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  • June 30, 2016
  • 02:08 AM
  • 169 views

Gestional exposure to Group B Streptococcus and an autism model

by Paul Whiteley in Questioning Answers

"Overall, these data show for the first time that gestational exposure to GBS [Group B Streptococcus] plays an important role in the generation of neurodevelopmental abnormalities reminiscent of human autism spectrum disorders (ASD)."I chose to discuss the findings reported by Marie-Julie Allard and colleagues [1] on this blog for various reasons. That this research team already have some research 'form' when it comes to looking at GBS [2] is one; another is the idea that they rep........ Read more »

Allard MJ, Bergeron JD, Baharnoori M, Srivastava LK, Fortier LC, Poyart C, & Sébire G. (2016) A sexually dichotomous, autistic-like phenotype is induced by Group B Streptococcus maternofetal immune activation. Autism research : official journal of the International Society for Autism Research. PMID: 27220806  

  • June 29, 2016
  • 08:01 AM
  • 68 views

Design guidlines for tandem fluorescent timers

by Gal Haimovich in Green Fluorescent Blog

Almost 4 years ago, I wrote a post on tandem fluorescent timers (tFTs). The idea is to have two different fluorescent proteins fused together to the protein of interest. In the paper from 4 years ago, it was superfolder GFP … Continue reading →... Read more »

Khmelinskii A, Meurer M, Ho CT, Besenbeck B, Füller J, Lemberg MK, Bukau B, Mogk A, & Knop M. (2016) Incomplete proteasomal degradation of green fluorescent proteins in the context of tandem fluorescent protein timers. Molecular biology of the cell, 27(2), 360-70. PMID: 26609072  

  • June 29, 2016
  • 06:20 AM
  • 160 views

Birdsong Babel: Different birds use different grammar rules

by gdw in FictionalFieldwork

Zizou listens carefully. She ignores her confines and tries to focus on the intruder’s song. There’s something odd about it. Something she can’t quite put her feather on. It’s familiar, yet… not familiar. The intruder is strong. He or she keeps signing incessantly. There’s no sight of him or her, though. She has to make a […]... Read more »

Olkowicz S, Kocourek M, Lučan RK, Porteš M, Fitch WT, Herculano-Houzel S, & Němec P. (2016) Birds have primate-like numbers of neurons in the forebrain. PNAS, 113(26), 7255-60. PMID: 27298365  

  • June 29, 2016
  • 02:49 AM
  • 125 views

Antipsychotic prescribing trends in autism meta-analysed

by Paul Whiteley in Questioning Answers

"Almost 1 in 10 antipsychotic-treated youth were diagnosed with ASD [autism spectrum disorder] and/or ID [intellectual disability], and 1 in 6 youth with ASD received antipsychotics."The findings reported by Su Young Park and colleagues [1] have not surprisingly garnered some media attention (see here). Meta-analysing the available peer-reviewed data on "the frequency of youth diagnosed with ASDs and/or ID among antipsychotic-treated youth, as well as antipsychotic use in you........ Read more »

Park SY, Cervesi C, Galling B, Molteni S, Walyzada F, Ameis SH, Gerhard T, Olfson M, & Correll CU. (2016) Antipsychotic Use Trends in Youth With Autism Spectrum Disorder and/or Intellectual Disability: A Meta-Analysis. Journal of the American Academy of Child and Adolescent Psychiatry, 55(6), 456-4680000. PMID: 27238064  

  • June 28, 2016
  • 02:07 AM
  • 145 views

An excess of ADHD among children born to glyphosate appliers?

by Paul Whiteley in Questioning Answers

The job of pesticide applicator is one that has been discussed on this blog before (see here). Minus any scaremongering, the conclusion of that post was that under certain circumstances (e.g. a high pesticide exposure event - HPEE), the effects of that particular occupation might be pretty far-reaching for the 'cognitive' as well as physical health of the individual concerned.Today I'm talking about other potential effects "needing confirmation by further studies" related to perhaps one of ........ Read more »

  • June 27, 2016
  • 03:03 AM
  • 130 views

Eating difficulties in adolescents with CFS/ME

by Paul Whiteley in Questioning Answers

I tread quite carefully when discussing the paper by Sarah Harris and colleagues [1] (open-access available here) on the potential causes and effects of 'eating difficulties' when it comes to adolescent chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME).Careful because (i) I don't want to confuse eating difficulties with eating disorder (they are not one and the same) and (ii) the suggestion that some of the young adults included for study "recognised how their eating difficulties were ........ Read more »

  • June 25, 2016
  • 03:42 AM
  • 144 views

HBOT and autism systematically reviewed

by Paul Whiteley in Questioning Answers

"Current evidence indicates that HBOT [Hyperbaric Oxygen Therapy] is not an effective treatment for children and youth with autism."That was the conclusion reached by Cynthia Goldfarb and colleagues [1] following their "systematic review of the literature evaluating the clinical impact of HBOT on behavior and development in ASD [autism spectrum disorder]." Drawing on guidance from the American Academy of Neurology and their "Classification of Recommendations", authors lo........ Read more »

Goldfarb, C., Genore, L., Hunt, C., Flanagan, J., Handley-Derry, M., Jethwa, A., Jones-Stokreef, N., Kirkpatrick, S., Richards, A., Rojnica, L.... (2016) Hyperbaric oxygen therapy for the treatment of children and youth with Autism Spectrum Disorders: An evidence-based systematic review. Research in Autism Spectrum Disorders, 1-7. DOI: 10.1016/j.rasd.2016.05.004  

  • June 24, 2016
  • 02:31 AM
  • 149 views

Is autism underdiagnosed in prisoners? Probably not...

by Paul Whiteley in Questioning Answers

The UK media today is awash with the result of 'that referendum'.Life however goes on here at Questioning Answers and today the recent opinion piece by Sarah Ashworth [1] talking about autism being 'underdiagnosed' in the prison population provides the starting material for today's post.Being careful not to generalise nor also 'excusing' the often important reasons why people end up in prison, I'm particularly interested in this area of discussion given what is increasingly being recognised with........ Read more »

Ashworth S. (2016) Autism is underdiagnosed in prisoners. BMJ (Clinical research ed.). PMID: 27255544  

  • June 23, 2016
  • 08:55 AM
  • 14 views

Weird stuff found in recreational drugs: Pot/LSD edition

by Rosin Cerate in Rosin Cerate

This is the fourth post in a series on strange substances accidentally or intentionally added to street drugs. When you're done here, check out the posts on alcohol, meth, opioids, and cocaine.In the autumn of 2007, hospitals near Leipzig, Germany admitted 29 people after they inadvertently smoked weed contaminated with lead. Yep, some dealer or grower decided it was a good idea to drop a bunch of small lead particles into the marijuana they were selling, presumably to increase its weight (lead ........ Read more »

Busse F, Omidi L, Timper K, Leichtle A, Windgassen M, Kluge E, & Stumvoll M. (2008) Lead poisoning due to adulterated marijuana. The New England Journal of Medicine, 358(15), 1641-1642. PMID: 18403778  

  • June 23, 2016
  • 02:53 AM
  • 101 views

ADHD symptoms improved with allergic rhinitis treatment

by Paul Whiteley in Questioning Answers

The findings reported by Ming-Tao Yang and colleagues [1] make for some brief blogging fodder today and the idea that: "Higher ADHD [attention-deficit hyperactivity disorder] scores in children with AR [allergic rhinitis] compared with healthy controls decreased significantly with AR treatment." Said AR treatment consisted of "nonpharmacologic intervention, oral antihistamines, and topical steroids."I know furrowed brows and eye-rolling might be the response of some people to........ Read more »

  • June 22, 2016
  • 10:30 AM
  • 101 views

eBooks – global market and trends – Part I: Print and digital publication in the global context

by SciELO in SciELO in Perspective

In recent years, a global industry of electronic books (ebooks) has emerged, with great force in the English language market and remarkable strength in the United States. There are indicators showing a race between traditional publishing industries and also global players such as Amazon and non-traditional ones, such as authors publishing individually and independently. A recent report published last April, divided into four major sections, presents detailed statistics on the production and mark........ Read more »

WISCHENBART, R.,, & et al. (2016) Global eBook: a report on market trends an developments. Rüdiger Wischenbart Content and Consulting (RWCC). info:/

  • June 22, 2016
  • 10:00 AM
  • 108 views

How Many Cats Are Stressed at the Vet?

by CAPB in Companion Animal Psychology Blog

New research shows just how stressed cats are at the vet, but there’s a lot we can do to help.A recent study found 30% of dogs are very stressed in the waiting room at the vet, and it turns out things are even worse for cats.It comes as no surprise to learn many cats are stressed by visits to the veterinarian. A new study by Chiara Mariti (University of Pisa) et al explores the scale of the problem, and has important suggestions for both cat guardians and vets on how to make things better.The ........ Read more »

Mariti, C., Bowen, J., Campa, S., Grebe, G., Sighieri, C., & Gazzano, A. (2016) Guardians' Perceptions of Cats' Welfare and Behavior Regarding Visiting Veterinary Clinics. Journal of Applied Animal Welfare Science, 1-10. DOI: 10.1080/10888705.2016.1173548  

  • June 22, 2016
  • 05:02 AM
  • 101 views

A preliminary psychology of how we're moved by watching dance

by BPS Research Digest in BPS Research Digest

If you're after chills down the spine, you might find that watching professional ballet dancers does the trick just as much as listening to music. Yet whereas the emotional effects of music are well researched – indeed, there are conferences and journals aplenty devoted to the psychology of music – scientists still know very little about the ways we are moved by watching dance.Now one of the first ever investigations into the emotional effects of dance has been published online at Acta ........ Read more »

Christensen, J., Pollick, F., Lambrechts, A., & Gomila, A. (2016) Affective responses to dance. Acta Psychologica, 91-105. DOI: 10.1016/j.actpsy.2016.03.008  

  • June 22, 2016
  • 03:07 AM
  • 99 views

Still 'nothing good comes from exposure to lead'

by Paul Whiteley in Questioning Answers

Consider this short-ish entry a sort of extension of other discussions on this blog on the topic of lead (Pb) (see here). As per the blog title, the systematic review published by Maryam Daneshparvar and colleagues [1] (open-access available here) adds to the quite voluminous peer-reviewed literature indicating that lead exposure, particularly during infancy and childhood, seems to be associated with nothing but adverse outcomes in terms of development and behaviour.Surveying the research litera........ Read more »

Daneshparvar M, Mostafavi SA, Zare Jeddi M, Yunesian M, Mesdaghinia A, Mahvi AH, & Akhondzadeh S. (2016) The Role of Lead Exposure on Attention-Deficit/ Hyperactivity Disorder ‎in Children: A Systematic Review. Iranian journal of psychiatry, 11(1), 1-14. PMID: 27252763  

  • June 21, 2016
  • 09:30 AM
  • 102 views

Osteoporosis: The Dying Osteocyte

by Hannah Davis in The 'Scope

New research into ways to fight bone loss... Read more »

  • June 21, 2016
  • 08:17 AM
  • 129 views

Weird stuff found in recreational drugs: Opioid edition

by Rosin Cerate in Rosin Cerate

This is the third post in a series on strange substances accidentally or intentionally added to street drugs. When you're done here, check out the posts on alcohol and meth.Opioids are drugs that affect the human body by binding to a group of related proteins conveniently known as opioid receptors. By connecting to these receptors in a certain manner, they convince receptor-bearing cells in the brain, spinal cord, and intestine to do useful things like reduce the sensation of pain (while making ........ Read more »

Brett M, Hallas G, & Mpamugo O. (2004) Wound botulism in the UK and Ireland. . Journal of Medical Microbiology, 53(6), 555-561. DOI: 10.1099/jmm.0.05379-0  

  • June 21, 2016
  • 05:42 AM
  • 120 views

Anonymity Doesn't Always Promote Online Aggression

by Neuroskeptic in Neuroskeptic_Discover

It's widely said that anonymity on the internet helps to promote aggressive, low quality or trolling comments. On this view, the anonymous commenter, knowing they cannot be held accountable, is free to do things that they would be ashamed to do under their real name.





But now German researchers Katja Rost and colleagues challenge this view, in a new study published in PLOS ONE. Rost et al. say that real names can actually be associated with more aggression than anonymous posts, based o... Read more »

  • June 21, 2016
  • 04:45 AM
  • 95 views

Puncturing the myth of the tireless leader – if you're sleep deprived you're unlikely to inspire anyone

by BPS Research Digest in BPS Research Digest

Sleep deprivation makes it harder for us to inspire others, or to be inspiredThere’s an archetype of the tireless leader who scorns slumber in favour of getting things done – Margaret Thatcher, Winston Churchill, Benjamin Franklin, to name a few. But if you think you’re going to inspire anybody by routinely working through the night, you might want to think again. Research published recently in the Journal of Applied Psychology shows that sleep deprivation has the specific effect of making........ Read more »

  • June 21, 2016
  • 03:05 AM
  • 106 views

'Self-treatment' with helminths and autism?

by Paul Whiteley in Questioning Answers

At the end of 2013 there was some media interest in the presentation of interim data at the 2013 Annual Meeting of the American College of Neuropsychopharmacology from a couple of studies being run by Prof. Eric Hollander.It's life Jim but not as we know it... @ CDCThe abstracts for the studies 'Trichuris Suis Ova (TSO) as an Immune-inflammatory Treatment for Repetitive Behaviors in ASD' and 'Hyperthermia and the Improvement of ASD Symptoms' can be found here (look under abstracts........ Read more »

  • June 20, 2016
  • 11:50 PM
  • 97 views

The “Sun” Temple

by teofilo in Gambler's House

Today is the summer solstice, on which I like to do posts about archaeoastronomy. Today I’d like to discuss a well-known site, Sun Temple at Mesa Verde, which as its name suggests has long been associated with astronomical observations. As we’ll see, however, it appears that some of the early interpretations of the site’s architecture […]... Read more »

Reyman JE. (1977) Solstice Misalignment at Sun Temple: Correcting Fewkes. The Kiva, 281-284. info:/

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