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  • May 23, 2015
  • 03:59 PM
  • 17 views

Omega-3 as an intervention for childhood behavioral problems

by Dr. Jekyll in Lunatic Laboratories

We don’t usually think of a child’s behavior as a diet issue, but if new findings hold true, then that might be the very case. In a new study, researchers suggest that omega-3, a fatty acid commonly found in fish oil, may have long-term neurodevelopmental effects that ultimately reduce antisocial and aggressive behavior problems in children.... Read more »

  • May 23, 2015
  • 03:53 AM
  • 28 views

Psychological morbidity of coeliac disease

by Paul Whiteley in Questioning Answers

"Anxiety, depression and fatigue are common complaints in patients with untreated celiac disease and contribute to lower quality of life."That was one of the conclusions reached in the paper by Fabiana Zingone and colleagues [1] (open-access available here) following their review of the research literature "on psychological morbidity of celiac disease." Celiac (coeliac) disease (CD), by the way, is the autoimmune condition classically treated via the use of a gluten-free diet (GFD). Readers........ Read more »

Zingone F, Swift GL, Card TR, Sanders DS, Ludvigsson JF, & Bai JC. (2015) Psychological morbidity of celiac disease: A review of the literature. United European gastroenterology journal, 3(2), 136-45. PMID: 25922673  

  • May 22, 2015
  • 03:11 PM
  • 42 views

Air pollution is causing your baby problems, but breastfeeding can help

by Dr. Jekyll in Lunatic Laboratories

Aitana Lertxundi has conducted her research work within the framework of the INma (Childhood and Environment) programme led by Jesús Ibarluzea of the Department of Health of the Government of the Basque Autonomous Community (region). The aim is to assess how exposure to environmental pollution during pregnancy affects health and also to examine the role of diet in physical and neurobehavioural development in infancy. The study focusses on the repercussions on motor and mental development during........ Read more »

  • May 22, 2015
  • 03:02 PM
  • 45 views

Are infections making you stupid?

by Dr. Jekyll in Lunatic Laboratories

New research shows that infections can impair your cognitive ability measured on an IQ scale. The study is the largest of its kind to date, and it shows a clear correlation between infection levels and impaired cognition. Anyone can suffer from an infection, for example in their stomach, urinary tract or skin. However, a new Danish study shows that a patient’s distress does not necessarily end once the infection has been treated.... Read more »

  • May 22, 2015
  • 04:07 AM
  • 45 views

Clinical trials for rare diseases – finding and keeping patients

by Danielle Stevenson in BHD Research Blog

International Clinical Trial day (May 20th) celebrates the medical advances as a result of clinical trials. Clinical trials are essential to ensure drug safety and efficacy, and the recent increase in the development of orphan drugs has led to an increase in rare disease clinical trials. The nature of rare diseases creates specific challenges for clinical trial design and patient recruitment.... Read more »

  • May 22, 2015
  • 02:24 AM
  • 46 views

Early Start Denver Model (ESDM) and autism: 2 year outcomes

by Paul Whiteley in Questioning Answers

"These results provide evidence that gains from early intensive intervention are maintained 2 years later. Notably, core autism symptoms improved in the ESDM [Early Start Denver Model] group over the follow-up period relative to the COM [community-intervention-as-usual] group."Those were some of the conclusions reported in amongst the potentially very important results from Annette Estes and colleagues [1] looking at "the sustained effects of early intervention" followin........ Read more »

Annette Estes, Jeffrey Munson, Sally J. Rogers, Jessica Greenson, Jamie Winter, & Geraldine Dawson. (2015) Long-Term Outcomes of Early Intervention in 6-Year-Old Children With Autism Spectrum Disorder. J Am Acad Child Adolesc Psychiatry. info:/10.1016/j.jaac.2015.04.005

  • May 21, 2015
  • 05:43 PM
  • 57 views

E-cigarettes don’t help smokers stop smoking (or smoke less)

by Megan Cartwright in Science-Based Writing

Electronic cigarettes don’t help people quit smoking or even smoke less. This conclusion – which further squashes hopes that e-cigarettes might enable America’s 42 million smokers to quit – comes from one of the largest studies of e-cigarette users to … Continue reading →... Read more »

Al-Delaimy WK, Myers MG, Leas EC, Strong DR, & Hofstetter CR. (2015) E-cigarette use in the past and quitting behavior in the future: a population-based study. American journal of public health, 105(6), 1213-9. PMID: 25880947  

  • May 21, 2015
  • 05:09 AM
  • 52 views

Respiratory illness and schizophrenia

by Paul Whiteley in Questioning Answers

"Schizophrenia is associated with impaired lung function and increased risk for pneumonia, COPD [Chronic obstructive pulmonary disease] and chronic bronchitis."That was the primary conclusion reached in the paper by Krista Partti and colleagues [1] who aimed to "compare the respiratory health of people with psychosis with that of the general population." Their findings, based on data from "a nationally representative sample of 8028 adult Finns" (Finns as in inhabitants of Finland) invo........ Read more »

Partti K, Vasankari T, Kanervisto M, Perälä J, Saarni SI, Jousilahti P, Lönnqvist J, & Suvisaari J. (2015) Lung function and respiratory diseases in people with psychosis: population-based study. The British journal of psychiatry : the journal of mental science. PMID: 25858177  

  • May 20, 2015
  • 08:06 AM
  • 48 views

What Can "Lived Experience" Teach Neuroscientists?

by Neuroskeptic in Neuroskeptic_Discover

A provocative paper says that neuroscientists who research mental health problems ought to listen to the views of people who have experienced those conditions.

The piece, from Australian authors Anthony Stratford and colleagues, is published in The Psychiatric Quarterly.



Here are some highlights:
Traditionally, mental health consumer [i.e. patient] involvement in research activities has largely been as "subjects"... the passive recipients of research activity... This approach does lit... Read more »

  • May 20, 2015
  • 04:49 AM
  • 42 views

Severe obesity pre-pregnancy and offspring developmental outcome

by Paul Whiteley in Questioning Answers

"Children whose mothers were severely obese before pregnancy had increased risk for adverse developmental outcomes."That was the conclusion reached in the paper by Heejoo Jo and colleagues [1] based on results derived from the Infant Feeding Practices Study II (IFPS II) "a US nationally distributed longitudinal study of maternal health and infant health and feeding practices." Said data included information on "maternal prepregnancy BMI [body mass index] and child psychosocia........ Read more »

  • May 19, 2015
  • 04:21 PM
  • 51 views

Suicide and skin color, or how being black is killing you

by Dr. Jekyll in Lunatic Laboratories

The great racial divide, despite all the evidence showing that racism, hate and frankly plain stupidity is alive and well, there are people who cannot accept it. This probably will not change anything for those people, but for the first time a new study shows that while suicide rates in children younger than 12 have remained steady for the past 20 years, there are significantly higher suicide rates among black children.... Read more »

Bridge, J., Asti, L., Horowitz, L., Greenhouse, J., Fontanella, C., Sheftall, A., Kelleher, K., & Campo, J. (2015) Suicide Trends Among Elementary School–Aged Children in the United States From 1993 to 2012. JAMA Pediatrics. DOI: 10.1001/jamapediatrics.2015.0465  

  • May 19, 2015
  • 04:50 AM
  • 48 views

Social anxiety affecting autism intervention outcome?

by Paul Whiteley in Questioning Answers

"Anxiety is an unpleasant state of inner turmoil" according to one definition. In other descriptions, words such as 'worry' and 'dread' are used (see here) describing how beyond the typical feelings of apprehension about a new situation for example, anxiety can turn into something altogether more serious and life-disrupting for some.There are various types of anxiety disorder (see here) to consider, but for the purposes of this post I'm going to focus on social anxiety disorder in the context of........ Read more »

  • May 18, 2015
  • 10:45 AM
  • 39 views

Brain Imaging and Conduct Disorder: Temporal Lobe Abnormalities

by William Yates, M.D. in Brain Posts

Conduct disorder is a complex behavioral disorder with significant risk for later adult psychopathology.There is increasing evidence for a biological basis for conduct disorder.Twin studies show a significant genetic contribution to the disorder.Brain imaging studies also point to biological factors in conduct disorder.Gregory Wallace and colleagues recently published a structural MRI study of conduct disorder in 22 adolescents between the ages of 10 and 18. Conduct disorder subjects were compar........ Read more »

Wallace GL, White SF, Robustelli B, Sinclair S, Hwang S, Martin A, & Blair RJ. (2014) Cortical and subcortical abnormalities in youths with conduct disorder and elevated callous-unemotional traits. Journal of the American Academy of Child and Adolescent Psychiatry, 53(4), 456-650. PMID: 24655655  

  • May 18, 2015
  • 06:26 AM
  • 63 views

‘Water, water, everywhere, Nor any drop to drink’ – Safe drinking water and Adequate sanitation are indispensable for eradicating Cholera

by Sarah Stephen in An ecological oratorio

What has Cholera to do with environment? Absolutely everything!  In this post, we look at why clean water and safe sanitation is essential for eradicating this dreadful disease from our planet. Access to clean drinking water and safe sanitation could eradicate cholera. (Image - Sam Stephen) Cholera, an acute intestinal infection caused by ingestion of food or liquids contaminated with the bacterium Vibrio cholerae, elicits the same fear today, as it did in the past. Although cholera has aff........ Read more »

Miwanda B, Moore S, Muyembe JJ, Nguefack-Tsague G, Kabangwa IK, Ndjakani DY, Mutreja A, Thomson N, Thefenne H, Garnotel E.... (2015) Antimicrobial Drug Resistance of Vibrio cholerae, Democratic Republic of the Congo. Emerging infectious diseases, 21(5), 847-51. PMID: 25897570  

Waldman RJ, Mintz ED, & Papowitz HE. (2013) The cure for cholera--improving access to safe water and sanitation. The New England journal of medicine, 368(7), 592-4. PMID: 23301693  

  • May 18, 2015
  • 05:04 AM
  • 54 views

Pregnancy vitamin D levels and offspring ADHD

by Paul Whiteley in Questioning Answers

"Higher maternal circulating levels of 25(OH)D3 in pregnancy are associated with lower risk of developing ADHD [attention deficit hyperactivity disorder]-like symptoms in childhood."Eva Morales and colleagues [1] came to that conclusion in their study - prospective study - looking at how estimated pregnancy vitamin D levels might have impacted on teacher-assessed ADHD-like symptoms in offspring when aged between 4 and 5 years old. Based on participants involved in the INMA project look........ Read more »

Morales E, Julvez J, Torrent M, Ballester F, Rodríguez-Bernal CL, Andiarena A, Vegas O, Castilla AM, Rodriguez-Dehli C, Tardón A.... (2015) Vitamin D in Pregnancy and Attention Deficit Hyperactivity Disorder-like Symptoms in Childhood. Epidemiology (Cambridge, Mass.). PMID: 25867115  

  • May 17, 2015
  • 11:46 PM
  • 70 views

Cities of the Future

by Aurametrix team in Environmental health

Picture your dream home. Chances are you did not think much about cutting edge technology, but more about luscious green grass, backyard oasis, fresh clean air, soothing pool of water or watching the sunset in your rocking chair. Scientific studies and crowdsourcing projects  showed that the amount of greenery is usually associated with beauty, quietness, or happiness, while broad streets, fortress-like buildings, and council houses are associated with ugly, noisy, and unhappy environments. ........ Read more »

Shaocai Yu. (2014) Water spray geoengineering to clean air pollution for mitigating haze in China’s cities. Environmental Chemistry Letters. info:/10.1007/s10311-013-0444-0

  • May 17, 2015
  • 11:03 PM
  • 67 views

A Look Into The Viruses That Control Your Stomach Bacterial Infections (Including Probiotics)

by Geoffrey Hannigan in Prophage

Biofilms continue to be hugely significant problems when treating bacterial infections. Biofilms are groups of bacteria that stick together and to a surface while surrounding themselves in a thick extracellular matrix. You can think of this as the collective bacteria sticking to a surface like a slimy ball of goo. These are very serious infections because...... Read more »

Rossmann, F., Racek, T., Wobser, D., Puchalka, J., Rabener, E., Reiger, M., Hendrickx, A., Diederich, A., Jung, K., Klein, C.... (2015) Phage-mediated Dispersal of Biofilm and Distribution of Bacterial Virulence Genes Is Induced by Quorum Sensing. PLOS Pathogens, 11(2). DOI: 10.1371/journal.ppat.1004653  

  • May 16, 2015
  • 03:57 AM
  • 81 views

Poverty affects autism ADHD?

by Paul Whiteley in Questioning Answers

A brief post for you today to bring to your attention the paper by Eirini Flouri and colleagues [1] who suggested that although socio-economic disadvantage (SED) was probably not a risk factor for autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD) when comorbid, "it was associated with elevated emotional problems among children with ASD + ADHD."Based on data derived from "209 children with ASD who took part in the UK's Millennium Cohort Study", an initia........ Read more »

  • May 15, 2015
  • 03:13 PM
  • 73 views

The fingerprint drug test

by Dr. Jekyll in Lunatic Laboratories

Researchers have demonstrated a new, noninvasive test that can detect cocaine use through a simple fingerprint. For the first time, this new fingerprint method can determine whether cocaine has been ingested, rather than just touched.... Read more »

  • May 15, 2015
  • 05:42 AM
  • 60 views

Autism's environmental exposome (part 2)

by Paul Whiteley in Questioning Answers

Back in June 2012, I posted an entry on this blog titled: 'Autism's environmental exposome: fish and pharmaceuticals' covering some work by Michael Thomas & Rebecca Klaper [1] (open-access). In it, authors suggested that unmetabolized psychoactive pharmaceuticals (UPPs) - residues from certain medicines - present in drinking (or in the case of this work, swimming) water may "induce autism-like gene expression patterns in fish."The UPPs in question were "FLX [fluoxetine], VNX [........ Read more »

Gaurav Kaushik, Michael A Thomas, & Ken A Aho. (2015) Psychoactive pharmaceuticals as environmental contaminants may disrupt highly inter-connected nodes in an Autism-associated protein-protein interaction network. BMC Bioinformatics. info:other/

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