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I am currently a 4th year Immunology PhD student equally interested in laboratory research AND science communication. When I'm not at the bench or reading the latest published immunology papers, you can find me writing, teaching (Immunology;Microbiology), running, playing soccer, brewing beer and going to concerts to find new music to love! My research foci includes: host-pathogen interactions, monocyte/macrophage activation and innate immune response during inflammation. Want to discuss a paper more in depth, have a question, or want to learn more about immunology research and its impact on how we treat disease?? Post comments directly on Escaping Anergy or e-mail me at escapinganergy[at]gmail[dot]com!
Blogs devoted to engaging the public with discussion about scientific research is vital to the advancement of our society, however these important sources of information need YOUR support to advocate science communication. Escaping Anergy was selected as a finalist for a blogging scholarship and needs YOUR vote to win!! Your support is greatly appreciated!!!... Read more »
Wilkins JS. (2008) The roles, reasons and restrictions of science blogs. Trends in ecology , 23(8), 411-3. PMID: 18597888
Immunology is complicated. It’s like a giant puzzle without a box depicting how the picture is supposed to look. It becomes further complicated, because every few years a new puzzle piece drops into the pile. The thing is, sometimes it feels as Sometimes that new piece in the “missing link” that can unify part of the puzzle, and other times it can’t seem to fit into the existing puzzle. In research, the puzzle, in its entirety, is never complete, but people are workin........ Read more »
Mosser, D., & Edwards, J. (2008) Exploring the full spectrum of macrophage activation. Nature Reviews Immunology, 8(12), 958-969. DOI: 10.1038/nri2448
Bones are “Often thought of as a rigid, unchanging entity, skeletal bone is actually the result of a dynamic process” involving a balancing act between the activity of bone formation by osteoblasts and bone destruction by osteoclasts. The harmony between these two processes is essential for maintaining strong bones. It is when the rate of bone resorption exceeds the rate of bone formation that leads to osteoporosis. Why does this happen? How can we slow the rate of resorption? Wh........ Read more »
Hsu YH, Chen WY, Chan CH, Wu CH, Sun ZJ, & Chang MS. (2011) Anti-IL-20 monoclonal antibody inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss. The Journal of experimental medicine, 208(9), 1849-61. PMID: 21844205
Sammuel Sia and colleagues published an exciting paper detailing their newest innovation: a novel diagnostic device that combines nanotechnology with immunology to create a test the size of an index card that costs as little as $1 to produce, and can screen for multiple infectious diseases simultaneously. For these reasons, this technology offers hope for fighting disease in resource-poor areas. Learn the immunology behind this device at Escaping Anergy: The Immunology Research Blog!... Read more »
Chin CD, Laksanasopin T, Cheung YK, Steinmiller D, Linder V, Parsa H, Wang J, Moore H, Rouse R, Umviligihozo G.... (2011) Microfluidics-based diagnostics of infectious diseases in the developing world. Nature medicine, 17(8), 1015-9. PMID: 21804541
The new study, published in two parts by Carl June’s group reveals novel innovations to gene therapy as a potential treatment of chronic lymphocytic leukemia (CLL). How did scientists engineer CLL patients' own T cells to seek and destroy cancerous cells? Learn the immunology behind the headlines at Escaping Anergy: The Immunology Research Blog!... Read more »
Kalos M, Levine BL, Porter DL, Katz S, Grupp SA, Bagg A, & June CH. (2011) T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Science translational medicine, 3(95). PMID: 21832238
Porter DL, Levine BL, Kalos M, Bagg A, & June CH. (2011) Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. The New England journal of medicine, 365(8), 725-33. PMID: 21830940
How does the immune system distinguish pathogenic bacteria from probiotic ones in the gut? Have bacteria evolved to evade immune attack in order to survive in our intestines, while at the same time playing a role in maintaining a healthy gut for us? Check out Escaping Anergy for an in-depth analysis and discussion of Round, et al.'s latest published Science paper!... Read more »
Round JL, Lee SM, Li J, Tran G, Jabri B, Chatila TA, & Mazmanian SK. (2011) The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science (New York, N.Y.), 332(6032), 974-7. PMID: 21512004
In addition to the "pulled from the scientific journal headlines" research discussed here, I thought it would be interesting to periodically showcase fascinating research that I read elsewhere. Awesome and interesting research about human health, disease and immunology is everywhere and sometimes, it's written about in a way that is clear, accurate and easy to understand! That last point is exactly what Escaping Anergy is all about: a place to see, interpret, discuss and most im........ Read more »
Cajochen C, Frey S, Anders D, Späti J, Bues M, Pross A, Mager R, Wirz-Justice A, & Stefani O. (2011) Evening exposure to a light-emitting diodes (LED)-backlit computer screen affects circadian physiology and cognitive performance. Journal of applied physiology (Bethesda, Md. : 1985), 110(5), 1432-8. PMID: 21415172
How does sleep impact our ability to properly activate our immune system? Can sleep play a role in designing better therapies and treatments for people fighting disease? These questions motivate Jan Born’s research group at the University of Lubeck in Germany to find new ways to make more efficient vaccines…without even changing the vaccine components! Learn more about the sleep trial at Escaping Anergy!... Read more »
Lange T, Dimitrov S, Bollinger T, Diekelmann S, & Born J. (2011) Sleep after vaccination boosts immunological memory. Journal of immunology (Baltimore, Md. : 1950), 187(1), 283-90. PMID: 21632713
How does diet impact immune function? Dr. Jenny Ting’s UNC research group recently published in Nature Immunology compelling data indicating how saturated fats activates a newly identified pathway involved in the development of Type 2 Diabetes. Check out Escaping Anergy for an in-depth analysis and implications of the data presented in this paper! ... Read more »
Wen H, Gris D, Lei Y, Jha S, Zhang L, Huang MT, Brickey WJ, & Ting JP. (2011) Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nature immunology, 12(5), 408-15. PMID: 21478880
New findings reveal how retinoic acid promotes disease pathology in Celiac Disease patients in which IL-15 levels in the gut are exceptionally increased. Find out more details regarding the experimental approach and implications with Escaping Anergy!... Read more »
DePaolo RW, Abadie V, Tang F, Fehlner-Peach H, Hall JA, Wang W, Marietta EV, Kasarda DD, Waldmann TA, Murray JA.... (2011) Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens. Nature, 471(7337), 220-4. PMID: 21307853
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