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  • April 7, 2017
  • 07:02 AM
  • 69 views

Which science is most “certain” according to the American public? 

by Rita Handrich in The Jury Room

When litigation cases rely on science or highly technical information, it is critical to help jurors understand the information underlying the case at a level that makes sense to them. If they do not understand your “science”, they will simply guess which party to vote for or “follow the crowd”. Here’s an example of what […]... Read more »

Broomell, S., & Kane, P. (2017) Public perception and communication of scientific uncertainty. Journal of Experimental Psychology: General, 146(2), 286-304. DOI: 10.1037/xge0000260  

  • April 7, 2017
  • 04:48 AM
  • 327 views

Folate-dependent one carbon metabolism and transsulfuration pathways: biomarkers for autism?

by Paul Whiteley in Questioning Answers

I found it a little unusual that the findings reported by Daniel Howsmon and colleagues [1] (open-access) talking about "multivariate statistical analysis presented herein [provided] unprecedented quantitative classification results for separating participants into ASD [autism spectrum disorder] and NEU [neurotypical] cohorts based solely on biochemical data" merited a rapid reply in a prominent science magazine pouring cold water on the results (see here). Not least bec........ Read more »

  • April 6, 2017
  • 02:44 AM
  • 330 views

"a single intravenous infusion of autologous umbilical cord blood" and autism

by Paul Whiteley in Questioning Answers

'Could stem cells offer hope for autism?' went one media headline referencing the very preliminary "phase I, open-label trial" published by Geraldine Dawson and colleagues [1] (open-access) detailing the experiences of a single intravenous infusion of autologous umbilical cord blood in 25 children with "a confirmed diagnosis of ASD [autism spectrum disorder]."Well, the results were promising in respect of important issues such as safety in light of the tenet 'first do no harm': "Assess........ Read more »

Geraldine Dawson, Jessica M. Sun, Katherine S. Davlantis, Michael Murias,, Lauren Franz, Jesse Troy, Ryan Simmons, Maura Sabatos-DeVito, Rebecca Durham, & Joanne Kurtzberg. (2017) Autologous Cord Blood Infusions Are Safe and Feasible in Young Children with Autism Spectrum Disorder: Results of a Single-Center Phase I Open-Label Trial. Stem Cells Translational Medicine. info:/10.1002/sctm.16-0474

  • April 5, 2017
  • 07:02 AM
  • 284 views

Your Black client is much more likely to be wrongfully convicted

by Doug Keene in The Jury Room

Those of us who’ve been around for a while have heard this repeatedly. But, lest you think times are changing, here’s some sobering data from a March, 2017 report co-edited by a Michigan State University College of Law Professor. From the beginning, this is a disturbing report. Here’s how it starts: African-Americans are only 13% […]... Read more »

Samuel R. Gross, Maurice Possley, & Klara Stephens. (2017) Race and Wrongful Convictions in the United States. . UC Irvine: National Registry of Exonerations. . info:/

  • April 5, 2017
  • 03:14 AM
  • 329 views

Paediatric congenital heart disease and autism risk (again)

by Paul Whiteley in Questioning Answers

"Risk of autism spectrum disorder screening status in children with congenital heart defects was higher than expected from population rates."So said the findings reported by Jessica Bean Jaworski and colleagues [1] who set about "to assess the rates of autism spectrum disorders in a large sample of children with a history of congenital heart defects and to assess medical, behavioral, and individual factors that may be associated with the risk of autism spectrum disorders." Covering a topic that ........ Read more »

Bean Jaworski JL, Flynn T, Burnham N, Chittams JL, Sammarco T, Gerdes M, Bernbaum JC, Clancy RR, Solot CB, Zackai EH.... (2017) Rates of autism and potential risk factors in children with congenital heart defects. Congenital heart disease. PMID: 28299880  

  • April 4, 2017
  • 11:00 AM
  • 314 views

Researchers Finally Ask: Does Your Cat Even Like To Be Around You?

by Miss Behavior in The Scorpion and the Frog

This cat has had enough and is running away from home. Photo by Danielle Menuey.While dogs happily and obliviously boast the reputation of being “man’s best friend”, cats have a reputation of being antisocial, independent, and downright grumpy. But do cats really deserve that? Scientists finally decided to find out.Kristin Vitale Shreve and Monique Udell from Oregon State University and Lindsay Mehrkam from Monmouth University asked 25 pet cats and 25 shelter cats their preferences. H........ Read more »

  • April 4, 2017
  • 02:55 AM
  • 285 views

Autism, ageing and comorbidity

by Paul Whiteley in Questioning Answers

I'm not spending too much time today on the findings published by Elizabeth Wise and colleagues [1] but did want to bring them to your attention. Looking at the presentation of "comorbidities and behavioral and neuropsychiatric symptoms" in relation to autism in the context of ageing, some important details were noted. Not least that "GI [gastrointestinal] disorders (68.9%) and seizure disorders (23%) were common, and 25.7% of the sample had a BMI [body mass index] >30" wh........ Read more »

  • April 3, 2017
  • 01:00 PM
  • 62 views

Medical practice precariousness at the Unified Health System — SUS

by SciELO in SciELO in Perspective | Press Releases

The medical practice in the Unified Health System is a study topic published in the journal Estudos de Psicologia (Campinas), which reveals the working conditions of these professionals and the impacts on personal health, analyzed through interviews and self-confidence. … Read More →... Read more »

  • April 3, 2017
  • 10:59 AM
  • 284 views

Criminal defense? Brain scans could show whether “they did it  on purpose”

by Rita Handrich in The Jury Room

When my kids were younger, I used to talk to them about the difference between intent and impact as they struggled to understand the varying reactions of people to their behavior. Back in 2009, we posted on some new research showing that we reacted more indignantly when bad deeds were done “on purpose”. Here is […]... Read more »

Vilares I, Wesley MJ, Ahn WY, Bonnie RJ, Hoffman M, Jones OD, Morse SJ, Yaffe G, Lohrenz T, & Montague PR. (2017) Predicting the knowledge-recklessness distinction in the human brain. Proceedings of the National Academy of Sciences of the United States of America, 114(12), 3222-3227. PMID: 28289225  

  • April 3, 2017
  • 03:10 AM
  • 294 views

Decreased urinary creatinine levels associated with autism (again)

by Paul Whiteley in Questioning Answers

One finding in particular stood out from those reported by Lussu and colleagues [1] following some nifty metabolomic investigations: decreased levels of urinary creatinine in their cohort of participants diagnosed as on the autism spectrum (n=21) compared with "controls (n = 21), these being siblings of autistic patients."Based on the "use of 1 H-NMR metabolomics to analyze the global biochemical signature of ASD [autism spectrum disorder] patients" researchers turned again to a fa........ Read more »

Lussu M, Noto A, Masili A, Rinaldi AC, Dessì A, De Angelis M, De Giacomo A, Fanos V, Atzori L, & Francavilla R. (2017) The urinary 1 H-NMR metabolomics profile of an italian autistic children population and their unaffected siblings. Autism research : official journal of the International Society for Autism Research. PMID: 28296209  

  • April 2, 2017
  • 06:17 AM
  • 261 views

The perfect multilingual

by Madalena Cruz-Ferreira in Being Multilingual

P { margin-bottom: 0.08in; } In case you’re wondering, let me reassure you straight away that yes, the title of this post is meant to be sarcastic. Perfect multilinguals do exist, of course, though only in the minds of those of us who mistake ideals of perfection for reality. Multilingual perfection awardees must satisfy a number of criteria. If you are, or were, a language learner as an adult, forget it: not having acquired all of your languages as a young child automatically makes you a n........ Read more »

  • April 2, 2017
  • 04:10 AM
  • 279 views

On the under-studied populations within the autism spectrum

by Paul Whiteley in Questioning Answers

I don't typically post on a Sunday, but given that today - 2nd April - is World Autism Awareness Day I've decided to make an exception. The theme of today's post is based around the notion that the autism spectrum is truly wide and heterogeneous, and although this is fairly universally acknowledged, the current peer-reviewed research literature on autism is perhaps not yet so accepting. So...Consistent with the idea that scientific research seems to go through cycles of themes/interests, th........ Read more »

Chakrabarti B. (2017) Commentary: Critical considerations for studying low-functioning autism. Journal of child psychology and psychiatry, and allied disciplines, 58(4), 436-438. PMID: 28346760  

  • April 1, 2017
  • 02:30 PM
  • 293 views

Educational Achievement and Religiosity

by Joshua Fisher in Text Savvy

Religiosity may be correlated with lower educational achievement because people have a finite amount of time and attention, and spending time learning about religion or engaging in religious activities necessarily takes time away from learning math and science.... Read more »

  • April 1, 2017
  • 04:16 AM
  • 301 views

Yet more bumetanide and autism findings

by Paul Whiteley in Questioning Answers

Bumetanide, a loop diuretic medicine typically used to treat heart failure, is probably not something that most people would associate with 'attenuating' some of the presented characteristics of autism. This Na-K-Cl cotransporter (NKCC) blocking drug (influencing chloride concentrations in neurons and impacting on the actions of gamma-Aminobutyric acid, GABA) has however made quite a few appearances in the peer-reviewed autism research literature (see here and see here) and beyond........ Read more »

Lemonnier, E., Villeneuve, N., Sonie, S., Serret, S., Rosier, A., Roue, M., Brosset, P., Viellard, M., Bernoux, D., Rondeau, S.... (2017) Effects of bumetanide on neurobehavioral function in children and adolescents with autism spectrum disorders. Translational Psychiatry, 7(3). DOI: 10.1038/tp.2017.10  

  • March 31, 2017
  • 12:10 PM
  • 315 views

Giving the underserved the care they deserve

by Aurametrix team in Aurametrix Blog

Nobody likes strong smells coming from other human beings. It's just that social convention: you are nice, if you smell nice, and you are a monster  - like Shakespeare's Caliban - if you smell bad. ​Caliban, often depicted as a Golumn-like creature, is one of the first cases of fish odor syndrome described in the literature. No amount of soap and water would help him to wash the smell away, as his body is constantly producing a pungent small molecule trimethylamine. ... Read more »

Guo Y, Hwang LD, Li J, Eades J, Yu CW, Mansfield C, Burdick-Will A, Chang X, Chen Y, Duke FF.... (2017) Genetic analysis of impaired trimethylamine metabolism using whole exome sequencing. BMC medical genetics, 18(1), 11. PMID: 28196478  

Callewaert C, Lambert J, & Van de Wiele T. (2016) Towards a bacterial treatment for armpit malodour. Experimental dermatology. PMID: 27892611  

  • March 31, 2017
  • 02:51 AM
  • 285 views

Coeliac disease, autism and more

by Paul Whiteley in Questioning Answers

"Compared with the general population, children with celiac disease had a 1.4-fold greater risk of future psychiatric disorders. Childhood celiac disease was identified as a risk factor for mood disorders, anxiety disorders, eating disorders, behavioral disorders, ADHD [attention-deficit hyperactivity disorder], ASD [autism spectrum disorder], and intellectual disability."So said the study findings reported by Agnieszka Butwicka and colleagues [1] who, yet again, relied on one of ........ Read more »

Butwicka A, Lichtenstein P, Frisén L, Almqvist C, Larsson H, & Ludvigsson JF. (2017) Celiac Disease Is Associated with Childhood Psychiatric Disorders: A Population-Based Study. The Journal of pediatrics. PMID: 28283256  

  • March 30, 2017
  • 03:12 AM
  • 288 views

[Objective] exposure to flame retardants and social behaviours

by Paul Whiteley in Questioning Answers

Although a few details of the study reported by Shannon Lipscomb and colleagues [1] (open-access) interested me, I was particularly taken by their use of "a silicone passive wristband sampler [worn] around his/her wrist or ankle" to "assess the child’s exposure to flame retardants" as part of their investigation "to determine if flame retardant exposure was associated with measurable differences in social behaviors among children ages 3–5 years."I've covered the topic of potential adver........ Read more »

Lipscomb ST, McClelland MM, MacDonald M, Cardenas A, Anderson KA, & Kile ML. (2017) Cross-sectional study of social behaviors in preschool children and exposure to flame retardants. Environmental health : a global access science source, 16(1), 23. PMID: 28274271  

  • March 29, 2017
  • 02:54 AM
  • 293 views

L-methylfolate administration and autism: a case report

by Paul Whiteley in Questioning Answers

I should have really titled this post 'another case report' given yesterday's entry on this blog talking about a case of [untreated] PKU and autistic behaviours/diagnosis. Here I am again talking about another N=1 with autism in mind and specifically the findings reported by Kim Siscoe & David Lohr [1] on how: "L-methylfolate supplementation improved symptoms of aggression and disruptive behavior in a child with autism who tested positive for the C677TT allele of the methyltetrahydrofolate r........ Read more »

  • March 28, 2017
  • 04:34 AM
  • 302 views

Presenting with the symptoms of autism and then diagnosed with phenylketonuria (PKU)

by Paul Whiteley in Questioning Answers

The case report from Betül Mazlum and colleagues [1] (open-access available here) illustrates once again that (a) the plural 'autisms' exist (see here) and (b) screening for inborn errors of metabolism (IEM) should be an important part of any autism assessment (see here). Indeed, screening for IEM should really be part of assessments for many different labels...Detailing a case report wherein a 3-year old child came to clinical attention for "speech delay and social problems", the authors ........ Read more »

Mazlum B, Anlar B, Kalkanoğlu-Sivri HS, Karlı-Oğuz K, Özusta Ş, & Ünal F. (2016) A late-diagnosed phenylketonuria case presenting with autism spectrum disorder in early childhood. The Turkish journal of pediatrics, 58(3), 318-322. PMID: 28266201  

  • March 27, 2017
  • 04:38 AM
  • 306 views

Detecting stereotypic behaviours through technology

by Paul Whiteley in Questioning Answers

"We have designed an Internet-of-Things (IoT) framework named WearSense that leverages the sensing capabilities of modern smartwatches to detect stereotypic behaviors in children with autism."So said the paper by Amir Mohammad Amiri and colleagues [1] (open-access available here) and, I have to say, something that really piqued my [research] attention. Describing how authors managed to design and construct a smartwatch with the ability to "detect three behaviors, including hand flapping, pa........ Read more »

Amiri AM, Peltier N, Goldberg C, Sun Y, Nathan A, Hiremath SV, & Mankodiya K. (2017) WearSense: Detecting Autism Stereotypic Behaviors through Smartwatches. Healthcare (Basel, Switzerland), 5(1). PMID: 28264474  

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