Researchers have reported that vitamin D supplementation for 3 years or more significantly decreases all-cause mortality in female patients with vitamin D insufficiency.
Vitamin DVitamin D:
Vitamin D is a fat-soluble vitamin that occurs in fish-liver oils and is often added to milk. They are essential for the formation of bones and teeth. Lack of vitamin D causes rickets. Vitamin D deficiency below baseline levels ........ Read more »
Yayuan Zheng et al. (2013) Meta-Analysis of Long-Term Vitamin D Supplementation on Overall Mortality. PLoS ONE. DOI: 10.1371/journal.pone.0082109
A couple of days ago, Elizabeth Grice (my research advisor) and I had a review published in this month's issue of Cold Spring Harbor Perspectives in Medicine...... Read more »
Hannigan GD, Grice EA. (2013) Microbial Ecology of the Skin in the Era of Metagenomics and Molecular Microbiology. Cold Spring Harb Perspect Med. DOI: 10.1101/cshperspect.a015362
This Month in Blastocystis Research (NOV 2013)is mainly about new diagnostics and various treatment options.... Read more »
Ali V, & Nozaki T. (2013) Iron-sulphur clusters, their biosynthesis, and biological functions in protozoan parasites. Advances in parasitology, 1-92. PMID: 23876871
Roberts T, Ellis J, Harkness J, Marriott D, & Stark D. (2013) Treatment failure in patients with chronic Blastocystis infection. Journal of medical microbiology. PMID: 24243286
Stark D, Roberts T, Ellis JT, Marriott D, & Harkness J. (2013) Evaluation of the EasyScreen™ Enteric Parasite Detection Kit for the detection of Blastocystis spp., Cryptosporidium spp., Dientamoeba fragilis, Entamoeba complex, and Giardia intestinalis from clinical stool samples. Diagnostic microbiology and infectious disease. PMID: 24286625
Tsaousis AD, Gentekaki E, Eme L, Gaston D, & Roger AJ. (2013) Evolution of the Cytosolic Iron/Sulfur cluster Assembly machinery in Blastocystis sp. and other microbial eukaryotes. Eukaryotic cell. PMID: 24243793
Zumaquero-Ríos JL, Sarracent-Pérez J, Rojas-García R, Rojas-Rivero L, Martínez-Tovilla Y, Valero MA, & Mas-Coma S. (2013) Fascioliasis and intestinal parasitoses affecting schoolchildren in atlixco, puebla state, Mexico: epidemiology and treatment with nitazoxanide. PLoS neglected tropical diseases, 7(11). PMID: 24278492
Many aspects of our lives are more or less governed by fashions, and parenting is no exception. From the rather dry mode of parenting of our grandparents (Babies fed and changed? Then let them cry themselves to sleep) to some … Continue reading →... Read more »
Randall BB, Paterson DS, Haas EA, Broadbelt KG, Duncan JR, Mena OJ, Krous HF, Trachtenberg FL, & Kinney HC. (2013) Potential asphyxia and brainstem abnormalities in sudden and unexpected death in infants. Pediatrics, 132(6). PMID: 24218471
Migraine headaches. That word should not be typed, let alone published. Even seeing the word “migraine” in print can bring waves of nausea to some headache sufferers. A migraine isThe post BPA Migraine? Can plastics cause migraines in people? BPA seems to make them worse in rats. appeared first on WODMasters.... Read more »
Christensen KL, Lorber M, Ye X, & Calafat AM. (2013) Reconstruction of bisphenol A intake using a simple pharmacokinetic model. Journal of exposure science . PMID: 24252884
The hormone testosterone has significant effects on brain function and structure.In the next few posts, I will review several recent research studies related to testosterone.Testosterone deficiency or hypogonadism is more common in obese compared to non-obese.The mechanism for this relationship is unclear. However, a recent study has outlined the effect of testosterone replacement on body weight.AA Yassin and G Doros examined the longitudinal changes in weight, waist circumference and body mass ........ Read more »
Yassin A, & Doros G. (2013) Testosterone therapy in hypogonadal men results in sustained and clinically meaningful weight loss. Clinical obesity, 3(3-4), 73-83. PMID: 24163704
Vigen R, O'Donnell CI, Barón AE, Grunwald GK, Maddox TM, Bradley SM, Barqawi A, Woning G, Wierman ME, Plomondon ME.... (2013) Association of testosterone therapy with mortality, myocardial infarction, and stroke in men with low testosterone levels. JAMA : the journal of the American Medical Association, 310(17), 1829-36. PMID: 24193080
Discusses the interpretation of a meta-analysis by Kramer et al (2013) of obesity, metabolic healthy and BMI.... Read more »
Kramer CK, Zinman B, & Retnakaran R. (2013) Are Metabolically Healthy Overweight and Obesity Benign Conditions?: A Systematic Review and Meta-analysis. Annals of internal medicine, 159(11), 758-69. PMID: 24297192
Private companies are selling a direct-to-consumer service that scans your genome for disease-associated variations in your DNA sequence. Who wouldn’t want to know their future risk of developing a disease? If the appropriate preventative measures are taken now then perhaps disease onset can be delayed? ... Read more »
Chua EW, & Kennedy MA. (2012) Current State and Future Prospects of Direct-to-Consumer Pharmacogenetics. Frontiers in pharmacology, 152. PMID: 22934000
Valles SA. (2012) Should direct-to-consumer personalized genomic medicine remain unregulated?: a rebuttal of the defenses. Perspectives in biology and medicine, 55(2), 250-65. PMID: 22643762
No, that wasn’t a typo. Today I came across this petition for rulemaking to FSIS from the Physicians Committee for Responsible Medicine.
First off: PCRM has some great programs that promote research, animal welfare, and better medicine. The overall merit of their organization cannot be judged by a single program or campaign they have in place.
Now let’s tear this petition apart, because I actually had to check their website to make sure it was real, and not an over-the-top sati........ Read more »
Physicians Committee for Responsible Medicine. (2013) Re: Fecal Contamination of Poultry and Meat. USDA Petition for Rulemaking. info:/
Staphylococcus aureus, or “Staph” as I’m going to call it, is a spherical bacterium that grows in grape-like bunches. It is mainly found in the nose and skin of humans and for most of the time is completely harmless there. Staph can cause many infections if it gains access to areas of the body that it’s not normally in, like a cut in the skin. From abscesses to boils and full on systemic infections (that’s infecting all of the major organs and blood), it’s a ........ Read more »
Thammavongsa V, Missiakas DM, & Schneewind O. (2013) Staphylococcus aureus degrades neutrophil extracellular traps to promote immune cell death. Science (New York, N.Y.), 342(6160), 863-6. PMID: 24233725
Brinkmann V, & Zychlinsky A. (2012) Neutrophil extracellular traps: is immunity the second function of chromatin?. The Journal of cell biology, 198(5), 773-83. PMID: 22945932
Adoption research can provide a unique perspective for understanding genetic and environmental contributions to brain disorders.In the adoption process, biological (genetic) influences occur outside the biological environment.A variety of adoption studies show genetic influences for risk of childhood and adult brain and behavior disorders. Adoptees with a biological parent with alcohol or drug abuse have higher rates of substance disorders even when raised in adoptive family environments without........ Read more »
Yoon G, Westermeyer J, Warwick M, & Kuskowski MA. (2012) Substance use disorders and adoption: findings from a national sample. PloS one, 7(11). PMID: 23166740
I've taken my time in posting this entry specifically dedicated to the paper by Virginia Chaidez and colleagues* which "puts to rest the idea that gastrointestinal problems among children with autism spectrum disorder are just an accumulation of case reports" according to one of the paper authors (see here). It's not that I don't see these findings to be absolutely fascinating, but rather that I wanted the research dust to settle a little before I added my [inflation adjusted] 10 ........ Read more »
Chaidez V, Hansen RL, & Hertz-Picciotto I. (2013) Gastrointestinal Problems in Children with Autism, Developmental Delays or Typical Development. Journal of autism and developmental disorders. PMID: 24193577
This week a widely-criticised paper claiming negative effects of Roundup and Roundup-tolerant genetically modified maize on rats was retracted by the journal Food and Chemical Toxicology. The author, Professor Seralini, stands by the results, but received a letter from the journal stating that “The panel had many concerns about the quality of the data, and ultimately recommended that the article should be withdrawn.”
Criticisms included inadequate numbers of rats to draw conclusions........ Read more »
Seralini, GE. (2013) Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize. Food and Chemical Toxicology. DOI: 10.1016/j.fct.2012.08.005
Homocysteine - the big H - really should have its own Twitter hashtag... #thebigH.Not only because of the range of health-related conditions which seem to be correlated with particular levels of this amino acid - think coronary heart disease and elevated homocysteine for example* or more recently cerebrovascular disease** - but also because of the body of work linking elevated homocysteine levels to diagnoses like autism and schizophrenia. (Yes, I know correlation does not equal causation).The B........ Read more »
Geller V, Friger M, Sela BA, & Levine J. (2013) Elevated homocysteine level in siblings of patients with schizophrenia. Psychiatry research. PMID: 24051177
We all injure ourselves often- a cut finger when doing the washing up, that scab we can’t resist picking. We don’t usually think much of it, maybe a quick curse, but the wound stops bleeding, stops hurting and heals. But what would happen if scabs didn’t form and if small cuts didn’t stop bleeding? Well for some people this is the case. Haemophilia A, a haemorrhagic disorder, is generally an X-linked recessive trait and effects 1 in 10000 males. It involves defects of p........ Read more »
Du LM, Nurden P, Nurden AT, Nichols TC, Bellinger DA, Jensen ES, Haberichter SL, Merricks E, Raymer RA, Fang J.... (2013) Platelet-targeted gene therapy with human factor VIII establishes haemostasis in dogs with haemophilia A. Nature communications, 2773. PMID: 24253479
Early orthodontic treatment for Class II malocclusion reduces the risk of trauma to the front teeth: How do we interpret this data; Odds, Risk and Numbers needed to treat? In my last blog, I described the results of our Cochrane Systematic review into the effectiveness of treatment for Class II malocclusion (http://goo.gl/9aLWlU). In the review […]The post Orthodontic treatment and trauma to the front teeth: Are the risks reduced? appeared first on Kevin O'Brien's Orthodontic........ Read more »
Badri Thiruvenkatachari,, Jayne E Harrison,, Helen V Worthington,, & Kevin D O'Brien. (2013) Orthodontic treatment for prominent upper front teeth in children. Cochrane Database of Systematic Reviews. DOI: 10.1002/14651858.CD003452.pub3
A brief look into the fascinating and puzzling world of prion proteins in disease. Endogenous cellular proteins capable of self-replicating and mediating neurodegeneration. ... Read more »
Acquatella-Tran Van Ba I, Imberdis T, & Perrier V. (2013) From Prion Diseases to Prion-Like Propagation Mechanisms of Neurodegenerative Diseases. International journal of cell biology, 975832. PMID: 24222767
Lee S, Antony L, Hartmann R, Knaus KJ, Surewicz K, Surewicz WK, & Yee VC. (2010) Conformational diversity in prion protein variants influences intermolecular beta-sheet formation. The EMBO journal, 29(1), 251-62. PMID: 19927125
Wasmer C, Lange A, Van Melckebeke H, Siemer AB, Riek R, & Meier BH. (2008) Amyloid fibrils of the HET-s(218-289) prion form a beta solenoid with a triangular hydrophobic core. Science (New York, N.Y.), 319(5869), 1523-6. PMID: 18339938
Brain Hippocampus Highlighted in GreenThere are a multitude of tools that provide measurements of cognitive and physical function.Choosing the best tools to assess and monitor Alzheimer's disease and other types of dementia is an important clinical task.A research team from the Netherlands recently reviewed the assessment of cognitive and physical assessment in older adults with dementia.Their goal was to provide a recommended set of tests that would improve consensus and aid in the research in ........ Read more »
Bossers WJ, van der Woude LH, Boersma F, Scherder EJ, & van Heuvelen MJ. (2012) Recommended measures for the assessment of cognitive and physical performance in older patients with dementia: a systematic review. Dementia and geriatric cognitive disorders extra, 2(1), 589-609. PMID: 23341825
Pain. Nobody particularly likes it, but with the pharmaceutical arsenal of pain relief medication at our disposal these days, many cases of pain can be tackled in one way or another.Tablets (before tablets) @ Wikipedia For those who watched the recent BBC series by the ever-intrepid Dr Michael Mosley titled 'Pain, pus and poison' on some of the important history behind the modern medical, chemical and pharmacy professions, pain was a feature of quite a few of the developments discussed........ Read more »
Brandlistuen RE, Ystrom E, Nulman I, Koren G, & Nordeng H. (2013) Prenatal paracetamol exposure and child neurodevelopment: a sibling-controlled cohort study. International journal of epidemiology. PMID: 24163279
Continuing from Part I of a paper that could, at best, be described as a convenience sample, since a quarter of patients were excluded from randomization because of attending physician bias.
What were the authors assuming when comparing GVL (GlideScope Video Laryngoscope) with DL (Direct Laryngoscopy) for intubation?... Read more »
Yeatts DJ, Dutton RP, Hu PF, Chang YW, Brown CH, Chen H, Grissom TE, Kufera JA, & Scalea TM. (2013) Effect of video laryngoscopy on trauma patient survival: a randomized controlled trial. The journal of trauma and acute care surgery, 75(2), 212-9. PMID: 23823612
Lee A, Fan LT, Gin T, Karmakar MK, & Ngan Kee WD. (2006) A systematic review (meta-analysis) of the accuracy of the Mallampati tests to predict the difficult airway. Anesthesia and analgesia, 102(6), 1867-78. PMID: 16717341
Lundstrøm LH, Vester-Andersen M, Møller AM, Charuluxananan S, L'hermite J, Wetterslev J, & Danish Anaesthesia Database. (2011) Poor prognostic value of the modified Mallampati score: a meta-analysis involving 177 088 patients. British journal of anaesthesia, 107(5), 659-67. PMID: 21948956
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