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  • December 18, 2014
  • 02:44 AM
  • 1 view

Correcting Metabolic Abnormalities May Help Lessen Urinary Problems

by Wiley Asia Blog in Wiley Asia Blog - Health Sciences

Metabolic syndrome is linked with an increased frequency and severity of lower urinary tract symptoms, but weight loss surgery may lessen these symptoms. The findings, which come from two studies published in BJU International, indicate that urinary problems may be added to the list of issues that can improve with efforts that address altered metabolism.

Lower urinary tract symptoms related to urinary frequency and urgency, bladder leakage, the need to urinate at night, and incomplete bladder........ Read more »

  • December 17, 2014
  • 02:54 PM
  • 17 views

Epigenetic changes and autism

by Gabriel in Lunatic Laboratories

Despite what you may think, the supposed “explosion” of children diagnosed with autism can directly attributed to better diagnosing techniques and — more importantly — the change of definition to make Autism spectrum disorders more broad. Thankfully more causes of autism have been found, none of them remotely related to vaccines and now scientists have found that chemical modifications to DNA’s packaging—known as epigenetic changes—can activate or repress genes involved in autism s........ Read more »

Gao, Z., Lee, P., Stafford, J., von Schimmelmann, M., Schaefer, A., & Reinberg, D. (2014) An AUTS2–Polycomb complex activates gene expression in the CNS. Nature, 516(7531), 349-354. DOI: 10.1038/nature13921  

Ntziachristos, P., Tsirigos, A., Welstead, G., Trimarchi, T., Bakogianni, S., Xu, L., Loizou, E., Holmfeldt, L., Strikoudis, A., King, B.... (2014) Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia. Nature, 514(7523), 513-517. DOI: 10.1038/nature13605  

  • December 17, 2014
  • 04:29 AM
  • 20 views

Folate receptor autoantibodies and (some) schizophrenia

by Paul Whiteley in Questioning Answers

I am the league's director, Silas Ramsbottom.Upon reading the paper published by Ramaekers and colleagues [1] talking about the use of folinic acid in cases of schizophrenia as a function of the presence of "Auto-antibodies against folate receptor alpha (FRα)", I raised a little smile. Not only because the authors suggested that there may be quite a lot more to see in this area on top of some already interesting discussions about the folate cycle and schizophrenia, but also because of the ........ Read more »

Ramaekers VT, Thöny B, Sequeira JM, Ansseau M, Philippe P, Boemer F, Bours V, & Quadros EV. (2014) Folinic acid treatment for schizophrenia associated with folate receptor autoantibodies. Molecular genetics and metabolism. PMID: 25456743  

  • December 16, 2014
  • 02:37 PM
  • 33 views

Methamphetamine use and the onset of parkinson’s

by Gabriel in Lunatic Laboratories

We’ve all seen the PSA’s trying to show the effects of meth use and in particular, what it does to your teeth. Typically, when it comes to drug use, people will not look at the long term side effects from their addiction instead thinking in the short term. This is unfortunate because as it turns out, methamphetamine users are three times more at risk for getting Parkinson’s disease than non-illicit drug users with even worse news for women, new research shows.... Read more »

  • December 16, 2014
  • 04:41 AM
  • 53 views

Thioredoxin... a new 'diagnosis indicator' for autism?

by Paul Whiteley in Questioning Answers

My name's Buttercup. You've met Baron von Shush."Our study demonstrated that serum TRX [thioredoxin] levels were associated with ASD [autism spectrum disorder], and elevated levels could be considered as a novel, independent diagnosis indicator of ASD." So was the conclusion reported by Qing-biao Zhang and colleagues [1] looking at serum levels of TRX in 80 children diagnosed with an ASD compared against "100 sex and age matched typically developing children".I'll freely admi........ Read more »

Zhang QB, Gao SJ, & Zhao HX. (2014) Thioredoxin: A novel, independent diagnosis marker in children with autism. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. PMID: 25433158  

  • December 15, 2014
  • 03:07 PM
  • 59 views

Finding the neurons that deal with distraction

by Gabriel in Lunatic Laboratories

What’s that over there!? The next time you are around people, count how many people are on their phone? Distractions invade every aspect of our lives. Status updates, text messages, email notifications all threaten to steal our attention away from the moment. While we fight the urge to check the phone, our brains are making constant judgment calls about where to focus attention. The brain must continually filter important information from irrelevant interference.... Read more »

Ahrens, S., Jaramillo, S., Yu, K., Ghosh, S., Hwang, G., Paik, R., Lai, C., He, M., Huang, Z., & Li, B. (2014) ErbB4 regulation of a thalamic reticular nucleus circuit for sensory selection. Nature Neuroscience. DOI: 10.1038/nn.3897  

  • December 15, 2014
  • 08:42 AM
  • 65 views

Who is Getting High in Europe (and Where)?

by William Yates, M.D. in Brain Posts

My research training is in psychiatric epidemiology. Alcohol and drug dependence have been two of my topic areas of research.So I found a recent novel study of the epidemiology of illicit drug use in Europe intriguing.Typical methods of looking for the prevalence of drug use in populations are direct diagnostic interviews and studies of emergency room attendees or autopsy cases with medical complications of drug use.However, Christopher Ort from Switzerland along with a host of European col........ Read more »

Ort C, van Nuijs AL, Berset JD, Bijlsma L, Castiglioni S, Covaci A, de Voogt P, Emke E, Fatta-Kassinos D, Griffiths P.... (2014) Spatial differences and temporal changes in illicit drug use in Europe quantified by wastewater analysis. Addiction (Abingdon, England), 109(8), 1338-52. PMID: 24861844  

  • December 15, 2014
  • 05:45 AM
  • 43 views

Malocclusion, orthodontics and quality of life

by Kevin OBrien in Kevin OBrien's Orthodontic Blog

Malocclusion, orthodontics and quality of life? One of the most important areas of orthodontic research that needs to be carried out is to clearly identify the effects of treatment. I have highlighted this in previous posts on the “the great unanswered questions” and “papers that have influenced me”. When we consider this area, I feel […]
The post Malocclusion, orthodontics and quality of life appeared first on Kevin O'Brien's Orthodontic Blog.
... Read more »

  • December 15, 2014
  • 04:45 AM
  • 55 views

Rates of medical illnesses in bipolar disorder

by Paul Whiteley in Questioning Answers

I've mentioned a few times on this blog that a diagnosis of autism or autism spectrum disorder (ASD) is by no means protective against any other diagnosis being received, be it based on a somatic illness or condition, or something more behaviourally defined.Reading through the paper by Liz Forty and colleagues [1] (open-access) it appears that a similar scenario might also pertain to other behaviourally-defined conditions as per the example of bipolar disorder (BD) and their conclusion: "Bi........ Read more »

Forty L, Ulanova A, Jones L, Jones I, Gordon-Smith K, Fraser C, Farmer A, McGuffin P, Lewis CM, Hosang GM.... (2014) Comorbid medical illness in bipolar disorder. The British journal of psychiatry : the journal of mental science. PMID: 25359927  

  • December 15, 2014
  • 02:31 AM
  • 46 views

Treatment for Elderly with Breast Cancer May Not Be as Effective

by Wiley Asia Blog in Wiley Asia Blog - Health Sciences

A new analysis has found that while clinical trial data support omitting radiation treatments in elderly women with early stage breast cancer, nearly two-thirds of these women continue to receive it. The findings are published early online in CANCER, a peer-reviewed journal of the American Cancer Society.

Results published in 2004 from a large, randomized clinical trial showed that adding radiation therapy to surgery plus tamoxifen does not reduce 5-year recurrence rates or prolong survival i........ Read more »

  • December 14, 2014
  • 01:28 PM
  • 74 views

Scientists find a drug (currently used) to turn white fat to brown

by Gabriel in Lunatic Laboratories

It seems like we’ve been on a weight loss campaign here at the labs, but there just has been so much new and interesting research on the subject to report on, this is no exception. Researchers have uncovered the mechanism by which white fat cells from humans (an important distinction) gets reprogrammed to become browner.... Read more »

Anne Loft, Isabel Forss, Majken Storm Siersbæk, Søren Fisker Schmidt, Ann-Sofie Bøgh Larsen, Jesper Grud Skat Madsen, Didier F. Pisani, Ronni Nielsen, Mads Malik Aagaard, Angela Mathison.... (2014) Browning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers. Genes . info:/10.1101/gad.250829.114

  • December 14, 2014
  • 04:48 AM
  • 61 views

Beware the inflated science related press release!

by Paul Whiteley in Questioning Answers

I'm not normally minded to post on a Sunday (day of rest and all that) but I did want to bring your attention to the results presented by Petroc Sumner and colleagues [1] (open-access) concluding that: "Exaggeration in news is strongly associated with exaggeration in press releases" when it comes to the media reporting of [some] health-related science news.The idea behind this particular study - which has been summarised pretty well in some of the accompanying media and in an editorial........ Read more »

  • December 13, 2014
  • 01:51 PM
  • 80 views

High fat diet leads to brain inflammation and obesity

by Gabriel in Lunatic Laboratories

The stomach strikes again, or so it seems. We’ve already covered how your stomach seemingly controls your brain and your blood-brain barrier, but now it seems that what you eat –not too indirectly related to your stomach– might make you fatter, but not in the way you might be thinking thinking. What you are eating may be causing inflammation in the brain.... Read more »

  • December 13, 2014
  • 11:56 AM
  • 58 views

Animal Research Sheds Light on Harmful Mood Disorders in New Mothers

by Wiley Asia Blog in Wiley Asia Blog - Social Science

In the days shortly after giving birth, most mothers experience a period of increased calmness and decreased stress responses, but around 20% of mothers experience anxiety. Some women may become depressed, and around one in a thousand can develop psychosis. The latest evidence indicates that these distressing responses to motherhood are still poorly understood, but that animal research could provide valuable clues to their causes.

Writing in the British Journal of Pharmacology, Dr David Slatt........ Read more »

Perani, C., & Slattery, D. (2014) Using animal models to study post-partum psychiatric disorders. British Journal of Pharmacology, 171(20), 4539-4555. DOI: 10.1111/bph.12640  

  • December 13, 2014
  • 05:19 AM
  • 66 views

Social communication disorder (SCD) reviewed

by Paul Whiteley in Questioning Answers

Sometimes I believe in as many as six impossible things before breakfast.A micropost if you will, for today, and a link to a potentially very important paper by Lauren Swineford and colleagues [1] (open-access) talking about the diagnostic concept: social (pragmatic) communication disorder (SCD) and it's various crossings with language impairments and autism spectrum disorder (ASD).SCD, as I've indicated in other posts (see here and see here) is something that the autism community in partic........ Read more »

  • December 12, 2014
  • 10:35 PM
  • 77 views

Guns And Controllers: Do Violent Video Games Cause Aggressive Behaviour? A Review Of Meta-Analytic Research

by Alexis Delanoir in How to Paint Your Panda

There is a lot of debate over whether or not violent video games manifest in violent behaviour. Consensus has not entirely been reached, but some suggest that the literature provides solid evidence for the hypothesis in question. In this post I examine meta-analytic reviews of the literature and weigh their significance, coming to the conclusion that violent video games most likely do cause aggressive behaviour and other negative social outcomes.... Read more »

  • December 12, 2014
  • 12:37 PM
  • 62 views

Long Sperm Are Winners

by Elizabeth Preston in Inkfish



It's tough to be sperm. Your entire existence centers on one race that you will almost definitely lose. You don't even get to take a warmup lap. Nevertheless, a glance at your competitors waiting at the starting line might give you some hints about who has an advantage. One factor that helps sperm win races is length—and not only for the reasons you might guess.

Long sperm generally have longer tails. This ought to make them faster and more powerful swimmers, which studies have confirmed........ Read more »

Clair Bennison, Nicola Hemmings, Jon Slate, & Tim Birkhead. (2014) Long sperm fertilize more eggs in a bird. Proceedings of the Royal Society B: Biological Sciences. info:/10.1098/rspb.2014.1897

  • December 11, 2014
  • 08:27 PM
  • 79 views

Depression And Stress/Mood Disorders: Causes Of Repetitive Negative Thinking And Ruminations

by Alexis Delanoir in How to Paint Your Panda

Repetitive Negative Thinking (RNT) has been suggested to be of clinical significance as a transdiagnostic process. Research has been conducted to explain the causes of RNT and ruminations but is limited. This article explores the causes and possible solutions to RNT, as well as its clinical implications concerning mood and stress disorders such as major depressive disorder (MDD).... Read more »

Ehring, T., & Watkins, E. (2008) Repetitive Negative Thinking as a Transdiagnostic Process. International Journal of Cognitive Therapy, 1(3), 192-205. DOI: 10.1680/ijct.2008.1.3.192  

Gibb, B., Grassia, M., Stone, L., Uhrlass, D., & McGeary, J. (2011) Brooding Rumination and Risk for Depressive Disorders in Children of Depressed Mothers. Journal of Abnormal Child Psychology, 40(2), 317-326. DOI: 10.1007/s10802-011-9554-y  

  • December 11, 2014
  • 07:14 PM
  • 59 views

Chronic fatigue syndrome by ASIA?

by Paul Whiteley in Questioning Answers

Unicorns, I love them. Unicorns, I love them. ASIA, in the context of this post, does not refer to the continent but rather the suggestion of an: ‘autoimmune (auto-inflammatory) syndrome induced by adjuvants’ and some potentially contentious findings reported by Nancy Agmon-Levin and colleagues [1].Describing a small cohort of participants diagnosed with chronic fatigue syndrome (CFS) and/or fibromyalgia (FM), the authors put forward the idea that "some cases CFS and FM can be........ Read more »

  • December 11, 2014
  • 12:31 PM
  • 57 views

Kidney Donors Over 60 Have Good Recipient Results

by Cristy at Living Donor 101 in Living Donors Are People Too

A single transplant center analysis of 181 living kidney donors categorized by age revealed that “donor age…was not a risk factor for patient or graft survival”. The death-uncensored graft survival rates in the 3 subgroups (.39; 40-59; 60+) were 64.5%, 76.0% and 90.9%, respectively, whereas their mean estimated glomerular filtration rates 1 year after transplantation were 40.7 …
Continue reading »
The post Kidney Donors Over 60 Have Good Recipient Results appeared........ Read more »

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