It may be time to leave “busy as a bee” with other dubious animal similes like “happy as a clam” and “drunk as a skunk.” That’s because some bees, it turns out, aren’t all that busy. A small group of hive members do the bulk of the foraging, while their sisters relax at home. But […]The post Some Bees Are Busier Than Others appeared first on Inkfish.... Read more »
Tenczar, P., Lutz, C., Rao, V., Goldenfeld, N., & Robinson, G. (2014) Automated monitoring reveals extreme interindividual variation and plasticity in honeybee foraging activity levels. Animal Behaviour, 41-48. DOI: 10.1016/j.anbehav.2014.06.006
The American Bar Association is seeking nominations until August 8, 2014 to help it decide on the Top 100 law blogs (“Blawgs”). We have been in the ABA Top 100 for the past 4 years and would like to make it 5! If you like this blog, please nominate us (it’s fast and free) here. […]
A new issue of The Jury Expert!
Who cares? The crime victim was old anyway!
“I punish you because you harmed him!”
... Read more »
Shariff AF, Greene JD, Karremans JC, Luguri JB, Clark CJ, Schooler JW, Baumeister RF, & Vohs KD. (2014) Free Will and Punishment: A Mechanistic View of Human Nature Reduces Retribution. Psychological science. PMID: 24916083
It’s hard to find the best person for the job through an interview. New research uncovers part of the problem: judging a candidate’s calibre becomes trickier when we’re also trying to sell them the benefits of joining the organisation.In an initial study, participants were asked to interview a person (another participant) who was acting as an applicant for a fictional position. Half the interviewers were told their priority was to get a good sense of the applicant, while the rest had to pr........ Read more »
Marr, J., & Cable, D. (2013) Do Interviewers Sell Themselves Short? The Effects of Selling Orientation on Interviewers' Judgments. Academy of Management Journal, 57(3), 624-651. DOI: 10.5465/amj.2011.0504
Scientists at the University of Tokyo have developed an approach with industrial potential to produce nano-sized composite silicon-based powders as negative electrodes for the next generation lithium ion batteries.... Read more »
Homma, K., Kambara, M., & Yoshida, T. (2014) High throughput production of nanocomposite SiO powders by plasma spray physical vapor deposition for negative electrode of lithium ion batteries . Science and Technology of Advanced Materials, 15(2), 25006. DOI: 10.1088/1468-6996/15/2/025006
"These results confirm the elevation of urinary p-cresol in a sizable set of small autistic children and spur interest into biomarker roles for p-cresol and p-cresylsulfate in autism".The peasant dance @ Wikipedia That was the primary conclusion from the paper by Gabriele and colleagues  looking at "three components of urinary p-cresol, namely p-cresylsulfate, p-cresylglucuronate and free p-cresol" in samples from 33 participants diagnosed with an autism spectrum disorder (ASD)........ Read more »
Gabriele S, Sacco R, Cerullo S, Neri C, Urbani A, Tripi G, Malvy J, Barthelemy C, Bonnet-Brihault F, & Persico AM. (2014) Urinary p-cresol is elevated in young French children with autism spectrum disorder: a replication study. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 1-8. PMID: 25010144
Where are they?
Close-up view of the meninges surrounding the brain.
The term meninges comes from the Greek for "membrane" and refers to the three membranes that surround the brain and spinal cord. The membrane layers (discussed in detail below) from the outside in are the: dura mater, arachnoid mater, and pia mater. Their positioning around the brain can be seen in the image to the right.What are they and what do they do?The brain is s........ Read more »
Fish might not be the first thing you think about when we talk spinal cord injury but that is exactly what scientists are doing. Don’t ask where they got the […]... Read more »
Lewandowski, G., & Steward, O. (2014) AAVshRNA-Mediated Suppression of PTEN in Adult Rats in Combination with Salmon Fibrin Administration Enables Regenerative Growth of Corticospinal Axons and Enhances Recovery of Voluntary Motor Function after Cervical Spinal Cord Injury. Journal of Neuroscience, 34(30), 9951-9962. DOI: 10.1523/JNEUROSCI.1996-14.2014
The plane crash in Ukraine brings up many questions related to loss and grief. How will those left behind cope with the devastating event? How can we support them? With regard to how young people cope with bereavement, Dr. Mariken Spuij’s recent articles provide new insights.... Read more »
Spuij M, Prinzie P, Dekovic M, van den Bout J, & Boelen PA. (2013) The effectiveness of Grief-Help, a cognitive behavioural treatment for prolonged grief in children: study protocol for a randomised controlled trial. Trials, 395. PMID: 24252587
I am a neuroscientist, and as a neuroscientist I have a strange belief that most of who we are comes from our brains. My entire career is based around understanding behavior from this neural level which I feel to be fairly justifiable. So when I see paper looking at the genetics of behavior, I expect to see at […]... Read more »
Ripke, S., Neale, B., Corvin, A., Walters, J., Farh, K., Holmans, P., Lee, P., Bulik-Sullivan, B., Collier, D., Huang, H.... (2014) Biological insights from 108 schizophrenia-associated genetic loci. Nature, 511(7510), 421-427. DOI: 10.1038/nature13595
Coming from a, to put it gently, very broken home, my babysitter was the television. Yep, so now that you are feeling nice and awkward let’s talk television. New research, […]... Read more »
Linebarger DL, Barr R, Lapierre MA, & Piotrowski JT. (2014) Associations Between Parenting, Media Use, Cumulative Risk, and Children's Executive Functioning. Journal of developmental and behavioral pediatrics : JDBP, 35(6), 367-77. PMID: 25007059
No matter how careful we are, at some point in all of our lives we will develop sunburn. Despite all of the NHS campaigns and warnings that sun damage can cause skin cancer, many of us will know at least one person who forgoes using suncream and lets themselves bake in the sun in the quest for the perfect summer glow. But what is sunburn? And why is it so dangerous? First we need to take a look at our skin.... Read more »
Bernard JJ, Cowing-Zitron C, Nakatsuji T, Muehleisen B, Muto J, Borkowski AW, Martinez L, Greidinger EL, Yu BD, & Gallo RL. (2012) Ultraviolet radiation damages self noncoding RNA and is detected by TLR3. Nature medicine, 18(8), 1286-90. PMID: 22772463
How many times can you say the word “gonad” in a sentence without giggling? If the answer is one, then I congratulate you on turning thirteen. If the answer is many, then you must be a biologist. Biologists appreciate the value of a good gonad, and so should you. The gonad of the worm C. elegans serves as an important model in which to study tissue organization and development, as you’ll see in the paper that accompanies today’s image. At the end of cell division, cytokinesis typical........ Read more »
Amini, R., Goupil, E., Labella, S., Zetka, M., Maddox, A., Labbe, J., & Chartier, N. (2014) C. elegans Anillin proteins regulate intercellular bridge stability and germline syncytial organization. originally published in the Journal of Cell Biology, 206(1), 129-143. DOI: 10.1083/jcb.201310117
How could someone determine what you eat from only examining the things you leave behind? To add to the challenge, you would be hypothetically deceased and unable to communicate your […]... Read more »
Buckley, S., Usai, D., Jakob, T., Radini, A., & Hardy, K. (2014) Dental Calculus Reveals Unique Insights into Food Items, Cooking and Plant Processing in Prehistoric Central Sudan. PLoS ONE, 9(7). DOI: 10.1371/journal.pone.0100808
Emphasis mine, of course: Among 395 donors who changed or initiated health insurance after donation, 27 (7%) reported difficulty; among those who reported difficulty, 15 were denied altogether, 12 were charged a higher premium and 8 were told they had a preexisting condition because they were kidney donors. Among 186 donors who changed or …
Continue reading »
The post Living Kidney Donors and Insurance Issues – Again appeared first on Living Donors Are People Too.
... Read more »
Boyarsky BJ, Massie AB, Alejo JL, Van Arendonk KJ, Wildonger S, Garonzik-Wang JM, Montgomery RA, Deshpande NA, Muzaale AD, & Segev DL. (2014) Experiences Obtaining Insurance After Live Kidney Donation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID: 25041695
The paper by Amanda Wood and colleagues  (open-access) makes a potentially very important contribution to the growing literature looking at how prenatal exposure to sodium valproate (VPA) may affect some children. Authors reported on: "regional structural cortical brain changes in humans exposed to VPA in utero" and specifically, increased cortical thickness in the left inferior frontal gyrus.Lightning and lava @ Oliver Spalt @ Wikipedia In case you need any background on the s........ Read more »
Wood, A., Chen, J., Barton, S., Nadebaum, C., Anderson, V., Catroppa, C., Reutens, D., O'Brien, T., & Vajda, F. (2014) Altered cortical thickness following prenatal sodium valproate exposure. Annals of Clinical and Translational Neurology. DOI: 10.1002/acn3.74
There has been a rash of great white shark sightings and attacks in the news recently. But, have attacks and sightings remained constant, or are they really on the increase? Several news studies provide evidence that the Marine Mammal Protection Act of 1972, the ban on commercial whaling in 1982, and the ban on great white hunting in 1997 have increased the number of sharks on the coasts of the North America and Australia. In addition, great white sharks live much longer than previously assumed,........ Read more »
Burgess GH, Bruce BD, Cailliet GM, Goldman KJ, Grubbs RD, Lowe CG, MacNeil MA, Mollet HF, Weng KC, & O'Sullivan JB. (2014) A Re-Evaluation of the Size of the White Shark (Carcharodon carcharias) Population off California, USA. PloS one, 9(6). PMID: 24932483
Curtis TH, McCandless CT, Carlson JK, Skomal GB, Kohler NE, Natanson LJ, Burgess GH, Hoey JJ, & Pratt HL Jr. (2014) Seasonal Distribution and Historic Trends in Abundance of White Sharks, Carcharodon carcharias, in the Western North Atlantic Ocean. PloS one, 9(6). PMID: 24918579
Sprivulis P. (2014) Western Australia coastal shark bites: A risk assessment. The Australasian medical journal, 7(2), 137-42. PMID: 24611078
Hamady LL, Natanson LJ, Skomal GB, & Thorrold SR. (2014) Vertebral bomb radiocarbon suggests extreme longevity in white sharks. PloS one, 9(1). PMID: 24416189
Scientists at the University of the Basque Country (UPV/EHU) have studied the effects of using lanthanum-based perovskite ceramic contact materials in solid oxide fuel cells (SOFCs).... Read more »
Morán-Ruiz, A., Vidal, K., Laguna-Bercero, M., Larrañaga, A., & Arriortua, M. (2014) Effects of using (La0.8Sr0.2)0.95Fe0.6Mn0.3Co0.1O3 (LSFMC), LaNi0.6Fe0.4O3−δ (LNF) and LaNi0.6Co0.4O3−δ (LNC) as contact materials on solid oxide fuel cells. Journal of Power Sources, 1067-1076. DOI: 10.1016/j.jpowsour.2013.10.031
Japanese Encephalitis Virus (JEV) is a causative agent of acute encephalitis in humans, and being an arthropod borne virus transmitted predominately by mosquitoes ( that primarily target domestic animals and humans, with an estimated mortality of up to 70000 deaths reported per annum. Upon infection the viral proteins localise to the ER where they induce the ER stress which eventually induces Caspase dependent apoptosis.
... Read more »
Shailendra K. Saxena. (2013) Japanese Encephalitis Virus: The Complex Biology of an Emerging Pathogen. Encephalitis. DOI: 10.5772/54111
Unni SK, Růžek D, Chhatbar C, Mishra R, Johri MK, & Singh SK. (2011) Japanese encephalitis virus: from genome to infectome. Microbes and infection / Institut Pasteur, 13(4), 312-21. PMID: 21238600
Cui J, Counor D, Shen D, Sun G, He H, Deubel V, & Zhang S. (2008) Detection of Japanese encephalitis virus antibodies in bats in Southern China. The American journal of tropical medicine and hygiene, 78(6), 1007-11. PMID: 18541785
Mori Y, Okabayashi T, Yamashita T, Zhao Z, Wakita T, Yasui K, Hasebe F, Tadano M, Konishi E, Moriishi K.... (2005) Nuclear localization of Japanese encephalitis virus core protein enhances viral replication. Journal of virology, 79(6), 3448-58. PMID: 15731239
Tsuda Y, Mori Y, Abe T, Yamashita T, Okamoto T, Ichimura T, Moriishi K, & Matsuura Y. (2006) Nucleolar protein B23 interacts with Japanese encephalitis virus core protein and participates in viral replication. Microbiology and immunology, 50(3), 225-34. PMID: 16547420
Szebeni, A., & Olson, M. (2008) Nucleolar protein B23 has molecular chaperone activities. Protein Science, 8(4), 905-912. DOI: 10.1110/ps.8.4.905
Uchil PD, Kumar AV, & Satchidanandam V. (2006) Nuclear localization of flavivirus RNA synthesis in infected cells. Journal of virology, 80(11), 5451-64. PMID: 16699025
Katoh H, Okamoto T, Fukuhara T, Kambara H, Morita E, Mori Y, Kamitani W, & Matsuura Y. (2013) Japanese encephalitis virus core protein inhibits stress granule formation through an interaction with Caprin-1 and facilitates viral propagation. Journal of virology, 87(1), 489-502. PMID: 23097442
Liao CL, Lin YL, Shen SC, Shen JY, Su HL, Huang YL, Ma SH, Sun YC, Chen KP, & Chen LK. (1998) Antiapoptotic but not antiviral function of human bcl-2 assists establishment of Japanese encephalitis virus persistence in cultured cells. Journal of virology, 72(12), 9844-54. PMID: 9811720
Ghosh Roy S, Sadigh B, Datan E, Lockshin RA, & Zakeri Z. (2014) Regulation of cell survival and death during Flavivirus infections. World journal of biological chemistry, 5(2), 93-105. PMID: 24921001
Tsao, C., Su, H., Lin, Y., Yu, H., Kuo, S., Shen, C., Chen, C., & Liao, C. (2008) Japanese encephalitis virus infection activates caspase-8 and -9 in a FADD-independent and mitochondrion-dependent manner. Journal of General Virology, 89(8), 1930-1941. DOI: 10.1099/vir.0.2008/000182-0
Yiang GT, Chen YH, Chou PL, Chang WJ, Wei CW, & Yu YL. (2013) The NS3 protease and helicase domains of Japanese encephalitis virus trigger cell death via caspase‑dependent and ‑independent pathways. Molecular medicine reports, 7(3), 826-30. PMID: 23291778
Yang TC, Shiu SL, Chuang PH, Lin YJ, Wan L, Lan YC, & Lin CW. (2009) Japanese encephalitis virus NS2B-NS3 protease induces caspase 3 activation and mitochondria-mediated apoptosis in human medulloblastoma cells. Virus research, 143(1), 77-85. PMID: 19463724
Wu, Y., Chang, C., Hung, C., Tsai, M., Schuyler, S., & Wang, R. (2011) Japanese encephalitis virus co-opts the ER-stress response protein GRP78 for viral infectivity. Virology Journal, 8(1), 128. DOI: 10.1186/1743-422X-8-128
Chen SO, Fang SH, Shih DY, Chang TJ, & Liu JJ. (2009) Recombinant core proteins of Japanese encephalitis virus as activators of the innate immune response. Virus genes, 38(1), 10-8. PMID: 19009340
Yamaguchi H, & Wang HG. (2004) CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells. The Journal of biological chemistry, 279(44), 45495-502. PMID: 15322075
Lu, M., Lawrence, D., Marsters, S., Acosta-Alvear, D., Kimmig, P., Mendez, A., Paton, A., Paton, J., Walter, P., & Ashkenazi, A. (2014) Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis. Science, 345(6192), 98-101. DOI: 10.1126/science.1254312
Han J, Back SH, Hur J, Lin YH, Gildersleeve R, Shan J, Yuan CL, Krokowski D, Wang S, Hatzoglou M.... (2013) ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nature cell biology, 15(5), 481-90. PMID: 23624402
Chang RY, Hsu TW, Chen YL, Liu SF, Tsai YJ, Lin YT, Chen YS, & Fan YH. (2013) Japanese encephalitis virus non-coding RNA inhibits activation of interferon by blocking nuclear translocation of interferon regulatory factor 3. Veterinary microbiology, 166(1-2), 11-21. PMID: 23755934
Sun J, Yu Y, & Deubel V. (2012) Japanese encephalitis virus NS1' protein depends on pseudoknot secondary structure and is cleaved by caspase during virus infection and cell apoptosis. Microbes and infection / Institut Pasteur, 14(11), 930-40. PMID: 22504173
New research suggests patients with both bipolar disorder and obsessive compulsive disorder should receive treatments for bipolar disorder alone. Bipolar and obsessive compulsive disorder therapies taken together can cause worsening of disease symptoms, making it difficult for physicians to treat both conditions. This is a concern as over 1 in 5 patients with bipolar disorder develop obsessive compulsive disorder during their lifetime.... Read more »
Pacchiarotti I, Bond DJ, Baldessarini RJ, & et al. (2013) The International Society for Bipolar Disorders (ISBD) task force report on antidepressant use in bipolar disorders. The American journal of psychiatry, 170(11), 1249-62. PMID: 24030475
Poor Voyager, he just can’t catch a break. We’ve said it’s hit interstellar space more times than we want to admit and in 2012, the Voyager mission team announced that […]... Read more »
G. Gloeckler, & L. A. Fisk. (2014) A test for whether or not Voyager 1 has crossed the heliopause. Geophysical Research Letters. info:/10.1002/2014GL060781
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