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Deconstructing the most sensationalistic recent findings in Human Brain Imaging, Cognitive Neuroscience, and Psychopharmacology
The Neurocritic
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by The Neurocritic in The Neurocritic
You've heard of Neuromarketing, which measures the neural activity of consumers (via fMRI or EEG) in response to various products or advertisements. Now, get ready for Genomarketing! The Neuroethics & Law Blog has alerted us to a recent paper by De Neve and Fowler (2009) reporting that people with a specific low efficiency variant of the gene for monoamine oxidase A are significantly more likely to have credit card debt. Monoamine oxidase A (MAO-A) is an enzyme that breaks down the monoamine........ Read more »
Beaver, K., & Holtfreter, K. (2009) Biosocial Influences on Fraudulent Behaviors. The Journal of Genetic Psychology, 170(2), 101-114. DOI: 10.3200/GNTP.170.2.101-114
by The Neurocritic in The Neurocritic
An American Werewolf in LondonIn the last post, we learned about the Psychopharmacology of Lycanthropy (and "endogenous lycanthropogens") from the April 1, 1992 issue of the Canadian Medical Association Journal (Davis et al., 1992). In a more serious review on clinical lycanthropy in the British Journal of Psychiatry Coll, O'Sullivan, and Browne (1985; PDF) began by stating:Lycanthropy is the delusion in which an individual believes he has been transformed into an animal, traditionally a wolf. D........ Read more »
Garlipp, P., Gödecke-Koch, T., Dietrich, D., & Haltenhof, H. (2004) Lycanthropy - psychopathological and psychodynamical aspects. Acta Psychiatrica Scandinavica, 109(1), 19-22. DOI: 10.1046/j.1600-0447.2003.00243.x
by The Neurocritic in The Neurocritic
Fig. 1 (Currier et al., 1971). Scalp EEG showing sharp wave activity from left anterior temporal region.In the last post we learned a bit about hypergraphia, a compulsion to write that sometimes occurs in those with temporal lobe epilepsy (TLE). According to the late behavioral neurologist Norman Geschwind (reprinted in 2009; also see Devinsky & Schachter, 2009), hypergraphia is one in a cluster of interictal [between seizure] personality traits in some TLE patients1 which can also include ........ Read more »
Ball, J. (1968) A CASE OF HAIR FETISHISM, TRANSVESTITISM, AND ORGANIC CEREBRAL DISORDER. Acta Psychiatrica Scandinavica, 44(3), 249-254. DOI: 10.1111/j.1600-0447.1968.tb07511.x
Jawad, S., Sidebothams, C., Sequira, R., & Jamil, N. (2009) Altered Sexual Orientation Following Dominant Hemisphere Infract [sic]. Journal of Neuropsychiatry, 21(3), 353-354. DOI: 10.1176/appi.neuropsych.21.3.353
Lesniak, R., Szymusik, A., & Chrzanowski, R. (1972) Multidirectional disorders of sexual drive in a case of brain tumour. Forensic Science, 1(3), 333-338. DOI: 10.1016/0300-9432(72)90031-3
by The Neurocritic in The Neurocritic
A proto-Live Journal moment from The Inman diary: a public and private confession, Volume 2. By Arthur Crew Inman. Edited by Daniel Aaron."HYPERGRAPHIA", a film currently in production......is a narrative feature recounting the true story of the notorious Boston eccentric and recluse Arthur Crew Inman (1895-1963) and of "THE INMAN DIARY" he created. Published by Harvard University Press, Inman's gargantuan diary is one of the great literary curiosities of our age, a sprawling memory piece of mor........ Read more »
Devinsky, J., & Schachter, S. (2009) Norman Geschwind’s contribution to the understanding of behavioral changes in temporal lobe epilepsy: The February 1974 lecture. Epilepsy , 15(4), 417-424. DOI: 10.1016/j.yebeh.2009.06.006
by The Neurocritic in The Neurocritic
Is there a difference?In The Neurocinema Collection™, we established that the term "neurocinema" doesn't really refer to movies with "Neuro" in the title or films about neurology. Instead, neuromarketers have have used the word in the following fashion:Neurocinema is a new filmmaking process that studies a viewer's sensorimotor, cognitive, and affective response to film stimuli. Researchers use technologies such as functional magnetic resonance imaging (fMRI) to measure changes in activity in ........ Read more »
Hasson, U. (2004) Intersubject Synchronization of Cortical Activity During Natural Vision. Science, 303(5664), 1634-1640. DOI: 10.1126/science.1089506
by The Neurocritic in The Neurocritic
Fig. 1 (Longo et al., 2009). The mirror box technique in which the subject has the experience of viewing their right hand, while in fact seeing their left hand reflected in a mirror.Sight modifies somatosensation, by either enhancing or diminishing the subjective intensity of touch (Kennett et al., 2001) and pain (Ramachandran & Altschuler, 2009), respectively. These phenomena provide fascinating and lesser studied examples of crossmodal integration, or how signals from one sensory modality ........ Read more »
Longo, M., Betti, V., Aglioti, S., & Haggard, P. (2009) Visually Induced Analgesia: Seeing the Body Reduces Pain. Journal of Neuroscience, 29(39), 12125-12130. DOI: 10.1523/JNEUROSCI.3072-09.2009
by The Neurocritic in The Neurocritic
"We only use 10% of our brains" is one of the most commonly held brain myths. But as the Neuroscience for Kids website tells us,There is no scientific evidence to suggest that we use only 10% of our brains.Neuroscientists, of course, already know that. But are there other false beliefs about the brain? Brain Mythology is a new column in the journal Brain Structure and Function, edited by Laszlo Zaborszky and Karl Zilles. In the first installment, Hilgetag and Barbas (2009) ask the question, Are ........ Read more »
Hilgetag, C., & Barbas, H. (2009) Are there ten times more glia than neurons in the brain?. Brain Structure and Function, 213(4-5), 365-366. DOI: 10.1007/s00429-009-0202-z
by The Neurocritic in The Neurocritic
OR: Neuroscience Shows Why Torture Doesn't WorkFormer CIA Agent Speaks Out - The controversial interrogation technique known as waterboarding, which the CIA agent says was used on [Abu] Zubaydah [see this Justice Department memo, PDF], occurs when a suspect has water poured over his mouth and nose to stimulate a drowning reflex as demonstrated in the picture to the left. (ABC News)With the Obama administration's recent release of the voluminous Bush-era memos authorizing torture, much has been ........ Read more »
Shane O'Mara. (2009) Torturing the Brain: On the folk psychology and folk neurobiology motivating ‘enhanced and coercive interrogation techniques’. Trends in Cognitive Science. info:/
by The Neurocritic in The Neurocritic
Despite everything else you've heard and read (and watched on ABC) recently, the answer is yes. Or maybe. At least in Scotland. Antidepressants might be UNDERprescribed by General Practitioners, according to a new study published in the British Journal of General Practice (Cameron et al., 2009). The authors conducted a chart review of 898 adults screened for anxiety and depression in a general practice setting. They concluded:Rather than prescribing indiscriminately (as has been widely assumed........ Read more »
Cameron, I., Lawton, K., & Reid, I. (2009) Appropriateness of antidepressant prescribing: an observational study in a Scottish primary-care setting. British Journal of General Practice, 59(566), 644-649. DOI: 10.3399/bjgp09X454061
Macdonald, S., Morrison, J., Maxwell, M., Munoz-Arroyo, R., Power, A., Smith, M., Sutton, M., & Wilson, P. (2009) ‘A coal face option’: GPs' perspectives on the rise in antidepressant prescribing. British Journal of General Practice, 59(566), 299-307. DOI: 10.3399/bjgp09X454106
by The Neurocritic in The Neurocritic
《Chinese Journal of Drug Dependence》1999-04Does anyone know what aerosol bioelectricity is?? And why it might be used to treat heroin addiction? The entire literature seems to be in Chinese. I came across that particular paper while searching for others, specifically reports on ablative psychosurgery1 for the treatment of opiate addiction in China (Gao et al., 2003 is the first in English). Hence, the title of the present post is a reference to the book by Elliot Valenstein, Great and Desp........ Read more »
Gao, G., Wang, X., He, S., Li, W., Wang, Q., Liang, Q., Zhao, Y., Hou, F., Chen, L., & Li, A. (2003) Clinical Study for Alleviating Opiate Drug Psychological Dependence by a Method of Ablating the Nucleus accumbens with Stereotactic Surgery. Stereotactic and Functional Neurosurgery, 81(1-4), 96-104. DOI: 10.1159/000075111
by The Neurocritic in The Neurocritic
Deep brain stimulation (DBS) for treatment-refractory psychiatric disorders has been gaining in popularity. The procedure involves neurosurgery to implant stimulating electrodes aimed at a target region inside the brain. It works using the same sort of pacemaker-like device used for DBS in Parkinson's disease, which has been remarkably successful at alleviating symptoms. DBS as a treatment for neurological disorders such as Parkinson's, primary generalised dystonia, atypical tremor syndromes, cl........ Read more »
Heinze, H. et al. (2009) Counteracting incentive sensitization in severe alcohol dependence using deep brain stimulation of the Nucleus accumbens: clinical and basic science aspects. Frontiers in Human Neuroscience. DOI: 10.3389/neuro.09.022.2009
Rabins, P. et al. (2009) Scientific and Ethical Issues Related to Deep Brain Stimulation for Disorders of Mood, Behavior, and Thought . Archives of General Psychiatry, 66(9), 931-937. info:/
by The Neurocritic in The Neurocritic
From the authors who brought you "Religion is the Xanax of the people" (aka Neural Markers of Religious Conviction) comes the finding that college students with lower grades are similar to religious zealots on a specific neural response to making an error. Meanwhile, students with high GPAs resemble atheists on the same neural marker. However, the new paper by Hirsh and Inzlicht (2009) did not draw a parallel to their previous study (Inzlicht et al., 2009). In fact, the two findings were interpr........ Read more »
Hirsh, J., & Inzlicht, M. (2009) Error-related negativity predicts academic performance. Psychophysiology. DOI: 10.1111/j.1469-8986.2009.00877.x
by The Neurocritic in The Neurocritic
Asian Smiley Emoticons Plush - Set Of 6In a study of cultural differences in the recognition of facial expressions......eye movements of 13 Western Caucasian and 13 East Asian people [were recorded] while they observed pictures of expressive faces and put them into categories: happy, sad, surprised, fearful, disgusted, angry, or neutral. The faces were standardized according to the so-called Facial Action Coding System (FACS) such that each expression displayed a specific combination of facial m........ Read more »
Jack RE, Blais C, Scheepers C, Schyns PG, Caldara R. (2009) Cultural Confusions Show that Facial Expressions Are Not Universal. Current Biology. info:/
by The Neurocritic in The Neurocritic
Homunculus image from Reinhard Blutner.OK kids, let's start today's lesson by viewing the G-Rated [i.e., genital-less] flash explanation of homunculus.The neuroanatomical definition of homunculus is a "distorted" representation of the sensorimotor body map (and its respective parts) overlaid upon primary somatosensory and primary motor cortices. The above figure illustrates the sensory homunculus, where each body part is placed onto the region of cortex that represents it, and the size of the bo........ Read more »
Michels, L., Mehnert, U., Boy, S., Schurch, B., & Kollias, S. (2009) The somatosensory representation of the human clitoris: An fMRI study. NeuroImage. DOI: 10.1016/j.neuroimage.2009.07.024
by The Neurocritic in The Neurocritic
Actor and Director Paul Wegener in The Golem: How He Came Into the World (1920), a German Expressionist masterpiece.Last week, we learned about the Zombie, the Nymphomaniac, and the Emotional Immaturity Masculine Protest Syndrome (Bierer, 1976a). In the second and final installment of the strange diagnoses of Austrian psychiatrist Joshua Bierer, M.D., F.R.C.PSYCH., D.ECON. & SOC.SC. (VIENNA), DIP.INDIV.PSYCH., we have the "Golem" syndrome:This is a man, who as a child has neither experienced........ Read more »
Bierer, J. (1976) Love--Making--An Act of Murder: The "Golem" Syndrome (G.S.). International Journal of Social Psychiatry, 22(3), 197-199. DOI: 10.1177/002076407602200305
by The Neurocritic in The Neurocritic
I have just discovered a treasure trove of surprising stupefying psychoanalytic articles that appeared in the International Journal of Social Psychiatry from 1976-1980. They were written by Austrian psychiatrist Joshua Bierer, M.D., F.R.C.PSYCH., D.ECON. & SOC.SC. (VIENNA), DIP.INDIV.PSYCH.... Read more »
Bierer, J. (1976) Zombie. International Journal of Social Psychiatry, 22(3), 200-201. DOI: 10.1177/002076407602200306
by The Neurocritic in The Neurocritic
Car surfing (for those who don't know) is......a form of acrobatics (or an illegal stunt if performed in public traffic) in which passengers of moving vehicles perform various stunts, including hanging out of the car or 'surfing' on the hood, trunk or on the roof of the vehicle while it is in motion. Car surfing has caused several people to be killed during the course of such stunts. The 1985 movie Teen Wolf was one movie which inspired many young people to try car surfing.[citation needed]The U........ Read more »
Wang A, Cohen AR, Robinson S. (2009) Neurological injuries from car surfing. Journal of Neurosurgery: Pediatrics. DOI: http://thejns.org/doi/full/10.3171/2009.4.PEDS08474
by The Neurocritic in The Neurocritic
Third place finisher Ryan Hall at the 2009 Boston Marathon. Photo courtesy of Martin Checkoway.Running a 26.2 mile marathon is an exhausting endeavor for anyone, from the top Ethiopian and Kenyan runners to the astounding 75 year old Jim Schleisman (who finished in 3:45:33) to the back of the pack casual joggers. Two psychologists from Columbia university reckoned that the physical stress of marathon running might result in cognitive impairments (Eich & Metcalfe, 2009). Although the benefits........ Read more »
Eich, T., & Metcalfe, J. (2009) Effects of the stress of marathon running on implicit and explicit memory. Psychonomic Bulletin , 16(3), 475-479. DOI: 10.3758/PBR.16.3.475
by The Neurocritic in The Neurocritic
According to a new meta-analysis in Psychological Medicine (Lynch et al., 2009), Cognitive Behavioral Therapy (CBT) is not helpful for those with schizophrenia and bipolar disorder, and any improvements seen in major depression are rather small:Conclusions: CBT is no better than non-specific control interventions in the treatment of schizophrenia and does not reduce relapse rates. It is effective in major depression but the size of the effect is small in treatment studies. On present evidence CB........ Read more »
Lynch, D., Laws, K., & McKenna, P. (2009) Cognitive behavioural therapy for major psychiatric disorder: does it really work? A meta-analytical review of well-controlled trials. Psychological Medicine, 1. DOI: 10.1017/S003329170900590X
by The Neurocritic in The Neurocritic
Olga Khokhlova, as painted by her husband, Pablo PicassoThe Left Side of Your Face Looks Distorted!The rare syndrome of unilateral left prosopometamorphopsia -- in which the left half of well-known and unfamiliar faces looks distorted -- was reported by Trojano et al. (2009) in a neuropsychological case study:D.G., a 24-year-old right-handed housewife with 8 years of formal education, suddenly developed severe migraine, confusional state, and blurred vision, mainly in her right visual hemifield,........ Read more »
Trojano, L., Conson, M., Salzano, S., Manzo, V., & Grossi, D. (2009) Unilateral left prosopometamorphopsia: A neuropsychological case study. Neuropsychologia, 47(3), 942-948. DOI: 10.1016/j.neuropsychologia.2008.12.015
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