Post List

  • March 8, 2016
  • 04:06 PM

Frankenstein’s E. Coli: How an artificial protein rescues dying cells

by Dr. Jekyll in Lunatic Laboratories

It’s alive, ALIVE! No really and it could one day have big implications for you and me. So it is not quite Frankenstein’s monster… yet. However, a new study has revealed how a synthetic protein revives E. coli cells that lack a life-sustaining gene, offering insight into how life can adapt to survive and potentially be reinvented.

... Read more »

Digianantonio, K., & Hecht, M. (2016) A protein constructed de novo enables cell growth by altering gene regulation. Proceedings of the National Academy of Sciences, 113(9), 2400-2405. DOI: 10.1073/pnas.1600566113  

  • March 8, 2016
  • 03:49 PM

Zika Virus induced mitotic arrest, apoptosis, DNA damage response and autophagy: recipe for disaster?

by thelonevirologist in Virology Tidbits

Zika Virus (ZIKV) was first isolated from monkeys in 1947 and until 2007 only isolated cases of infection in humans were reported although serologic studies suggested widespread distribution in Africa and Southeast Asia. In 2007 however ZIKV of the Asian lineage caused an outbreak in Yap/Federal Micronesia followed by an outbreak in French Polynesia in 2013 and the current outbreak in Central & South America and the Caribbean. ZIKV is mainly transmitted via infected Aedes spp.mosquitoes but sexu........ Read more »

DICK GW, KITCHEN SF, & HADDOW AJ. (1952) Zika virus. I. Isolations and serological specificity. Transactions of the Royal Society of Tropical Medicine and Hygiene, 46(5), 509-20. PMID: 12995440  

DICK GW. (1952) Zika virus. II. Pathogenicity and physical properties. Transactions of the Royal Society of Tropical Medicine and Hygiene, 46(5), 521-34. PMID: 12995441  

Calvet, G., Aguiar, R., Melo, A., Sampaio, S., de Filippis, I., Fabri, A., Araujo, E., de Sequeira, P., de Mendonça, M., de Oliveira, L.... (2016) Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study. The Lancet Infectious Diseases. DOI: 10.1016/S1473-3099(16)00095-5  

Brasil, P., Pereira, Jr., J., Raja Gabaglia, C., Damasceno, L., Wakimoto, M., Ribeiro Nogueira, R., Carvalho de Sequeira, P., Machado Siqueira, A., Abreu de Carvalho, L., Cotrim da Cunha, D.... (2016) Zika Virus Infection in Pregnant Women in Rio de Janeiro — Preliminary Report. New England Journal of Medicine. DOI: 10.1056/NEJMoa1602412  

Bell TM, Field EJ, & Narang HK. (1971) Zika virus infection of the central nervous system of mice. Archiv fur die gesamte Virusforschung, 35(2), 183-93. PMID: 5002906  

Tang, H., Hammack, C., Ogden, S., Wen, Z., Qian, X., Li, Y., Yao, B., Shin, J., Zhang, F., Lee, E.... (2016) Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell Stem Cell. DOI: 10.1016/j.stem.2016.02.016  

Ryan EL, Hollingworth R, & Grand RJ. (2016) Activation of the DNA Damage Response by RNA Viruses. Biomolecules, 6(1). PMID: 26751489  

Park JM, Choi JY, Yi JM, Chung JW, Leem SH, Koh SS, & Kang TH. (2015) NDR1 modulates the UV-induced DNA-damage checkpoint and nucleotide excision repair. Biochemical and biophysical research communications, 461(3), 543-8. PMID: 25912875  

Joffre C, Codogno P, Fanto M, Hergovich A, & Camonis J. (2016) STK38 at the crossroad between autophagy and apoptosis. Autophagy, 1-2. PMID: 26890257  

Joffre C, Dupont N, Hoa L, Gomez V, Pardo R, Gonçalves-Pimentel C, Achard P, Bettoun A, Meunier B, Bauvy C.... (2015) The Pro-apoptotic STK38 Kinase Is a New Beclin1 Partner Positively Regulating Autophagy. Current biology : CB, 25(19), 2479-92. PMID: 26387716  

Hamel R, Dejarnac O, Wichit S, Ekchariyawat P, Neyret A, Luplertlop N, Perera-Lecoin M, Surasombatpattana P, Talignani L, Thomas F.... (2015) Biology of Zika Virus Infection in Human Skin Cells. Journal of virology, 89(17), 8880-96. PMID: 26085147  

Beller M, Thiel K, Thul PJ, & Jäckle H. (2010) Lipid droplets: a dynamic organelle moves into focus. FEBS letters, 584(11), 2176-82. PMID: 20303960  

Shrivastava S, Devhare P, Sujijantarat N, Steele R, Kwon YC, Ray R, & Ray RB. (2015) Knockdown of Autophagy Inhibits Infectious Hepatitis C Virus Release by the Exosomal Pathway. Journal of virology, 90(3), 1387-96. PMID: 26581990  

  • March 8, 2016
  • 07:39 AM

Does being in a bad mood affect your mental performance?

by BPS Research Digest in BPS Research Digest

We've all had days when we got out of the wrong side of the bed and the world looked greyer than usual. This daily variation in mood is a potential problem for psychologists who want to use tests to compare people's mental ability – competing job candidates, for example. Mood, like tiredness and motivation, could be another factor that leads some people to perform below par, by their own standards, thus distorting the test results. Indeed, there's some evidence that being in a bad mood is dist........ Read more »

  • March 8, 2016
  • 06:47 AM

How Einstein Could Still Save the Earth

by Jeffrey Daniels in United Academics

Gravitational waves, detected by LIGO, might have implications for finding black holes.... Read more »

  • March 8, 2016
  • 02:38 AM

What does age do to the presentation of psychiatric comorbidity in autism?

by Paul Whiteley in Questioning Answers

"As expected, adults with ASD [autism spectrum disorder] experienced more psychological symptoms and distress compared to a typically developing comparison group." But: "lifetime diagnoses for any psychiatric disorder were less often present in older than in younger adults with ASD, suggesting reduced psychopathology in late adulthood, a pattern that has been commonly observed in large typical aging studies."Those were some of the findings reported by Anne Lever & Hilde Geurts........ Read more »

  • March 8, 2016
  • 12:48 AM

Minimalist Running Shoes and Injury Risk

by Craig Payne in Running Research Junkie

Minimalist Running Shoes and Injury Risk... Read more »

Grier, T., Canham-Chervak, M., Bushman, T., Anderson, M., North, W., & Jones, B. (2016) Minimalist Running Shoes and Injury Risk Among United States Army Soldiers. The American Journal of Sports Medicine. DOI: 10.1177/0363546516630926  

  • March 7, 2016
  • 08:16 PM

Impact Related Factors and Running Injury

by Craig Payne in Running Research Junkie

Impact Related Factors and Running Injury... Read more »

  • March 7, 2016
  • 04:15 PM

Preemies’ gut bacteria reveal vast scope of antibiotic resistance

by Dr. Jekyll in Lunatic Laboratories

Yesterday we blogged about the emergent and increasing antibiotic resistance problem, which was good -- or bad timing -- depending on how you look at it. A new study of gut bacteria in premature infants reveals the vast scope of the problem of antibiotic resistance and gives new insight into the extreme vulnerability of these young patients, according to researchers.

... Read more »

Gibson, M., Wang, B., Ahmadi, S., Burnham, C., Tarr, P., Warner, B., & Dantas, G. (2016) Developmental dynamics of the preterm infant gut microbiota and antibiotic resistome. Nature Microbiology, 16024. DOI: 10.1038/nmicrobiol.2016.24  

  • March 7, 2016
  • 10:05 AM

Making booze feel bad

by Rosin Cerate in Rosin Cerate

Alcohol-sensitizing drugs are used to ruin the experience of consuming alcohol. This can be helpful for people seeking treatment for alcohol dependence, but otherwise sounds absolutely terrible. After consuming an adult beverage, alcohol is absorbed into your bloodstream and carried to your liver. There, it is set upon by two enzymes. The first, alcohol dehydrogenase, converts alcohol into acetaldehyde. The second enzyme, aldehyde dehydrogenase, converts the acetaldehyde into acetic acid (the st........ Read more »

  • March 7, 2016
  • 06:26 AM

Writing-Induced Fugue State

by The Neurocritic in The Neurocritic

Who is this, wandering around the crowded street, afraid of everything, trusting no one? “There must be something wrong, somewhere.”But maybe I’m safer since I look disheveled. Who are these people? Where is this place?Did I write that? When did that happen? I don’t remember. I can’t stop writing. I can’t stop walking, either, which is a problem because it’s hard to write and walk at the same time.In the early 1940s, Austrian Psychiatrist Dr. Erwin Stengel wrote a pair of papers........ Read more »

  • March 7, 2016
  • 05:10 AM

This one physiological measure has a surprisingly strong link with men's and women's propensity for violence

by BPS Research Digest in BPS Research Digest

By guest blogger Richard StephensI have a professional interest in the naughty. In my recent book Black Sheep The Hidden Benefits of Being Bad I explored in a light hearted fashion the psychology around the upsides of various antisocial behaviours – things like swearing, drinking, affairs and untidiness to name a few. However, this post is about physical violence, a much more serious form of bad behaviour for which I see no upside at all.Thankfully there is some fascinating psychology into the........ Read more »

  • March 7, 2016
  • 02:53 AM

Patients with psychiatric disorders who request euthanasia (continued)

by Paul Whiteley in Questioning Answers

Once again the uncomfortable topic of euthanasia and assisted suicide (EAS) is covered on this blog (see here for the last entry) as I discuss the findings reported by Scott Kim and colleagues [1] who reported on the "characteristics of patients receiving EAS for psychiatric conditions and how the practice is regulated in the Netherlands."Accompanied by some media interest (see here), the Kim paper provides an important overview of the: "Clinical and social characteristics of patients, physician........ Read more »

  • March 6, 2016
  • 11:51 PM

From evolutionary morphology to Godzilla

by adam phillips in It Ain't Magic

I recently spoke with Chief Scientist Shigeru Kuratani about evolutionary morphology, sci-fi monsters, the genius of Alien, and more.... Read more »

Sugahara, F., Pascual-Anaya, J., Oisi, Y., Kuraku, S., Aota, S., Adachi, N., Takagi, W., Hirai, T., Sato, N., Murakami, Y.... (2016) Evidence from cyclostomes for complex regionalization of the ancestral vertebrate brain. Nature, 531(7592), 97-100. DOI: 10.1038/nature16518  

  • March 6, 2016
  • 09:46 PM

Helping Both Humans and Dogs: A Recent Study of Canine Atopic Dermatitis

by Geoffrey Hannigan in Prophage

Atopic dermatitis (AD), which is also referred to as Eczema, is a very common dermatological disease, especially in children. It is estimated that AD affects 10% of children. The disease presents as dry, scaly, itchy skin. Atopic dermatitis can be especially problematic when the victim (often a child)...... Read more »

  • March 6, 2016
  • 09:45 PM

Can cognitive behavioral therapy for insomnia also treat fatigue, pain, and mood symptoms in individuals with traumatic brain injury?

by William Lu in The Quantum Lobe Chronicles

Hi All! I haven't updated in a quite a while because work as a rehabilitation psychologist has taken up most of my time. However, I was able to get a paper published recently in the journal NeuroRehabilitation. It was based on work done during my postdoc. The aim was to investigate whether cognitive behavioral therapy for insomnia would treat not only insomnia, but fatigue, pain, and mood in individuals with traumatic brain injury. It was a small case study, but I included a lot of rich detail f........ Read more »

  • March 6, 2016
  • 06:10 PM

Antibiotic resistance, evolution, and our future

by Dr. Jekyll in Lunatic Laboratories

Without the discovery of antibiotics we could not — and most certainly would not — be living in the world we do today. It was a discovery that would save countless lives, while simultaneously compromising our future. From the use (and unfortunate misuse) of antibiotics, we gave rise to more virulent bacteria that have become resistant to more and more types of antibiotics.

... Read more »

  • March 6, 2016
  • 05:54 PM

Testing the evolution of resistance by experiment

by Dr. Jekyll in Lunatic Laboratories

When the first antibiotics became available 70 years ago, they were often described as miracles of human ingenuity, rather like plastics or bright permanent dyes, which were discovered at roughly the same time. Packaged in vials or pills, they seemed like our inventions rather a chance gift of evolution and one that evolution might also rescind.

... Read more »

  • March 6, 2016
  • 01:07 PM

The hand of Code: Developmental transcriptomics in haddock

by sceintists from the Marine group at CEES in Marine Science blog

The development of haddock embryos is highly impacted by oil exposure as discussed in a previous
post. In a new study Sørhus et al. explored the link between transcriptional changes and developmental processes such as pattern formation and organogenesis. The question is to understand the abnormal development in fish.

... Read more »

  • March 6, 2016
  • 12:58 PM

Yes, Science Advances One Funeral at a Time

by Paco Jariego in Mind the Post

“A new scientific truth does not triumph by convincing its opponents and making them see the light, but rather because its opponents eventually die, and a new generation grows up that is familiar with it.” Max Planck Knowledge accumulation is of central importance to scientific progress and economic growth. Yet we know little about how this process works, and particularly […]... Read more »

Pierre Azoulay, Christian Fons-Rosen, & Joshua S. Graff Zivin. (2015) Does Science Advance One Funeral at a Time?. NBER Working Papers. DOI: 10.3386/w21788  

  • March 6, 2016
  • 07:46 AM

No, We Can't "Upload Knowledge To Your Brain"

by Neuroskeptic in Neuroskeptic_Discover

According to a spectacularly misleading article in the Telegraph: Scientists discover how to 'upload knowledge to your brain'
Feeding knowledge directly into your brain, just like in sci-fi classic The Matrix, could soon take as much effort as falling asleep, scientists believe. Researchers claim to have developed a simulator which can feed information directly into a person’s brain and teach them new skills in a shorter amount of time...

Researchers from HRL Laboratories, based in Cali... Read more »

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