One of the main mysteries confounding development of an HIV vaccine is why some people infected with the virus make the desired antibodies after several years, but a vaccine can't seem to induce the same response.
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M. Anthony Moody1,2,3,*,†, Isabela Pedroza-Pacheco4,†, Nathan A. Vandergrift1,5, Cecilia Chui4, Krissey E. Lloyd1, Robert Parks1, Kelly A. Soderberg1, Ane T. Ogbe4, Myron S. Cohen6, Hua-Xin Liao1,5, Feng Gao1,5, Andrew J. McMichael, David C. Montefiori, Laurent Verkoczy, Garnett Kelsoe, Jinghe Huang, Patrick R. Shea, Mark Connors, Persephone Borrow, & Barton F. Haynes. (2016) Immune perturbations in HIV-1–infected individuals who make broadly neutralizing antibodies. Science Immunology . info:/10.1126/sciimmunol.aag0851
I will admit I have never thought about the question: how many spikes is your brain emitting every second? And how many could it emit? Lucy notwithstanding, it is probably something less than ‘all of them’. Beyond the obvious “that is called epilepsy”, … Continue reading →... Read more »
Hasenstaub, A., Otte, S., Callaway, E., & Sejnowski, T. (2010) Metabolic cost as a unifying principle governing neuronal biophysics. Proceedings of the National Academy of Sciences, 107(27), 12329-12334. DOI: 10.1073/pnas.0914886107
It's not been a good month for the theory of ego-depletion - the idea that self-control is a limited resource that can be depleted by overuse. Two weeks ago, researchers reported evidence of bias in the published literature examinig the question of whether glucose can reverse ego-depletion.
Now, the very existence of the ego-depletion phenomenon has been questioned by an international collaboration of psychologists who conducted a preregistered replication attempt (RRR). The results have just... Read more »
Hagger, M., & Chatzisarantis, N. (2016) A Multilab Preregistered Replication of the Ego-Depletion Effect. Perspectives on Psychological Science, 11(4), 546-573. DOI: 10.1177/1745691616652873
When research has more fairly compared PS-I with I-PS, it has concluded that, in general, the sequence doesn't matter all that much, though there are some positive trends on conceptual and transfer assessments for PS-I.... Read more »
Loibl, K., Roll, I., & Rummel, N. (2016) Towards a Theory of When and How Problem Solving Followed by Instruction Supports Learning. Educational Psychology Review. DOI: 10.1007/s10648-016-9379-x
A diet high in saturated fat can make your brain struggle to control what you eat. If people are looking to lose weight, stay clear of saturated fat. Consuming these types of fatty food affects a part of the brain called the hypothalamus, which helps regulate hunger.
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Viggiano, E., Mollica, M., Lionetti, L., Cavaliere, G., Trinchese, G., De Filippo, C., Chieffi, S., Gaita, M., Barletta, A., De Luca, B.... (2016) Effects of an High-Fat Diet Enriched in Lard or in Fish Oil on the Hypothalamic Amp-Activated Protein Kinase and Inflammatory Mediators. Frontiers in Cellular Neuroscience. DOI: 10.3389/fncel.2016.00150
Finding flight MH370, origins of human speech, declining penguin colonies, safe carbon storage, and stressed out reef sharks: Here are five of the latest scientific studies published open-access this week.... Read more »
Jansen, E., Coppini, G., & Pinardi, N. (2016) Drift simulation of MH370 debris using superensemble techniques. Natural Hazards and Earth System Sciences, 16(7), 1623-1628. DOI: 10.5194/nhess-16-1623-2016
Lameira, A., Hardus, M., Mielke, A., Wich, S., & Shumaker, R. (2016) Vocal fold control beyond the species-specific repertoire in an orang-utan. Scientific Reports, 30315. DOI: 10.1038/srep30315
Cimino, M., Lynch, H., Saba, V., & Oliver, M. (2016) Projected asymmetric response of Adélie penguins to Antarctic climate change. Scientific Reports, 28785. DOI: 10.1038/srep28785
Kampman, N., Busch, A., Bertier, P., Snippe, J., Hangx, S., Pipich, V., Di, Z., Rother, G., Harrington, J., Evans, J.... (2016) Observational evidence confirms modelling of the long-term integrity of CO2-reservoir caprocks. Nature Communications, 12268. DOI: 10.1038/ncomms12268
Mourier, J., Maynard, J., Parravicini, V., Ballesta, L., Clua, E., Domeier, M., & Planes, S. (2016) Extreme Inverted Trophic Pyramid of Reef Sharks Supported by Spawning Groupers. Current Biology. DOI: 10.1016/j.cub.2016.05.058
I was really, really pleased to read the paper by Melanie Uhde and colleagues  (open-access) I don't mind telling you. Covering a topic close to my blogging and research heart - sensitivity to wheat or gluten but not coeliac disease - the authors provide some much needed scientific clarification when it comes to how gluten or wheat might impact on some of those "who reported symptoms in response to wheat intake and in whom coeliac disease and wheat allergy were ruled out." Some media int........ Read more »
Uhde, M., Ajamian, M., Caio, G., De Giorgio, R., Indart, A., Green, P., Verna, E., Volta, U., & Alaedini, A. (2016) Intestinal cell damage and systemic immune activation in individuals reporting sensitivity to wheat in the absence of coeliac disease. Gut. DOI: 10.1136/gutjnl-2016-311964
A new study, which followed 180 preterm infants from birth to age seven, found that babies who were fed more breast milk within the first 28 days of life had had larger volumes of certain regions of the brain at term equivalent and had better IQs, academic achievement, working memory, and motor function.
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Mandy B. Belfort, MD, Peter J. Anderson, PhD, Victoria A. Nowak, MBBS, Katherine J. Lee, PhD, Charlotte Molesworth, Deanne K. Thompson, PhD, Lex W. Doyle, MD, & Terrie E. Inder, MBChB, MD. (2016) Breast Milk Feeding, Brain Development, and Neurocognitive Outcomes: A 7-Year Longitudinal Study in Infants Born at Less Than 30 Weeks' Gestation. The Journal of Pediatrics. DOI: http://dx.org/10.1016/j.jpeds.2016.06.045
In a Brain Post from 2012 I reviewed a study of fatigue in elite athletic performance. This study supported a key role in the brain insula in regulating the perception of exercise-induced fatigue. You can access this post by clicking HERE.An update on this topic was recently published in PloS One by a research team in Australia.This study compared performance on a cognitive task after extreme 20 minute cycling time trial. Professional cyclists were compared to recreational cyclists on the Stroop........ Read more »
Martin K, Staiano W, Menaspà P, Hennessey T, Marcora S, Keegan R, Thompson KG, Martin D, Halson S, & Rattray B. (2016) Superior Inhibitory Control and Resistance to Mental Fatigue in Professional Road Cyclists. PloS one, 11(7). PMID: 27441380
by Piter Kehoma Boll In order to celebrate the 5oth Friday Fellow, which was posted today, I decided to bring you an extra Friday Fellow! Afterall, there are plenty of interesting lifeforms to be shown. As I have never presented … Continue reading →... Read more »
Beddingfield, S., & McClintock, J. (1993) Feeding behavior of the sea star Astropecten articulatus (Echinodermata: Asteroidea): an evaluation of energy-efficient foraging in a soft-bottom predator. Marine Biology, 115(4), 669-676. DOI: 10.1007/BF00349375
by Piter Kehoma Boll Recently the appearance of a new pokémon, Cutiefly, has brought a lot of attention to the real world species in which it is based. So why not bring it to Friday Fellow so that you may … Continue reading →... Read more »
Brooks, A. (2012) Identification of Bombyliid Parasites and Hyperparasites of Phalaenidae of the Prairie Provinces of Canada, with Descriptions of Six Other Bombyliid Pupae (Diptera). The Canadian Entomologist, 84(12), 357-373. DOI: 10.4039/Ent84357-12
Jazykov (Zakhvatkin), A. (2009) Parasites and Hyperparasites of the Egg-pods of injurious Locusts (Acridodea) of Turkestan. Bulletin of Entomological Research, 22(03), 385. DOI: 10.1017/S0007485300029904
Science headlines eh? Who would trust them and their sometimes inflated press releases?I start today with a science headline taken from the BBC website reading: "Pregnancy multivitamins 'are a waste of money'" based on the findings of a review article  published in the journal Drug and Therapeutics Bulletin.In it we are told that complex multi-vitamin and mineral supplements are 'unlikely to be needed and are an unnecessary expense' during the nine months that made us. Further that certain vi........ Read more »
Medication roulette, if you have ever had to deal with depression or other types of mental illness you know what I'm talking about. You take a pill that could help or could cause all sorts of horrid side effects. You cross your fingers as you take that first pill and in the 4-6 weeks it takes to start working you cross your fingers, hope, wish and probably even dread the outcome. But why does it take so long for antidepressants to start working in the first place and what could be done to c........ Read more »
Erb, S., Schappi, J., & Rasenick, M. (2016) Antidepressants Accumulate in Lipid Rafts Independent of Monoamine Transporters to Modulate Redistribution of the G protein, Gα . Journal of Biological Chemistry. DOI: 10.1074/jbc.M116.727263
Deep space missions could increase the chances of cardiovascular diseases, thereby increasing the chances of deaths in astronauts.
NASA’s Apollo program sent 9 manned missions and 24 astronauts above the low Earth orbit (LEO) during decades of 1960s and 1970s. Those missions also included Apollo 11, which was used to take Neil Armstrong and Buzz Aldrin to the moon. However, it appears that such beyond Earth missions........ Read more »
Delp, M., Charvat, J., Limoli, C., Globus, R., & Ghosh, P. (2016) Apollo Lunar Astronauts Show Higher Cardiovascular Disease Mortality: Possible Deep Space Radiation Effects on the Vascular Endothelium. Scientific Reports, 29901. DOI: 10.1038/srep29901
Gron gazed across the plain from inside a tuft of long grass. There. Just in front of the far hillock. Gazelles. Meals on legs. He vaguely remembered mother carrying him through cooler forests when he was not yet old enough to walk. He had never understood why they had left. But he had learned, had […]... Read more »
Zeder MA. (2008) Domestication and early agriculture in the Mediterranean Basin: Origins, diffusion, and impact. Proceedings of the National Academy of Sciences of the United States of America, 105(33), 11597-604. PMID: 18697943
Lazaridis, I., Nadel, D., Rollefson, G., Merrett, D., Rohland, N., Mallick, S., Fernandes, D., Novak, M., Gamarra, B., Sirak, K.... (2016) Genomic insights into the origin of farming in the ancient Near East. Nature. DOI: 10.1038/nature19310
The paper by Traolach Brugha and colleagues  makes for some blogging fodder today and the suggestion that: "The combined prevalence of autism in adults of all ages in England was 11/1000."Just before going through the Brugha paper it is perhaps appropriate to put it into some context based on other work from this group previously covered on this blog (see here) and the findings again by Brugha and colleagues  (a further report on their findings that time around can be seen h........ Read more »
Brugha TS, Spiers N, Bankart J, Cooper SA, McManus S, Scott FJ, Smith J, & Tyrer F. (2016) Epidemiology of autism in adults across age groups and ability levels. The British journal of psychiatry : the journal of mental science. PMID: 27388569
A team of Toronto scientists has found similarities in brain impairments in children with autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder (OCD). The study involved brain imaging of white matter in 200 children with autism, ADHD, OCD or no diagnosis.
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Ameis, S., Lerch, J., Taylor, M., Lee, W., Viviano, J., Pipitone, J., Nazeri, A., Croarkin, P., Voineskos, A., Lai, M.... (2016) A Diffusion Tensor Imaging Study in Children With ADHD, Autism Spectrum Disorder, OCD, and Matched Controls: Distinct and Non-Distinct White Matter Disruption and Dimensional Brain-Behavior Relationships. American Journal of Psychiatry. DOI: 10.1176/appi.ajp.2016.15111435
The e-book Global report shows that the traditional model based on large publishing houses was insufficient to incorporate the possibilities of technological advances. On the one hand, the new reading models through smartphones and subscription platforms and on the other hand, self-publishing of ebooks open opportunities to both individual authors and non-profit organizations in the educational field to produce and distribute their own works at low cost and minimal infrastructure requirements. &........ Read more »
WISCHENBART, R.,, & et al. (2016) Global eBook: a report on market trends an developments. Rüdiger Wischenbart Content and Consulting (RWCC). info:/
If you're ever lost in a remote European forest, you might be able to get your bearings by finding a herd of roe deer. These animals like to align themselves roughly north-south, whether they're standing still or fleeing danger.
Roe deer are small, reddish or grayish grazers common in Europe and Asia. Petr Obleser, of the Czech University of Life Sciences in Prague, and his coauthors studied the behavior of these skittish herbivores to look for evidence that they can sense the earth's ma........ Read more »
One would think that people with few friends and living in poverty are more at risk for PTSD than those with a strong support network and many resources. And that's true.
However, it is a different story when you look at the country-, rather than the individual level. Countries with more resources, such as the USA and the Netherlands, have higher levels of PTSD than countries with fewer resources (e.g. Colombia, South Africa).
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Dückers ML, Alisic E, & Brewin CR. (2016) A vulnerability paradox in the cross-national prevalence of post-traumatic stress disorder. The British Journal of Psychiatry. PMID: 27445357
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