14 posts · 12,873 views
A blog discussing zoonotic diseases and public health (both in general and the latest research) interspersed with a PhD student's musings on her own research...
This week in the online journal club #microtwjc we will be discussing this paper titled “Schmallenberg Virus Pathogenesis, Tropis and Interaction with the Innate Immune System of the Host” (Varela M, Schnettler E, Caporale M, Murgia C, Barry G, et al. (2013) Schmallenberg Virus Pathogenesis, Tropism and Interaction with the Innate Immune System of the [...]... Read more »
Varela, M., Schnettler, E., Caporale, M., Murgia, C., Barry, G., McFarlane, M., McGregor, E., Piras, I., Shaw, A., Lamm, C.... (2013) Schmallenberg Virus Pathogenesis, Tropism and Interaction with the Innate Immune System of the Host. PLoS Pathogens, 9(1). DOI: 10.1371/journal.ppat.1003133
@DiseaseMapper recently tweeted a link to a very interesting paper (which happily is also free to access so you can read it too – the link is here ) Why do I think this paper is so interesting? Firstly, because it is a useful reminder that zoonotic infections (those that pass from animals to man and [...]... Read more »
As you can see the blog hiatus is over – it’s not that things have got a lot quieter (they haven’t), I’ve just missed blogging! And what better way to get back into things than with a random anecdote… When a friend asked if I would like a fish pedicure for my birthday my initial [...]... Read more »
Verner-Jeffreys DW, Baker-Austin C, Pond MJ, Rimmer GSE, Kerr R, Stone D, Griffin R, White P, Stinton N, Denham K.... (2012) Zoonotic Disease Pathogens in Fish Used for Pedicure. Emerging Infectious Diseases. DOI: 10.3201/eid1806.111782
I’ve been meaning to write about bovine TB for some time. The news in December that there will be a badger cull trial in England has finally spurred me into actually doing so. Before I start I should mention that this post will not be about the political aspects of the cull decision. Nor will [...]... Read more »
de la Rua-Domenech, R. (2006) Human Mycobacterium bovis infection in the United Kingdom: Incidence, risks, control measures and review of the zoonotic aspects of bovine tuberculosis. Tuberculosis, 86(2), 77-109. DOI: 10.1016/j.tube.2005.05.002
A group of researchers (see reference below) have been looking at a very interesting new method of vaccine delivery: using trypanosomes. T. (megatrypanum) theileri is found infecting cattle worldwide. It is transmitted by flies and gains entry to the animal either through broken skin or via mucous membranes and once the animal is infected it tends to carry low [...]... Read more »
Mott, G., Wilson, R., Fernando, A., Robinson, A., MacGregor, P., Kennedy, D., Schaap, D., Matthews, J., & Matthews, K. (2011) Targeting Cattle-Borne Zoonoses and Cattle Pathogens Using a Novel Trypanosomatid-Based Delivery System. PLoS Pathogens, 7(10). DOI: 10.1371/journal.ppat.1002340
So in Part 1 I discussed the set of guidelines, or postulates, designed by Robert Koch (and his colleagues) that helps scientists get the evidence they need to establish that a specific infectious agent causes a specific infectious disease. 1) Establish association of the organism with the disease. 2) Isolate the organism and grow in [...]... Read more »
Fredericks DN, & Relman DA. (1996) Sequence-based identification of microbial pathogens: a reconsideration of Koch's postulates. Clinical microbiology reviews, 9(1), 18-33. PMID: 8665474
Diseases don’t always behave exactly as we expect them too. Sometimes, even when we think we’ve worked out most things about them, they can surprise us. A case study published in Dermatology Online Journal – Orf parapoxvirus infection from a cat scratch by J Frandsen et al (see below for full ref) – is a nice [...]... Read more »
It’s been estimated that 3 out of every 4 emerging human diseases comes from animals and today has brought news of what has the potential to be another one. Scientists in California have published in PLoS Pathogens their research on: Cross-Species Transmission of a Novel Adenovirus Associated with a Fulminant Pneumonia Outbreak in a New World Monkey Colony [...]... Read more »
Chen, E., Yagi, S., Kelly, K., Mendoza, S., Maninger, N., Rosenthal, A., Spinner, A., Bales, K., Schnurr, D., Lerche, N.... (2011) Cross-Species Transmission of a Novel Adenovirus Associated with a Fulminant Pneumonia Outbreak in a New World Monkey Colony. PLoS Pathogens, 7(7). DOI: 10.1371/journal.ppat.1002155
So to celebrate (that is really not the right word) World Zoonosis Day I have another post for you all – this one is looking at some very cool research into Campylobacter jejuni (hence the my earlier background posts here and here). The paper is Standing Genetic Variation in Contingency Loci Drives the Rapid Adaptation of Campylobacter [...]... Read more »
Jerome, J., Bell, J., Plovanich-Jones, A., Barrick, J., Brown, C., & Mansfield, L. (2011) Standing Genetic Variation in Contingency Loci Drives the Rapid Adaptation of Campylobacter jejuni to a Novel Host. PLoS ONE, 6(1). DOI: 10.1371/journal.pone.0016399
As I mentioned here, I recently had a lovely holiday hill walking. It was great. Unfortunately I’m not very good at it (for ‘good at it’ you should probably actually read ‘fit’). I also fell over. A lot. On one of the many occasions that I fell hands down into the heather and long grass [...]... Read more »
Marcu, A., Uzzell, D., & Barnett, J. (2011) Making sense of unfamiliar risks in the countryside: The case of Lyme disease. Health . DOI: 10.1016/j.healthplace.2011.03.010
When discussing zoonoses it is very easy to think of only those diseases that pass from animals to humans and completely forget those that go the other way. Indeed, some people refer to diseases that pass from humans to animals as ‘reverse zoonooses’ (although the WHO defines zoonotic diseases as ‘a group of infectious diseases [...]... Read more »
Every, A., Selwood, L., Castano-Rodriguez, N., Lu, W., Windsor, H., Wee, J., Swierczak, A., Marshall, B., Kaakoush, N., Mitchell, H.... (2011) Did transmission of Helicobacter pylori from humans cause a disease outbreak in a colony of Stripe-faced Dunnarts (Sminthopsis macroura)?. Veterinary Research, 42(1), 26. DOI: 10.1186/1297-9716-42-26
I don’t like spiders. I don’t kill them because I appreciate they keep the flies down etc. etc. but I really don’t like them. Actually, it isn’t them per se, but their legs… So why I started looking at another paper on eight-legged critters I have no idea! But it’s a very interesting paper, and [...]... Read more »
Anisuzzaman, ., Islam, M., Alim, M., Miyoshi, T., Hatta, T., Yamaji, K., Matsumoto, Y., Fujisaki, K., & Tsuji, N. (2011) Longistatin, a Plasminogen Activator, Is Key to the Availability of Blood-Meals for Ixodid Ticks. PLoS Pathogens, 7(3). DOI: 10.1371/journal.ppat.1001312
This blog is and will mostly be about zoonotic diseases but I hope you will forgive me for every now and then straying off topic. Today the reason for my slight deviation from the norm is because this work is just so cool! Researchers have regrown nerves using spider silk – it sounds more like [...]... Read more »
Radtke, C., Allmeling, C., Waldmann, K., Reimers, K., Thies, K., Schenk, H., Hillmer, A., Guggenheim, M., Brandes, G., & Vogt, P. (2011) Spider Silk Constructs Enhance Axonal Regeneration and Remyelination in Long Nerve Defects in Sheep. PLoS ONE, 6(2). DOI: 10.1371/journal.pone.0016990
A look at new research into atypical scrapie in sheep suggesting that it may be present in peripheral tissues.... Read more »
Andréoletti, O., Orge, L., Benestad, S., Beringue, V., Litaise, C., Simon, S., Le Dur, A., Laude, H., Simmons, H., Lugan, S.... (2011) Atypical/Nor98 Scrapie Infectivity in Sheep Peripheral Tissues. PLoS Pathogens, 7(2). DOI: 10.1371/journal.ppat.1001285
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