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  • January 27, 2015
  • 04:33 AM
  • 5 views

Siblings, genetics and the autisms (plural)

by Paul Whiteley in Questioning Answers

The paper by Ryan Yuen and colleagues [1] suggesting that most siblings with autism do not share the same genetic variations thought to contribute to the condition has garnered quite a few media headlines of late (see here and see here).Applying the concept of whole-genome sequencing whereby the complete genetic blueprint of a person is mapped to provide "the most comprehensive collection of an individual's genetic variation" [2], 340 genomes from 85 families with two children with a d........ Read more »

Yuen, R., Thiruvahindrapuram, B., Merico, D., Walker, S., Tammimies, K., Hoang, N., Chrysler, C., Nalpathamkalam, T., Pellecchia, G., Liu, Y.... (2015) Whole-genome sequencing of quartet families with autism spectrum disorder. Nature Medicine. DOI: 10.1038/nm.3792  

  • January 26, 2015
  • 09:21 PM
  • 8 views

High-Dose Statin May Protect Heart Surgery Patients’ Kidney Health

by Wiley Asia Blog in Wiley Asia Blog - Health Sciences

Acute kidney injury often arises after major surgery because the kidneys can be deprived of normal blood flow during the procedure. The use of contrast media, or dyes, can contribute to this problem. In patients undergoing coronary angiography or percutaneous coronary intervention, which are heart procedures that use dyes to help surgeons visualize the arteries, a high dose of the statin atorvastatin was linked with a reduction in blood levels of creatinine, a marker of kidney injury, as well as........ Read more »

  • January 26, 2015
  • 05:36 PM
  • 23 views

You can’t unboil an egg? Well… now you can

by Dr. Jekyll in Lunatic Laboratories

There is a saying, “you can’t unboil an egg.” Usually this is just illustrating cause and effect; you can’t turn back time, or what’s done is done. Well now scientists have successfully unboiled an egg, so suck it thermodynamics. An international team of chemists have accomplished this feat – an innovation that could dramatically reduce costs for cancer treatments, food production and other segments of the $160 billion global biotechnology industry, according to the findings.... Read more »

Yuan, T., Ormonde, C., Kudlacek, S., Kunche, S., Smith, J., Brown, W., Pugliese, K., Olsen, T., Iftikhar, M., Raston, C.... (2015) Shear-Stress-Mediated Refolding of Proteins from Aggregates and Inclusion Bodies. ChemBioChem. DOI: 10.1002/cbic.201402427  

  • January 26, 2015
  • 04:32 PM
  • 23 views

The secret for a longer life? Kill your unfit cells

by Isabel Torres in Science in the clouds

If you had the choice, would you like to live until you’re 130 years old? New research in fruit flies shows that manipulating a single gene can extend their lifespan up to 60%, suggesting that living well into your hundreds might become a reality in the foreseeable future.Dying of old age is a strange thing. Why does our health decline just because we’re old? Although the answer might at first seem obvious or simple, it really isn’t. There are countless theories of ageing, a few popular ev........ Read more »

  • January 26, 2015
  • 06:23 AM
  • 42 views

Is it necessary to use brain imaging to understand teen girls' sexual decision making?

by The Neurocritic in The Neurocritic

“It is feasible to recruit and retain a cohort of female participants to perform a functional magnetic resonance imaging [fMRI] task focused on making decisions about sex, on the basis of varying levels of hypothetical sexual risk, and to complete longitudinal prospective diaries following this task. Preliminary evidence suggests that risk level differentially impacts brain activity related to sexual decision making in these women [i.e., girls aged 14-15 yrs], which may be related to pas........ Read more »

  • January 26, 2015
  • 04:44 AM
  • 35 views

What factors are linked to behavioural crises in autism?

by Paul Whiteley in Questioning Answers

The question posed in the title of this post was asked and [partly] answered by the paper by Vincent Guinchat and colleagues [1] based on the analysis of 58 adolescents diagnosed with an autism spectrum disorder (ASD) and "hospitalized for severe challenging behaviors." Challenging behaviours, by the way, refers to a whole spectrum of presentations which doesn't just include aggressive or violent behaviours (see here). Indeed, I recently talked about irritability and autism (see here), whic........ Read more »

  • January 24, 2015
  • 01:39 PM
  • 76 views

Lucid dreaming: The similarities between dreaming and wakefulness

by Dr. Jekyll in Lunatic Laboratories

To control one’s dreams and to live out there what is impossible in real life — a truly tempting idea. Some people — so-called lucid dreamers — can do this. Researchers have discovered that the brain area which enables self-reflection is larger in lucid dreamers. Thus, lucid dreamers are possibly also more self-reflecting when they are awake.... Read more »

Filevich E, Dresler M, Brick TR, & Kühn S. (2015) Metacognitive mechanisms underlying lucid dreaming. The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(3), 1082-8. PMID: 25609624  

  • January 24, 2015
  • 05:34 AM
  • 55 views

Hartnup disease in coeliac disease: lessons for 'some' autism?

by Paul Whiteley in Questioning Answers

The paper by Thomas Ciecierega and colleagues [1] (open-access) talking about 'refractory' coeliac disease (CD) - a lack of, or diminished response to a gluten-free diet (the primary management option for CD) - and the subsequent diagnosis of Hartnup disease in a young girl is fodder for today's brief post.I already had a big bowl of curly-toed weirdo for breakfast.Describing how authors first diagnosed her with CD but witnessed "only mild clinical and laboratory improvement"........ Read more »

  • January 23, 2015
  • 03:25 PM
  • 72 views

Exotic Pets: Emerging Risk Factor for Salmonellosis in Children

by Pranab Chatterjee in Scepticemia

The increasing trend of having exotic reptiles as pets may lead to an increase in reptile associated infections such as Salmonellosis, especially in the children in the household. ... Read more »

  • January 23, 2015
  • 01:53 PM
  • 63 views

First Partially Successful Vaccine Developed Against Prion Disease in Deer

by Pranab Chatterjee in Scepticemia

The first partially successful vaccine against a prion disease (Chronic Wasting Disease in white tailed deer) is good news, but the journey has just begun. ... Read more »

  • January 23, 2015
  • 06:30 AM
  • 66 views

NAC risperidone = decreased irritability in autism?

by Paul Whiteley in Questioning Answers

It's been a while since I talked about NAC - N-acetylcysteine - on this blog with either autism or schizophrenia in mind (see here and see here respectively). Today I'm going to remedy that situation by bringing the paper by Nikoo and colleagues [1] to your attention, and their observation: "N-acetylcysteine can be considered as an adjuvant therapy for ADs [autistic disorders] with beneficial therapeutic outcomes." Adjuvant therapy by the way, refers to a sort of add-on therapy.We have........ Read more »

  • January 22, 2015
  • 05:50 PM
  • 155 views

Belief’s effect on biochemistry in cases of addiction

by Dr. Jekyll in Lunatic Laboratories

Ever wonder what makes people susceptible to addiction? Think about it, some people can stop addictive painkillers without a problem and others, well others are not so lucky. So the big question is are there more than biophysical factors at play in addiction? A new study shows that cognitive beliefs play a significant role in a person’s neurological response to an addictive substance and that belief can diminish the neurological effects of an addictive drug.... Read more »

Gu, X., Lohrenz, T., Salas, R., Baldwin, P., Soltani, A., Kirk, U., Cinciripini, P., & Montague, P. (2015) Belief about nicotine selectively modulates value and reward prediction error signals in smokers. Proceedings of the National Academy of Sciences, 201416639. DOI: 10.1073/pnas.1416639112  

  • January 22, 2015
  • 02:06 PM
  • 72 views

Black Tar Heroin: Lower HIV Transmission vs Higher Bacterial Infections?

by Pranab Chatterjee in Scepticemia

The rise of street-cut, unsanitary preparations of Black Tar Heroin has allegedly reduced HIV transmission but at the cost of higher numbers of fatal, bacterial infections, notably botulism, clusters of which have been regularly identified in California.... Read more »

  • January 22, 2015
  • 01:45 PM
  • 72 views

Modeling an epidemic to help guide public health policies (Ebola, West Africa)

by Aurelie in Coffee break Science

By mid-December 2014, about 18,000 individuals had been reported to be infected by the Ebola virus currently causing an epidemic in West Africa. On January 12, 2015, the World Health Organization’s (WHO) latest report stated an updated total of more … Continue reading →... Read more »

Drake JM, Kaul RB, Alexander LW, O'Regan SM, Kramer AM, Pulliam JT, Ferrari MJ, & Park AW. (2015) Ebola cases and health system demand in liberia. PLoS biology, 13(1). PMID: 25585384  

  • January 22, 2015
  • 06:22 AM
  • 71 views

At-risk kids avoiding an autism diagnosis?

by Paul Whiteley in Questioning Answers

The paper from Jonathan Green and colleagues [1] (open-access) discussing results based on a "two-site, two-arm assessor-blinded randomised controlled trial of families with an infant at familial high risk of autism aged 7–10 months, testing the adapted Video Interaction to Promote Positive Parenting (iBASIS-VIPP) versus no intervention" caught quite a few eyes recently. With accompanying media headlines such as 'Parents May Be Able to Lower Kids’ Autism Risk' you can imagine the interest cr........ Read more »

Jonathan Green, Tony Charman, Andrew Pickles, Ming W Wan, Mayada Elsabbagh, Vicky Slonims, Carol Taylor, Janet McNally, Rhonda Booth, Teodora Gliga.... (2015) Parent-mediated intervention versus no intervention for infants at high risk of autism: a parallel, single-blind, randomised trial. The Lancet Psychiatry. info:/http://dx.doi.org/10.1016/S2215-0366(14)00091-1

  • January 22, 2015
  • 04:45 AM
  • 66 views

Experts and autism screening triage

by Paul Whiteley in Questioning Answers

Whilst hopefully using the word 'triage' in the right way in the title of this post, I want to briefly talk today about the paper by Terisa Gabrielsen and colleagues [1] (full-text version here) and their observation that when it came to "brief but highly focused observations", a group of psychologists (well, two of them) "with toddler and autism expertise" missed over a third of cases of children who required additional examination/screening for autism or autistic traits.I am Meredith........ Read more »

Terisa P. Gabrielsen, Megan Farley, Leslie Speer, Michele Villalobos, Courtney N. Baker, & Judith Miller. (2015) Identifying Autism in a Brief Observation. Pediatrics. info:/10.1542/peds.2014-1428

  • January 21, 2015
  • 03:56 PM
  • 69 views

Fish, mercury, and pregnancy: Good news for seafood lovers

by Dr. Jekyll in Lunatic Laboratories

People freak out when they hear mercury is in something and sometimes for good reasons. In vaccinations for example a very small amount of ethyl-mercury WAS used as a preservative in vaccines, people got scared so now it is not used in most vaccines. Methylmercury* however is found in seafood and larger fish in particular (in much, much higher concentrations than in vaccines mind you). They may sound the same, but the methylmercury in fish is far more toxic. That said, it turns out that fish isn........ Read more »

Gutiérrez, F., & Leon, L. (2000) Elemental Mercury Embolism to the Lung. New England Journal of Medicine, 342(24), 1791-1791. DOI: 10.1056/NEJM200006153422405  

JJ Strain,, Alison J Yeates,, Edwin van Wijngaarden,, Sally W Thurston,, Maria S Mulhern,, Emeir M McSorley,, Gene E Watson,, Tanzy M Love,, Tristram H Smith,, Kelley Yost,.... (2015) Prenatal exposure to methyl mercury from fish consumption and polyunsaturated fatty acids: associations with child development at 20 mo of age in an observational study in the Republic of Seychelles. The American Journal of Clinical Nutrition . info:/10.3945/​ajcn.114.100503

  • January 21, 2015
  • 05:34 AM
  • 63 views

Features of autism in childhood epilepsy

by Paul Whiteley in Questioning Answers

"In conclusion, features of ASD [autism spectrum disorder] were common in children with epilepsy regardless of cognitive ability."Whoa, whoa, whoa! Sorry, Blondie. I don't do backstorySo said Colin Reily and colleagues [1] in their paper examining facets of autism in cases of childhood epilepsy. Suggesting also that the Autism Spectrum Screening Questionnaire (ASSQ) might be "a useful screening instrument in this population, and combining parent and teacher forms was opt........ Read more »

Reilly C, Atkinson P, Das KB, Chin RF, Aylett SE, Burch V, Gillberg C, Scott RC, & Neville BG. (2014) Features of autism spectrum disorder (ASD) in childhood epilepsy: A population-based study. Epilepsy , 86-92. PMID: 25529303  

  • January 20, 2015
  • 03:01 PM
  • 74 views

You can live longer, but not healthier

by Dr. Jekyll in Lunatic Laboratories

We all want to live longer and thanks to medical technologies our life expectancies have dramatically increased. Which would be handy if we could actually enjoy the extra years. Unfortunately a study of long-lived mutant C. elegans by scientists shows that the genetically altered worms spend a greater portion of their life in a frail state and exhibit less activity as they age than typical nematodes. These findings suggest that genes that increase longevity may not significantly increase healthy........ Read more »

Bansal A, Zhu LJ, Yen K, & Tissenbaum HA. (2015) Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants. Proceedings of the National Academy of Sciences of the United States of America. PMID: 25561524  

  • January 20, 2015
  • 02:59 PM
  • 25 views

New systematic reviews on orthodontics and gingival health.

by Kevin OBrien in Kevin OBrien's Orthodontic Blog

New systematic  reviews on orthodontics and gingival health. This week saw the on-line publication of two systematic reviews on  orthodontics and gingival health. The first was concerned with the effect of clear aligners and the second was with professionally applied oral hygiene measures. Both were published behind the European Journal of Orthodontics paywall and are […]
The post New systematic reviews on orthodontics and gingival health. appeared first on Kevin O'Brien's Ort........ Read more »

Rossini G, Parrini S, Castroflorio T, Deregibus A, & Debernardi CL. (2014) Periodontal health during clear aligners treatment: a systematic review. European journal of orthodontics. PMID: 25548145  

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