In cancer genomics, we typically identify somatic alterations by sequencing DNA from both a tumor and a matched normal “control” sample from the same patient. The Cancer Genome Atlas and other large-scale efforts to characterize tumor genomes have typically used this approach, because it allows mutation callers (like VarScan 2) to distinguish between inherited variation and acquired (somatic) […]... Read more »
Hiltemann S, Jenster G, Trapman J, van der Spek P, & Stubbs A. (2015) Discriminating somatic and germline mutations in tumor DNA samples without matching normals. Genome research. PMID: 26209359
The link between the mind and brain is tricky enough for expert psychologists and neuroscientists to grapple with, let alone young children. Nonetheless, they grow up with their own naive understanding. For example, there's some cute research from the 90s that found, somewhere between age 7 and 9, most children come to see the brain as containing thoughts and memories – they'll say that a skunk with a brain transplant from a rabbit will have memories of being a rabbit. Younger kids, by co........ Read more »
Rossi, S., Lanoë, C., Poirel, N., Pineau, A., Houdé, O., & Lubin, A. (2015) When I Met my brain: Participating in a neuroimaging study influences children’s naïve mind–brain conceptions. Trends in Neuroscience and Education. DOI: 10.1016/j.tine.2015.07.001
I briefly want to bring the paper from Lucia Billeci and colleagues  to your attention today and the suggestion that following their systematic review of the current peer-reviewed literature, there seemed to be something of "an association between ASD [autism spectrum disorder] and AD [atopic dermatitis]."Atopic, by the way, refers to sensitivity to allergens, and in the case of AD, how such sensitivity manifests on the skin causing itchiness, redness and the skin to ........ Read more »
Billeci L, Tonacci A, Tartarisco G, Ruta L, Pioggia G, & Gangemi S. (2015) Association Between Atopic Dermatitis and Autism Spectrum Disorders: A Systematic Review. American journal of clinical dermatology. PMID: 26254000
Take Home Message: A systematic review of 11 studies revealed that patients who either received anterior cruciate ligament (ACL) reconstruction or remained deficient (ACL-D) reported lower quality of life than the general healthy population.... Read more »
Filbay, S., Culvenor, A., Ackerman, I., Russell, T., & Crossley, K. (2015) Quality of life in anterior cruciate ligament-deficient individuals: a systematic review and meta-analysis. British Journal of Sports Medicine, 49(16), 1033-1041. DOI: 10.1136/bjsports-2015-094864
MedicalResearch.com Interview with: Roger S. Ho, MD, MS, MPH, FAAD Assistant Professor The Ronald O. Perelman Department of Dermatology NYU Langone Medical Center Medical Research: What is the background for this study? What are the main findings? Dr. Ho: In … Continue reading →
The post Psoriasis Patients Have Increased Risk Of Depression appeared first on MedicalResearch.com Medical Research Interviews and News.
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Roger S. Ho, MD, MS, MPH, FAAD. (2015) Psoriasis Patients Have Increased Risk Of Depression. MedicalResearch.com. info:/
by Laura Smith-Khan in Language on the Move
When people arrive in countries like Australia, seeking to be recognised as refugees and offered protection, it is obviously important that they are able to communicate their experiences and respond to any doubts the authorities may have about their claims. … Continue reading →... Read more »
Crock, M. . (2011) Immigration, Refugees and Forced Migration: Law, policy and practice in Australia. Annandale: The Federation Press. info:/
There are many examples throughout nature of microorganisms like bacteria, viruses, and parasites influencing the neurobiology and behavior of their hosts. For example, the rabies virus enters the nervous system almost immediately after a bite or scratch and travels to the brain, where it influences neural activity to make aggressive behavior more likely. This, of course, is beneficial for the virus as it increases the probability its infected host will make contact with another susceptible host........ Read more »
Cryan, J., & Dinan, T. (2012) Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nature Reviews Neuroscience, 13(10), 701-712. DOI: 10.1038/nrn3346
The history of Bahamas mosquitofish is written in their genitals. Though you'd have a hard time locating a female fish's reproductive parts, they tell a story of predators, suitors, and finding a way to regain control.
Gambusia hubbsi arrived at Andros Island, in the Bahamas, about 15,000 years ago. The little fish live in vertical, water-filled caves called blue holes. Populations separated from each other by these caves are in the process of evolving into different species, pushed by ........ Read more »
Anderson CM, & Langerhans RB. (2015) Origins of female genital diversity: Predation risk and lock-and-key explain rapid divergence during an adaptive radiation. Evolution; international journal of organic evolution. PMID: 26259062
MedicalResearch.com Interview with: John P. Haran MD Assistant Professor of Emergency Medicine University of Massachusetts Medical School, Worcester, MA Medical Research: What is the background for this study? What are the main findings? Dr. Haran: The Infectious Disease Society of … Continue reading →
The post Study Finds Poor Adherence To Guidelines For Skin and Soft Tissue Infections appeared first on MedicalResearch.com Medical Research Interviews and News.
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John P. Haran MD. (2015) Study Finds Poor Adherence To Guidelines For Skin and Soft Tissue Infections. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Candida Rebello, PhD candidate Louisiana State University Pennington Biomedical Research Center School of Nutrition and Food Sciences Baton Rouge , Louisiana MedicalResearch: What is the background for this study? What are the main findings? Response: Oats … Continue reading →
The post Instant Oatmeal at Breakfast Reduced Hunger and Food Intake At Lunch appeared first on MedicalResearch.com Medical Research Interviews and News.
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Candida Rebello, PhD candidate. (2015) Instant Oatmeal at Breakfast Reduced Hunger and Food Intake At Lunch. MedicalResearch.com. info:/
Murderers who kill intimate partners and family members have a significantly different psychological and forensic profile from murderers who kill people they don’t know, reports a new Northwestern Medicine study that examined the demographics, psychiatric history and neuropsychology of these individuals.... Read more »
West-Smith, M. (2014) Book Review: Survived by one: The life and mind of a family mass murderer. Criminal Justice Review, 39(2), 222-224. DOI: 10.1177/0734016814523119
MedicalResearch.com Interview with: William W. Huang, MD, MPH Assistant Professor and Program Director Wake Forest School of Medicine Department of Dermatology Winston-Salem, NC 27104 Medical Research: What is the background for this study? What are the main findings? Dr. Huang: … Continue reading →
The post How Many Screening Tests Are Needed For Psoriasis Patients on Biologics? appeared first on MedicalResearch.com Medical Research Interviews and News.
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William W. Huang, MD, MPH. (2015) How Many Screening Tests Are Needed For Psoriasis Patients on Biologics?. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Anna Lin, MBA, PHD Senior Epidemiologist, Health Services Research American Cancer Society, Inc. 250 Williams St. Atlanta, GA 30303 Medical Research: What is the background for this study? Dr. Lin: Evidence-based guidelines recommend the use of adjuvant chemotherapy … Continue reading →
The post Distance, Insurance and Number of Oncologists Limit Access To Chemotherapy appeared first on MedicalResearch.com Medical Research Interviews and News.
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Anna Lin, MBA, PHD. (2015) Distance, Insurance and Number of Oncologists Limit Access To Chemotherapy. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Søren Friis, Senior Scientist, Associate Professor, MD Danish Cancer Society Research Center Danish Cancer Society Department of Public Health University of Copenhagen Faculty of Health Institute of Clinical Medicine Department of Clinical Epidemiology Aarhus University Denmark Medical Research: … Continue reading →
The post Only Regular Use of Low Dose Aspirin Offers Colon Cancer Protection appeared first on MedicalResearch.com Medical Research ........ Read more »
Søren Friis, Senior Scientist, Associate Professor, MD. (2015) Only Regular Use of Low Dose Aspirin Offers Colon Cancer Protection. MedicalResearch.com. info:/
Young adults – defined here as people aged 18 to 29 – are the most skilled liars, while teens are the most prolific. That's according to a new study published in Acta Psychologica that claims to be the first ever to investigate lying behaviour across the entire lifespan.The research involved members of the public who were visitors at the Science Centre NEMO in Amsterdam. In all, 1005 people took part, aged from 6 to 77. To test lying ability, Evelyne Debey and her colleagues presented the pa........ Read more »
Debey, E., De Schryver, M., Logan, G., Suchotzki, K., & Verschuere, B. (2015) From junior to senior Pinocchio: A cross-sectional lifespan investigation of deception. Acta Psychologica, 58-68. DOI: 10.1016/j.actpsy.2015.06.007
MedicalResearch.com Interview with: Hardeep Singh, MD MPH Chief, Health Policy, Quality and Informatics Program, Houston Veterans Affairs Health Services Research Center for Innovations Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine Houston TX 77030 Medical Research: … Continue reading →
The post Electronic Messages Improved Timeliness of Cancer Diagnosis appeared first on MedicalResearch.com Medical Research Interviews and News.
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Hardeep Singh, MD MPH. (2015) Electronic Messages Improved Timeliness of Cancer Diagnosis. MedicalResearch.com. info:/
This is brand new so I can only get the abstract. A prospective cohort of 100 living kidney donors at the University of Heidelberg were followed for a median of 10 years. [Note: median means mid-point, so half were more than ten and half less than ten] Clinical data was available for 97 donors …
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The post Living Kidney Donors Decrease in Qualify of Life Measures 10 years Later appeared first on Living Donors Are People Too.
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Klop, K., Janki, S., Dooper, P., Weimar, W., Ijzermans, J., & Kok, N. (2015) More than a decade after live donor nephrectomy - a prospective cohort study. Transplant International. DOI: 10.1111/tri.12589
MedicalResearch.com Interview with: Justine Moonen and Jessica Foster-Dingley On behalf of the principal investigators: Roos van der Mast, Ton de Craen, Wouter de Ruijter and Jeroen van der Grond Department of Psychiatry, Leiden University Medical Center Leiden, the Netherlands Medical … Continue reading →
The post Discontinuing Blood Pressure Medication In Older Adults Did Not Improve Cognition appeared first on MedicalResearch.com Medical Research Interviews and News.
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Justine Moonen and Jessica Foster-Dingley. (2015) Discontinuing Blood Pressure Medication In Older Adults Did Not Improve Cognition. MedicalResearch.com. info:/
Integrating "new math knowledge with previous knowledge and experience" is not as interwoven with students' intrinsic personal/emotional qualities as we like to think. It may not matter that they have low or high self-esteem or that they fear or do not fear mathematics or that they have or do not have test anxiety or that they like to challenge themselves or not.... Read more »
I'll freely admit that until reading the paper by François Féron and colleagues  (open-access available here) I had never heard of MOCOS (MOlybdenum COfactor Sulfurase) before.Described as "an enzyme of the purine metabolism that sulfurates the molybdenum cofactor, thus allowing the two downstream enzymes—xanthine dehydrogenase (XDH) and aldehyde oxidase (AOX1)—to be active", researchers reported that in nasal stem cells provided by a small group of adults diagnosed with an autism ........ Read more »
Féron F, Gepner B, Lacassagne E, Stephan D, Mesnage B, Blanchard MP, Boulanger N, Tardif C, Devèze A, Rousseau S.... (2015) Olfactory stem cells reveal MOCOS as a new player in autism spectrum disorders. Molecular psychiatry. PMID: 26239292
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