"These results demonstrate that n-3 PUFAs dietary supplementation, although not a panacea, has a considerable therapeutic value for FXS [Fragile X syndrome] and potentially for ASD [autism spectrum disorder], suggesting a major mediating role of neuroinflammatory mechanisms".A view @ Wikipedia That was the conclusion reached by Susanna Pietropaolo and colleagues  who "evaluated the impact of n-3 PUFA dietary supplementation in a mouse model of fragile X syndrome ........ Read more »
Pietropaolo S, Goubran MG, Joffre C, Aubert A, Lemaire-Mayo V, Crusio WE, & Layé S. (2014) Dietary supplementation of omega-3 fatty acids rescues fragile X phenotypes in Fmr1-Ko mice. Psychoneuroendocrinology, 119-129. PMID: 25080404
Patellofemoral Joint Stress during Running with Alterations in Foot Strike Pattern... Read more »
Nathan Vannatta C, & Kernozek TW. (2014) Patellofemoral Joint Stress during Running with Alterations in Foot Strike Pattern. Medicine and science in sports and exercise. PMID: 25202853
We like to give treatments that produce results that we can see and logically attribute to the treatments we gave.
We like to give IV (IntaVenous) furosemide (Lasix – frusemide in Commonwealth countries) for CHF (Congestive Heart Failure).
1. The patient had CHF.
2. I gave IV furosemide.
3. The patient produced urine.... Read more »
Figueras J, & Weil MH. (1978) Blood volume prior to and following treatment of acute cardiogenic pulmonary edema. Circulation, 57(2), 349-55. PMID: 618625
Francis GS, Siegel RM, Goldsmith SR, Olivari MT, Levine TB, & Cohn JN. (1985) Acute vasoconstrictor response to intravenous furosemide in patients with chronic congestive heart failure. Activation of the neurohumoral axis. Annals of internal medicine, 103(1), 1-6. PMID: 2860833
Hoffman JR, & Reynolds S. (1987) Comparison of nitroglycerin, morphine and furosemide in treatment of presumed pre-hospital pulmonary edema. Chest, 92(4), 586-93. PMID: 3115687
Sometimes, the employer is even in a bigger need than the job seeker. And the most used instrument which can bring these two together is a resume.... Read more »
Mark Wilson. (2012) How To Redesign Your Resume For A Recruiter’s 6-Second Attention Span. fastcodesign.com. info:/
Multiple sclerosis (MS) is an unpredictable, often disabling disease of the central nervous system that disrupts the flow of information within the brain, and between the brain and body. The exact cause is unknown, however people with multiple sclerosis lose myelin in the gray matter of their brains and the loss is closely correlated with the severity of the disease, according to a new magnetic resonance imaging (MRI) study.... Read more »
Vasily L. Yarnykh, James D. Bowen, Alexey Samsonov, Pavle Repovic, Angeli Mayadev, Peiqing Qian, Beena Gangadharan, Bart P. Keogh, Kenneth R. Maravilla, & Lily K. Jung Henson. (2014) Fast Whole-Brain Three-dimensional Macromolecular Proton Fraction Mapping in Multiple Sclerosis. Radiological Society of North America . info:/10.1148/radiol.14140528
Do dogs that are deaf and/or blind have specific behavioural traits? New research sets out to investigate – and finds they are very similar to dogs with normal hearing and vision.Photo: Amy Rene / ShutterstockNo one knows exactly how many dogs have hearing or vision problems. Congenital deafness and/or blindness occur in several breeds. In some cases this is related to coat colours – for example the double merle gene in Australian Shepherds is linked to deafness and blindness– and at........ Read more »
Farmer-Dougan, V., Quick, A., Harper, K., Schmidt, K., & Campbell, D. (2014) Behavior of Hearing or Vision Impaired and Normal Hearing and Vision Dogs (Canis lupus familiaris): Not the same but not that different . Journal of Veterinary Behavior. info:/
Andrew Pelling has a new application for the apple, but it is not the latest i-gizmo from Cupertino, CA. Pelling and colleagues at the University of Ottawa have come up with a possible solution to the limitations of traditional, two-dimensional (2D) cell culture, which does not reproduce the microenvironment and tissue architecture that surrounds cells in a living organism—the apple, the one-a-day fruit that keeps the doctor away and is an essential ingredient to the All-American pie. Pell........ Read more »
Modulevsky DJ, Lefebvre C, Haase K, Al-Rekabi Z, & Pelling AE. (2014) Apple derived cellulose scaffolds for 3D mammalian cell culture. PloS one, 9(5). PMID: 24842603
“Giving implies to make the other person a giver also.” So said Eric Fromm whose quote starts this research paper which travels to the heart of mutual aid. The clear message? In helping other, we help ourselves. The recovery saying “We only keep what we have by giving it away” hits the mark in this respect. What [...]
The post Altruism and AlAnon: in helping we are helped appeared first on Recovery Review.
... Read more »
Kuuluvainen, V., & Isotalus, P. (2014) Supporting others – Supporting oneself: Members’ evaluations of supportive communication in Al-Anon mutual-aid groups. Studies in Communication Sciences. DOI: 10.1016/j.scoms.2014.03.009
A strange and provocative paper by Alexander Panchin and colleagues proposes an unorthodox new idea called the “biomeme hypothesis”, which posits that the impulse behind some religious rituals could be driven by mind-altering parasites.... Read more »
Panchin AY, Tuzhikov AI, & Panchin YV. (2014) Midichlorians--the biomeme hypothesis: is there a microbial component to religious rituals?. Biology direct, 9(1), 14. PMID: 24990702
Breaking into the zeitgeist recently, Docker popped into my sphere from several disparate sources. Seems to me that this is a potential problem-solver for some of the reproducibility and sharing dramas that we have been wrestling with in genomics. Sharing of data sets and versions of analysis software is being tackled in a number of […]... Read more »
The rapid adoption of next-gen exome and genome sequencing for clinical use (i.e. with patient DNA) raises some difficult questions about the return of results to patients and their families. In contrast to traditional genetic testing, which usually checks for variants in specific genes, high-throughput sequencing has the potential to reveal a number of secondary […]... Read more »
Tabor HK, Auer PL, Jamal SM, Chong JX, Yu JH, Gordon AS, Graubert TA, O'Donnell CJ, Rich SS, Nickerson DA.... (2014) Pathogenic variants for mendelian and complex traits in exomes of 6,517 European and african americans: implications for the return of incidental results. American journal of human genetics, 95(2), 183-93. PMID: 25087612
Bacteria have evolved a type of motion that is a lot like a snot-powered rocket, so getting from point A to point B must be pretty important. Bacteria have evolved no fewer, and probably a lot more, than eight different ways to move around. New research is defining the physics and molecular biology of these modes of transportation, including a pseudo-cytoskeleton, helical conveyor belts, and something called “reverse and flick.”... Read more »
Balish MF. (2014) Giant steps toward understanding a mycoplasma gliding motor. Trends in microbiology, 22(8), 429-31. PMID: 24986074
Kinosita Y, Nakane D, Sugawa M, Masaike T, Mizutani K, Miyata M, & Nishizaka T. (2014) Unitary step of gliding machinery in Mycoplasma mobile. Proceedings of the National Academy of Sciences of the United States of America, 111(23), 8601-6. PMID: 24912194
Jin F, Conrad JC, Gibiansky ML, & Wong GC. (2011) Bacteria use type-IV pili to slingshot on surfaces. Proceedings of the National Academy of Sciences of the United States of America, 108(31), 12617-22. PMID: 21768344
Indian Purple FrogCredit: Karthickbala at ta.wikipedia (CC-BY-SA-3.0)via Wikimedia CommonsKingdom: AnimaliaPhylum: ChordataClass: AmphibiaOrder: AnuraFamily: SooglossidaeGenus: NasikabatrachusSpecies: Nasikabatrachus sahyadrensisConservation Status: EndageredCommon name(s): Indian purple frog, Pignosed frog, Indian purple frogMeet the Indian puple frog, an endangered and odd-looking species of frog from the mountains of India’s Western Ghats.The species was formally described o........ Read more »
Biju SD, & Bossuyt F. (2003) New frog family from India reveals an ancient biogeographical link with the Seychelles. Nature, 425(6959), 711-4. PMID: 14562102
Thomas A, Suyesh R, Biju SD, & Bee MA. (2014) Vocal behavior of the elusive purple frog of India (Nasikabatrachus sahyadrensis), a fossorial species endemic to the Western Ghats. PloS one, 9(2). PMID: 24516517
Some years ago I proposed a set of solutions to the classical Yang-Mills equations displaying a massive behavior. For a massless theory this is somewhat unexpected. After a criticism by Terry Tao I had to admit that, for a generic gauge, such solutions are just asymptotic ones assuming the coupling runs to infinity (see here […]... Read more »
Marco Frasca. (2009) Mapping a Massless Scalar Field Theory on a Yang-Mills Theory: Classical Case. Mod. Phys. Lett. A 24, 2425-2432 (2009). arXiv: 0903.2357v4
Knock Knock!Who's There?ImaIma who?Ima psychologist. I'm here cos you won't open up.When dance partners perform, their bodily movements become synchronised. This is deliberate on their part, of course, and we can see the timed interplay of their actions. What psychologists have begun to realise is that this kind of bodily synchrony also occurs between people in many everyday situations, except in these cases the physical "dance" is unintentional and it's more subtle, such as when two people sitt........ Read more »
In a post not-so-long-ago I talked about an interesting piece of research by Ahn and colleagues  suggesting that a ketogenic diet might yet hold some promise to "modify complex social behaviors and mitochondrial respiration" affected in the "prenatal valproic acid (VPA) rodent model of ASD [autism spectrum disorder]". The idea being that exposure to valproic acid (valproate) during the nine months that made us might carry some heightened risk for adverse effects on offspring development (see ........ Read more »
Wellmann KA, Varlinskaya EI, & Mooney SM. (2014) D-Cycloserine Ameliorates Social Alterations That Result From Prenatal Exposure To Valproic Acid. Brain research bulletin. PMID: 25130667
Kim JW, Seung H, Kwon KJ, Ko MJ, Lee EJ, Oh HA, Choi CS, Kim KC, Gonzales EL, You JS.... (2014) Subchronic Treatment of Donepezil Rescues Impaired Social, Hyperactive, and Stereotypic Behavior in Valproic Acid-Induced Animal Model of Autism. PloS one, 9(8). PMID: 25133713
Despite the great strides that have been made toward a more egalitarian society in the United States over the past 50 years, events like what occurred in Ferguson last month are a bleak reminder of the racial tensions that still exist here. Of course, the United States is not alone in this respect; throughout the world we can see abundant examples of strain between different races, as well as between any groups with dissimilar characteristics. In fact, it seems that the quickness with which we f........ Read more »
Genetics and Running Economy... Read more »
Bertuzzi R, Pasqua LA, Bueno S, Lima-Silva AE, Matsuda M, Marquezini M, & Saldiva PH. (2014) Is the COL5A1 rs12722 Gene Polymorphism Associated with Running Economy?. PloS one, 9(9). PMID: 25188268
As a male we are at higher risk for heart disease, we are also at higher risk for stroke. It’s that pesky testosterone, sure it has its benefits, don’t get me wrong I think testosterone over all is great. Estrogen has it’s own downsides too, things like certain cancers for example. Well estrogen has some other benefits and as it turns out, the same sex hormone that helps protect females from stroke may also reduce their risk of autism.... Read more »
Amanda Crider,, Roshni Thakkar,, Anthony O Ahmed, & Anilkumar Pillai. (2014) Dysregulation of estrogen receptor beta (ERβ), aromatase (CYP19A1), and ER co-activators in the middle frontal gyrus of autism spectrum disorder subjects. Molecular Autism . info:/10.1186/2040-2392-5-46
When I think about modern cemeteries, I usually perceive them as quiet resting places for the deceased. As I drive by them they are usually well kept, maintained green spaces […]... Read more »
Koji Mizoguchi. (2014) The centre of their life-world: the archaeology of experience at the Middle cemetery of Tateiwa-Hotta, JapanYayoi. Antiquity, 836-850. info:/
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