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E3 Engaging Epigenetics Experts
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- February 22, 2013
- 09:00 AM
- 116 views
Introducing Aba-seq for Enzyme Based High-Res Mapping of Mammalian Hydroxymethylomes
by Nicole Kelesoglu in E3 Engaging Epigenetics Experts
New England Biolabs is well known for its extensive in house research programs - churning out numerous publications every year. The role of hydroxymethylation as a possible cancer biomarker is a topic of keen interest for all Epigenetics researchers. So, NEB researchers are especially enthused about their recent publication in Cell, along with their collaborators from Emory University School of Medicine.... Read more »
Sun Z, Terragni J, Borgaro JG, Liu Y, Yu L, Guan S, Wang H, Sun D, Cheng X, Zhu Z.... (2013) High-resolution enzymatic mapping of genomic 5-hydroxymethylcytosine in mouse embryonic stem cells. Cell reports, 3(2), 567-76. PMID: 23352666
- January 14, 2013
- 09:00 AM
- 154 views
New Years Resolution, Reflection on Cancer Research
by Nicole Kelesoglu in E3 Engaging Epigenetics Experts
Recent news in cancer research points to the importance of epigenetics and cell signalling in the "war on cancer".... Read more »
Watson J. (2013) Oxidants, antioxidants and the current incurability of metastatic cancers. Open biology, 3(1), 120144. PMID: 23303309
- December 11, 2012
- 03:00 AM
- 175 views
Sirtuin3 Reprograms Mitochondrial Epigenetic Pathways: How Diet Affects Age
by Nicole Kelesoglu in E3 Engaging Epigenetics Experts
Epigenetic pathways among those ID'd as regulated by Sirtuin3 in mitochondria during calorie restriction reprogramming.... Read more »
Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ.... (2012) Calorie Restriction and SIRT3 Trigger Global Reprogramming of the Mitochondrial Protein Acetylome. Molecular cell. PMID: 23201123
- November 26, 2012
- 01:00 AM
- 173 views
SMRT Sequencing Studies Methyltransferease Driven Virulence in E.coli (0104:H4)
by Nicole Kelesoglu in E3 Engaging Epigenetics Experts
Epigenetic analysis shows new roles for restriction modification methyltransferases in developing pathogenic bacteria.... Read more »
Fang G, Munera D, Friedman DI, Mandlik A, Chao MC, Banerjee O, Feng Z, Losic B, Mahajan MC, Jabado OJ.... (2012) Genome-wide mapping of methylated adenine residues in pathogenic Escherichia coli using single-molecule real-time sequencing. Nature biotechnology. PMID: 23138224
- November 4, 2012
- 10:06 PM
- 216 views
The Easy Way to Study Microbe Methylomes... use SMRT sequencing!
by Nicole Kelesoglu in E3 Engaging Epigenetics Experts
Research advance put forth by scientists from New England Biolabs & Pacific Biosciences™ demonstrates how the 3rd generation SMRT DNA sequencing system is used to explore bacterial methylomes.... Read more »
Murray IA, Clark TA, Morgan RD, Boitano M, Anton BP, Luong K, Fomenkov A, Turner SW, Korlach J, & Roberts RJ. (2012) The methylomes of six bacteria. Nucleic acids research. PMID: 23034806
- October 17, 2012
- 02:39 PM
- 303 views
A Better Way to Discriminate iPSCs vs ESCs
by Nicole Kelesoglu in E3 Engaging Epigenetics Experts
Hint: using their methylomes!... Read more »
Ruiz S, Diep D, Gore A, Panopoulos AD, Montserrat N, Plongthongkum N, Kumar S, Fung HL, Giorgetti A, Bilic J.... (2012) Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America, 109(40), 16196-201. PMID: 22991473
- October 4, 2012
- 10:14 PM
- 294 views
Essence of Breast Cancer Profiling using Integrative Functional Genomics
by Nicole Kelesoglu in E3 Engaging Epigenetics Experts
New method invented to prioritize cancer SNPs to demonstrate those essential to disease profiles.... Read more »
Cowper-Sal Lari R, Zhang X, Wright JB, Bailey SD, Cole MD, Eeckhoute J, Moore JH, & Lupien M. (2012) Breast cancer risk-associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression. Nature genetics. PMID: 23001124
- August 17, 2012
- 08:30 AM
- 314 views
5hmC Regulates Cellular Differentiation
by Nicole Kelesoglu in E3 Engaging Epigenetics Experts
Researchers describe epigenetic and transcription factor relationships in cellular differentiation, in Nucleic Acids Research paper. ... Read more »
Sérandour AA, Avner S, Oger F, Bizot M, Percevault F, Lucchetti-Miganeh C, Palierne G, Gheeraert C, Barloy-Hubler F, Péron CL.... (2012) Dynamic hydroxymethylation of deoxyribonucleic acid marks differentiation-associated enhancers. Nucleic acids research. PMID: 22730288
- August 6, 2012
- 09:00 AM
- 308 views
Detecting Gene Doping in Sports: MicroRNA biomarker sought
by Nicole Kelesoglu in E3 Engaging Epigenetics Experts
World Anti-Doping Agency (WADA) currently uses the biological passport monitoring system. WADA also funds R&D of direct monitoring methods for gene doping, an emerging concern...including microRNA studies. ... Read more »
Elmo W.I. Neuberger, Magdelena Jurkiewicz, Dirk A. Moser and Perikles Simon. (2012) Detection of EPO gene doping in blood. Drug Testt. Analysis. DOI: 10.1002/dta.1347
Neuberger EW, Jurkiewicz M, Moser DA, & Simon P. (2012) Detection of EPO gene doping in blood. Drug testing and analysis. PMID: 22508654
- July 12, 2012
- 11:10 PM
- 362 views
Will the Long History of Breast Cancer Research Culminate with Epigenetics Based Personalized Medicine?
by Nicole Kelesoglu in E3 Engaging Epigenetics Experts
Ancient history breast cancer prognosis and a new method contributes epigenetics based biomarkers.... Read more »
ana Jeschke, Leander Van Neste, Sabine C. Glöckner, Mashaal Dhir, Marilia Freitas Calmon, Valérie Deregowski, Wim Van Criekinge, Ilse Vlassenbroeck, Alexander Koch, Timothy A. Chan.... (2012) Biomarkers for detection and prognosis of breast cancer identified by a functional hypermethylome screen. Epigenetics. DOI: 10.4161/epi.20445
- June 28, 2012
- 10:57 PM
- 408 views
“Divergent Epigenetic Landscapes” of AML viewed through RRBS
by Nicole Kelesoglu in E3 Engaging Epigenetics Experts
Acute myeloid leukemia bone marrow samples analysed with an enhanced method of reduced representational bisulfite sequencing. Hoping this will translate into generating AML treatment plans.... Read more »
Akalin A, Garrett-Bakelman FE, Kormaksson M, Busuttil J, Zhang L, Khrebtukova I, Milne TA, Huang Y, Biswas D, Hess JL.... (2012) Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia. PLoS genetics, 8(6). PMID: 22737091
- June 13, 2012
- 11:17 PM
- 381 views
O-GlcNAcylation Epigenetic Mark is Palatable Research
by Nicole Kelesoglu in E3 Engaging Epigenetics Experts
O-GlcNAcylation is part of the "histone code" and interacts with other epigenetic machinery, to link our diet to some diseases. Plus a Stephen Wright quote, just for fun.
... Read more »
Hanover, J., Krause, M., & Love, D. (2012) Post-translational modifications: Bittersweet memories: linking metabolism to epigenetics through O-GlcNAcylation. Nature Reviews Molecular Cell Biology, 13(5), 312-321. DOI: 10.1038/nrm3334
- May 30, 2012
- 10:24 PM
- 442 views
Trangenerational Epigenetic Inheritance: An Environmental Toxin Exposure & Stress Combinational Phenotype
by Nicole Kelesoglu in E3 Engaging Epigenetics Experts
Facinating PNAS paper describing an epigenetic phenotype requiring both embryonic exposure to the crop fungicide Vinclozolin,and adolescent exposure to stress. This work was a collaborative effort between the Michael Skinner and David Crews groups. ... Read more »
Crews, D., Gillette, R., Scarpino, S., Manikkam, M., Savenkova, M., & Skinner, M. (2012) Epigenetic transgenerational inheritance of altered stress responses. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.1118514109
- May 17, 2012
- 03:00 AM
- 331 views
Viral MicroRNA Mimicing Cellular MicroRNA? and a New Dual-Fluorescent Reporter System
by Nicole Kelesoglu in E3 Engaging Epigenetics Experts
A team out of the Chinese Academy of Sciences has reported both a new dual-fluorescent reporter system, and an insight on a suspected general phenomenon of functionally matched viral and cellular microRNA in viral-host interactions. ... Read more »
You X, Zhang Z, Fan J, Cui Z, & Zhang XE. (2012) Functionally Orthologous Viral and Cellular MicroRNAs Studied by a Novel Dual-Fluorescent Reporter System. PloS one, 7(4). PMID: 22558366
- May 1, 2012
- 10:59 PM
- 414 views
Oxidative Bisulfite Sequencing (oxBS-Seq) A Brilliant Advance for Epigenetics
by Nicole Kelesoglu in E3 Engaging Epigenetics Experts
Genomewide single nucleotide resolution of hydroxymethylation is now possible, with an innovative method added to bisulfite sequencing! Also, Epigenetic plasticity, is the 5hmC mark a "pause button"? ... Read more »
Booth, M., Branco, M., Ficz, G., Oxley, D., Krueger, F., Reik, W., & Balasubramanian, S. (2012) Quantitative Sequencing of 5-Methylcytosine and 5-Hydroxymethylcytosine at Single-Base Resolution. Science. DOI: 10.1126/science.1220671
- April 17, 2012
- 08:30 AM
- 471 views
Twin studies, Autism Risk, Epigenetic Molecular Trails in Utero
by Nicole Kelesoglu in E3 Engaging Epigenetics Experts
An example of how twin studies provide unique epigenetic research opportunies...with Austism research in mind.... Read more »
Gao Y, He Z, Wang Z, Luo Y, Sun H, Zhou Y, Huang L, Li M, Fang Q, & Jiang S. (2012) Increased Expression and Altered Methylation of HERVWE1 in the Human Placentas of Smaller Fetuses from Monozygotic, Dichorionic, Discordant Twins. PloS one, 7(3). PMID: 22457770
- April 3, 2012
- 12:00 AM
- 454 views
Dosage Makes All the Difference! Zahnow & Baylin Labs Show Epigenetic Reprogramming of Cancer
by Nicole Kelesoglu in E3 Engaging Epigenetics Experts
Preclinical results of DNA methylation inhibitor treatments in leukemic and solid tumor cells,from a super Cancer Cell paper. Hint:Cancer stem cells beware!... Read more »
Tsai, H., Li, H., Van Neste, L., Cai, Y., Robert, C., Rassool, F., Shin, J., Harbom, K., Beaty, R., Pappou, E.... (2012) Transient Low Doses of DNA-Demethylating Agents Exert Durable Antitumor Effects on Hematological and Epithelial Tumor Cells. Cancer Cell, 21(3), 430-446. DOI: 10.1016/j.ccr.2011.12.029
- March 19, 2012
- 10:35 PM
- 466 views
Further Evidence of the Importance of 5-hydroxymethylation in Cancer
by Nicole Kelesoglu in E3 Engaging Epigenetics Experts
Highlighting the trend and a recent Oncogene paper showing possible clinical diagnostic utility of 5-hmC as a broad cancer biomarker. Further clue on demethylation dynamics included. ... Read more »
Yang H, Liu Y, Bai F, Zhang JY, Ma SH, Liu J, Xu ZD, Zhu HG, Ling ZQ, Ye D.... (2012) Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation. Oncogene. PMID: 22391558
- March 5, 2012
- 10:51 PM
- 426 views
It's not over until the RNA sings...
by Nicole Kelesoglu in E3 Engaging Epigenetics Experts
ChIP-seq paper shows epigenetic regulation of natural antisense, a prerequisite for transcriptional interference function... Read more »
Conley AB, & King Jordan I. (2012) Epigenetic regulation of human cis-natural antisense transcripts. Nucleic acids research, 40(4), 1438-45. PMID: 22371288
- January 9, 2012
- 10:58 PM
- 479 views
Will Epigenetics Help Overcome Cisplatin Resistance in Ovarian Cancers?
by Nicole Kelesoglu in E3 Engaging Epigenetics Experts
Getting past disappointments from 2011 clinical trials for ovarian cancer. Two groups publish open access Methylome data sets identifying chemotherapy resistance gene targets.... Read more »
Yu W, Jin C, Lou X, Han X, Li L, He Y, Zhang H, Ma K, Zhu J, Cheng L.... (2011) Global analysis of DNA methylation by methyl-capture sequencing reveals epigenetic control of Cisplatin resistance in ovarian cancer cell. PloS one, 6(12). PMID: 22216282
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