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Beaker
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Researchers have been working for decades to develop nanoparticles that deliver cancer drugs directly to tumors, minimizing the toxic side effects of chemotherapy. However, even with the best nanoparticles, only small amounts of the treatment actually reach the tumor. Scientists at MIT, Sanford-Burnham and the University of California, San Diego (UCSD) may have found a [...]... Read more »
von Maltzahn, G., Park, J., Lin, K., Singh, N., Schwöppe, C., Mesters, R., Berdel, W., Ruoslahti, E., Sailor, M., & Bhatia, S. (2011) Nanoparticles that communicate in vivo to amplify tumour targeting. Nature Materials, 10(7), 545-552. DOI: 10.1038/nmat3049
by in Beaker
Atherosclerotic plaque is the fatty material that builds up on arterial walls, where it can lead to heart disease and stroke. Atherosclerosis is currently treated with dietary changes, angioplasty (which uses a balloon to move the plaque aside) or more invasive procedures. Using drugs to break up these fatty plaques would be an enticing alternative, [...]... Read more »
Hamzah J, Kotamraju VR, Seo JW, Agemy L, Fogal V, Mahakian LM, Peters D, Roth L, Gagnon MK, Ferrara KW.... (2011) Specific penetration and accumulation of a homing peptide within atherosclerotic plaques of apolipoprotein E-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. PMID: 21482787
by in Beaker
One of the problems with nanoparticles is that, well, they’re just so small, making them difficult to study. Researchers may have solved that problem by building an instrument that can detect nanoparticles as small as tens of nanometers (billionths of a meter).... Read more »
Fraikin JL, Teesalu T, McKenney CM, Ruoslahti E, & Cleland AN. (2011) A high-throughput label-free nanoparticle analyser. Nature nanotechnology. PMID: 21378975
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