Just like OM research, SCM research is dominated by three research methodologies: (1) analytical modelling research (optimization, computational, and simulation models etc.), (2) quantitative empirical research (surveys etc., and (3) case study research. There has been a recent trend towards multi-methodological research that combines different methodologies. A new article by Choi, Cheng and Zhao, titled […]... Read more »
Choi, T., Cheng, T., & Zhao, X. (2015) Multi-Methodological Research in Operations Management. Production and Operations Management. DOI: 10.1111/poms.12534
The NEJM has come out with a very interesting paper: Evaluation of Convalescent Plasma for Ebola Virus Disease in Guinea. The explosive outbreak of Ebola Virus Disease in West Africa last year had hijacked the headlines and media space in a big way. Multiple solutions were touted, including the vaccine trial STRIVE. Few articles, however, looked…... Read more »
van Griensven J, Edwards T, de Lamballerie X, Semple MG, Gallian P, Baize S, Horby PW, Raoul H, Magassouba N, Antierens A.... (2016) Evaluation of Convalescent Plasma for Ebola Virus Disease in Guinea. The New England journal of medicine, 374(1), 33-42. PMID: 26735992
When you have a fever, your nose is stuffed and your headache is spreading to your toes, your body is telling you to stay home in bed. Feeling sick is an evolutionary adaptation according to a hypothesis put forward by Prof. Guy Shakhar of the Weizmann Institute’s Immunology Department and Dr. Keren Shakhar of the Psychology Department of the College of Management Academic Studies.... Read more »
Shakhar, K., & Shakhar, G. (2015) Why Do We Feel Sick When Infected—Can Altruism Play a Role?. PLOS Biology, 13(10). DOI: 10.1371/journal.pbio.1002276
I wrote about the disaster-in-the-making discovery of transmissible resistance to colistin, a last resort antibiotic, when the Lancet Infectious Diseases published a paper based on data coming out from surveillance in China. At that point of time, the isolation of the transmissible gene providing resistance (mcr1 gene) gained a lot of attention. Maryn McKenna’s blog post went…... Read more »
Poirel, L., Kieffer, N., Liassine, N., Thanh, D., & Nordmann, P. (2016) Plasmid-mediated carbapenem and colistin resistance in a clinical isolate of Escherichia coli. The Lancet Infectious Diseases. DOI: 10.1016/S1473-3099(16)00006-2
Text by Lauri Laanisto Another paper from the Mediterranen. This time Ülo has participated in a study dealing with a paradox regarding Quercus coccifera´s ecophysiological functioning in different climate zones. The paper is rather techincal, so I´m not gonna try … Continue reading →... Read more »
Peguero-Pina JJ, Sisó S, Fernández-Marín B, Flexas J, Galmés J, García-Plazaola JI, Niinemets Ü, Sancho-Knapik D, & Gil-Pelegrín E. (2015) Leaf functional plasticity decreases the water consumption without further consequences for carbon uptake in Quercus coccifera L. under Mediterranean conditions. Tree physiology. PMID: 26705310
How does the brain encode physical pain? Which brain areas (if any) respond only to painful stimuli?
A new paper reports that one supposedly "pain-selective" brain region, the posterior insula, doesn't actually specifically encode pain - it activates in response to diverse non-painful stimuli as well. The study appears in PLoS Biology and it comes from Giulia Liberati and colleagues of the Université catholique de Louvain, Belgium.
Liberati et al. found that the insula responds to non-... Read more »
Liberati G, Klöcker A, Safronova MM, Ferrão Santos S, Ribeiro Vaz JG, Raftopoulos C, & Mouraux A. (2016) Nociceptive Local Field Potentials Recorded from the Human Insula Are Not Specific for Nociception. PLoS Biology, 14(1). PMID: 26734726
So: "In conclusion, the present meta-analysis found that folate deficiency is associated to SZ [schizophrenia], and subgroups which did not reach enough statistical power need further investigation in the future."That was the research bottom line discussed in the paper by Dan Wang and colleagues  on a topic that has been of some interest to this blog down the years (see here and see here for example). Folate (folic acid if you will) is a pretty vital nutrient that, among other thing........ Read more »
Wang D, Zhai JX, & Liu DW. (2015) Serum folate levels in schizophrenia: A meta-analysis. Psychiatry research. PMID: 26652840
MedicalResearch.com Interview with: Rhonda Bassel-Duby, Ph.D. and Dr. Chengzu Long, PhD Department of Molecular Biology UT Southwestern Medical Center Dallas, TX 75390-9148 Medical Research: What is the background for this study? What are the main findings? Response: Duchenne muscular dystrophy (DMD), … Continue reading →
The post CRISPR Successfully Restores Gene Function in Animal Model of Duchenne Muscular Dystrophy appeared first on MedicalResearch.com.
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Rhonda Bassel-Duby, Ph.D. and, & Dr. Chengzu Long, Graduate Student. (2016) CRISPR Successfully Restores Gene Function in Animal Model of Duchenne Muscular Dystrophy. MedicalResearch.com. info:/
A study by researchers at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) has identified a new mechanism through which hematopoietic stem cells (HSCs) control both their own proliferation and the characteristics of the niche that houses them. This control is exercised by the protein E-Selectin Ligand-1 (ESL-1).... Read more »
Leiva, M., Quintana, J., Ligos, J., & Hidalgo, A. (2016) Haematopoietic ESL-1 enables stem cell proliferation in the bone marrow by limiting TGFβ availability. Nature Communications, 10222. DOI: 10.1038/ncomms10222
MedicalResearch.com Interview with: Sam P. Most, M.D., F.A.C.S. Professor, Departments of Otolaryngology-Head & Neck Surgery and Surgery (Division of Plastic Surgery, by courtesy) Chief, Division of Facial Plastic & Reconstructive Surgery Stanford University School of Medicine Stanford, CA Medical Research: What … Continue reading →
The post Medical Therapy In Patients With Severe Nasal Obstruction Likely To Fail appeared first on MedicalResearch.com.
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Sam P. Most, M.D., F.A.C.S. (2016) Medical Therapy In Patients With Severe Nasal Obstruction Likely To Fail. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Svetlana Popova, M.D., Ph.Ds., M.P.H. Senior Scientist Social and Epidemiological Research, Centre for Addiction and Mental Health Associate Professor, Epidemiology Division, Dalla Lana School of Public Health, University of Toronto Associate Professor, Factor-Inwentash Faculty of Social Work, … Continue reading →
The post Fetal Alcohol Syndrome Linked to 400 Comorbid Conditions appeared first on MedicalResearch.com.
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Svetlana Popova, M.D., Ph.Ds., M.P.H. (2016) Fetal Alcohol Syndrome Linked to 400 Co-morbid Conditions. MedicalResearch.com. info:/
Rigatoni pomodorini e tonno. Today the FDA released the updated Dietary Recommendations for the USA. The whole document is available on the Internet for free, and you should read it:http://health.gov/dietaryguidelines/2015/guidelines/People are going to hate me for this post, but I'm going to post it anyway because somebody needs to say it. When I open Facebook, half of the posts are about how women should love their bodies. What gets me is that nobody says that loving your body is not only........ Read more »
U.S. Department of Health and Human Services and the U.S. Department of Agriculture. (2015) Dietary Guidelines for Americans 2015-2020, Eigth Edition. health.org. DOI: 10.1037/e516742014-001
Mancini, J., Filion, K., Atallah, R., & Eisenberg, M. (2015) Systematic Review of the Mediterranean Diet for Long-Term Weight Loss. The American Journal of Medicine. DOI: 10.1016/j.amjmed.2015.11.028
Schwingshackl L, & Hoffmann G. (2015) Adherence to Mediterranean diet and risk of cancer: an updated systematic review and meta-analysis of observational studies. Cancer medicine. PMID: 26471010
The media are on the warpath again! This time, it's alcohol. But is this new?... Read more »
Department of Health. (2016) Alcohol Guidelines Review – Report from the Guidelines development group to the UK Chief Medical Officers. www.gov.uk. info:/
Bagnardi, V., Rota, M., Botteri, E., Tramacere, I., Islami, F., Fedirko, V., Scotti, L., Jenab, M., Turati, F., Pasquali, E.... (2012) Light alcohol drinking and cancer: a meta-analysis. Annals of Oncology, 24(2), 301-308. DOI: 10.1093/annonc/mds337
The prescription opioid crisis of overdosing and overprescribing has reached epic proportions, according to the North American media. Just last week, we learned that 91% of patients who survive opioid overdose are prescribed more opioids! The CDC calls it an epidemic, and notes there's been “a 200% increase in the rate of overdose deaths involving opioid pain relievers and heroin.” A recent paper in the Annual Review of Public Health labels it a “public health crisis” and proposes “int........ Read more »
Panksepp, J., & Yovell, Y. (2014) Preclinical Modeling of Primal Emotional Affects (SEEKING, PANIC and PLAY): Gateways to the Development of New Treatments for Depression. Psychopathology, 47(6), 383-393. DOI: 10.1159/000366208
Tenore, P. (2008) Psychotherapeutic Benefits of Opioid Agonist Therapy. Journal of Addictive Diseases, 27(3), 49-65. DOI: 10.1080/10550880802122646
Watt, D., & Panksepp, J. (2009) Depression: An Evolutionarily Conserved Mechanism to Terminate Separation Distress? A Review of Aminergic, Peptidergic, and Neural Network Perspectives. Neuropsychoanalysis, 11(1), 7-51. DOI: 10.1080/15294145.2009.10773593
Yovell, Y., Bar, G., Mashiah, M., Baruch, Y., Briskman, I., Asherov, J., Lotan, A., Rigbi, A., & Panksepp, J. (2015) Ultra-Low-Dose Buprenorphine as a Time-Limited Treatment for Severe Suicidal Ideation: A Randomized Controlled Trial. American Journal of Psychiatry. DOI: 10.1176/appi.ajp.2015.15040535
Text by Lauri Laanisto A big part research done nowadays in various plant (eco)physiology labs all over the world is about calibrating different methods and measurement approaches. There are innumerable ways of how to measure some specific function in some … Continue reading →... Read more »
De Kauwe MG, Lin YS, Wright IJ, Medlyn BE, Crous KY, Ellsworth DS, Maire V, Prentice IC, Atkin OK, Rogers A.... (2015) A test of the 'one-point method' for estimating maximum carboxylation capacity from field-measured, light-saturated photosynthesis. The New phytologist. PMID: 26719951
Tumour cells can create immunosuppressive microenvironments by hijacking natural mechanisms such as PD-L1 expression to impair T-cell function. Several new immunotherapy treatments target the PD-1/PD-L1 pathway and have produced some long-lasting responses in patients (Motzer et al., 2015) but not all patients respond. High expression of PD-L1 in clear cell RCC (ccRCC) has been shown to correlate with metastasis and poor outcome (Thompson et al., 2007). New research from Messai et al. (2015) has........ Read more »
Messai Y, Gad S, Noman MZ, Le Teuff G, Couve S, Janji B, Kammerer SF, Rioux-Leclerc N, Hasmim M, Ferlicot S.... (2015) Renal Cell Carcinoma Programmed Death-ligand 1, a New Direct Target of Hypoxia-inducible Factor-2 Alpha, is Regulated by von Hippel-Lindau Gene Mutation Status. European urology. PMID: 26707870
Psychologists have already identified a multitude of factors – besides actually how hungry we are – that influence the amount we choose to eat, from the size of the portion, to the company we're dining with. To this list, we can now add the weight of our waiter or waitress. According to new field research in the journal Environment and Behaviour, when people are served by an overweight person, they are more likely to order desert, and they tend to consume more alcoholic drinks.The finding le........ Read more »
Do ring, T., & Wansink, B. (2015) The Waiters Weight: Does a Servers BMI Relate to How Much Food Diners Order?. Environment and Behavior. DOI: 10.1177/0013916515621108
Sleep apnoea defined as "a condition where the walls of the throat relax and narrow during sleep, interrupting normal breathing" is not natural fodder for this blog. When however it is mentioned in the context of autism as it was in the paper by Ikuko Hirata and colleagues  it becomes a little more relevant; more so when one realises that sleep issues and autism might actually be quite an important topic (see here).Hirata et al describe the assessment of sleep problems in "965 commu........ Read more »
Hirata, I., Mohri, I., Kato-Nishimura, K., Tachibana, M., Kuwada, A., Kagitani-Shimono, K., Ohno, Y., Ozono, K., & Taniike, M. (2016) Sleep problems are more frequent and associated with problematic behaviors in preschoolers with autism spectrum disorder. Research in Developmental Disabilities, 86-99. DOI: 10.1016/j.ridd.2015.11.002
MedicalResearch.com Interview with: Marc Haspeslagh, MD Dermpat, Ardooie, Belgium Department of Dermatology University Hospital, Ghent, Belgium Medical Research: What is the background for this study? Dr. Haspeslagh: In daily practice, most pathology laboratories process skin biopsy specimens without access to the clinical … Continue reading →
The post Dermoscopy May Improve Pathology Interpretation of Skin Tumors appeared first on MedicalResearch.com.
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Marc Haspeslagh, MD. (2016) Dermoscopy May Improve Pathology Interpretation of Skin Tumors. MedicalResearch.com. info:/
All it took was one mutation more than 600 million years ago. With that random act, a new protein function was born that helped our single-celled ancestor transition into an organized multicellular organism. That’s the scenario — done with some molecular time travel — that emerged from basic research in the lab of University of Oregon biochemist Ken Prehoda.... Read more »
Anderson, D., Whitney, D., Hanson-Smith, V., Woznica, A., Campodonico-Burnett, W., Volkman, B., King, N., Prehoda, K., & Thornton, J. (2016) Evolution of an ancient protein function involved in organized multicellularity in animals. eLife. DOI: 10.7554/eLife.10147
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