultural important animals such as chicken, cattle, and pigs. To date only six human CoV (HCoV) have been identified, namely ........ Read more »

Han, H., Wen, H., Zhou, C., Chen, F., Luo, L., Liu, J., & Yu, X. (2015) Bats as reservoirs of severe emerging infectious diseases. Virus Research, 1-6. DOI: 10.1016/j.virusres.2015.05.006  

Menachery VD, Yount BL Jr, Sims AC, Debbink K, Agnihothram SS, Gralinski LE, Graham RL, Scobey T, Plante JA, Royal SR.... (2016) SARS-like WIV1-CoV poised for human emergence. Proceedings of the National Academy of Sciences of the United States of America. PMID: 26976607  

Munster, V., Adney, D., van Doremalen, N., Brown, V., Miazgowicz, K., Milne-Price, S., Bushmaker, T., Rosenke, R., Scott, D., Hawkinson, A.... (2016) Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis). Scientific Reports, 21878. DOI: 10.1038/srep21878  

Thornbrough JM, Jha BK, Yount B, Goldstein SA, Li Y, Elliott R, Sims AC, Baric RS, Silverman RH, & Weiss SR. (2016) Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation. mBio, 7(2). PMID: 27025250  

Li Y, Banerjee S, Wang Y, Goldstein SA, Dong B, Gaughan C, Silverman RH, & Weiss SR. (2016) Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses. Proceedings of the National Academy of Sciences of the United States of America, 113(8), 2241-6. PMID: 26858407  

Castelli, J., Wood, K., & Youle, R. (1998) The 2-5A system in viral infection and apoptosis. Biomedicine , 52(9), 386-390. DOI: 10.1016/S0753-3322(99)80006-7  

  • April 28, 2016
  • 11:30 AM
  • 165 views

Sophie Deneve and the efficient neural code

by neuroecology in Neuroecology

Neuroscientists have a schizophrenic view of how neurons. On the one hand, we say, neurons are ultra-efficient and are as precise as possible in their encoding of the world. On the other hand, neurons are pretty noisy, with the variability in … Continue reading →... Read more »

Denève, S., & Machens, C. (2016) Efficient codes and balanced networks. Nature Neuroscience, 19(3), 375-382. DOI: 10.1038/nn.4243  

  • April 28, 2016
  • 10:45 AM
  • 192 views

Phylo.io a new interactive way of visualising and comparing trees

by Christophe Dessimoz in Open Reading Frame

The paper introducing our new tree visualisation tool Phylo.io was just published in MBE.

Yet another tool to display trees, you might say, and indeed, so it is. But for all the tools that have been developed over the years, there are very few that scale to large trees, make it easy to compare trees side-by-side, and simply run in a browser on any computer or mobile device.

To fill this gap, we created Phylo.io.

Story behind the paper

The project started as a student summer internshi........ Read more »

  • April 28, 2016
  • 09:33 AM
  • 228 views

Breathing Bordeaux is entirely different from drinking it!

by Rosin Cerate in Rosin Cerate

It was the summer of 1882, and grape farmers in the Médoc region of southwest France (north of Bordeaux, on the Atlantic coast) had a problem.Schoolchildren (or university students, or just anyone travelling the roads along which the grapevines grew, depending on what source you're reading) were pilfering their grapes. To try and ward them off, some farmers decided to dissolve some slaked lime and copper sulfate in water and spray it on their grapevines closest to the roads. The idea was... Read more »

  • April 28, 2016
  • 06:19 AM
  • 229 views

Portrait of a linguistic shirker

by Ingrid Piller in Language on the Move








I recently pointed out that the widespread belief that migrants refuse to learn the language of their new country does not stack up against the realities of adult language learning. I summarized the research that shows that adult language learning is complex and difficult and rarely an all-out success; to blame migrants for their failure to learn a new language (well) is adding insult to injury.
The German-language club (“Stammtisch”) in New York founded by G........ Read more »

  • April 28, 2016
  • 03:46 AM
  • 181 views

The Neural Precursors of Spontaneous Thoughts

by Neuroskeptic in Neuroskeptic_Discover

Back in 2013, I wondered if we would ever discover the neural basis of spontaneous thoughts. Why, I asked, do certain ideas just "pop" into our minds at particular times? Now a new paper published in Neuroimage, Canadian neuroscientists Melissa Ellamil and colleagues reports on the neural basis of spontaneous thoughts.



Ellamil et al. recruited a group of 18 volunteers, all of whom were highly experienced practitioners of mindfulness meditation. These individuals were selected, the authors... Read more »

  • April 28, 2016
  • 02:55 AM
  • 212 views

What parents of children with autism expect from their child's therapists

by Paul Whiteley in Questioning Answers

"Parents ultimately wanted therapists to produce positive outcomes for their children and were willing to sacrifice other desired qualities, as long as the therapy program was effective."and"The SLPs [Speech-Language Pathologists] expressed strong support for evidence-based practice (EBP) and indicated that they thought parents expected their children would be provided with evidence-based interventions."Those quotes come from two papers recently published in the same journal; the first........ Read more »

  • April 27, 2016
  • 04:55 PM
  • 330 views

Addiction, it’s in your genes… maybe

by Dr. Jekyll in Lunatic Laboratories

Why does one person who tries cocaine get addicted, while another might use it and then leave it alone? Why do some people who kick a drug habit manage to stay clean, while others relapse? And why do some families seem more prone to addiction than others? According to a new study, the road to answering these questions may have a lot to do with specific genetic factors that vary from individual to individual.

... Read more »

Flagel, S., Chaudhury, S., Waselus, M., Kelly, R., Sewani, S., Clinton, S., Thompson, R., Watson, S., & Akil, H. (2016) Genetic background and epigenetic modifications in the core of the nucleus accumbens predict addiction-like behavior in a rat model. Proceedings of the National Academy of Sciences, 201520491. DOI: 10.1073/pnas.1520491113  

  • April 27, 2016
  • 04:42 PM
  • 250 views

Measuring happiness on social media

by Dr. Jekyll in Lunatic Laboratories

Happiness. It’s something we all strive for, but how do we measure it — as a country? A global community? Not so surprisingly, researchers are turning to social media to answer these questions and more. In a newly published study, computer scientists used two years of Twitter data to measure users’ life satisfaction, a component of happiness.

... Read more »

  • April 27, 2016
  • 02:23 PM
  • 217 views

Rafting Ants Have Designated Stations

by Elizabeth Preston in Inkfish



Sometimes at the climax of a Star Trek episode, the captain would yell out "Battle stations!" and send the crew scurrying frantically through the corridors. It wasn't really clear what those battle stations were. Presumably, crew members headed to posts they'd been previously assigned, and this let the whole ship react to the crisis efficiently.

Certain ants respond to a crisis by binding their bodies together into floating rafts. And like the Star Trek crew, they seem to have designat........ Read more »

  • April 27, 2016
  • 10:35 AM
  • 214 views

Food to Restore a Heart

by Aurametrix team in Health Technologies

We know that diet, exercise and low-stress life will keep the heart healthy. But sometimes things happen that are beyond our control. Thanks to more coordinated, faster emergency response and improved treatment, heart attacks aren't as deadly as they used to be. But survivors still face a substantial risk of further cardiovascular events. How to restore after a heart attack and prevent another one? What to do besides obvious things such as taking medications, reducing stress, calories, avoidin........ Read more »

Li S, Flint A, Pai JK, Forman JP, Hu FB, Willett WC, Rexrode KM, Mukamal KJ, & Rimm EB. (2014) Low carbohydrate diet from plant or animal sources and mortality among myocardial infarction survivors. Journal of the American Heart Association, 3(5). PMID: 25246449  

  • April 27, 2016
  • 10:00 AM
  • 165 views

Why Science Matters to Our Dogs and Cats

by CAPB in Companion Animal Psychology Blog

Science – and science blogging – can help animal welfare in important ways.We wish our companion animals to lead a charmed life and always be happy. We want our dogs and cats to have a wonderful relationship with us. But we can’t achieve this if we don’t know what they need and how we should interact with them.Last year, some readers took part in a survey of who reads science blogs. The preliminary results are out, and it’s got me thinking about why science – and science blogging –........ Read more »

  • April 27, 2016
  • 09:39 AM
  • 160 views

Video Tip of the Week: SoyBase CMap

by Mary in OpenHelix

Over the years I’ve started to follow a lot of farmers on twitter. It might sound odd to folks who are immersed in human genomics and disease. But I actually find the plant and animal genomics communities to be pushing tech faster and further to the hands of end-users than a lot of the clinical […]... Read more »

Grant, D., Nelson, R., Cannon, S., & Shoemaker, R. (2009) SoyBase, the USDA-ARS soybean genetics and genomics database. Nucleic Acids Research, 38(Database). DOI: 10.1093/nar/gkp798  

  • April 27, 2016
  • 08:35 AM
  • 229 views

Your Body Has A Photographic Memory

by Mark Lasbury in As Many Exceptions As Rules

For the first time anywhere - an easy explanation of your immune system in 1500 words! For the low, low price of zero dollars you can find out how your body protects you better the second time you are exposed to a disease. Special bonus offer – we’ll throw in how vaccines work and why you need one every year for the flu, although your old flu vaccines might still be helping you. ... Read more »

  • April 27, 2016
  • 07:02 AM
  • 97 views

A cure for the know-it-all: “Reflecting on explanatory ability” 

by Doug Keene in The Jury Room

Most of us think we know more than we actually do and sometimes, that sense is taken to an extreme that can be annoying (as well as inaccurate). Two years ago, we wrote about a study on modulating political extremism and mentioned the recommended strategy was similar to one we use to topple self-appointed “experts” […]

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Guilt-proneness and the ability to recog........ Read more »

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