Post List

  • July 19, 2010
  • 04:13 PM

[Direct Connection] Sweet and Sour: Glucose-6-Phosphate, Anoxia, and Enzyme Regulation

by Alejandro Montenegro-Montero in MolBio Research Highlights

The “Direct Connection” section of MolBio Research Highlights includes blog posts discussing primary research articles in the field, but the interesting thing about it is that these posts are written by the authors themselves. This allows them to discuss the background, results and implications of their work with a wider audience and in a more relaxed format. Further, as it provides a direct link... Read more »

  • July 19, 2010
  • 04:03 PM

Prehistoric “bear-dog” Amphicyon was built like a “bear-lion”

by Laelaps in Laelaps

In surveying the diversity of living organisms, the 20th century evolutionary theorist Theodosius Dobzhansky did not see "a formless mass of randomly combining genes and traits." Instead he perceived pockets of discontinuity organized around available ecological niches - clusters of occupied "adaptive peaks" separated by rifts and valleys representing vacant spots in the natural world. [...]... Read more »

Christine Argot. (2010) Morphofunctional analysis of the postcranium of Amphicyon major (Mammalia, Carnivora, Amphicyonidae) from the Miocene of Sansan(Gers, France) compared to three extant carnivores: Ursus arctos, Panthera leo, and Canis lupus. Geodivertistas, 32(1), 65-106. info:/

  • July 19, 2010
  • 02:29 PM


by Journal Watch Online in Journal Watch Online

Homo sapiens are dominating an increasing share of the mainland United States. Cities, towns, roads and other human land uses already shape about one-third of the landmass in the Lower 48 states, concludes a new analysis. By 2030, we could add a new “human footprint” the size of Indiana.
That forecast comes from a new […] Read More »... Read more »

  • July 19, 2010
  • 12:19 PM

This Week in the Universe: July 13th – July 19th

by S.C. Kavassalis in The Language of Bad Physics

What have people been talking about this week in high energy physics, astrophysics, gravitation, general relativity and quantum gravity?... Read more »

F. Courbin, M. Tewes, S. G. Djorgovski, D. Sluse, A. Mahabal, F. Rerat, & G. Meylan. (2010) First case of strong gravitational lensing by a QSO : SDSS J0013 1523 at z . Astronomy . arXiv: 1002.4991v2

Daniel T. Cumberbatch, Joyce. A. Guzik, Joseph Silk, L. Scott Watson, & Stephen M. West. (2010) Light WIMPs in the Sun: Constraints from Helioseismology. arXiv. arXiv: 1005.5102v1

Eugenio Bianchi, & Carlo Rovelli. (2010) Why all these prejudices against a constant?. arXiv. arXiv: 1002.3966v3

Attila Meszaros, Lajos G. Balazs, Zsolt Bagoly, & Peter Veres. (2010) Impact on cosmology of the celestial anisotropy of the short gamma-ray bursts. Baltic Astronomy, Vol.18, 293-296 (2009). arXiv: 1005.1558v1

Chris Clarkson, & Roy Maartens. (2010) Inhomogeneity and the foundations of concordance cosmology. Class. Quantum Grav. 27 124008 (2010). arXiv: 1005.2165v2

Mosconi, M., Fujii, K., Mengoni, A., Domingo-Pardo, C., Käppeler, F., Abbondanno, U., Aerts, G., Álvarez-Pol, H., Alvarez-Velarde, F., Andriamonje, S.... (2010) Neutron physics of the Re/Os clock. I. Measurement of the (n,γ) cross sections of ^{186,187,188}Os at the CERN n_TOF facility. Physical Review C, 82(1). DOI: 10.1103/PhysRevC.82.015802  

Nikodem J. Poplawski. (2010) Cosmology with torsion - an alternative to cosmic inflation. arXiv. arXiv: 1007.0587v1

Petr Horava, & Charles M. Melby-Thompson. (2010) General Covariance in Quantum Gravity at a Lifshitz Point. arXiv. arXiv: 1007.2410v1

Samuel E. Gralla, & Robert M. Wald. (2009) Derivation of Gravitational Self-Force. arXiv. arXiv: 0907.0414v1

J. Ambjorn, A. Goerlich, J. Jurkiewicz, & R. Loll. (2010) CDT---an Entropic Theory of Quantum Gravity. arXiv. arXiv: 1007.2560v1

  • July 19, 2010
  • 12:08 PM

Breaking up before you know it

by eHarmony Labs in eHarmony Labs Blog

Can a word test tell you how you feel about your relationship? Read more.... Read more »

  • July 19, 2010
  • 12:04 PM

PI3-kinase (PI3K): a hot topic in cancer research

by Sally Church in Pharma Strategy Blog

Recently at a couple of scientific cancer meetings, American Urology Association (AUA) and American Society of Clinical Oncology (ASCO), Frank McCormick described a fascinating talk about how a wac-a-mole approach to figuring out how the phosphatidylinositol 3'-kinase (PI3-kinase or PI3K)...... Read more »

O'Brien, C., Wallin, J., Sampath, D., GuhaThakurta, D., Savage, H., Punnoose, E., Guan, J., Berry, L., Prior, W., Amler, L.... (2010) Predictive Biomarkers of Sensitivity to the Phosphatidylinositol 3' Kinase Inhibitor GDC-0941 in Breast Cancer Preclinical Models. Clinical Cancer Research, 16(14), 3670-3683. DOI: 10.1158/1078-0432.CCR-09-2828  

Turke, A., & Engelman, J. (2010) PIKing the Right Patient. Clinical Cancer Research, 16(14), 3523-3525. DOI: 10.1158/1078-0432.CCR-10-1201  

Miron, A., Varadi, M., Carrasco, D., Li, H., Luongo, L., Kim, H., Park, S., Cho, E., Lewis, G., Kehoe, S.... (2010) PIK3CA Mutations in In situ and Invasive Breast Carcinomas. Cancer Research, 70(14), 5674-5678. DOI: 10.1158/0008-5472.CAN-08-2660  

  • July 19, 2010
  • 10:00 AM

Y Chromosome II: What Is Even On It?

by Kele in Kele's Science Blog

Last time, we discussed a brief historical account of the Y chromosome research-wise. Initially up to 17 traits were attributed to the chromosome but Stern and later Ohno argued that it was instead largely devoid of gene content. While they were mostly right, and we will see why, that view is now a bit simplistic [...]... Read more »

Mark T. Ross, Darren V. Grafham, Alison J. Coffey, Steven Scherer, Stephan Beck1, Jane Rogers1, & David R. Bentley. (2005) The DNA sequence of the human X chromosome. Nature, 325-337. info:/10.1038/nature03440

Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, Cordum HS, Hillier L, Brown LG, Repping S, Pyntikova T, Ali J, Bieri T.... (2003) The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. Nature, 423(6942), 825-37. PMID: 12815422  

  • July 19, 2010
  • 09:32 AM

Measuring Synchrony - pt 1 of ??

by Brandon Goodell in Bored Lunatic

This is the first in a multi-part series analyzing the paper linked below.  The paper uses several measures of synchrony and tests them against some real-world data to compare their performance.  Today I will be talking about the frequency-coherence measure of synchrony.

I really love being a scientist.  The coolest bit about research, as far as I can tell, is that it's hard.  You are exploring the unknown.  This paper is exploring the unknown - in the past two decade,........ Read more »

  • July 19, 2010
  • 09:19 AM

DMS(P): the amazing story of a pervasive indicator molecule in the marine food web

by Hannah Waters in Culturing Science – biology as relevant to us earthly beings

Dimethylsulfide.  Does that word mean anything to you?  “Why yes,” you organic chemistry nerds may say, “It clearly is a molecule of sulfur with two methyl groups attached.”  That’s as far as I could have gotten – until this past week, when I inundated myself with information on dimethylsulfide (DMS) due to a paper published [...]... Read more »

G. V. Wolfe, M. Steinke, & G. O. Kirst. (1997) Grazing-activated chemical defence in a unicellular marine alga. Nature, 894-897. info:/

  • July 19, 2010
  • 08:00 AM

We Believe Because We Evolved That Way part one

by Lorimer Moseley in BodyInMind

Why we have a placebo effect – Part I By Peter Blanch For a long time now, I have stood with my feet precariously placed on two icebergs that sometimes slowly drift apart and sometimes drift back together again (obviously increasing and decreasing my sensation of precariousness).  The first iceberg is where I started as [...]... Read more »

Watts, G. (2001) The power of nothing . New Scientist . info:/

  • July 19, 2010
  • 08:00 AM

The continued increase in human longevity

by EcoPhysioMichelle in C6-H12-O6 (old)

I have a raging science crush on Tom Kirkwood, the director of the Institute for Ageing and Health at Newcastle University. I was lucky enough to read one of his manuscripts in the review stage several years ago, and ever since then I’ve been absolutely hooked on his work on human aging. In undergrad I [...]... Read more »

Kirkwood, T. (2008) A systematic look at an old problem. Nature, 451(7179), 644-647. DOI: 10.1038/451644a  

  • July 19, 2010
  • 08:00 AM

Neural plasticity isn’t new

by Zen Faulkes in NeuroDojo

A recent post on neuroscience of learning got me thinking about how several people are talking about brain plasticity as though it is a huge revelation of the last couple of decades. From the post:

Only twenty years ago most people in the world of neuroscience believed that the connections between the neurons in your brain were fixed by the time you were a teenager (or even younger)
This is a distortion of history, I think. Ideas about neural plasticity were bubbling around well before 1990s. F........ Read more »

Castellucci VF, & Kandel ER. (1974) A Quantal Analysis of the Synaptic Depression Underlying Habituation of the Gill-Withdrawal Reflex in Aplysia. Proceedings of the National Academy of Sciences of the United States of America, 71(12), 5004-5008. info:/

  • July 19, 2010
  • 07:57 AM

Tales of Passion and Disgust

by The Neurocritic in The Neurocritic

Robert Mapplethorpe - St. SebastianThe previous post (Pleasure or Pain?) described the visual stimuli and behavioral results (subjective emotional ratings) from an experiment examining brain activity in response to pictures from four categories: neutral, disgust-inducing, erotic, and sadomasochistic (Stark et al., 2005). The participants were 24 adults, 12 of whom identified as having sadomasochistic sexual preferences (SM) and 12 without (non-SM).Some of the results were of no surprise to an........ Read more »

STARK, R., SCHIENLE, A., GIROD, C., WALTER, B., KIRSCH, P., BLECKER, C., OTT, U., SCHAFER, A., SAMMER, G., & ZIMMERMANN, M. (2005) Erotic and disgust-inducing pictures—Differences in the hemodynamic responses of the brain. Biological Psychology, 70(1), 19-29. DOI: 10.1016/j.biopsycho.2004.11.014  

  • July 19, 2010
  • 07:14 AM

Looking at a scary future

by Becky in It Takes 30

Roy Kishony pointed me to this fascinating but worrying paper (D’Costa et al.  2006.  Sampling the antibiotic resistome Science. 311 374-7), which has apparently influenced the work of the Kishony lab quite a bit. The authors wanted to know what kinds of antibiotic resistance genes exist in the wild.  Often it turns out that the [...]... Read more »

D'Costa VM, McGrann KM, Hughes DW, & Wright GD. (2006) Sampling the antibiotic resistome. Science (New York, N.Y.), 311(5759), 374-7. PMID: 16424339  

  • July 19, 2010
  • 07:05 AM

Sex after dawn: Marriage and natural selection

by Jeremy Yoder in Denim and Tweed

The book Sex at Dawn, by Christopher Ryan and Cacilda Jethá, has had a lot of press in the last month—it first popped up on my radar with Eric Michael Johnson's review for SEED, and then it became unavoidable (for me, anyway) when Dan Savage devoted a whole column and podcast to it. The thesis of Sex at Dawn is that early humans were highly promiscuous, and that modern expectations of monogamy are probably not consistent with our biology. I haven't read the book yet, but the discussion surrou........ Read more »

  • July 19, 2010
  • 06:56 AM

It's never too late to memorise a 60,000 word poem

by BPS Research Digest in BPS Research Digest

Pounding the treadmill in 1993, John Basinger, aged 58, decided to complement his physical exercise by memorising the 12 books, 10,565 lines and 60,000 words that comprise the Second Edition of John Milton's epic poem Paradise Lost. Nine years later he achieved his goal, performing the poem from memory over a three-day period, and since then he has recited the poem publicly on numerous occasions. When the psychologist John Seamon of Wesleyan University witnessed one of those performances in Dece........ Read more »

  • July 19, 2010
  • 06:00 AM

Article Review: Facebook, Professionalism, and Physicians

by Michelle Lin in Academic Life In Emergency Medicine

Facebook is worldwide. The medical educator's dilemma about Facebook and professionalism seems universal. How do we teach medical students the importance of the digital footprints on publicly viewable websites? A landmark article, published by Dr. Chretein in JAMA in 2009, surveyed U.S. medical school deans on unprofessional behavior on Facebook. She found that 60% of medical schools documented incidences of unprofessional online postings.In contrast, Medical Education just published a cross-sec........ Read more »

  • July 19, 2010
  • 05:30 AM

Not everything's caused by obesity: Brain and memory function edition

by Yoni Freedhoff in Weighty Matters

Good lord.I know people like to blame obesity for everything. Every disease, every problem - everything.You know what I'm blaming on it today? Authors' and peer reviewers' attitudes about their studies and results.Last Tuesday I was asked by CTV to read a study that was pending publication in the Journal of the American Geriatrics Society so that I could comment on it for the national news. The study looked at 8,745 women between the ages of 65-79 free of dementia and evaluated their weight a........ Read more »

  • July 19, 2010
  • 03:00 AM

Some more junk DNA shown to have function

by Bjørn Østman in Pleiotropy

Drosophila junk DNA found to have a regulatory function.... Read more »

Kondo, T., Plaza, S., Zanet, J., Benrabah, E., Valenti, P., Hashimoto, Y., Kobayashi, S., Payre, F., & Kageyama, Y. (2010) Small Peptides Switch the Transcriptional Activity of Shavenbaby During Drosophila Embryogenesis. Science, 329(5989), 336-339. DOI: 10.1126/science.1188158  

  • July 19, 2010
  • 02:43 AM

English-Only at Bon Secours

by Ingrid Piller in Language on the Move

From what I read, there is a nursing shortage in the Global North. From North America to Japan and from Europe to the Gulf countries, rich societies suffer from a “care deficit,” which they fill by importing – mostly female … Continue reading →... Read more »

Piller, Ingrid, & Takahashi, Kimie. (2011) At the intersection of gender, language and transnationalism. Nik Coupland. Ed. Handbook of Language and Globalisation. Malden, MA: Blackwell, 540-554. info:/

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