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Beaker
62 posts
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- January 17, 2013
- 08:33 AM
- 136 views
Diabetic fruit flies support buzz about dietary sugar dangers
by Sanford- Burnham in Beaker
First fruit fly model of diet-induced type 2 diabetes shows how high-sugar diet affects the heart and reveals new therapeutic opportunities... Read more »
Na, J., Musselman, L., Pendse, J., Baranski, T., Bodmer, R., Ocorr, K., & Cagan, R. (2013) A Drosophila Model of High Sugar Diet-Induced Cardiomyopathy. PLoS Genetics, 9(1). DOI: 10.1371/journal.pgen.1003175
- January 10, 2013
- 03:27 PM
- 173 views
Type 2 diabetes: a cellular metabolism problem
by Sanford- Burnham in Beaker
A new computational model of sugar transport in the pancreas reveals a metabolic "tipping point” in type 2 diabetes—a discovery that may form the basis for new efforts to prevent and treat the disease.... Read more »
Luni, C., Marth, J., & Doyle, F. (2012) Computational Modeling of Glucose Transport in Pancreatic β-Cells Identifies Metabolic Thresholds and Therapeutic Targets in Diabetes. PLoS ONE, 7(12). DOI: 10.1371/journal.pone.0053130
- January 9, 2013
- 09:20 AM
- 185 views
How belly fat differs from thigh fat—and why it matters
by Sanford- Burnham in Beaker
Researchers discover that the genes active in a person’s belly fat are significantly different than those in his or her thigh fat, a finding that could shift the way we approach unwanted belly fat—from banishing it to relocating it.... Read more »
Karastergiou K, Fried SK, Xie H, Lee MJ, Divoux A, Rosencrantz MA, Chang RJ, & Smith SR. (2013) Distinct developmental signatures of human abdominal and gluteal subcutaneous adipose tissue depots. The Journal of clinical endocrinology and metabolism, 98(1), 362-71. PMID: 23150689
- December 25, 2012
- 08:00 AM
- 92 views
Top 10 most-read blog posts of 2012: #7
by Sanford- Burnham in Beaker
Dr. Matt Petroski and colleagues outline a new method to test a tumor’s resistance to an experimental therapy and pinpoint the genetic culprit before testing the drug in patients—providing a new path toward personalized medicine.... Read more »
Toth JI, Yang L, Dahl R, & Petroski MD. (2012) A gatekeeper residue for NEDD8-activating enzyme inhibition by MLN4924. Cell reports, 1(4), 309-16. PMID: 22832224
- December 24, 2012
- 08:00 AM
- 107 views
Top 10 most-read blog posts of 2012: #8
by Sanford- Burnham in Beaker
Sanford-Burnham researchers convince transplanted stem cell-derived neurons to direct cognitive function—getting us a step closer to using these cells to treat Alzheimer’s disease and other neurodegenerative conditions.... Read more »
Piña-Crespo JC, Talantova M, Cho EG, Soussou W, Dolatabadi N, Ryan SD, Ambasudhan R, McKercher S, Deisseroth K, & Lipton SA. (2012) High-Frequency Hippocampal Oscillations Activated by Optogenetic Stimulation of Transplanted Human ESC-Derived Neurons. The Journal of Neuroscience, 32(45), 15837-42. PMID: 23136422
- December 19, 2012
- 02:00 PM
- 125 views
Transplanted neural stem cells treat ALS in mouse model
by Sanford- Burnham in Beaker
In 11 independent studies, a consortium of ALS researchers shows that transplanting neural stem cells into the spinal cord of an ALS mouse model slows disease onset and progression, improves motor function, and significantly prolongs survival.... Read more »
Teng YD, Benn SC, Kalkanis SN, Shefner JM, Onario RC, Cheng B, Lachyankar MB, Marconi M, Li J, Yu D.... (2012) Multimodal Actions of Neural Stem Cells in a Mouse Model of ALS: A Meta-Analysis. Science translational medicine, 4(165). PMID: 23253611
- December 3, 2012
- 09:04 AM
- 143 views
“Junk DNA” drives embryonic development
by Sanford- Burnham in Beaker
Dr. Mark Mercola and his team discovered that microRNAs play an important role in germ layer formation--the process that determines which cells become which organs during embryonic development.... Read more »
Colas AR, McKeithan WL, Cunningham TJ, Bushway PJ, Garmire LX, Duester G, Subramaniam S, & Mercola M. (2012) Whole-genome microRNA screening identifies let-7 and mir-18 as regulators of germ layer formation during early embryogenesis. Genes . PMID: 23152446
- November 27, 2012
- 03:01 PM
- 171 views
Compound found in rosemary protects against macular degeneration in laboratory model
by Sanford- Burnham in Beaker
Researchers discover that carnosic acid, a component of the herb rosemary, promotes eye health in rodents—providing a possible new approach for treating conditions such as age-related macular degeneration.... Read more »
Rezaie T, McKercher SR, Kosaka K, Seki M, Wheeler L, Viswanath V, Chun T, Joshi R, Valencia M, Sasaki S.... (2012) Protective effect of carnosic acid, a pro-electrophilic compound, in models of oxidative stress and light-induced retinal degeneration. Investigative ophthalmology . PMID: 23081978
- November 15, 2012
- 02:28 PM
- 202 views
Neurons made from stem cells drive brain activity after transplantation in laboratory model
by Sanford- Burnham in Beaker
Sanford-Burnham researchers convince transplanted stem cell-derived neurons to direct cognitive function—getting us a step closer to using these cells to treat Alzheimer’s disease and other neurodegenerative conditions.... Read more »
Piña-Crespo JC, Talantova M, Cho EG, Soussou W, Dolatabadi N, Ryan SD, Ambasudhan R, McKercher S, Deisseroth K, & Lipton SA. (2012) High-Frequency Hippocampal Oscillations Activated by Optogenetic Stimulation of Transplanted Human ESC-Derived Neurons. The Journal of Neuroscience, 32(45), 15837-42. PMID: 23136422
- November 12, 2012
- 09:19 AM
- 165 views
For brain tumors, origins matter
by Sanford- Burnham in Beaker
Brain tumors arising from different cell types might need different--and more personalized--treatment approaches.... Read more »
Emmenegger BA, Hwang EI, Moore C, Markant SL, Brun SN, Dutton JW, Read TA, Fogarty MP, Singh AR, Durden DL.... (2012) Distinct roles for fibroblast growth factor signaling in cerebellar development and medulloblastoma. Oncogene. PMID: 23045271
- November 8, 2012
- 08:26 AM
- 207 views
Hunting neuron killers in Alzheimer’s and TBI
by Sanford- Burnham in Beaker
Sanford-Burnham researchers discovered that the protein appoptosin prompts neurons to commit suicide in several neurological conditions—giving them a new therapeutic target for Alzheimer's disease and traumatic brain injury.... Read more »
Zhang H, Zhang YW, Chen Y, Huang X, Zhou F, Wang W, Xian B, Zhang X, Masliah E, Chen Q.... (2012) Appoptosin is a Novel Pro-Apoptotic Protein and Mediates Cell Death in Neurodegeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(44), 15565-15576. PMID: 23115192
- October 3, 2012
- 02:17 PM
- 163 views
Growing breast cancer stem cells to get at the tumor’s root
by Sanford- Burnham in Beaker
Sanford-Burnham researchers developed a technique for growing cancer stem cells -- an advance that will help them search for new approaches for preventing breast tumor recurrence. ... Read more »
David J. Castro, Jochen Maurer, Lionel Hebbard, & Robert G. Oshima. (2012) ROCK1 Inhibition Promotes the Self-Renewal of a Novel Mouse Mammary Cancer Stem Cell. Stem Cells. DOI: 10.1002/stem.1224
- August 2, 2012
- 12:01 PM
- 260 views
Mending a broken heart—with a molecule that turns stem cells into heart cells
by Sanford- Burnham in Beaker
Sanford-Burnham researchers discovered a molecule that converts stem cells into heart cells, which could be used to replace diseased or damaged tissue in heart disease patients.... Read more »
Erik Willems, Joaquim Cabral-Teixeira, Dennis Schade, Wenqing Cai, Patrick Reeves, Paul J. Bushway, Marion Lanier, Christopher Walsh, Tomas Kirchhausen, Juan Carlos Izpisua Belmonte.... (2012) Small Molecule-Mediated TGF-β Type II Receptor Degradation Promotes Cardiomyogenesis in Embryonic Stem Cells. Cell Stem Cell. info:/doi:10.1016/j.stem.2012.04.025
- July 18, 2012
- 01:01 PM
- 282 views
New heart failure trigger could change the way cardiovascular drugs are made
by Sanford- Burnham in Beaker
Dr. Pilar Ruiz-Lozano and colleagues find that the switch between healthy and failing heart depends on the way one particular heart protein is activated—important news for drug makers targeting the protein to treat cardiovascular disease.... Read more »
Maria Cecilia Scimia, Cecilia Hurtado, Saugata Ray, Scott Metzler, Ke Wei, Jianming Wang, Chris E. Woods, Nicole H. Purcell, Daniele Catalucci, Takashi Akasaka.... (2012) APJ acts as a dual receptor in cardiac hypertrophy. Nature. DOI: 10.1038/nature11263
- May 9, 2012
- 12:43 PM
- 380 views
It’s a trap! New laboratory technique captures microRNA targets
by Sanford- Burnham in Beaker
Dr. Tariq Rana and colleagues developed a new method called miR-TRAP to allow scientists to better understand the roles microRNAs play in human development and disease.... Read more »
Baigude H, Ahsanullah, Li Z, Zhou Y, & Rana TM. (2012) miR-TRAP: A Benchtop Chemical Biology Strategy to Identify microRNA Targets. Angewandte Chemie (International ed. in English). PMID: 22566243
- March 12, 2012
- 03:00 PM
- 360 views
Rare bone disorder reveals new insights into autism
by Sanford- Burnham in Beaker
Sanford-Burnham researchers discover the molecular basis of autistic symptoms in children with a rare bone disorder— findings that also provide new insights for the general autistic population.... Read more »
Irie F, Badie-Mahdavi H, & Yamaguchi Y. (2012) Autism-like socio-communicative deficits and stereotypies in mice lacking heparan sulfate. Proceedings of the National Academy of Sciences of the United States of America. PMID: 22411800
- March 8, 2012
- 12:58 PM
- 382 views
Exciting clinical trial news for children with inherited bone disease
by Sanford- Burnham in Beaker
A paper published in the New England Journal of Medicine reveals the stunning results of a clinical trial testing ENB-0040, an enzyme replacement therapy for a rare bone disorder called hypophosphatasia.... Read more »
Whyte MP, Greenberg CR, Salman NJ, Bober MB, McAlister WH, Wenkert D, Van Sickle BJ, Simmons JH, Edgar TS, Bauer ML.... (2012) Enzyme-replacement therapy in life-threatening hypophosphatasia. The New England journal of medicine, 366(10), 904-13. PMID: 22397652
- February 16, 2012
- 02:01 PM
- 461 views
How the body fends off bacteria
by Sanford- Burnham in Beaker
A team led by scientists at Sanford-Burnham and Scripps Research develop the first 3D look at interaction between immune sensor and protein that helps bacteria move.... Read more »
Yoon, S., Kurnasov, O., Natarajan, V., Hong, M., Gudkov, A., Osterman, A., & Wilson, I. (2012) Structural Basis of TLR5-Flagellin Recognition and Signaling. Science, 335(6070), 859-864. DOI: 10.1126/science.1215584
- February 6, 2012
- 03:01 PM
- 451 views
Tasting fructose with the pancreas
by Sanford- Burnham in Beaker
Dr. Björn Tyrberg and colleagues discover taste receptors in pancreatic beta cells that can sense fructose and stimulate insulin secretion.... Read more »
Kyriazis GA, Soundarapandian MM, & Tyrberg B. (2012) Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion. Proceedings of the National Academy of Sciences of the United States of America. PMID: 22315413
- February 2, 2012
- 12:00 PM
- 356 views
Molecular switch that allows melanoma to resist therapy
by Sanford- Burnham in Beaker
Sanford-Burnham researchers identify protein kinase Cɛ as a molecular switch that determines tumor-promoting or -suppressing activity in skin cells.... Read more »
Lau E, Kluger H, Varsano T, Lee K, Scheffler I, Rimm DL, Ideker T, & Ronai ZA. (2012) PKCε Promotes Oncogenic Functions of ATF2 in the Nucleus while Blocking Its Apoptotic Function at Mitochondria. Cell, 148(3), 543-55. PMID: 22304920
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