"Although some associations between ADHD [attention-deficit hyperactivity disorder] and offending may be accounted for by co-morbidity with substance use disorders, early onset of offending and repeated violent offending appear to be directly related to ADHD."That was the conclusion reached by Jan Román-Ithier and colleagues  reporting on their study designed to "examine correlates of childhood ADHD symptoms among prisoners." Based on a sample adult prison population (N=1179) where........ Read more »
Román-Ithier, J., González, R., Vélez-Pastrana, M., González-Tejera, G., & Albizu-García, C. (2016) Attention deficit hyperactivity disorder symptoms, type of offending and recidivism in a prison population: The role of substance dependence. Criminal Behaviour and Mental Health. DOI: 10.1002/cbm.2009
Aerobic exercise can significantly help people coping with the long-term mental health condition schizophrenia, according to a new study. Through combining data from 10 independent clinical trials with a total of 385 patients with schizophrenia, Joseph Firth found that around 12 weeks of aerobic exercise training can significant improve patients' brain functioning.
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Firth, J., Stubbs, B., Rosenbaum, S., Vancampfort, D., Malchow, B., Schuch, F., Elliott, R., Nuechterlein, K., & Yung, A. (2016) Aerobic Exercise Improves Cognitive Functioning in People With Schizophrenia: A Systematic Review and Meta-Analysis. Schizophrenia Bulletin. DOI: 10.1093/schbul/sbw115
Intestinal flora has multiple influences on human health, but researchers have revealed that it is also likely to have an effect on the body's response to drugs. Recent research suggests that changes in the intestinal flora, caused by antibacterial and antibiotic drugs or individual differences between people, may have an effect on a person's response to drugs including side effects. The research focused on the changes in proteins due to the condition of intestinal flora that affect th........ Read more »
Kuno, T., Hirayama-Kurogi, M., Ito, S., & Ohtsuki, S. (2016) Effect of Intestinal Flora on Protein Expression of Drug-Metabolizing Enzymes and Transporters in the Liver and Kidney of Germ-Free and Antibiotics-Treated Mice. Molecular Pharmaceutics, 13(8), 2691-2701. DOI: 10.1021/acs.molpharmaceut.6b00259
Although mostly trying to avoid any politics-talk on this blog I am going to make some reference to it in this post set in the context of the Persian Gulf War otherwise known at the First Iraq War.The recent publication of the Chilcot report describing the case for the UK's involvement in the 2003 Iraq War (the second Iraq War) has further lit up an already illuminating year in British politics, by perhaps adding fuel to the notion that 'finishing the job' might have been an ........ Read more »
Johnson GJ, Slater BC, Leis LA, Rector TS, & Bach RR. (2016) Blood Biomarkers of Chronic Inflammation in Gulf War Illness. PloS one, 11(6). PMID: 27352030
Researchers have discovered that our brain actively takes sugar from the blood. Prior to this, researchers around the world had assumed that this was a purely passive process. An international team reports that transportation of sugar into the brain is regulated by so-called glial cells that react to hormones such as insulin or leptin; previously it was thought that this was only possible for neurons.
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García-Cáceres, C., Quarta, C., Varela, L., Gao, Y., Gruber, T., Legutko, B., Jastroch, M., Johansson, P., Ninkovic, J., Yi, C.... (2016) Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability. Cell, 166(4), 867-880. DOI: 10.1016/j.cell.2016.07.028
by Piter Kehoma Boll Certainly the most widespread, adaptable and well-known honey-producing bee is Apis melifera, commonly known as honeybee for obvious reasons. But there are a lot of other honey makers all over the world. Today I’m going to present … Continue reading →... Read more »
Miorin, P., Levy Junior, N., Custodio, A., Bretz, W., & Marcucci, M. (2003) Antibacterial activity of honey and propolis from Apis mellifera and Tetragonisca angustula against Staphylococcus aureus. Journal of Applied Microbiology, 95(5), 913-920. DOI: 10.1046/j.1365-2672.2003.02050.x
Sawaya, A., Cunha, I., Marcucci, M., de Oliveira Rodrigues, R., & Eberlin, M. (2006) Brazilian Propolis of Tetragonisca angustula and Apis mellifera. Apidologie, 37(3), 398-407. DOI: 10.1051/apido:2006011
New York Magazine has published a great article about how grad student Steven Ludeke tried to correct mistakes in the research of Pete Hatemi and Brad Verhulst. Overall, Ludeke summarises his experience as ‘not recommendable’. Back in my undergraduate years I spotted an error in an article by David DeMatteo and did little to correct it. […]... Read more »
DeMatteo, D., Heilbrun, K., & Marczyk, G. (2006) An empirical investigation of psychopathy in a noninstitutionalized and noncriminal sample. Behavioral Sciences , 24(2), 133-146. DOI: 10.1002/bsl.667
Gao, Y., & Raine, A. (2010) Successful and unsuccessful psychopaths: A neurobiological model. Behavioral Sciences . DOI: 10.1002/bsl.924
Kunert, R. (2016) Internal conceptual replications do not increase independent replication success. Psychonomic Bulletin . DOI: 10.3758/s13423-016-1030-9
Rucević S. (2010) Psychopathic personality traits and delinquent and risky sexual behaviors in Croatian sample of non-referred boys and girls. Law and human behavior, 34(5), 379-91. PMID: 19728057
Germline mutations of the folliculin gene are normally responsible for Birt–Hogg–Dubé (BHD) syndrome. The 3D structure of the C-terminal domain of folliculin (FLCN), folliculin-CT, has been previously determined (Nookala et al., 2012). FLCN is a tumor suppressor and a guanine nucleotide exchange factor (GEF) for Rab35. GEF activity of FLCN towards its GTPase might be essential for cellular processes. Most of the reported FLCN mutations lead to the BHD phenotype (Lim et al., 20........ Read more »
Verma S, Tyagi C, Goyal S, Pandey B, Jamal S, Singh A, & Grover A. (2016) Mutations induce conformational changes in folliculin C-terminal domain: possible cause of loss of guanine exchange factor activity and Birt-Hogg-Dubé syndrome. Journal of biomolecular structure , 1-6. PMID: 27484154
A bit of a lazy post for you today with lots of quotes based on the findings reported by Ragnar Nesvåg and colleagues  asking some important questions about 'off-label' use of antipsychotics.Drawing on population-based data from Norway concerning "which substances, and for which mental disorder diagnoses, antipsychotic drugs were prescribed to 0–18-year-old boys and girls" the conclusions drawn make for some interesting reading.So: "In total, 0.18% of Norwegian children and adolescent........ Read more »
Nesvåg, R., Hartz, I., Bramness, J., Hjellvik, V., Handal, M., & Skurtveit, S. (2016) Mental disorder diagnoses among children and adolescents who use antipsychotic drugs. European Neuropsychopharmacology. DOI: 10.1016/j.euroneuro.2016.07.001
Should we have people providing "fake" acupuncture in the Emergency Department?
If so, how should we do this?
Since it is not the acupuncture, but the patient's reaction to the "ceremony of the placebo" that appears to be providing the pain relief, how many different ways might we vary the "treatment" to improve the placebo effect?... Read more »
Grissa, M., Baccouche, H., Boubaker, H., Beltaief, K., Bzeouich, N., Fredj, N., Msolli, M., Boukef, R., Bouida, W., & Nouira, S. (2016) Acupuncture vs intravenous morphine in the management of acute pain in the ED. The American Journal of Emergency Medicine. DOI: 10.1016/j.ajem.2016.07.028
Espay, A., Norris, M., Eliassen, J., Dwivedi, A., Smith, M., Banks, C., Allendorfer, J., Lang, A., Fleck, D., Linke, M.... (2015) Placebo effect of medication cost in Parkinson disease: A randomized double-blind study. Neurology, 84(8), 794-802. DOI: 10.1212/WNL.0000000000001282
Waber RL, Shiv B, Carmon Z, Ariely D. (2008) Commercial Features of Placebo and Therapeutic Efficacy. JAMA, 299(9), 1016. DOI: 10.1001/jama.299.9.1016
Cherkin, D., Sherman, K., Avins, A., Erro, J., Ichikawa, L., Barlow, W., Delaney, K., Hawkes, R., Hamilton, L., Pressman, A.... (2009) A Randomized Trial Comparing Acupuncture, Simulated Acupuncture, and Usual Care for Chronic Low Back Pain. Archives of Internal Medicine, 169(9), 858. DOI: 10.1001/archinternmed.2009.65
Goldman, R., Stason, W., Park, S., Kim, R., Schnyer, R., Davis, R., Legedza, A., & Kaptchuk, T. (2008) Acupuncture for Treatment of Persistent Arm Pain Due to Repetitive Use. The Clinical Journal of Pain, 24(3), 211-218. DOI: 10.1097/AJP.0b013e31815ec20f
There's a reason it's called a gut feeling. The brain and the gut are connected by intricate neural networks that signal hunger and satiety, love and fear, even safety and danger. These networks employ myriad chemical signals that include dopamine, a powerful neurotransmitter most famous for its role in reward and addiction.
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Xiou Cao, & Alejandro Aballay. (2016) Neural inhibition of dopaminergic signaling enhances immunity in a cell non-autonomous manner. Current Biology. info:/http://dx.doi.org/10.1016/j.cub.2016.06.036
There was always that nagging feeling of not being accepted, of whispers behind his back. They pretended to be open-minded, but in reality not belonging to the group of professionals was reason enough to dismiss his work and findings. In their eyes, he was just a solicitor. A hobbyist. He was tolerated, but their derision […]... Read more »
De Groote, I., Flink, L., Abbas, R., Bello, S., Burgia, L., Buck, L., Dean, C., Freyne, A., Higham, T., Jones, C.... (2016) New genetic and morphological evidence suggests a single hoaxer created ‘Piltdown man’. Royal Society Open Science, 3(8), 160328. DOI: 10.1098/rsos.160328
"In this nationwide sample of live births we observed no association between induction of labor and offspring ASD [autism spectrum disorder] within sibling comparison. Our findings suggest that concern for ASD should not factor into the clinical decision about whether to induce labor."So said the findings reported by Anna Sara Oberg and colleagues  supposedly providing some reassurance to mums-to-be and other groups around the likelihood of offspring autism when birth or l........ Read more »
Oberg, A., D’Onofrio, B., Rickert, M., Hernandez-Diaz, S., Ecker, J., Almqvist, C., Larsson, H., Lichtenstein, P., & Bateman, B. (2016) Association of Labor Induction With Offspring Risk of Autism Spectrum Disorders. JAMA Pediatrics. DOI: 10.1001/jamapediatrics.2016.0965
Last week, I discussed how male quality in birds may be related to their song. How do males evaluate females in return? The answer may lie in their nests.... Read more »
Cantarero, A., López-Arrabé, J., Plaza, M., Saavedra-Garcés, I., & Moreno, J. (2016) Males feed their mates more and take more risks for nestlings with larger female-built nests: an experimental study in the Nuthatch Sitta europaea. Behavioral Ecology and Sociobiology, 70(8), 1141-1150. DOI: 10.1007/s00265-016-2122-2
If you read my blog often, it's no surprise I suffer from PTSD, depression, and anxiety issues. Maybe it's from my military service, but maybe it's my father's, or his father's, maybe it's an insidious family legacy that was just never noticed. This is because having both parents and grandparents with major depressive disorder (MDD) was associated with higher risk of MDD for grandchildren, which could help identify those who may benefit from early intervention.
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Myrna M. Weissman, PhD, Obianuju O. Berry, MD, MPH, Virginia Warner, DrPH, Marc J. Gameroff, PhD, Jamie Skipper, MS, Ardesheer Talati, PhD, Daniel J. Pilowsky, MD, MPH, & Priya Wickramaratne, PhD. (2016) A 30-Year Study of 3 Generations at High Risk and Low Risk for Depression. JAMA Psychiatry . info:/10.1001/jamapsychiatry.2016.1586
Scientists tracked down the evidence for a common statement about bite strength in dogs – and found it lacking.Have you ever read comments about the strength of a dog’s jaw when it bites? These statements are often made in relation to certain types of dog, like pit bulls. Maybe some people take it as fact. But what if it’s not true?A recent paper by Dr. Gary Patronek (Cummings School of Veterinary Medicine, Tufts University) et al traced citations in the literature and went back to the ori........ Read more »
Patronek, G., Bradley, J., & Cleary, D. (2016) Who is minding the bibliography? Daisy chaining, dropped leads, and other bad behavior using examples from the dog bite literature. Journal of Veterinary Behavior: Clinical Applications and Research, 17-19. DOI: 10.1016/j.jveb.2016.06.004
One cannot over estimate the ways that water affects life on Earth. Beyond its chemical properties, some animals have evolved to substitute water for a rigid skeleton. Hydrostatic skeletons can be used for support, but also as water vascular systems that provide pressure for vascular transport and respiration. A recent review by William H. Kier sheds light on the interactions of different fibers and tissues in water based skeletons. Yet some plants can withstand a loss of 60% of their water, whe........ Read more »
A hands-free ultrasound unit at 1 MHz failed to increase the temperature deep in the gastrocnemius after 10 minutes.... Read more »
Melanson, H., Draper, D., Mitchell, U., & Eggett, D. (2016) Comparison of Hands-free Ultrasound and Traditional Ultrasound for Therapeutic Treatment. Athletic Training , 8(4), 177-184. DOI: 10.3928/19425864-20160505-01
Although research stories stating a link (an association if you will) between condition A and factor X make for interesting reading, not all science is so blessed with such news-worthy findings. That's not to say that 'negative findings' are any less important than the 'hey, we found this...' studies, just that they don't perhaps tend to grab the headlines as much as those finding something.In saying all that I'm standing up for negative findings today and some rather interesting science reporte........ Read more »
Duringer J, Fombonne E, & Craig M. (2016) No Association between Mycotoxin Exposure and Autism: A Pilot Case-Control Study in School-Aged Children. Toxins, 8(7). PMID: 27447670
It's not a fad diet, it is an actual diet -- as in the way a person eats normally -- and it may do more than just help your waistline. The Mediterranean diet can improve your mind, as well your heart.
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Hardman, R., Kennedy, G., Macpherson, H., Scholey, A., & Pipingas, A. (2016) Adherence to a Mediterranean-Style Diet and Effects on Cognition in Adults: A Qualitative Evaluation and Systematic Review of Longitudinal and Prospective Trials. Frontiers in Nutrition. DOI: 10.3389/fnut.2016.00022
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