10 posts · 17,686 views
Escaping Anergy: Providing scientific stimulation to fully activate the public's interest in immunology, human health, and disease...one research study at a time. Anergy is a term to describe a state of immune unresponsiveness. To Escape Anergy, an immune cell must receive extra stimulation, in order to function to the best of its ability. The purpose of this blog is to serve the interested public by providing in-depth analysis and discussion of the latest published research in the field of immunology. By providing scientific stimulation to fully activate the public's understanding of immunology,this blog hopes to reignite the public's support and interest in understanding and solving the biggest concerns in human health and disease.
Heather
10 posts
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- November 16, 2011
- 07:54 AM
- 771 views
On the importance of science research blogs and how YOU can vote to support students who blog about science!
by Heather in Escaping Anergy: The Immunology Research Blog
Blogs devoted to engaging the public with discussion about scientific research is vital to the advancement of our society, however these important sources of information need YOUR support to advocate science communication. Escaping Anergy was selected as a finalist for a blogging scholarship and needs YOUR vote to win!! Your support is greatly appreciated!!!... Read more »
Wilkins JS. (2008) The roles, reasons and restrictions of science blogs. Trends in ecology , 23(8), 411-3. PMID: 18597888
- October 27, 2011
- 02:46 PM
- 912 views
Discussion Forum: How Dogma Hinders the Advancement of Basic Research
by Heather in Escaping Anergy: The Immunology Research Blog
Immunology is complicated. It’s like a giant puzzle without a box depicting how the picture is supposed to look. It becomes further complicated, because every few years a new puzzle piece drops into the pile. The thing is, sometimes it feels as Sometimes that new piece in the “missing link” that can unify part of the puzzle, and other times it can’t seem to fit into the existing puzzle. In research, the puzzle, in its entirety, is never complete, but people are workin........ Read more »
Mosser, D., & Edwards, J. (2008) Exploring the full spectrum of macrophage activation. Nature Reviews Immunology, 8(12), 958-969. DOI: 10.1038/nri2448
- October 10, 2011
- 01:28 PM
- 1,108 views
Silencing "The Silent Killer": Researchers reveal promising new strategy to prevent and diagnose osteoporosis
by Heather in Escaping Anergy: The Immunology Research Blog
Bones are “Often thought of as a rigid, unchanging entity, skeletal bone is actually the result of a dynamic process” involving a balancing act between the activity of bone formation by osteoblasts and bone destruction by osteoclasts. The harmony between these two processes is essential for maintaining strong bones. It is when the rate of bone resorption exceeds the rate of bone formation that leads to osteoporosis. Why does this happen? How can we slow the rate of resorption? Wh........ Read more »
Hsu YH, Chen WY, Chan CH, Wu CH, Sun ZJ, & Chang MS. (2011) Anti-IL-20 monoclonal antibody inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss. The Journal of experimental medicine, 208(9), 1849-61. PMID: 21844205
- August 19, 2011
- 11:02 AM
- 8,493 views
Thinking Small To Save Big: new research combines nanotechnology with immunology to develop an inexpensive, accurate diagnostic tool for the developing world
by Heather in Escaping Anergy: The Immunology Research Blog
Sammuel Sia and colleagues published an exciting paper detailing their newest innovation: a novel diagnostic device that combines nanotechnology with immunology to create a test the size of an index card that costs as little as $1 to produce, and can screen for multiple infectious diseases simultaneously. For these reasons, this technology offers hope for fighting disease in resource-poor areas. Learn the immunology behind this device at Escaping Anergy: The Immunology Research Blog!... Read more »
Chin CD, Laksanasopin T, Cheung YK, Steinmiller D, Linder V, Parsa H, Wang J, Moore H, Rouse R, Umviligihozo G.... (2011) Microfluidics-based diagnostics of infectious diseases in the developing world. Nature medicine, 17(8), 1015-9. PMID: 21804541
- August 13, 2011
- 11:38 PM
- 1,148 views
T cells Receive Molecular Ammo to Kill Cancer: new research highlights the great potential of immunotherapy to treat leukemia
by Heather in Escaping Anergy: The Immunology Research Blog
The new study, published in two parts by Carl June’s group reveals novel innovations to gene therapy as a potential treatment of chronic lymphocytic leukemia (CLL). How did scientists engineer CLL patients' own T cells to seek and destroy cancerous cells? Learn the immunology behind the headlines at Escaping Anergy: The Immunology Research Blog!... Read more »
Kalos M, Levine BL, Porter DL, Katz S, Grupp SA, Bagg A, & June CH. (2011) T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Science translational medicine, 3(95). PMID: 21832238
Porter DL, Levine BL, Kalos M, Bagg A, & June CH. (2011) Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. The New England journal of medicine, 365(8), 725-33. PMID: 21830940
- August 5, 2011
- 05:20 PM
- 1,327 views
Learning to live together: new research explains how bacteria's urge to survive in our gut promotes intestinal health
by Heather in Escaping Anergy: The Immunology Research Blog
How does the immune system distinguish pathogenic bacteria from probiotic ones in the gut? Have bacteria evolved to evade immune attack in order to survive in our intestines, while at the same time playing a role in maintaining a healthy gut for us? Check out Escaping Anergy for an in-depth analysis and discussion of Round, et al.'s latest published Science paper!... Read more »
Round JL, Lee SM, Li J, Tran G, Jabri B, Chatila TA, & Mazmanian SK. (2011) The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science (New York, N.Y.), 332(6032), 974-7. PMID: 21512004
- July 7, 2011
- 12:10 PM
- 945 views
On human health, interesting the public, and good scientific journalism...
by Heather in Escaping Anergy: The Immunology Research Blog
In addition to the "pulled from the scientific journal headlines" research discussed here, I thought it would be interesting to periodically showcase fascinating research that I read elsewhere. Awesome and interesting research about human health, disease and immunology is everywhere and sometimes, it's written about in a way that is clear, accurate and easy to understand! That last point is exactly what Escaping Anergy is all about: a place to see, interpret, discuss and most im........ Read more »
Cajochen C, Frey S, Anders D, Späti J, Bues M, Pross A, Mager R, Wirz-Justice A, & Stefani O. (2011) Evening exposure to a light-emitting diodes (LED)-backlit computer screen affects circadian physiology and cognitive performance. Journal of applied physiology (Bethesda, Md. : 1985), 110(5), 1432-8. PMID: 21415172
- July 5, 2011
- 03:06 PM
- 915 views
How to get the most out of your next vaccine? A full night's sleep may enhance protection against viral infections
by Heather in Escaping Anergy: The Immunology Research Blog
How does sleep impact our ability to properly activate our immune system? Can sleep play a role in designing better therapies and treatments for people fighting disease? These questions motivate Jan Born’s research group at the University of Lubeck in Germany to find new ways to make more efficient vaccines…without even changing the vaccine components! Learn more about the sleep trial at Escaping Anergy!... Read more »
Lange T, Dimitrov S, Bollinger T, Diekelmann S, & Born J. (2011) Sleep after vaccination boosts immunological memory. Journal of immunology (Baltimore, Md. : 1950), 187(1), 283-90. PMID: 21632713
- June 7, 2011
- 03:35 PM
- 1,163 views
Think twice before diving into a high-fat diet: New research indicates how saturated fatty acids promote the development of Type 2 Diabetes
by Heather in Escaping Anergy: The Immunology Research Blog
How does diet impact immune function? Dr. Jenny Ting’s UNC research group recently published in Nature Immunology compelling data indicating how saturated fats activates a newly identified pathway involved in the development of Type 2 Diabetes. Check out Escaping Anergy for an in-depth analysis and implications of the data presented in this paper! ... Read more »
Wen H, Gris D, Lei Y, Jha S, Zhang L, Huang MT, Brickey WJ, & Ting JP. (2011) Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nature immunology, 12(5), 408-15. PMID: 21478880
- May 13, 2011
- 02:49 PM
- 904 views
Hold the Carrots! Vitamin A May Exacerbate Celiac Disease Symptoms-New study reveals how retinoic acid and IL-15 cooperatively promote gut inflammation
by Heather in Escaping Anergy: The Immunology Research Blog
New findings reveal how retinoic acid promotes disease pathology in Celiac Disease patients in which IL-15 levels in the gut are exceptionally increased. Find out more details regarding the experimental approach and implications with Escaping Anergy!... Read more »
DePaolo RW, Abadie V, Tang F, Fehlner-Peach H, Hall JA, Wang W, Marietta EV, Kasarda DD, Waldmann TA, Murray JA.... (2011) Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens. Nature, 471(7337), 220-4. PMID: 21307853
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