All publicly-funded research to be fully accessible by 2020.... Read more »
Enserink, M. (2016) In dramatic statement, European leaders call for ‘immediate’ open access to all scientific papers by 2020. Science. DOI: 10.1126/science.aag0577
Zika Virus (ZIKV) is an emerging member of the Flaviviridae that in the past months spread to over 30 countries in the Americas alone that has been associated with the emergence of microcephaly, a condition associated with abnormal brain development, in Brazil and elsewhere.
Recent studies confirmed the presence of ZIKV in the amniotic fluid as well in the brain and CNS of neonates, suggesting that ZIKV can infect embryonal and foetal tissue by crossing the placental barrier. In addition, ZIKV ........ Read more »
Driggers RW, Ho CY, Korhonen EM, Kuivanen S, Jääskeläinen AJ, Smura T, Rosenberg A, Hill DA, DeBiasi RL, Vezina G.... (2016) Zika Virus Infection with Prolonged Maternal Viremia and Fetal Brain Abnormalities. The New England journal of medicine, 374(22), 2142-51. PMID: 27028667
Cugola, F., Fernandes, I., Russo, F., Freitas, B., Dias, J., Guimarães, K., Benazzato, C., Almeida, N., Pignatari, G., Romero, S.... (2016) The Brazilian Zika virus strain causes birth defects in experimental models. Nature. DOI: 10.1038/nature18296
Dang J, Tiwari SK, Lichinchi G, Qin Y, Patil VS, Eroshkin AM, & Rana TM. (2016) Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3. Cell stem cell. PMID: 27162029
Hanners, N., Eitson, J., Usui, N., Richardson, R., Wexler, E., Konopka, G., & Schoggins, J. (2016) Western Zika Virus in Human Fetal Neural Progenitors Persists Long Term with Partial Cytopathic and Limited Immunogenic Effects. Cell Reports. DOI: 10.1016/j.celrep.2016.05.075
Noronha Ld, Zanluca C, Azevedo ML, Luz KG, & Santos CN. (2016) Zika virus damages the human placental barrier and presents marked fetal neurotropism. Memorias do Instituto Oswaldo Cruz, 111(5), 287-93. PMID: 27143490
Joerink M, Rindsjö E, van Riel B, Alm J, & Papadogiannakis N. (2011) Placental macrophage (Hofbauer cell) polarization is independent of maternal allergen-sensitization and presence of chorioamnionitis. Placenta, 32(5), 380-5. PMID: 21419483
Wan Z, Lin X, Li T, Zhou A, Yang M, Hu D, Feng L, Peng S, Fan L, Tu S.... (2016) Genetic variant in CXCL13 gene is associated with susceptibility to intrauterine infection of hepatitis B virus. Scientific reports, 26465. PMID: 27212637
Wu KY, Zuo GL, Li XF, Ye Q, Deng YQ, Huang XY, Cao WC, Qin CF, & Luo ZG. (2016) Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice. Cell research, 26(6), 645-54. PMID: 27174054
Garcez PP, Loiola EC, Madeiro da Costa R, Higa LM, Trindade P, Delvecchio R, Nascimento JM, Brindeiro R, Tanuri A, & Rehen SK. (2016) Zika virus impairs growth in human neurospheres and brain organoids. Science (New York, N.Y.), 352(6287), 816-8. PMID: 27064148
Hamel R, Dejarnac O, Wichit S, Ekchariyawat P, Neyret A, Luplertlop N, Perera-Lecoin M, Surasombatpattana P, Talignani L, Thomas F.... (2015) Biology of Zika Virus Infection in Human Skin Cells. Journal of virology, 89(17), 8880-96. PMID: 26085147
Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, Yao B, Shin J, Zhang F, Lee EM.... (2016) Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell stem cell, 18(5), 587-90. PMID: 26952870
Miner JJ, Cao B, Govero J, Smith AM, Fernandez E, Cabrera OH, Garber C, Noll M, Klein RS, Noguchi KK.... (2016) Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise. Cell, 165(5), 1081-91. PMID: 27180225
Bayer A, Lennemann NJ, Ouyang Y, Bramley JC, Morosky S, Marques ET Jr, Cherry S, Sadovsky Y, & Coyne CB. (2016) Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection. Cell host , 19(5), 705-12. PMID: 27066743
Young OM, Tang Z, Niven-Fairchild T, Tadesse S, Krikun G, Norwitz ER, Mor G, Abrahams VM, & Guller S. (2015) Toll-like receptor-mediated responses by placental Hofbauer cells (HBCs): a potential pro-inflammatory role for fetal M2 macrophages. American journal of reproductive immunology (New York, N.Y. : 1989), 73(1), 22-35. PMID: 25345551
MacMicking, J. (2012) Interferon-inducible effector mechanisms in cell-autonomous immunity. Nature Reviews Immunology, 12(5), 367-382. DOI: 10.1038/nri3210
Xu DZ, Yan YP, Zou S, Choi BC, Wang S, Liu P, Bai G, Wang X, Shi M, & Wang X. (2001) Role of placental tissues in the intrauterine transmission of hepatitis B virus. American journal of obstetrics and gynecology, 185(4), 981-7. PMID: 11641689
Ng CT, Mendoza JL, Garcia KC, & Oldstone MB. (2016) Alpha and Beta Type 1 Interferon Signaling: Passage for Diverse Biologic Outcomes. Cell, 164(3), 349-52. PMID: 26824652
Morosky S, Lennemann NJ, & Coyne CB. (2016) BPIFB6 Regulates Secretory Pathway Trafficking and Enterovirus Replication. Journal of virology, 90(10), 5098-107. PMID: 26962226
Arita M, Wakita T, & Shimizu H. (2012) Valosin-containing protein (VCP/p97) is required for poliovirus replication and is involved in cellular protein secretion pathway in poliovirus infection. Journal of virology, 86(10), 5541-53. PMID: 22379090
Burlaud-Gaillard J, Sellin C, Georgeault S, Uzbekov R, Lebos C, Guillaume JM, & Roingeard P. (2014) Correlative scanning-transmission electron microscopy reveals that a chimeric flavivirus is released as individual particles in secretory vesicles. PloS one, 9(3). PMID: 24681578
Ranjbar S, Haridas V, Jasenosky LD, Falvo JV, & Goldfeld AE. (2015) A Role for IFITM Proteins in Restriction of Mycobacterium tuberculosis Infection. Cell reports, 13(5), 874-83. PMID: 26565900
Smith S, Weston S, Kellam P, & Marsh M. (2014) IFITM proteins-cellular inhibitors of viral entry. Current opinion in virology, 71-7. PMID: 24480526
Warren CJ, Griffin LM, Little AS, Huang IC, Farzan M, & Pyeon D. (2014) The antiviral restriction factors IFITM1, 2 and 3 do not inhibit infection of human papillomavirus, cytomegalovirus and adenovirus. PloS one, 9(5). PMID: 24827144
Wang L, Tian Y, & Ou JH. (2015) HCV induces the expression of Rubicon and UVRAG to temporally regulate the maturation of autophagosomes and viral replication. PLoS pathogens, 11(3). PMID: 25807108
Patel A, Mohl BP, & Roy P. (2016) Entry of Bluetongue Virus Capsid Requires the Late Endosome-specific Lipid Lysobisphosphatidic Acid. The Journal of biological chemistry, 291(23), 12408-19. PMID: 27036941
It's official: "the vast majority of high-functioning adults with ASD [autism spectrum disorder] are interested in romantic relationships." Yes, the scientific findings reported by Sandra Strunz and colleagues  have said as much.Sorry to be so sarcastic about them but coming from a place where the words 'the bleedin' obvious' are commonly used, I couldn't believe that in 2016 anyone would genuinely believe otherwise. Yes, I know the autism awareness et al message still has some........ Read more »
Strunz S, Schermuck C, Ballerstein S, Ahlers CJ, Dziobek I, & Roepke S. (2016) Romantic Relationships and Relationship Satisfaction Among Adults With Asperger Syndrome and High-Functioning Autism. Journal of clinical psychology. PMID: 27196958
Headache, Guillaume DELEBARRE (Guigui-Lille)A recent neuroessay in the New York Times asked, Can Tylenol Help Heal a Broken Heart?What’s crazy about the pain of a broken heart is that your body perceives it as physical pain.No it does not. Do you feel heartbroken every time you stub your toe?Well... I guess the social pain = physical pain isomorphism is a one way street. Anyway, the author continued:In research published in 2010, scientists found that acetaminophen can reduce physical and neur........ Read more »
Butcher, B., & Carmody, J. (2012) Sex differences in analgesic response to ibuprofen are influenced by expectancy: A randomized, crossover, balanced placebo-designed study. European Journal of Pain, 16(7), 1005-1013. DOI: 10.1002/j.1532-2149.2011.00104.x
VANGELISTI, A., PENNEBAKER, J., BRODY, N., & GUINN, T. (2014) Reducing social pain: Sex differences in the impact of physical pain relievers. Personal Relationships, 21(2), 349-363. DOI: 10.1111/pere.12036
Scientists have unlocked a crucial part of the mystery as to how our DNA can replicate and repair itself - something which is essential for all life forms. The new research has revealed how branched DNA molecules are removed from the iconic double-helical structure -a process which scientists have been looking to unlock for over 20 years.
... Read more »
AlMalki, F., Flemming, C., Zhang, J., Feng, M., Sedelnikova, S., Ceska, T., Rafferty, J., Sayers, J., & Artymiuk, P. (2016) Direct observation of DNA threading in flap endonuclease complexes. Nature Structural . DOI: 10.1038/nsmb.3241
The size and shape of your junk may depend on how much sex your ancestors had… that is, at least, if you are a burying beetle. Buring beetles caught in the act. Photo by Jena Johnson. Burying beetles are unusual among insects in that they provide parental care and are often monogamous. When burying beetle pairs find a small dead bird or rodent, they pluck it bald, coat it in antibacterial and antifungal body secretions, and dig a hole around it. The female lays her eggs around the carcass-ba........ Read more »
Hopwood, P., Head, M., Jordan, E., Carter, M., Davey, E., Moore, A., & Royle, N. (2016) Selection on an antagonistic behavioral trait can drive rapid genital coevolution in the burying beetle, . Evolution. DOI: 10.1111/evo.12938
As basic and clinical sciences advance, it becomes increasing important to understand the role of multidisciplinary efforts in scientific progress. In this post, I propose rethinking and renaming the medically-related neuroscience disciplines into a new specialty called neuroscience medicine.Basic neuroscience research has evolved and emerged as a powerful discipline due to the increasing use of multidisciplinary research teams. Basic neuroscience involves collaboration of various scientifi........ Read more »
Venture into the Brazilian swamp with Chiara and the Wildlife Conservation Society.... Read more »
Barros, E., Pashanasi, B., Constantino, R., & Lavelle, P. (2002) Effects of land-use system on the soil macrofauna in western Brazilian Amazonia. Biology and Fertility of Soils, 35(5), 338-347. DOI: 10.1007/s00374-002-0479-z
REVEALED: UK cancer scientists' pensions invested in tobacco.
....And this UK cancer scientist, for one, is Not Happy....... Read more »
AG McCluskey. (2016) Best Laid Plans. Zongo's Cancer Diaries. info:/
Seaweed is one of those tricky biological groups, as membership isn't just about being a close relative. It typically includes plant-like organisms found among several types of algae - green, brown, and red - and depending on who you're talking to also includes masses of cyanobacteria (which are distant relatives of algae). Functionally, all seaweeds enjoy growing in salty water and use the sun to manufacture sugary meals for themselves. Their need for sun means they are found in sunlit coastal ........ Read more »
Di Matola T, Zeppa P, Gasperi M, & Vitale M. (2014) Thyroid dysfunction following a kelp-containing marketed diet. BMJ Case Reports. PMID: 25355748
Fuge R. (2007) Iodine deficiency: An ancient problem in a modern world. AMBIO, 36(1), 70-72. DOI: 10.1579/0044-7447(2007)36[70:IDAAPI]2.0.CO;2
by Rita Handrich in The Jury Room
John Oliver recently took on mass media coverage of scientific findings on his HBO show, Last Week Tonight. The result is a searing video mocking the distortions and misinterpretations (and even flat-out lies) about research findings as presented in mass media. Since his episode aired (a link to the video is at the end of […]
Reports of novel or contradictory health research reduces public trust in science
Top 10 Most Read Posts During 2012!
Pew Research says 15% of Ame........ Read more »
Mischkowski D, Crocker J, & Way BM. (2016) From painkiller to empathy killer: acetaminophen (paracetamol) reduces empathy for pain. Social Cognitive and Affective Neuroscience. PMID: 27217114
Depression has been called a "we-disease" because when the dark clouds arrive, it's not just the depressed person who is affected, but all those close to them. A new study in the Journal of Social and Personal Relationship explored these spillover effects in the context of romantic couples, where one or both individuals have a diagnosis of clinical depression. The US study broke new ground by asking both partners in each couple to provide their perspective on how depression had affected their re........ Read more »
Sharabi, L., Delaney, A., & Knobloch, L. (2015) In their own words: How clinical depression affects romantic relationships. Journal of Social and Personal Relationships, 33(4), 421-448. DOI: 10.1177/0265407515578820
Only 39% of respondents from NCAA institutions indicated that they had a written mental health screening plan. There is a wide variability between mental health screening practices among NCAA institutions.... Read more »
Kroshus E. (2016) Variability in Institutional Screening Practices Related to Collegiate Student-Athlete Mental Health. Journal of Athletic Training. PMID: 27111587
Although the public perception of science is that researchers go around 'proving' or 'disproving' that A leads to B or X causes Y, it is still surprisingly rare to see the word 'causal' in many areas of peer-reviewed research. Aside from the fact that science generally works around the concept of 'probability' - producing data pertinent to discussions on whether something is more or less likely to be true/false - most science is not so forthright in its conclusions. Certainly science covering th........ Read more »
Inoshita M, Numata S, Tajima A, Kinoshita M, Umehara H, Nakataki M, Ikeda M, Maruyama S, Yamamori H, Kanazawa T.... (2016) A significant causal association between C-reactive protein levels and schizophrenia. Scientific reports, 26105. PMID: 27193331
Last month I wrote a post about exosome internalization by recipient cells. One of the topics I discussed was the lack of good quantitative data in the exosomal field, and what the current data tells us about the efficiency and … Continue reading →... Read more »
Chiu YJ, Cai W, Shih YV, Lian I, & Lo YH. (2016) A Single-Cell Assay for Time Lapse Studies of Exosome Secretion and Cell Behaviors. Small (Weinheim an der Bergstrasse, Germany). PMID: 27254278
by Jinhyun Cho in Language on the Move
The Linguistic Ethnography Forum’s e-seminar devoted to Ingrid Piller’s recent book Linguistic Diversity and Social Justice: An Introduction to Applied...... Read more »
We recently examined how global and how open the literature on Posttraumatic Stress Disorder is.
Not so global, and not so open.
Only 13% of the publications of 2012 regarded samples in low- or middle-income countries and 58% were behind a paywall.
It worries me that practicing psychologists can’t access the latest research on therapy effectiveness...
... Read more »
Fodor, K., & et al. (2014) Is traumatic stress research global? A bibliometric analysis. European Journal of Psychotraumatology. DOI: 10.3402/ejpt.v5.23269
"Mouse study finds link between gut bacteria and neurogenesis" went the press release accompanying the paper by Luisa Möhle and colleagues  (open-access). Describing the results of a mouse study - that's MOUSE study - researchers reported that "treatment of adult mice with antibiotics decreases hippocampal neurogenesis and memory retention."The antibiotic mix used on study mice was quite an aggressive one: "ampicillin plus sulbactam (1.5 g/l; Pfizer), vancomycin (500 mg/l; Cell Pharm), ........ Read more »
Luisa Möhle, Daniele Mattei, Markus M. Heimesaat, Stefan Bereswill, André Fischer, Marie Alutis, Timothy French, Dolores Hambardzumyan, Polly Matzinger, Ildiko R. Dunay.... (2016) Ly6Chi Monocytes Provide a Link between Antibiotic-Induced Changes in Gut Microbiota and Adult Hippocampal Neurogenesis. Cell Reports. info:/10.1016/j.celrep.2016.04.074
The mosquito-borne Zika virus linked to microcephaly and other neurological problems in newborns of affected mothers directly infects the brain progenitor cells destined to become neurons. The team of researchers used a strain of Zika currently impacting the Americas, and found that the virus infects about 20 percent of cells on average, evades immune system detection, and continues to replicate for weeks.
... Read more »
Natasha W. Hanners,, Jennifer L. Eitson,, Noriyoshi Usui,, R. Blake Richardson,, Eric M. Wexler,, Genevieve Konopka,, & John W. Schoggins. (2016) Western Zika Virus in Human Fetal Neural Progenitors Persists Long Term with Partial Cytopathic and Limited Immunogenic Effects. Cell Reports. DOI: http://dx.org/10.1016/j.celrep.2016.05.075
Are humans natural, irrational optimists? According to many psychologists, humans show a fundamental optimism bias, a tendency to underestimate our chances of suffering negative events. It's said that when thinking about harmful events, such as contracting cancer, most people believe that their risk is lower than that of 'the average person'. So, on average, people rate themselves as safer than the average. Moreover, people are also said to show biased belief updating. Faced with evidence that t........ Read more »
Punit Shah, Adam J. L. Harris, Geoffrey Bird, Caroline Catmur, & Ulrike Hahn. (2016) A Pessimistic View of Optimistic Belief Updating. Cognitive Psychology. info:/
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