Last February, Dr. Sam Parnia, an intensive care physician who has been researching near-death experiences for the past 15 years, published his new book ‘Erasing death: The Science That is Rewriting the Boundaries Between Life and Death’. Following the release of that book, Dr. Parnia was interviewed on National Public Radio in the US. It wasn’t so much this interview that sparked my interest, as much as the comments that followed. “It’s hard to believe that this gu........ Read more »
van Lommel P, van Wees R, Meyers V, & Elfferich I. (2001) Near-death experience in survivors of cardiac arrest: a prospective study in the Netherlands. Lancet, 358(9298), 2039-45. PMID: 11755611
tumblr: bellapaige88On average, 9.5/1000 population has epilepsy in Low and Middle Income Countries (LAMIC). A research which has resulted in the global campaign against epilepsy has shown, the gap between treatment need and the treatment provision worldwide is approximately 70% . This large ‘treatment gap’, i.e., lack of appropriate treatment for a large number of patients with epilepsy, due to a number of causes including inability to identify cases, inability to deliver adequate treatm........ Read more »
Mbuba CK, Ngugi AK, Newton CR, & Carter JA. (2008) The epilepsy treatment gap in developing countries: a systematic review of the magnitude, causes, and intervention strategies. Epilepsia, 49(9), 1491-503. PMID: 18557778
Pal, D., Das, T., & Sengupta, S. (2000) Case-control and qualitative study of attrition in a community epilepsy programme in rural India. Seizure, 9(2), 119-123. DOI: 10.1053/seiz.1999.0357
Mani KS, Rangan G, Srinivas HV, Srindharan VS, & Subbakrishna DK. (2001) Epilepsy control with phenobarbital or phenytoin in rural south India: the Yelandur study. Lancet, 357(9265), 1316-20. PMID: 11343735
Wang WZ, Wu JZ, Wang DS, Dai XY, Yang B, Wang TP, Yuan CL, Scott RA, Prilipko LL, de Boer HM.... (2003) The prevalence and treatment gap in epilepsy in China: an ILAE/IBE/WHO study. Neurology, 60(9), 1544-5. PMID: 12743252
Staying hydrated is good advice for men who’ve had kidney stones before, but sugar-sweetened sodas and fruit punch may not be the best choice of fluids.... Read more »
Ferraro, P., Taylor, E., Gambaro, G., & Curhan, G. (2013) Soda and Other Beverages and the Risk of Kidney Stones. Clinical Journal of the American Society of Nephrology. DOI: 10.2215/CJN.11661112
The U.S. Centers for Disease Control has published a comprehensive summary of the epidemiology of childhood brain disorders in the most recent Morbidity and Mortality Weekly Report.This report produced some sensationalized headlines that up to 20% of children suffer from a mental disorder. However, I was more interested in looking at the prevalence estimates for some of the individual disorders from the report.The report collates data collected from a variety of surveys and data sets inclu........ Read more »
Perou R, Bitsko RH, Blumberg SJ, Pastor P, Ghandour RM, Gfroerer JC, Hedden SL, Crosby AE, Visser SN, Schieve LA.... (2013) Mental health surveillance among children - United States, 2005-2011. Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002), 62(2), 1-35. PMID: 23677130
I'm gonna try and be fairly brief in this post on the paper by Valerio Napolioni and colleagues* (open-access) looking at plasma cytokine profiles in cases of autism and their asymptomatic siblings. Brief because (a) the paper is open-access and (b) the participant groups (autism: n=25; sibling controls n=25) were relatively small so one has to be quite careful in extrapolating the findings with any large degree of confidence.Siblings by Paul Klee @ WikiPaintings Just in case you are ........ Read more »
Napolioni V, Ober-Reynolds B, Szelinger S, Corneveaux JJ, Pawlowski T, Ober-Reynolds S, Kirwan J, Persico AM, Melmed RD, Craig DW.... (2013) Plasma cytokine profiling in sibling pairs discordant for autism spectrum disorder. Journal of neuroinflammation, 38. PMID: 23497090
Take Home Message: Hyaluronic acid injections decrease factors related to collagen degradation. Some blood tests may differentiate responders and nonresponders to these injections.
Knee osteoarthritis, one of the leading causes of disability, has no cure and current treatments commonly involve medications to decrease inflammation and pain. Hyaluronic acid (HA) injections have become a popular form of treatment for knee osteoarthritis. However, the mechanism of action has yet to be determ........ Read more »
Henrotin Y, Chevalier X, Deberg M, Balblanc JC, Richette P, Mulleman D, Maillet B, Rannou F, Piroth C, Mathieu P.... (2013) Early decrease of serum biomarkers of type II collagen degradation (Coll2-1) and joint inflammation (Coll2-1 NO2 ) by hyaluronic acid intra-articular injections in patients with knee osteoarthritis: A research study part of the Biovisco study. Journal of Orthopaedic Research, 31(6), 901-7. PMID: 23423846
“Our ancient countess was refused her desires will To bathe in pure fresh blood She’d peasant virgins killed Elizabeth, in the chasm where was my soul Forever young, Elizabeth Bathorii in the castle of your death You’re still alive, Elizabeth” -“Elizabeth”, Ghost As folklore has it, Elizabeth Bathorii, Countess of Hungary, often bath........ Read more »
Villeda SA, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, Stan TM, Fainberg N, Ding Z, Eggel A.... (2011) The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature, 477(7362), 90-4. PMID: 21886162
Loffredo FS, Steinhauser ML, Jay SM, Gannon J, Pancoast JR, Yalamanchi P, Sinha M, Dall'osso C, Khong D, Shadrach JL.... (2013) Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy. Cell, 153(4), 828-39. PMID: 23663781
Zhang G, Li J, Purkayastha S, Tang Y, Zhang H, Yin Y, Li B, Liu G, & Cai D. (2013) Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH. Nature, 497(7448), 211-6. PMID: 23636330
A new paper in the journal European Neurology reports on a remarkable case of perceptual distortion that’ll please any connoisseur of neurogothic: A 48-year-old woman woke up one morning without knowing where she was. She recognized her husband and finally realized that she was at home, but reported that she felt that all surroundings appeared [...]... Read more »
Delgado MG, & Bogousslavsky J. (2013) 'Distorteidolias' - Fantastic Perceptive Distortion. A New, Pure Dorsomedial Thalamic Syndrome. European neurology, 70(1), 6-9. PMID: 23652461
Is 'cloning' appropriate terminology for somatic cell nuclear transfer derivation of human embryonic stem cells?... Read more »
Tachibana, M., Amato, P., Sparman, M., Gutierrez, N., Tippner-Hedges, R., Ma, H., Kang, E., Fulati, A., Lee, H., Sritanaudomchai, H.... (2013) Human Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer. Cell. DOI: 10.1016/j.cell.2013.05.006
In two recent posts, I have referenced a relatively-average psychologist (again, this psychologist need not bear any resemblance to any particular person, living or dead). I found this relatively-average psychologist to be severely handicapped in their ability to think about … Continue reading →... Read more »
Smallegange, R., van Gemert, G., van de Vegte-Bolmer, M., Gezan, S., Takken, W., Sauerwein, R., & Logan, J. (2013) Malaria Infected Mosquitoes Express Enhanced Attraction to Human Odor. PLoS ONE, 8(5). DOI: 10.1371/journal.pone.0063602
Blue Harvest @ Wikipedia @ Family GuyI need to create a suitable atmosphere for this post, so try this music for size and think Blue Harvest...Right. The wait is over. The discussions / arguments / objections / agreements are all confined to history. Drum roll, spotlight centre-stage... enter DSM-5 and into unknown territory we all go, particularly with autism, sorry.. autism spectrum disorders (ASDs) in mind.As you can see from the link above to the new diagnostic guidelines from the Ameri........ Read more »
Lai M-C, Lombardo MV, Chakrabarti B, & Baron-Cohen S. (2013) Subgrouping the Autism “Spectrum": Reflections on DSM-5. PLoS Biology. info:/
Preferred Foot Strike Pattern and Soft Tissue Vibration... Read more »
Enders H, von Tscharner V, & Nigg BM. (2013) The effects of preferred and non-preferred running strike patterns on tissue vibration properties. Journal of science and medicine in sport / Sports Medicine Australia. PMID: 23642961
by Andrea in Science of Eating Disorders
Navigating health service systems can seem daunting, to say the least. Making phone calls, getting doctor appointments and referrals, attending intake appointments, and preparing oneself for treatment can be both mentally and physically draining. When children and adolescents develop eating disorders, their parents become the main navigators in this scenario, making decisions and arrangements for their under-18-year-olds. But what happens when these adolescents reach the age of 18, and sti........ Read more »
Dimitropoulos, G., Tran, A., Agarwal, P., Sheffield, B., & Woodside, B. (2013) Challenges in Making the Transition Between Pediatric and Adult Eating Disorder Programs: A Qualitative Study From the Perspective of Service Providers. Eating Disorders, 21(1), 1-15. DOI: 10.1080/10640266.2013.741964
Hypnotherapy is the use of the hypnotic state in combination with other psychological strategies acquired from behavioural, cognitive and analytical therapy as well as from neuro linguistic programming (NLP). The main purpose of hypnotherapy is the achievement of your particular goal.... Read more »
Anna Pons. (2013) What is hypnotherapy?. Clinical Hypnotherapy. info:/
Scurvy was a debilitating ailment that commonly affected sailors in the 18th Century. In 1747, James Lind conducted one of the first ever clinical trials, by giving sailors with scurvy different dietary supplements and documenting the effects on their health. In … Continue reading →... Read more »
DiMasi JA, Hansen RW, & Grabowski HG. (2003) The price of innovation: new estimates of drug development costs. Journal of health economics, 22(2), 151-85. PMID: 12606142
McCormack FX, Inoue Y, Moss J, Singer LG, Strange C, Nakata K, Barker AF, Chapman JT, Brantly ML, Stocks JM.... (2011) Efficacy and safety of sirolimus in lymphangioleiomyomatosis. The New England journal of medicine, 364(17), 1595-606. PMID: 21410393
Take Home Message: Fitness level may influence baseline concussion symptom reporting with fitter individuals reporting fewer concussion symptoms. Athletes also appear to report more concussion symptoms when reporting after exercise.
Baseline testing in concussion management, including graded symptom assessment, has become commonplace in multiple sports on almost every level of competition. Different assessment tools (e.g., Sideline Concussion Assessment Tool [SCAT3], Immediate Post-Concussi........ Read more »
Mrazik, M., Naidu, D., Lebrun, C., Game, A., & Matthews-White, J. (2013) Does an Individual's Fitness Level Affect Baseline Concussion Symptoms?. Journal of Athletic Training, 2147483647. DOI: 10.4085/1062-6050-48.3.19
We love them and yet we hate them. They get censored, augmented, reduced, replaced, covered, exposed. They get grilled, occasionally, but those are not the ones I'm talking about. We want to see them and yet we pretend we don't. We criticize them and yet we forget what they are made for, the most beautiful thing of all: nourish a new life.Yes, I'm talking about breasts. Angelina Jolie's breasts have been extensively discussed this week, more now that they are reportedly gone than when they were ........ Read more »
Hall, J., Lee, M., Newman, B., Morrow, J., Anderson, L., Huey, B., & King, M. (1990) Linkage of early-onset familial breast cancer to chromosome 17q21. Science, 250(4988), 1684-1689. DOI: 10.1126/science.2270482
Bernstein, L. (2008) Identifying population-based approaches to lower breast cancer risk. Oncogene. DOI: 10.1038/onc.2009.348
by Patrick Bartosch in Beaker
Sanford-Burnham researchers identified a potential drug target to prevent the hardening of arteries in patients with atherosclerosis. The gene Dkk1 encodes a protein that plays a key role in increasing the population of connective-tissue cells during wound repair, but prolonged Dkk1 signaling in cells lining blood vessels can lead to fibrosis and a stiffening of artery walls.... Read more »
Cheng, S., Shao, J., Behrmann, A., Krchma, K., & Towler, D. (2013) Dkk1 and Msx2-Wnt7b Signaling Reciprocally Regulate the Endothelial-Mesenchymal Transition in Aortic Endothelial Cells. Arteriosclerosis, Thrombosis, and Vascular Biology. DOI: 10.1161/ATVBAHA.113.300647
Using human tissue in medical research throws up a number of different challenges. In our third 2012 NC3Rs 3Rs Prize post, Professor Gareth Sanger from Queen Mary, University of London, discusses how tissue removed from the stomach and intestine can actually help overcome some of these challenges. Is this a viable alternative to using animals for gastrointestinal research? Professor Sanger’s research suggests it could be.... Read more »
Broad, J., Mukherjee, S., Samadi, M., Martin, J., Dukes, G., & Sanger, G. (2012) Regional- and agonist-dependent facilitation of human neurogastrointestinal functions by motilin receptor agonists. British Journal of Pharmacology, 167(4), 763-774. DOI: 10.1111/j.1476-5381.2012.02009.x
Researchers have found that the people, who develop skin cancer, may have less chances of developing Alzheimer’s disease in the older ages.
Alzheimer’s disease is a degenerative disorder that affects the brain and causes dementia, especially late in life.
In this new study, researchers worked on 1,102 volunteers with an average age of 79. They were studied for about 3.7 years. In the beginning of the study, 109 peop........ Read more »
White, R., Lipton, R., Hall, C., & Steinerman, J. (2013) Nonmelanoma skin cancer is associated with reduced Alzheimer disease risk. Neurology, 80(21), 1966-1972. DOI: 10.1212/WNL.0b013e3182941990
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