Metabolic syndrome is linked with an increased frequency and severity of lower urinary tract symptoms, but weight loss surgery may lessen these symptoms. The findings, which come from two studies published in BJU International, indicate that urinary problems may be added to the list of issues that can improve with efforts that address altered metabolism.
Lower urinary tract symptoms related to urinary frequency and urgency, bladder leakage, the need to urinate at night, and incomplete bladder........ Read more »
Pashootan, P., Ploussard, G., Cocaul, A., de Gouvello, A., & Desgrandchamps, F. (2014) Association between metabolic syndrome and severity of lower urinary tract symptoms (LUTS): an observational study in a 4666 European men cohort. BJU International. DOI: 10.1111/bju.12931
Despite what you may think, the supposed “explosion” of children diagnosed with autism can directly attributed to better diagnosing techniques and — more importantly — the change of definition to make Autism spectrum disorders more broad. Thankfully more causes of autism have been found, none of them remotely related to vaccines and now scientists have found that chemical modifications to DNA’s packaging—known as epigenetic changes—can activate or repress genes involved in autism s........ Read more »
Gao, Z., Lee, P., Stafford, J., von Schimmelmann, M., Schaefer, A., & Reinberg, D. (2014) An AUTS2–Polycomb complex activates gene expression in the CNS. Nature, 516(7531), 349-354. DOI: 10.1038/nature13921
Ntziachristos, P., Tsirigos, A., Welstead, G., Trimarchi, T., Bakogianni, S., Xu, L., Loizou, E., Holmfeldt, L., Strikoudis, A., King, B.... (2014) Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia. Nature, 514(7523), 513-517. DOI: 10.1038/nature13605
I am the league's director, Silas Ramsbottom.Upon reading the paper published by Ramaekers and colleagues  talking about the use of folinic acid in cases of schizophrenia as a function of the presence of "Auto-antibodies against folate receptor alpha (FRα)", I raised a little smile. Not only because the authors suggested that there may be quite a lot more to see in this area on top of some already interesting discussions about the folate cycle and schizophrenia, but also because of the ........ Read more »
Ramaekers VT, Thöny B, Sequeira JM, Ansseau M, Philippe P, Boemer F, Bours V, & Quadros EV. (2014) Folinic acid treatment for schizophrenia associated with folate receptor autoantibodies. Molecular genetics and metabolism. PMID: 25456743
We’ve all seen the PSA’s trying to show the effects of meth use and in particular, what it does to your teeth. Typically, when it comes to drug use, people will not look at the long term side effects from their addiction instead thinking in the short term. This is unfortunate because as it turns out, methamphetamine users are three times more at risk for getting Parkinson’s disease than non-illicit drug users with even worse news for women, new research shows.... Read more »
Curtin K, Fleckenstein AE, Robison RJ, Crookston MJ, Smith KR, & Hanson GR. (2014) Methamphetamine/amphetamine abuse and risk of Parkinson's disease in Utah: A population-based assessment. Drug and alcohol dependence. PMID: 25479916
My name's Buttercup. You've met Baron von Shush."Our study demonstrated that serum TRX [thioredoxin] levels were associated with ASD [autism spectrum disorder], and elevated levels could be considered as a novel, independent diagnosis indicator of ASD." So was the conclusion reported by Qing-biao Zhang and colleagues  looking at serum levels of TRX in 80 children diagnosed with an ASD compared against "100 sex and age matched typically developing children".I'll freely admi........ Read more »
Zhang QB, Gao SJ, & Zhao HX. (2014) Thioredoxin: A novel, independent diagnosis marker in children with autism. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. PMID: 25433158
What’s that over there!? The next time you are around people, count how many people are on their phone? Distractions invade every aspect of our lives. Status updates, text messages, email notifications all threaten to steal our attention away from the moment. While we fight the urge to check the phone, our brains are making constant judgment calls about where to focus attention. The brain must continually filter important information from irrelevant interference.... Read more »
Ahrens, S., Jaramillo, S., Yu, K., Ghosh, S., Hwang, G., Paik, R., Lai, C., He, M., Huang, Z., & Li, B. (2014) ErbB4 regulation of a thalamic reticular nucleus circuit for sensory selection. Nature Neuroscience. DOI: 10.1038/nn.3897
My research training is in psychiatric epidemiology. Alcohol and drug dependence have been two of my topic areas of research.So I found a recent novel study of the epidemiology of illicit drug use in Europe intriguing.Typical methods of looking for the prevalence of drug use in populations are direct diagnostic interviews and studies of emergency room attendees or autopsy cases with medical complications of drug use.However, Christopher Ort from Switzerland along with a host of European col........ Read more »
Ort C, van Nuijs AL, Berset JD, Bijlsma L, Castiglioni S, Covaci A, de Voogt P, Emke E, Fatta-Kassinos D, Griffiths P.... (2014) Spatial differences and temporal changes in illicit drug use in Europe quantified by wastewater analysis. Addiction (Abingdon, England), 109(8), 1338-52. PMID: 24861844
Malocclusion, orthodontics and quality of life? One of the most important areas of orthodontic research that needs to be carried out is to clearly identify the effects of treatment. I have highlighted this in previous posts on the “the great unanswered questions” and “papers that have influenced me”. When we consider this area, I feel […]
The post Malocclusion, orthodontics and quality of life appeared first on Kevin O'Brien's Orthodontic Blog.
... Read more »
Al-Omari, I., Al-Bitar, Z., Sonbol, H., Al-Ahmad, H., Cunningham, S., & Al-Omiri, M. (2014) Impact of bullying due to dentofacial features on oral health–related quality of life. American Journal of Orthodontics and Dentofacial Orthopedics, 146(6), 734-739. DOI: 10.1016/j.ajodo.2014.08.011
Benson, P., Da'as, T., Johal, A., Mandall, N., Williams, A., Baker, S., & Marshman, Z. (2014) Relationships between dental appearance, self-esteem, socio-economic status, and oral health-related quality of life in UK schoolchildren: A 3-year cohort study. The European Journal of Orthodontics. DOI: 10.1093/ejo/cju076
I've mentioned a few times on this blog that a diagnosis of autism or autism spectrum disorder (ASD) is by no means protective against any other diagnosis being received, be it based on a somatic illness or condition, or something more behaviourally defined.Reading through the paper by Liz Forty and colleagues  (open-access) it appears that a similar scenario might also pertain to other behaviourally-defined conditions as per the example of bipolar disorder (BD) and their conclusion: "Bi........ Read more »
A new analysis has found that while clinical trial data support omitting radiation treatments in elderly women with early stage breast cancer, nearly two-thirds of these women continue to receive it. The findings are published early online in CANCER, a peer-reviewed journal of the American Cancer Society.
Results published in 2004 from a large, randomized clinical trial showed that adding radiation therapy to surgery plus tamoxifen does not reduce 5-year recurrence rates or prolong survival i........ Read more »
Palta, M., Palta, P., Bhavsar, N., Horton, J., & Blitzblau, R. (2014) The use of adjuvant radiotherapy in elderly patients with early-stage breast cancer: Changes in practice patterns after publication of Cancer and Leukemia Group B 9343. Cancer. DOI: 10.1002/cncr.28937
It seems like we’ve been on a weight loss campaign here at the labs, but there just has been so much new and interesting research on the subject to report on, this is no exception. Researchers have uncovered the mechanism by which white fat cells from humans (an important distinction) gets reprogrammed to become browner.... Read more »
Anne Loft, Isabel Forss, Majken Storm Siersbæk, Søren Fisker Schmidt, Ann-Sofie Bøgh Larsen, Jesper Grud Skat Madsen, Didier F. Pisani, Ronni Nielsen, Mads Malik Aagaard, Angela Mathison.... (2014) Browning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers. Genes . info:/10.1101/gad.250829.114
I'm not normally minded to post on a Sunday (day of rest and all that) but I did want to bring your attention to the results presented by Petroc Sumner and colleagues  (open-access) concluding that: "Exaggeration in news is strongly associated with exaggeration in press releases" when it comes to the media reporting of [some] health-related science news.The idea behind this particular study - which has been summarised pretty well in some of the accompanying media and in an editorial........ Read more »
Sumner, P., Vivian-Griffiths, S., Boivin, J., Williams, A., Venetis, C., Davies, A., Ogden, J., Whelan, L., Hughes, B., Dalton, B.... (2014) The association between exaggeration in health related science news and academic press releases: retrospective observational study. BMJ, 349(dec09 7). DOI: 10.1136/bmj.g7015
The stomach strikes again, or so it seems. We’ve already covered how your stomach seemingly controls your brain and your blood-brain barrier, but now it seems that what you eat –not too indirectly related to your stomach– might make you fatter, but not in the way you might be thinking thinking. What you are eating may be causing inflammation in the brain.... Read more »
Valdearcos, M., Robblee, M., Benjamin, D., Nomura, D., Xu, A., & Koliwad, S. (2014) Microglia Dictate the Impact of Saturated Fat Consumption on Hypothalamic Inflammation and Neuronal Function. Cell Reports. DOI: 10.1016/j.celrep.2014.11.018
In the days shortly after giving birth, most mothers experience a period of increased calmness and decreased stress responses, but around 20% of mothers experience anxiety. Some women may become depressed, and around one in a thousand can develop psychosis. The latest evidence indicates that these distressing responses to motherhood are still poorly understood, but that animal research could provide valuable clues to their causes.
Writing in the British Journal of Pharmacology, Dr David Slatt........ Read more »
Perani, C., & Slattery, D. (2014) Using animal models to study post-partum psychiatric disorders. British Journal of Pharmacology, 171(20), 4539-4555. DOI: 10.1111/bph.12640
Sometimes I believe in as many as six impossible things before breakfast.A micropost if you will, for today, and a link to a potentially very important paper by Lauren Swineford and colleagues  (open-access) talking about the diagnostic concept: social (pragmatic) communication disorder (SCD) and it's various crossings with language impairments and autism spectrum disorder (ASD).SCD, as I've indicated in other posts (see here and see here) is something that the autism community in partic........ Read more »
Swineford, L., Thurm, A., Baird, G., Wetherby, A., & Swedo, S. (2014) Social (pragmatic) communication disorder: a research review of this new DSM-5 diagnostic category. Journal of Neurodevelopmental Disorders, 6(1), 41. DOI: 10.1186/1866-1955-6-41
There is a lot of debate over whether or not violent video games manifest in violent behaviour. Consensus has not entirely been reached, but some suggest that the literature provides solid evidence for the hypothesis in question. In this post I examine meta-analytic reviews of the literature and weigh their significance, coming to the conclusion that violent video games most likely do cause aggressive behaviour and other negative social outcomes.... Read more »
Anderson, CA, & Bushman, BJ. (2001) Effects of Violent Video Games on Aggressive Behavior, Aggressive Cognition, Aggressive Affect, Physiological Arousal, And Prosocial Behavior: A Meta-Analytic Review of the Scientific Literature. Psychological Science. DOI: 10.1037/e315012004-001
Anderson CA, Shibuya A, Ihori N, Swing EL, Bushman BJ, Sakamoto A, Rothstein HR, & Saleem M. (2010) Violent video game effects on aggression, empathy, and prosocial behavior in eastern and western countries: a meta-analytic review. Psychological bulletin, 136(2), 151-73. PMID: 20192553
Ferguson, C., & Kilburn, J. (2009) The Public Health Risks of Media Violence: A Meta-Analytic Review. The Journal of Pediatrics, 154(5), 759-763. DOI: 10.1016/j.jpeds.2008.11.033
Greitemeyer, T., & Mugge, D. (2014) Video Games Do Affect Social Outcomes: A Meta-Analytic Review of the Effects of Violent and Prosocial Video Game Play. Personality and Social Psychology Bulletin, 40(5), 578-589. DOI: 10.1177/0146167213520459
Huesmann, L. (2010) Nailing the coffin shut on doubts that violent video games stimulate aggression: Comment on Anderson et al. (2010). Psychological Bulletin, 136(2), 179-181. DOI: 10.1037/a0018567
It's tough to be sperm. Your entire existence centers on one race that you will almost definitely lose. You don't even get to take a warmup lap. Nevertheless, a glance at your competitors waiting at the starting line might give you some hints about who has an advantage. One factor that helps sperm win races is length—and not only for the reasons you might guess.
Long sperm generally have longer tails. This ought to make them faster and more powerful swimmers, which studies have confirmed........ Read more »
Clair Bennison, Nicola Hemmings, Jon Slate, & Tim Birkhead. (2014) Long sperm fertilize more eggs in a bird. Proceedings of the Royal Society B: Biological Sciences. info:/10.1098/rspb.2014.1897
Repetitive Negative Thinking (RNT) has been suggested to be of clinical significance as a transdiagnostic process. Research has been conducted to explain the causes of RNT and ruminations but is limited. This article explores the causes and possible solutions to RNT, as well as its clinical implications concerning mood and stress disorders such as major depressive disorder (MDD).... Read more »
Clasen, P., Wells, T., Knopik, V., McGeary, J., & Beevers, C. (2011) 5-HTTLPR and BDNF Val66Met polymorphisms moderate effects of stress on rumination. Genes, Brain and Behavior, 10(7), 740-746. DOI: 10.1111/j.1601-183X.2011.00715.x
Cox, S., Mezulis, A., & Hyde, J. (2010) The influence of child gender role and maternal feedback to child stress on the emergence of the gender difference in depressive rumination in adolescence. Developmental Psychology, 46(4), 842-852. DOI: 10.1037/a0019813
Ehring, T., & Watkins, E. (2008) Repetitive Negative Thinking as a Transdiagnostic Process. International Journal of Cognitive Therapy, 1(3), 192-205. DOI: 10.1680/ijct.2008.1.3.192
Freeston, M., Ladouceur, R., Provencher, M., & Blais, F. (1995) Strategies used with intrusive thoughts: Context, appraisal, mood, and efficacy. Journal of Anxiety Disorders, 9(3), 201-215. DOI: 10.1016/0887-6185(95)00002-6
Gibb, B., Grassia, M., Stone, L., Uhrlass, D., & McGeary, J. (2011) Brooding Rumination and Risk for Depressive Disorders in Children of Depressed Mothers. Journal of Abnormal Child Psychology, 40(2), 317-326. DOI: 10.1007/s10802-011-9554-y
Hilt, L., Armstrong, J., & Essex, M. (2012) Early family context and development of adolescent ruminative style: Moderation by temperament. Cognition , 26(5), 916-926. DOI: 10.1080/02699931.2011.621932
KOVACS, M., SHERRILL, J., GEORGE, C., POLLOCK, M., TUMULURU, R., & HO, V. (2006) Contextual Emotion-Regulation Therapy for Childhood Depression: Description and Pilot Testing of a New Intervention. Journal of the American Academy of Child , 45(8), 892-903. DOI: 10.1097/01.chi.0000222878.74162.5a
McEvoy, P., Watson, H., Watkins, E., & Nathan, P. (2013) The relationship between worry, rumination, and comorbidity: Evidence for repetitive negative thinking as a transdiagnostic construct. Journal of Affective Disorders, 151(1), 313-320. DOI: 10.1016/j.jad.2013.06.014
Nolen-Hoeksema, S. (1991) Responses to depression and their effects on the duration of depressive episodes. Journal of Abnormal Psychology, 100(4), 569-582. DOI: 10.1037//0021-843X.100.4.569
Nolen-Hoeksema, S., Stice, E., Wade, E., & Bohon, C. (2007) Reciprocal relations between rumination and bulimic, substance abuse, and depressive symptoms in female adolescents. Journal of Abnormal Psychology, 116(1), 198-207. DOI: 10.1037/0021-843X.116.1.198
Nota, J., & Coles, M. (2014) Duration and Timing of Sleep are Associated with Repetitive Negative Thinking. Cognitive Therapy and Research. DOI: 10.1007/s10608-014-9651-7
Strauss, J., Muday, T., McNall, K., & Wong, M. (1997) Response Style Theory Revisited: Gender Differences and Stereotypes in Rumination and Distraction. Sex Roles, 36(11/12), 771-792. DOI: 10.1023/A:1025679223514
Watkins, E. (2008) Constructive and unconstructive repetitive thought. Psychological Bulletin, 134(2), 163-206. DOI: 10.1037/0033-2909.134.2.163
Unicorns, I love them. Unicorns, I love them. ASIA, in the context of this post, does not refer to the continent but rather the suggestion of an: ‘autoimmune (auto-inflammatory) syndrome induced by adjuvants’ and some potentially contentious findings reported by Nancy Agmon-Levin and colleagues .Describing a small cohort of participants diagnosed with chronic fatigue syndrome (CFS) and/or fibromyalgia (FM), the authors put forward the idea that "some cases CFS and FM can be........ Read more »
Agmon-Levin N, Zafrir Y, Kivity S, Balofsky A, Amital H, & Shoenfeld Y. (2014) Chronic fatigue syndrome and fibromyalgia following immunization with the hepatitis B vaccine: another angle of the 'autoimmune (auto-inflammatory) syndrome induced by adjuvants' (ASIA). Immunologic research. PMID: 25427994
A single transplant center analysis of 181 living kidney donors categorized by age revealed that “donor age…was not a risk factor for patient or graft survival”. The death-uncensored graft survival rates in the 3 subgroups (.39; 40-59; 60+) were 64.5%, 76.0% and 90.9%, respectively, whereas their mean estimated glomerular filtration rates 1 year after transplantation were 40.7 …
Continue reading »
The post Kidney Donors Over 60 Have Good Recipient Results appeared........ Read more »
Tanaka, S. (2014) Old-for-Old Age Matching in Living Donor Kidney Transplantation: A Single-Center Experience. Journal of Transplantation Technologies , 04(02). DOI: 10.4172/2161-0991.1000141
Do you write about peer-reviewed research in your blog? Use ResearchBlogging.org to make it easy for your readers — and others from around the world — to find your serious posts about academic research.
If you don't have a blog, you can still use our site to learn about fascinating developments in cutting-edge research from around the world.
Research Blogging is powered by SMG Technology.
To learn more, visit seedmediagroup.com.