miRNAs are a class of small RNAs that regulate gene expression via RNA silencing machinery. Some viruses also encode miRNAs, contributing to the complex virus-host interactions. A better understanding of viral miRNA functions would be useful in designing new preventive strategies for treating diseases induced by viruses. To meet the challenge for how viruses module host gene expression by their encoded miRNAs, we measured the functional........ Read more »
Yu, G., & He, Q. (2011) Functional similarity analysis of human virus-encoded miRNAs. Journal of Clinical Bioinformatics, 1(1), 15. DOI: 10.1186/2043-9113-1-15
As an in vitro model for type II human lung cancer, A549 cells resist cytotoxicity via phosphorylation of proteins as demonstrated by many studies. However, to date, no large-scale phosphoproteome investigation has been conducted on A549. Here, we performed a systematical analysis of the phosphoproteome of A549 by using mass spectrometry (MS)-based strategies. This investigation led to the identification of 337 phosphorylation sites on 181 phosphoproteins. Among them, 67 phosphoproteins and ........ Read more »
Yu G, Xiao CL, Lu CH, Jia HT, Ge F, Wang W, Yin XF, Jia HL, He JX, & He QY. (2010) Phosphoproteome profile of human lung cancer cell line A549. Molecular bioSystems. PMID: 21060948
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