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  • October 24, 2014
  • 02:51 AM
  • 3 views

Autism, siblings and DSM-5 Social Communication Disorder

by Paul Whiteley in Questioning Answers

A quick post to bring to your attention the paper by Meghan Miller and colleagues [1] who concluded that: "Pragmatic language problems are present in some siblings of children with ASD [autism spectrum disorder] as early as 36 months of age". Further: "As the new DSM-5 diagnosis of Social (Pragmatic) Communication Disorder (SCD) is thought to occur more frequently in family members of individuals with ASD, it is possible that some of these siblings will meet criteria for SCD as th........ Read more »

  • October 23, 2014
  • 05:58 PM
  • 12 views

The Genes Responsible for Immune System Reset after Infection

by Gabriel in Lunatic Laboratories

We’ve all been sick before, the aches and pains that come with it– most of the time including a fever — are all responses to our immune system kicking into high gear. But what if your body didn’t reverse course and go back to a, let’s call it” relaxed state.” Once the battle is won, the body’s efforts would be wasted on energy costing defense. A bad thing when the body really should be focusing on repairing the damage done by the foreign invaders.... Read more »

Brian Head,, & Alejandro Aballay. (2014) Recovery from an Acute Infection in C. elegans Requires the GATA Transcription Factor ELT-2. PLoS Genetics. info:/10.1371/journal.pgen.1004609

  • October 23, 2014
  • 10:20 AM
  • 16 views

Smartphone App Boosts Alcoholism Treatment Outcome

by William Yates, M.D. in Brain Posts

Smartphone apps and other mobile technology are emerging as promising tools in medical treatment.A recent randomized study published in JAMA Psychiatry found evidence that a smartphone app improves alcoholism treatment outcomes.David Gustafson and colleagues conducted a study funded by the National Institute of Alcohol Abuse and Alcoholism.A series of 349 adults with DSM-IV alcohol dependence were enrolled as they entered a alcoholism residential treatment program.Approximately half of the subje........ Read more »

Gustafson DH, McTavish FM, Chih MY, Atwood AK, Johnson RA, Boyle MG, Levy MS, Driscoll H, Chisholm SM, Dillenburg L.... (2014) A smartphone application to support recovery from alcoholism: a randomized clinical trial. JAMA psychiatry, 71(5), 566-72. PMID: 24671165  

  • October 23, 2014
  • 09:05 AM
  • 23 views

The Monster Mash – Diseases That May Have Spawned Monster Legends

by Bill Sullivan in The 'Scope

Creepy diseases that produce symptoms that mimic characteristics associated with legendary monsters!... Read more »

Schulenburg-Brand D, Katugampola R, Anstey AV, & Badminton MN. (2014) The cutaneous porphyrias. Dermatologic clinics, 32(3), 369. PMID: 24891059  

Deshmukh S, & Prashanth S. (2012) Ectodermal dysplasia: a genetic review. International journal of clinical pediatric dentistry, 5(3), 197-202. PMID: 25206167  

Ramirez-Bermudez J, Aguilar-Venegas LC, Crail-Melendez D, Espinola-Nadurille M, Nente F, & Mendez MF. (2010) Cotard syndrome in neurological and psychiatric patients. The Journal of neuropsychiatry and clinical neurosciences, 22(4), 409-16. PMID: 21037126  

  • October 23, 2014
  • 04:46 AM
  • 26 views

Postpartum depression and the broader autism phenotype?

by Paul Whiteley in Questioning Answers

"The findings suggest that pregnant women with BAP [broader autism phenotype] have an elevated risk for PPD [postpartum depression]".That was the conclusion reached by Ryosuke Asano and colleagues [1] based on their analysis of data derived from the Hamamatsu Birth Cohort (HBC) Study [2]. The idea being that the more subtle presentation of issues linked to a diagnosis of autism spectrum disorder (the BAP) might predispose to a great likelihood of other behavioural or psychiat........ Read more »

Asano, R., Tsuchiya, K., Takei, N., Harada, T., Kugizaki, Y., Nakahara, R., Nakayasu, C., Okumura, A., Suzuki, Y., Takagai, S.... (2014) Broader autism phenotype as a risk factor for postpartum depression: Hamamatsu Birth Cohort (HBC) Study. Research in Autism Spectrum Disorders, 8(12), 1672-1678. DOI: 10.1016/j.rasd.2014.08.010  

  • October 22, 2014
  • 03:55 PM
  • 36 views

Converting Skin Cells to Neurons: A Fight Against Huntington’s

by Gabriel in Lunatic Laboratories

Neurological diseases are some of the hardest to fight against (in my opinion). The big reason is the brain, we still know so little about it and treatment for anything effecting it can be difficult to say the least. Take Huntington’s disease, an ultimately fatal neurodegenerative disorder. There is no cure and no real treatment, but that might change relatively soon thanks to a new discovery.... Read more »

Victor, M., Richner, M., Hermanstyne, T., Ransdell, J., Sobieski, C., Deng, P., Klyachko, V., Nerbonne, J., & Yoo, A. (2014) Generation of Human Striatal Neurons by MicroRNA-Dependent Direct Conversion of Fibroblasts. Neuron, 84(2), 311-323. DOI: 10.1016/j.neuron.2014.10.016  

  • October 22, 2014
  • 08:05 AM
  • 40 views

Death By Haunted House

by Mark Lasbury in As Many Exceptions As Rules

People enjoy a good scare at Halloween, it’s an epinephrine rush without the bother of real danger. But could you actually be scared to death? Science says yes, it should really be called the fight, flight, faint, or fatality response. In susceptible people, a severe fright can literally change the shape of the heart and destroy the efficient pumping of blood. Unfortunately, something similar can happen in infants, and it can be lethal as well.... Read more »

  • October 22, 2014
  • 07:29 AM
  • 33 views

Crucial gene for Malaria Transmission

by Pieter Carrière in United Academics

A new step in battling Malaria: making transmission its weakest link. Scientists could prevent the development of gametocytes.... Read more »

Kafsack BF, Rovira-Graells N, Clark TG, Bancells C, Crowley VM, Campino SG, Williams AE, Drought LG, Kwiatkowski DP, Baker DA.... (2014) A transcriptional switch underlies commitment to sexual development in malaria parasites. Nature, 507(7491), 248-52. PMID: 24572369  

Kåhrström CT. (2014) Parasite development: master regulator of sex. Nature reviews. Microbiology, 12(4), 233. PMID: 24608336  

Rovira-Graells N, Gupta AP, Planet E, Crowley VM, Mok S, Ribas de Pouplana L, Preiser PR, Bozdech Z, & Cortés A. (2012) Transcriptional variation in the malaria parasite Plasmodium falciparum. Genome research, 22(5), 925-38. PMID: 22415456  

Gardner, M., Hall, N., Fung, E., White, O., Berriman, M., Hyman, R., Carlton, J., Pain, A., Nelson, K., Bowman, S.... (2002) Genome sequence of the human malaria parasite Plasmodium falciparum. Nature, 419(6906), 498-511. DOI: 10.1038/nature01097  

  • October 22, 2014
  • 04:26 AM
  • 42 views

Autism, parental concerns and socioeconomic status

by Paul Whiteley in Questioning Answers

I'd like to think that there are some rather important messages to be taken from the paper by Xiang Sun and colleagues [1] on level of parental concern, socioeconomic status (SES) and risk of autism. Not only did the authors conclude that: "a higher SES was not associated with the risk of having ASC [autism spectrum conditions]" they also found that: "No child met ASC criteria where parents expressed no concerns".Do you prefer "fashion victim" or "ensembly challenged"?SES - including variab........ Read more »

  • October 22, 2014
  • 12:05 AM
  • 37 views

Knee Cartilage Changes Following ACL Rupture

by Kyle Harris in Sports Medicine Research (SMR): In the Lab & In the Field

Following an anterior cruciate ligament (ACL) rupture overall cartilage thickness in the tibiofemoral joint increased at an average of 0.4% per year. Patients under 25 years of age showed greater cartilage thickening than older patients.... Read more »

  • October 21, 2014
  • 07:01 PM
  • 48 views

Footwear and Flatfeet: Correlation or Causation?

by Craig Payne in Running Research Junkie

Footwear and Flatfeet: Correlation or Causation?
... Read more »

Watanabe, E., McBride, C., Tora, A., Ayode, D., Farrell, D., & Davey, G. (2014) Use of footwear and foot condition among rural Ethiopian school children. Journal of Epidemiology and Global Health. DOI: 10.1016/j.jegh.2014.06.001  

  • October 21, 2014
  • 11:25 AM
  • 52 views

Sleep Problems in Alcoholism Treatment

by William Yates, M.D. in Brain Posts

In a previous post, I summarized a research study six month outcome of insomnia in a group of subjects treated for alcoholism.This study found a high persistence of insomnia despite reduction, and in many cases abstinence, from alcohol.A second study recently published by investigators at the National Institute of Health provides some additional insight into this topic.Gwenyth Wallen and colleagues studied a series of 164 participants admitted to a 4-6 week inpatient program for alcohol dependen........ Read more »

  • October 21, 2014
  • 07:00 AM
  • 57 views

Not Quite Dead Yet

by Mark E. Lasbury in The 'Scope

History shows that premature burial was more common than people might want to believe. Many burial traditions, including the Irish wake, stem from trying to prevent someone from being buried alive. How might this happen? Several medical conditions can lead to a poor decision on burial time. ... Read more »

Christopher Dibble. (2010) The Dead Ringer: Medicine, Poe, and the fear of premature burial. Historia Medicinae. info:/

  • October 21, 2014
  • 04:53 AM
  • 50 views

Antibiotics and childhood obesity: a weighty correlation

by Paul Whiteley in Questioning Answers

It's been a few weeks since the publication of the paper by L. Charles Bailey and colleagues [1] correlating early multiple exposure to broad spectrum antibiotics with obesity in infancy. On purpose I've left it a while before talking about this research so as to let the scientific dust settle a little and get a flavour for some of the discussions about this research (see here and see here).You're a true vulgarian, aren't you?A few details about the Bailey study first:Looking at the el........ Read more »

Bailey LC, Forrest CB, Zhang P, Richards TM, Livshits A, & DeRusso PA. (2014) Association of Antibiotics in Infancy With Early Childhood Obesity. JAMA pediatrics. PMID: 25265089  

  • October 20, 2014
  • 10:56 AM
  • 57 views

Persistent Insomnia and Alcoholism

by William Yates, M.D. in Brain Posts

Sleep problems complicate the treatment and recovery in alcoholism. Heavy alcohol consumption modifies the nature of sleep architecture.A high blood alcohol concentration at bedtime may promote sleep early in the sleep cycle.However, as alcohol levels decline, sleep is often interrupted with limiting rapid eye movement (REM) sleep duration.Shortened total sleep time with alcohol can produce a lack of feeling well rested on awakening.For those with alcoholism or alcohol dependence, successfu........ Read more »

Brower KJ, Krentzman A, & Robinson EA. (2011) Persistent insomnia, abstinence, and moderate drinking in alcohol-dependent individuals. The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions, 20(5), 435-40. PMID: 21838842  

  • October 20, 2014
  • 05:38 AM
  • 59 views

Removing Disease from the Genome

by Gunnar de Winter in United Academics

Using agenetic cut-and-paste system, scientists have removed and replaced the gene causing muscular dystrophy in mice.... Read more »

Long C, McAnally JR, Shelton JM, Mireault AA, Bassel-Duby R, & Olson EN. (2014) Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA. Science (New York, N.Y.), 345(6201), 1184-8. PMID: 25123483  

  • October 20, 2014
  • 04:36 AM
  • 58 views

Reasons for visiting ER by those with autism

by Paul Whiteley in Questioning Answers

ER - Emergency Room - or as we call it here in Blighty Accident & Emergency (A & E), is never a particularly desirable place to visit given the emphasis on illness or injury of yourself or loved one. That being said, staff there do a sterling job sometimes under very stressful circumstances, responding to all-manner of complaints, some of which are life-threatening.The paper by Dorothea Iannuzzi and colleagues [1] sought to identify some of the medical reasons why ER visit........ Read more »

Iannuzzi DA, Cheng ER, Broder-Fingert S, & Bauman ML. (2014) Brief Report: Emergency Department Utilization by Individuals with Autism. Journal of autism and developmental disorders. PMID: 25261249  

  • October 20, 2014
  • 12:05 AM
  • 55 views

Novel NSAID has Differential Tissue Effects in the Treatment of Chronic Rotator Cuff Repairs

by Sarah Ilkhanipour Rooney in Sports Medicine Research (SMR): In the Lab & In the Field

Licofelone, a non-steroidal anti-inflammatory treatment, has tissue-specific effects. In a rotator cuff repair rat model, this drug reduces functional muscle regeneration but improves tendon healing.... Read more »

  • October 19, 2014
  • 07:11 PM
  • 68 views

Running Shoes Can Control Motion

by Craig Payne in Running Research Junkie

Running Shoes Can Control Motion... Read more »

  • October 19, 2014
  • 06:39 PM
  • 79 views

Pain is not a "Thing"

by Bronwyn Thompson in Healthskills: Skills for Healthy Living

ResearchBlogging.org
I’m reading some fascinating books at the moment. I’m such a pain geek I take pain books away with me on holiday! Anyway, the two books to hit me between the eyeballs recently are The Pain Chronicles by Melanie Thernstrom (published 2010), and The Story of Pain by Joanna Bourke (published 2014). What makes both of these books fascinating is that these both look at the history of pain and pain management, and explore the “what it is like” to be in pai........ Read more »

Ashton-James, C., Richardson, D., Williams, A., Bianchi-Berthouze, N., & Dekker, P. (2014) Impact of pain behaviors on evaluations of warmth and competence. PAIN®. DOI: 10.1016/j.pain.2014.09.031  

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