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  • July 3, 2015
  • 04:37 PM
  • 5 views

REM sleep critical for young brain development; medication interferes

by Dr. Jekyll in Lunatic Laboratories

Rapid eye movement or REM sleep actively converts waking experiences into lasting memories and abilities in young brains reports a new study. The finding broadens the understanding of children’s sleep needs and calls into question the increasing use of REM-disrupting medications such as stimulants and antidepressants.

... Read more »

Michelle C. Dumoulin Bridi, Sara J. Aton, Julie Seibt, Leslie Renouard, Tammi Coleman1, & Marcos G. Frank. (2015) Rapid eye movement sleep promotes cortical plasticity in the developing brain. Science Advances. info:/10.1126/sciadv.1500105

  • July 3, 2015
  • 04:05 PM
  • 2 views

Novel DNA repair mechanism brings new horizons

by Dr. Jekyll in Lunatic Laboratories

The DNA molecule is chemically unstable giving rise to DNA lesions of different nature. That is why DNA damage detection, signaling and repair, collectively known as the DNA damage response, are needed. A group of researchers discovered a new mechanism of DNA repair, which opens up new perspectives for the treatment and prevention of neurodegenerative diseases.... Read more »

Nikolay A. Pestov, Nadezhda S. Gerasimova, Olga I. Kulaeva, & Vasily M. Studitsky. (2015) Structure of transcribed chromatin is a sensor of DNA damage. Science Advances. info:/10.1126/sciadv.1500021

  • July 3, 2015
  • 06:02 AM
  • 25 views

5 Tips For Better Sleep

by Elisabeth Buhl Thubron in United Academics

Adding some ‘worry time’ to your day could work better than pills.... Read more »

  • July 3, 2015
  • 04:56 AM
  • 16 views

Vitamin D metabolic gene variants and risk for autism

by Paul Whiteley in Questioning Answers

I was really rather happy to see the "preliminary evidence" reported by Rebecca Schmidt and colleagues [1] when it came to examining whether selected vitamin D metabolic gene variants might show linkage to autism spectrum disorder (ASD) based on data derived from the CHARGE initiative.For quite a while now I've discussed the various peer-reviewed science on the topic of vitamin D deficiency / insufficiency with autism in mind on this blog (see here and see here for example). Specifically, h........ Read more »

Schmidt RJ, Hansen RL, Hartiala J, Allayee H, Sconberg JL, Schmidt LC, Volk HE, & Tassone F. (2015) Selected vitamin D metabolic gene variants and risk for autism spectrum disorder in the CHARGE Study. Early human development, 91(8), 483-489. PMID: 26073892  

  • July 2, 2015
  • 11:57 AM
  • 30 views

Digesting bread and pasta can release biologically active molecules

by Dr. Jekyll in Lunatic Laboratories

Biologically active molecules released by digesting bread and pasta can survive digestion and potentially pass through the gut lining, suggests new research. The study reveals the molecules released when real samples of bread and pasta are digested, providing new information for research into gluten sensitivity.... Read more »

  • July 2, 2015
  • 02:34 AM
  • 36 views

Acute bipolar depression and immune alterations

by Paul Whiteley in Questioning Answers

"Individuals with acute bipolar depression show immune alterations. Some of the alterations are similar to those found in acute mania."That was the bottom line reported by Faith Dickerson and colleagues [1] following their analysis of blood samples provided by "82 individuals with acute bipolar depression, 147 with acute mania, and 280 controls." Looking for the presence of various antibodies to "human herpesviruses, gliadin, Toxoplasma gondii, and endogenous retroviruses as well as for C-reacti........ Read more »

Dickerson F, Katsafanas E, Schweinfurth LA, Savage CL, Stallings C, Origoni A, Khushalani S, Lillehoj E, & Yolken R. (2015) Immune alterations in acute bipolar depression. Acta psychiatrica Scandinavica. PMID: 26061032  

  • July 1, 2015
  • 02:19 PM
  • 52 views

New epigenetic mechanism revealed in brain cells

by Dr. Jekyll in Lunatic Laboratories

For decades, researchers in the genetics field have theorized that the protein spools around which DNA is wound, histones, remain constant in the brain, never changing after development in the womb. Now, researchers from the Icahn School of Medicine at Mount Sinai have discovered that histones are steadily replaced in brain cells throughout life – a process which helps to switch genes on and off.... Read more »

Maze, I., Wenderski, W., Noh, K., Bagot, R., Tzavaras, N., Purushothaman, I., Elsässer, S., Guo, Y., Ionete, C., Hurd, Y.... (2015) Critical Role of Histone Turnover in Neuronal Transcription and Plasticity. Neuron, 87(1), 77-94. DOI: 10.1016/j.neuron.2015.06.014  

  • July 1, 2015
  • 06:24 AM
  • 45 views

Offspring autism risk and advancing parental age (differences)

by Paul Whiteley in Questioning Answers

Parental age at offspring conception/birth in relation to offspring autism risk has been a recurrent theme in autism research circles for quite a few years now. I've covered it more than once on this blog (see here for example) and the various suggestions that advancing parental age in particular, might elevate the risk of offspring autism.Set in this context, the paper by Sven Sandin and colleagues [1] (open-access) (a name not unfamiliar to this blog) adds to the research evidence based on the........ Read more »

Sandin S, Schendel D, Magnusson P, Hultman C, Surén P, Susser E, Grønborg T, Gissler M, Gunnes N, Gross R.... (2015) Autism risk associated with parental age and with increasing difference in age between the parents. Molecular psychiatry. PMID: 26055426  

  • July 1, 2015
  • 01:43 AM
  • 66 views

Technologies and Generations

by Aurametrix team in Health Technologies

Children no longer obey their parents; every man wants to write a book and the end of the world is evidently approaching. So said a clay tablet inscribed almost 5 thousand years ago. But the world still stands, although we do go through golden and dark ages and societies rise and fall. Technology's golden age is now. or so we hope. How are current generations influenced by it and how will they shape the future world? Even as they age, Baby Boomers embrace emerging technologies such as smartphone........ Read more »

Costanza, D., Badger, J., Fraser, R., Severt, J., & Gade, P. (2012) Generational Differences in Work-Related Attitudes: A Meta-analysis. Journal of Business and Psychology, 27(4), 375-394. DOI: 10.1007/s10869-012-9259-4  

Becton, J., Walker, H., & Jones-Farmer, A. (2014) Generational differences in workplace behavior. Journal of Applied Social Psychology, 44(3), 175-189. DOI: 10.1111/jasp.12208  

  • June 30, 2015
  • 02:56 PM
  • 51 views

Women’s faces get redder at ovulation, but human eyes can’t pick up on it

by Dr. Jekyll in Lunatic Laboratories

Previous studies have shown that men find female faces more attractive when the women are ovulating, but the visual clues that allow this are unclear. Now, new research investigating whether it might be to do with subtle changes in skin colour has shown that women’s faces do increase in redness during ovulation, but the levels of change are just under the detectable range of the human eye.... Read more »

Hannah Rowland, & Robert Burriss. (2015) Women’s faces get redder at ovulation, but human eyes can’t pick up on it. PLOS ONE. info:/

  • June 30, 2015
  • 12:55 PM
  • 43 views

Bipolar Disorder: Novel Clinical Trials II

by William Yates, M.D. in Brain Posts

This is the second post reviewing recent novel trials for the treatment of bipolar disorder.Again, for my sources I am using are clinicaltrials.gov and PubMed.Clicking on the study title will take you to the clinicaltrials.gov site for more detailed protocol information.Allopurinol Maintenance Study for Bipolar DisorderThis completed study examined the effect of 300 to 600 mg per day of allopurinol on mania prevention. Allopurinol is a drug used primarily for the treatment of gout or kidney ston........ Read more »

  • June 30, 2015
  • 12:32 PM
  • 40 views

Omega-3 supplements and antioxidants may help with preclinical Alzheimer’s disease

by Dr. Jekyll in Lunatic Laboratories

Here’s more evidence that fish oil supplementation and antioxidants might be beneficial for at least some people facing Alzheimer’s disease. A new report describes the findings of a very small study in which people with mild clinical impairment, such as those in the very early stages of the disease, saw clearance of the hallmark amyloid-beta protein and reduced inflammation in neurological tissues. Although the findings involved just 12 patients over the course of 4 to 17 months, the finding........ Read more »

Fiala M, Halder RC, Sagong B, Ross O, Sayre J, Porter V, & Bredesen DE. (2015) ω-3 Supplementation increases amyloid-β phagocytosis and resolvin D1 in patients with minor cognitive impairment. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. PMID: 25805829  

  • June 30, 2015
  • 05:06 AM
  • 47 views

Low glycemic index diet reduces symptoms of mouse autism

by Paul Whiteley in Questioning Answers

A quote to begin: "Overall, the manuscript supports the idea that ASD [autism spectrum disorder] results from gene–environment interactions and that in the presence of a genetic predisposition to ASD, diet can make a large difference in the expression of the condition."The manuscript in question was by Antonio Currais and colleagues [1] reporting some rather interesting results based on the 'dangermouse' that is the BTBR mouse model of autism. Researchers from the Salk Inst........ Read more »

  • June 29, 2015
  • 07:55 PM
  • 57 views

You may already be beating cancer

by Angela Reisetter in Steeped in Science

A look at living with disease close at hand, using a couple different papers. Living with Risk.... Read more »

  • June 29, 2015
  • 03:26 PM
  • 63 views

How your brain knows it’s summer

by Dr. Jekyll in Lunatic Laboratories

Researchers led by Toru Takumi at the RIKEN Brain Science Institute in Japan have discovered a key mechanism underlying how animals keep track of the seasons. The study shows how circadian clock machinery in the brain encodes seasonal changes in daylight duration through GABA activity along with changes in the amount of chloride located inside certain neurons.... Read more »

Myung J, Hong S, DeWoskin D, Schutter E, Forger, DB, and Takumi T. (2015) GABA-mediated repulsive coupling between circadian clock neurons in the SCN encodes seasonal time. Proceedings of the National Academy of Sciences. info:/10.1073/pnas.1421200112

  • June 29, 2015
  • 08:00 AM
  • 70 views

Stand and Deliver: We Think Better on Our Feet — Literally

by Jeremiah Stanghini in Jeremiah Stanghini

Did you see the post from ScienceDaily a couple of months ago? As it turns out, we think better when we’re on our feet. Maybe more importantly though, given how much we tend to sit throughout the day, standing is a good way to … Continue reading →... Read more »

Dornhecker, M., Blake, J., Benden, M., Zhao, H., & Wendel, M. (2015) The effect of stand-biased desks on academic engagement: an exploratory study. International Journal of Health Promotion and Education, 1-10. DOI: 10.1080/14635240.2015.1029641  

  • June 29, 2015
  • 06:49 AM
  • 50 views

Cancer Breakthrough: New Devise Optomizes Lymphoma Treatment

by Agnese Mariotti in United Academics

CIVO tests cancer drugs in human lymphomas in only 72 hours.... Read more »

Klinghoffer, R., Bahrami, S., Hatton, B., Frazier, J., Moreno-Gonzalez, A., Strand, A., Kerwin, W., Casalini, J., Thirstrup, D., You, S.... (2015) A technology platform to assess multiple cancer agents simultaneously within a patient's tumor. Science Translational Medicine, 7(284), 284-284. DOI: 10.1126/scitranslmed.aaa7489  

  • June 29, 2015
  • 04:57 AM
  • 69 views

Fermented foods and social anxiety?

by Paul Whiteley in Questioning Answers

Stumbling across a headline that reads: 'Study Finds Decreased Social Anxiety Among Young Adults Who Eat Fermented Foods' was bound to pique my blogging interest. When I eventually tracked down the source paper behind the headline I became more and more intrigued as today I bring to your attention the study findings reported by Matthew Hilimire and colleagues [1].Implementing "a cross-sectional approach to determine whether consumption of fermented foods likely to contain probiotics interac........ Read more »

Hilimire MR, DeVylder JE, & Forestell CA. (2015) Fermented foods, neuroticism, and social anxiety: An interaction model. Psychiatry research, 228(2), 203-8. PMID: 25998000  

  • June 28, 2015
  • 03:10 PM
  • 52 views

Blood & Fog: The Military's Germ Warfare Tests in San Francisco

by Rebecca Kreston in BODY HORRORS

The Nuremberg Code was drafted in 1947 following the appalling revelations of human experimentation committed in Nazi concentration camps. The overarching goal of the Code was to establish a set of rules for the ethical conduct of research using human subjects, guaranteeing that the rights and welfare of such participants would be protected. Two important principles guide and define this Code: the concept of voluntary, informed consent and that no experiment shall be conducted in which "there i........ Read more »

WHEAT RP, ZUCKERMAN A, & RANTZ LA. (1951) Infection due to chromobacteria; report of 11 cases. A.M.A. archives of internal medicine, 88(4), 461-6. PMID: 14867953  

  • June 28, 2015
  • 01:34 PM
  • 62 views

Pharma Make The Most of A Negative Result

by Neuroskeptic in Neuroskeptic_Discover

A misleading piece of statistical rhetoric has appeared in a paper about an experimental antidepressant treatment. The study is published in the Journal of Affective Disorders. JAD is a respectable mid-ranked psychiatry journal - yet on this occasion they seem to have dropped the ball badly.



The study examined whether the drug armodafinil (Nuvigil) improved mood in people with bipolar disorder who were in a depressive episode. In a double-blind trial, 462 patients were randomized to treat... Read more »

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