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  • November 13, 2016
  • 08:39 AM
  • 194 views

Damn You, Darwin! Pt1. Cat & Mouse

by AG McCluskey in Zongo's Cancer Diaries

The emergence of therapy resistance in tumours can be described using Darwinian evolutionary theory. This post provides a brief description of Darwin's theory. The next post will apply the theory to tumour development.... Read more »

  • October 11, 2016
  • 10:37 AM
  • 209 views

Nae Trainers!

by AG McCluskey in Zongo's Cancer Diaries

This post covers multi-drug resistance in tumours....and why a cancer cell is like a Nightclub!... Read more »

Review article. (2000) Cancer multidrug resistance. Nature Biotechnology, 18(Supp). DOI: 10.1038/80051  

AG McCluskey. (2016) Nae Trainers!. Zongo's Cancer Diaries. info:/

  • October 3, 2016
  • 12:08 PM
  • 295 views

The 7 Most Interesting Extrasolar Systems.

by Jeffrey Daniels in United Academics

Beyond the well-known Solar System, there is an immensity of other unique systems... Read more »

Johanna K. Teske, Stephen A. Shectman, Steve S. Vogt, Matías Díaz, R. Paul Butler, Jeffrey D. Crane, Ian B. Thompson, & Pamela Arriagada. (2016) The Magellan PFS Planet Search Program: Radial Velocity and Stellar Abundance Analyses of the 360 AU, Metal-Poor Binary "Twins" HD 133131A . Astronomical Journal,. arXiv: 1608.06216v2

Orosz, J., Welsh, W., Carter, J., Fabrycky, D., Cochran, W., Endl, M., Ford, E., Haghighipour, N., MacQueen, P., Mazeh, T.... (2012) Kepler-47: A Transiting Circumbinary Multiplanet System. Science, 337(6101), 1511-1514. DOI: 10.1126/science.1228380  

R. Di Stefano, & A. Ray. (2016) Globular Clusters as Cradles of Life and Advanced Civilizations. ASTROPHYSICAL JOURNAL , 827(1). arXiv: 1601.03455v1

Marcelo Tucci Maia, Jorge Melendez, & Ivan Ramirez. (2014) High precision abundances in the 16 Cyg binary system: a signature of the rocky core in the giant planet. ASTROPHYSICAL JOURNAL LETTERS , 790(2). arXiv: 1407.4132v1

Anglada-Escudé, G., Amado, P., Barnes, J., Berdiñas, Z., Butler, R., Coleman, G., de la Cueva, I., Dreizler, S., Endl, M., Giesers, B.... (2016) A terrestrial planet candidate in a temperate orbit around Proxima Centauri. Nature, 536(7617), 437-440. DOI: 10.1038/nature19106  

Borucki, W., Agol, E., Fressin, F., Kaltenegger, L., Rowe, J., Isaacson, H., Fischer, D., Batalha, N., Lissauer, J., Marcy, G.... (2013) Kepler-62: A Five-Planet System with Planets of 1.4 and 1.6 Earth Radii in the Habitable Zone. Science, 340(6132), 587-590. DOI: 10.1126/science.1234702  

Stephen R. Kane, & Dawn M. Gelino. (2014) On the Inclination and Habitability of the HD 10180 System. ASTROPHYSICAL JOURNAL, 792(2). arXiv: 1408.4150v1

  • September 16, 2016
  • 09:45 PM
  • 359 views

Contiguity Effective for Deductive Inference

by Joshua Fisher in Text Savvy

Even if the benefits of retrieval practice were limited to improvements in recall (as prior research has demonstrated), such improvements do not stand in the way of improvements to higher-order reasoning, such as inference-making. (And shaping the path for students, such as improving informational contiguity can have a positive effect too.)... Read more »

  • September 12, 2016
  • 06:19 AM
  • 281 views

Strength In Numbers

by AG McCluskey in Zongo's Cancer Diaries

This post describes the concept behind combination therapies for cancer. Why are they needed? Why can they fail...?... Read more »

Komarova, N., & Boland, C. (2013) Cancer: Calculated treatment. Nature, 499(7458), 291-292. DOI: 10.1038/499291a  

AG McCluskey. (2016) Strength in Numbers. Zongo's Cancer Diaries. info:/

  • August 23, 2016
  • 11:30 AM
  • 375 views

Otulipenia – A New Inflammatory Disease

by Rita dos Santos Silva in United Academics

Researchers from the U.S. National Institutes of Health, working in collaboration with Turkish and British teams, discovered a new inflammatory disease.... Read more »

Zhou, Q., Wang, H., Schwartz, D., Stoffels, M., Park, Y., Zhang, Y., Yang, D., Demirkaya, E., Takeuchi, M., Tsai, W.... (2015) Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease. Nature Genetics, 48(1), 67-73. DOI: 10.1038/ng.3459  

Elliott, P., Nielsen, S., Marco-Casanova, P., Fiil, B., Keusekotten, K., Mailand, N., Freund, S., Gyrd-Hansen, M., & Komander, D. (2014) Molecular Basis and Regulation of OTULIN-LUBAC Interaction. Molecular Cell, 54(3), 335-348. DOI: 10.1016/j.molcel.2014.03.018  

  • August 23, 2016
  • 11:29 AM
  • 361 views

Otulipenia – A New Inflammatory Disease

by Rita dos Santos Silva in United Academics

Researchers from the U.S. National Institutes of Health, working in collaboration with Turkish and British teams, discovered a new inflammatory disease.... Read more »

Zhou, Q., Wang, H., Schwartz, D., Stoffels, M., Park, Y., Zhang, Y., Yang, D., Demirkaya, E., Takeuchi, M., Tsai, W.... (2015) Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease. Nature Genetics, 48(1), 67-73. DOI: 10.1038/ng.3459  

Elliott, P., Nielsen, S., Marco-Casanova, P., Fiil, B., Keusekotten, K., Mailand, N., Freund, S., Gyrd-Hansen, M., & Komander, D. (2014) Molecular Basis and Regulation of OTULIN-LUBAC Interaction. Molecular Cell, 54(3), 335-348. DOI: 10.1016/j.molcel.2014.03.018  

  • August 16, 2016
  • 10:43 AM
  • 311 views

The Angry Silence

by AG McCluskey in Zongo's Cancer Diaries

The experience of cancer patients has changed in many ways over the last 30 years. One massive improvement is that patients can talk about their diseases more freely.

And this may not just make them feel better, it might help to make them better too.......... Read more »

MacMillan Cancer Support. (2016) Cancer: Then and Now. Diagnosis, treatment and aftercare from 1970–2016. MacMillan Cancer Support. info:/

  • August 1, 2016
  • 07:22 AM
  • 349 views

Live Long & Prosper!

by AG McCluskey in Zongo's Cancer Diaries

Good news for cancer patients in the UK, as 10-year survival rates show big improvements.... Read more »

MacMillan Cancer Support. (2016) Cancer: Then and Now. Diagnosis, treatment and aftercare from 1970–2016. MacMillan Cancer Support. info:/

  • July 30, 2016
  • 07:30 PM
  • 457 views

Problem Solving, Instruction: Chicken, Egg

by Joshua Fisher in Text Savvy

When research has more fairly compared PS-I with I-PS, it has concluded that, in general, the sequence doesn't matter all that much, though there are some positive trends on conceptual and transfer assessments for PS-I.... Read more »

  • July 18, 2016
  • 08:30 PM
  • 535 views

Interleaving Study Is Not Interleaving Learning

by Joshua Fisher in Text Savvy

In the latest research, the authors found that a blocked schedule (presenting examples from one category at a time) outperformed an interleaved schedule (interspersing examples from all the categories) for category learning when the examples to be classified were more highly discriminable. This result was consistent across the two experiments in the study (p = 0.055 and p = 0.04). Importantly, however, although interleaving was a better strategy for learning categories of lower discriminability,........ Read more »

  • June 17, 2016
  • 07:11 AM
  • 393 views

Computer Says No: Anti-cancer therapy and Autoimmune disease: Part II

by AG McCluskey in Zongo's Cancer Diaries

Scientists have been investigating the use of cancer therapies to treat Autoimmune disease. And the reasoning behind this? Treat the immune system like a computer program...... Read more »

Dr Harold L Atkins, MDcorrespondenceemail, Marjorie Bowman, MScN, David Allan, MD, Grizel Anstee, MD, Prof Douglas L Arnold, MD, Prof Amit Bar-Or, MD, Isabelle Bence-Bruckler, MD, Paul Birch, MLT, Prof Christopher Bredeson, MD, Jacqueline Chen, PhD, Prof . (2016) Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial. The Lancet. info:/http://dx.doi.org/10.1016/S0140-6736(16)30169-6

AG McCluskey. (2016) Computer Says No. Zongo's Cancer Diaries. info:/

  • May 27, 2016
  • 12:10 PM
  • 546 views

Enhance the Salience of Relevant Variables

by Joshua Fisher in Text Savvy

Performing the discrete mode of presentation test strongly enhances the salience of the relevant variable, perimeter, and somewhat decreases that of area. This enhancement supports appropriate solution strategies that lead to improved performance. This effect is robust and transfers to continuous mode of presentation for at least 10 days. In line with this conclusion, a student who performed the continuous test after the discrete one commented that, “It [continuous] was harder this time bu........ Read more »

  • May 26, 2016
  • 11:22 AM
  • 506 views

Patent-ly Obvious...?

by AG McCluskey in Zongo's Cancer Diaries

Did you know that there may be bits of your own body that you don't own? That may be owned by someone else? No?? Then you need to know more about Gene Patenting...... Read more »

Liddicoat J, Whitton T, & Nicol D. (2015) Are the gene-patent storm clouds dissipating? A global snapshot. Nature biotechnology, 33(4), 347-52. PMID: 25850055  

AG McCluskey. (2016) Patent-ly Obvious..?. Zongo's Cancer Diaries. info:/

  • May 25, 2016
  • 04:00 PM
  • 616 views

Humiliation from stares are worse than tiny seats for obese air travelers

by Dr. Jekyll in Lunatic Laboratories

Feelings of shame and humiliation bother obese air passengers more than tight seat belts and tiny seats, according to a study published by Ben-Gurion University of the Negev (BGU) researchers. Participants interviewed for the study recounted the typical challenges they encounter while boarding, in-flight and deplaning.

... Read more »

Yaniv Poria, & Jeremy Beal. (2016) An Exploratory Study about Obese People’s Flight Experience . Journal of travel research. info:/10.1177/0047287516643416

  • May 24, 2016
  • 01:14 PM
  • 577 views

Raising The Standards Of Open Access Journals

by Nesru Koroso in United Academics

The Directory of Open Access Journals bans dubious journals from its index.... Read more »

  • May 13, 2016
  • 08:32 AM
  • 499 views

The One And Only

by AG McCluskey in Zongo's Cancer Diaries

In future, the way that a patient's cancer is diagnosed and treated will be different. Every person is unique. And therefore every person's cancer is unique too...

Welcome to Personalised Medicine.... Read more »

Nik-Zainal, S., Davies, H., Staaf, J., Ramakrishna, M., Glodzik, D., Zou, X., Martincorena, I., Alexandrov, L., Martin, S., Wedge, D.... (2016) Landscape of somatic mutations in 560 breast cancer whole-genome sequences. Nature. DOI: 10.1038/nature17676  

Morganella, S., Alexandrov, L., Glodzik, D., Zou, X., Davies, H., Staaf, J., Sieuwerts, A., Brinkman, A., Martin, S., Ramakrishna, M.... (2016) The topography of mutational processes in breast cancer genomes. Nature Communications, 11383. DOI: 10.1038/ncomms11383  

AG McCluskey. (2016) The One And Only. Zongo's Cancer Diaries. info:/

  • May 12, 2016
  • 12:30 PM
  • 537 views

The Pantanal Diaries III: Ready to Mix

by Chiara Civardi in United Academics

Emerge into Brazil’s swamp, with Chiara and the Wildlife Conservation Society.... Read more »

Rodrigo Luiz Simas de Aguiar, & Keny Marques Lima. (2012) A arte rupestre em cavernas da região noroeste de Mato Grosso do Sul discussões preliminares. Espeleo-Tema, 23(2). info:/

  • May 10, 2016
  • 06:36 AM
  • 563 views

Psychosis: Understanding The Symptoms

by Pieter Carrière in United Academics

Dealing with psychotic patients takes more than looking at their diagnostic labels.... Read more »

Heering, H., Koevoets, G., Koenders, L., Machielsen, M., Meijer, C., Kubota, M., de Nijs, J., Cahn, W., Hulshoff Pol, H., de Haan, L.... (2015) Structural MRI Differences between Patients with and without First Rank Symptoms: A Delusion?. Frontiers in Psychiatry. DOI: 10.3389/fpsyt.2015.00107  

Perälä, J., Suvisaari, J., Saarni, S., Kuoppasalmi, K., Isometsä, E., Pirkola, S., Partonen, T., Tuulio-Henriksson, A., Hintikka, J., Kieseppä, T.... (2007) Lifetime Prevalence of Psychotic and Bipolar I Disorders in a General Population. Archives of General Psychiatry, 64(1), 19. DOI: 10.1001/archpsyc.64.1.19  

  • May 6, 2016
  • 08:47 AM
  • 509 views

Fight The Good Fight?

by AG McCluskey in Zongo's Cancer Diaries

A lot of cancer research funding in the UK comes from charities. But how do they raise the funds? And does the end justify the means?... Read more »

O'Toole, L., Nurse, P., & Radda, G. (2003) An analysis of cancer research funding in the UK. Nature Reviews Cancer, 3(2), 139-143. DOI: 10.1038/nrc994  

AG McCluskey. (2016) Fight The Good Fight?. Zongo's Cancer Diaries. info:/

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