3 posts · 808 views
Focused discussion on fungal ecology and evolution especially fungal disease and human-fungal interactions.
The demise of the dinosaur and reptile dominance at the K-T boundary has been the subject of so much speculation, that it can be hard to filter out the rampant storytelling from the underlying observations. In a fairly recent Pearl piece in PLoS Pathogens, Arturo Casadevall summarizes and advances his idea for a fungal role in the rise of mammals and the end of reptilian dominance.Many of the key bits in the argument focus on mammalian resistance to fungal infection due to endothermy and the int........ Read more »
Basidiobolus (the fungus that pictured on the background image of this blog) still seems to be gaining steam as a possibly emerging and/or frequently mis- or undiagnosed pathogen in incompetent humans (see my previous hacky post about this). In another paper out in the Journal of Medical Microbiology, Geramizadeh et al. report 14 more cases over the last decade in southern Iran (Fars province). Although only a single case is reported with positive culture identification, the other cases were pre........ Read more »
Bita Geramizadeh, Razieh Foroughi, Marzieh Keshtkarjahromi, Seyedali Malekhosseini, & Abdolvahab Alborzi. (2012) Gastrointestinal basidiobolomycosis, an emerging infection in immunocompetent host: a report of 14 patients . Journal of Medical Microbiology. DOI: 10.1099/jmm.0.046839-0
In Cryptococcus neoformans var. grubii (Cng) copy number variation (CNV) is happening on at least two levels. On one hand Chow et al. show not only that there natural polymorphism in copy number in a tandem repeat of a gene (ARR3), but that copy number can be selected for via arsenite. ARR3, the arsenite efflux transporter gene they found was located in the subtelomeric region of Chromosome 3, and subtelomeric regions are thought to undergo structural variation at a higher rate than other parts ........ Read more »
Eve W. L. Chow, Carl A. Morrow, Julianne T. Djordjevic, Ian A. Wood, & James A. Fraser. (2012) Microevolution of Cryptococcus neoformans Driven by Massive Tandem Gene Amplification . Molecular Biology and Evolution. DOI: 10.1093/molbev/mss066
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