Adriane Fugh-Berman (Georgetown University, United States) exposes the campaign of Wyeth and DesignWrite to falsely market hormone replacement therapy in non-symptomatic women, thereby profiting from a medical treatment which is not based on science. This news feature was written on September 13, 2010.... Read more »
Fugh-Berman, A. J. (2010) The Haunting of Medical Journals: How Ghostwriting Sold “HRT”. PLoS Medicine, 7(9). DOI: 10.1371/journal.pmed.1000335
I could actually head this post with the title ‘Essential Skills for Living’ and leave out the pain part, because as I reflect on the events over the past week, and the aftermath as residents of Christchurch start to demolish then rebuild their homes and businesses, these same skills apply. How do people live well … Read more... Read more »
BERKING, M., WUPPERMAN, P., REICHARDT, A., PEJIC, T., DIPPEL, A., & ZNOJ, H. (2008) Emotion-regulation skills as a treatment target in psychotherapy☆. Behaviour Research and Therapy. DOI: 10.1016/j.brat.2008.08.005
Flink, I., Nicholas, M., Boersma, K., & Linton, S. (2009) Reducing the threat value of chronic pain: A preliminary replicated single-case study of interoceptive exposure versus distraction in six individuals with chronic back pain. Behaviour Research and Therapy, 47(8), 721-728. DOI: 10.1016/j.brat.2009.05.003
In this post I'd like to revisit the Kouper paper (2010) and even more important, the way it was accepted among science bloggers. First of all, let's start with the blogs studied. The paper says that "The blogs were sampled via the Internet search for "science blogs" and "blogs about science" and by following scientific news on the moment of data collection in Summer, 2008". I'm not sure why Ms. Kouper felt the need to make both searches because Uncle Google, bless its PageRank heart, gives, as........ Read more »
Kouper, I. (2010) Science blogs and public engagement with science: practices, challenges, and opportunities. Jcom, 9(1). info:/
Since we were talking about GPCRs the other day, here's a nice overview of some of the experimental challenges associated with membrane proteins and how researchers are trying to overcome them. These challenges are associated not just with the crystallization, but with the whole shebang. Although many clever tricks have emerged, we have a long way to go, and at least a few of the tricks sound like brute trial and error.To begin with, it's not that easy to get your expression system to produce am........ Read more »
Baker, M. (2010) Making membrane proteins for structures: a trillion tiny tweaks. Nature Methods, 7(6), 429-434. DOI: 10.1038/nmeth0610-429
by Fred Neidhardt in Small Things Considered
by Fred Neidhardt
Growth dominates the attention of many bacteriologists. It has done so for over a century, inspiring explorations into the complex biochemistry and physiology that produce new cells able to grow, survive harsh environments, and live to grow another day.
Likewise, since the earliest days of microbiology, virulence has been a central focus. In fact, studies of how bacteria cause disease have in sheer number dominated the field for the simple reason that more than intellect........ Read more »
The human body is not just an organism, it’s an ecosystem. To the billions of microscopic bacteria, viruses and fungi living in the various nooks and crannies of our intestines, mouth, nose, and other areas, we are the world, the environment that drives their evolution. Though scientists and physicians have long known that humans are [...]... Read more »
Poroyko V, White JR, Wang M, Donovan S, Alverdy J, Liu DC, & Morowitz MJ. (2010) Gut microbial gene expression in mother-fed and formula-fed piglets. PloS one, 5(8). PMID: 20805981
A recent study from Dr. Charles Holahan and colleagues has been posted on the new articles section of Alcoholism: Clinical and Experimental Research. This study examined the role of alcohol consumption and mortality in a group of men and women between the ages of 55 and 65 followed for twenty years. The media highlighted this study often headlining that heavy drinking was linked lower mortality rates than being abstinent from alcohol. This study deserves further analysis and co........ Read more »
Holahan CJ, Schutte KK, Brennan PL, Holahan CK, Moos BS, & Moos RH. (2010) Late-Life Alcohol Consumption and 20-Year Mortality. Alcoholism, clinical and experimental research. PMID: 20735372
Floods just aren’t what they used to be. The construction of dams has dramatically altered the flow of flood waters in more than half of the large rivers in the United States, and in many smaller waterways too, according to a new analysis.
Although rising rivers can wash away homes and threaten lives, ecologists have […] Read More »... Read more »
FitzHugh, T., & Vogel, R. (2010) The impact of dams on flood flows in the United States. River Research and Applications. DOI: 10.1002/rra.1417
As I walk through an art museum, I casually stroll around the exhibits stopping and pausing at various pieces that catch my eye. Usually the artists are Monet or Degas; I definitely have my favorites. But what is it about these paintings that catch our eyes? What kinds of things do we notice and pay [...]... Read more »
Locher, P., Krupinski, E., Mello-Thoms, C., & Nodine, C. (2008) Visual interest in pictorial art during an aesthetic experience. Spatial Vision, 21(1), 55-77. DOI: 10.1163/156856808782713762
by Michele in Promega Connections
Embryonic development in multicellular eukaryotic organisms is an intricate dance of signals that determine when and where genes are expressed, allowing the zygote to produce the cells that will ultimately differentiate in to the tissues and organs of the adult. Some of this gene expression is regulated by maternal and zygotic transcription factors, but much [...]... Read more »
Furuhashi, H., Takasaki, T., Rechtsteiner, A., Li, T., Kimura, H., Checchi, P., Strome, S., & Kelly, W. (2010) Trans-generational epigenetic regulation of C. elegans primordial germ cells. Epigenetics , 3(1), 15. DOI: 10.1186/1756-8935-3-15
Dinosaur skin impressions are pretty rare, and, even among the known collection of these soft-tissue traces, not all dinosaurs are equally well-represented. There are plenty of skin impressions from hadrosaurs, but stegosaurs are among the dinosaurs in which the skin texture is still largely unknown. Now, as reported by paleontologists Nicolai Christiansen and Emanuel Tschopp, [...]... Read more »
Christiansen, N., & Tschopp, E. (2010) Exceptional stegosaur integument impressions from the Upper Jurassic Morrison Formation of Wyoming. Swiss Journal of Geosciences. DOI: 10.1007/s00015-010-0026-0
There's a paradox at the heart of modern psychiatry, according to an important new paper by Dr Charles E. Dean, Psychopharmacology: A house divided.It's a long and slightly rambling article, but Dean's central point is pretty simple. The medical/biological model of psychiatry assumes that there are such things as psychiatric diseases. Something biological goes wrong, presumably in the brain, and this causes certain symptoms. Different pathologies cause different symptoms - in other words, there ........ Read more »
Supply chain risk management must look beyond the individual supplier and look at dependencies within the entire supplier portfolio. Such dependencies may not be obvious at first sight, and this paper presents one very good approach towards discovering these dependencies. [ ... ]... Read more »
Wagner, S., Bode, C., & Koziol, P. (2009) Supplier default dependencies: Empirical evidence from the automotive industry. European Journal of Operational Research, 199(1), 150-161. DOI: 10.1016/j.ejor.2008.11.012
We usually think about organisms diversifying by moving in to fill previously unoccupied or recently-vacated niches—areas free of predators, or where native species have vanished, or with abundant, underutilized resources. The idea is that organisms seize opportunities, and that seems to be the major story told by decades of work on the Galapagos finches by Peter and Rosemary Grant.
Is this ... Read more »
Arnegard ME, McIntyre PB, Harmon LJ, Zelditch ML, Crampton WG, Davis JK, Sullivan JP, Lavoué S, & Hopkins CD. (2010) Sexual signal evolution outpaces ecological divergence during electric fish species radiation. The American naturalist, 176(3), 335-56. PMID: 20653442
I am not a bariatric surgeon. My main clinical interest is in the prevention of obesity related chronic diseases.
I believe strongly that timely psychosocial and medical interventions can help most people successfully manage their weight problem - at a minimum, conservative treatment can help patients at least stop the weight gain.
Unfortunately, this is so far [...]... Read more »
McGauran A. (2010) More obesity surgery in England would save money, economic analysis shows. BMJ (Clinical research ed.). PMID: 20826523
This animal could kill seven people.
No wonder it looks a little smug.
That newt “Sure, you might try and eat me, but when your brain stops, I’ll have the last laugh, sucker.”
And that newt wouldn’t be kidding.
Some rough skinned newts (Taricha granulosa) have something in common with poison dart frogs, blue-ringed octopus, and pufferfish. They all contain within them a poison called tetrodotoxin.
Tetrodotoxin is a neurotoxin that stops neurons from initiating action potentials. I........ Read more »
Lee C, Jones D, Ahern C, Sarhan M, & Ruben P. (2010) Biophysical costs associated with tetrodotoxin resistance in the sodium channel pore of the garter snake, Thamnophis sirtalis. Journal of Comparative Physiology A. DOI: 10.1007/s00359-010-0582-9
The publisher Henry Holt and Company was kind enough to send me a review copy of Guy Deutscher's new book Through the Language Glass: Why the World Looks Different in Other Languages which bills itself as "demonstrating that language does in fact reflect culture in ways that are anything but trivial" but which also goes beyond that and purports to demonstrate that language affects thought, if only via habits of mind.This is part one of a two part review. I expect to post Part 2 next Monday, Sept........ Read more »
Guy Deutscher. (2010) Through the Language Glass: Why the World Looks Different in Other Languages. Metropolitan Books. info:/
How do cells do mechanical work to move, and divide? The filaments that make up the cytoskeleton, which provide the structure required for large-scale movement, are some of the most extraordinary assemblies in biology. These filaments are dynamic (they form where they are needed, then dissolve again), and they’re amazingly long and thin: tens of [...]... Read more »
Lee K, Gallop JL, Rambani K, & Kirschner MW. (2010) Self-assembly of filopodia-like structures on supported lipid bilayers. Science (New York, N.Y.), 329(5997), 1341-5. PMID: 20829485
"The problem with being on call every other night is that you miss half the cases!"Excessive resident fatigue was just par for training in the old days of Medicine before duty hours came into effect, thanks to the ACGME. In 2008, the Institute of Medicine (IOM) provided more restrictive duty-hour recommendations. Key leaders in Emergency Medicine convened to develop a consensus response to these IOM recommendations. The following is a summary of the response, published in Journal of Emergency Me........ Read more »
Wagner MJ, Wolf S, Promes S, McGee D, Hobgood C, Doty C, McErlean MA, Janssen A, Smith-Coggins R, Ling L.... (2010) Duty hours in emergency medicine: balancing patient safety, resident wellness, and the resident training experience: a consensus response to the 2008 institute of medicine resident duty hours recommendations. The Journal of emergency medicine, 39(3), 348-55. PMID: 20634017
by Peter Janiszewski, Ph.D. in Obesity Panacea
Welcome to our 5-part series delving into the fascinating and seemingly paradoxical research on people who despite being obese, remain metabolically-healthy. Today, we’ll start with an introduction.
To date, countless epidemiological studies have shown that as you move from a normal weight (BMI = 18.5-24.9 kg/m2) towards overweight (BMI = 25-29.9kg/m2) and obesity (BMI ≥ 30 kg/m2) the risk of many diseases increases exponentially.
Does this imply that every individual carrying excess ........ Read more »
Albrink, M., & Meigs, J. (1965) THE RELATIONSHIP BETWEEN SERUM TRIGLYCERIDES AND SKINFOLD THICKNESS IN OBESE SUBJECTS. Annals of the New York Academy of Sciences, 131(1 Adipose Tissu), 673-683. DOI: 10.1111/j.1749-6632.1965.tb34830.x
Sims, E. (2001) Are there persons who are obese, but metabolically healthy?. Metabolism, 50(12), 1499-1504. DOI: 10.1053/meta.2001.27213
Karelis, A. (2004) Metabolic and Body Composition Factors in Subgroups of Obesity: What Do We Know?. Journal of Clinical Endocrinology , 89(6), 2569-2575. DOI: 10.1210/jc.2004-0165
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