A quote to begin: "... in this small trial of children with non-syndromic ASD [autism spectrum disorder] and language impairment, treatment with high-dose folinic acid for 12 weeks resulted in improvement in verbal communication as compared with placebo, particularly in those participants who were positive for FRAAs [folate receptor-α autoantibody]."Those were the findings reported by Richard Frye and colleagues  (open-access) continuing a research theme from this group l........ Read more »
Frye, R., Slattery, J., Delhey, L., Furgerson, B., Strickland, T., Tippett, M., Sailey, A., Wynne, R., Rose, S., Melnyk, S.... (2016) Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial. Molecular Psychiatry. DOI: 10.1038/mp.2016.168
"In this study, we again show that acetaminophen use is associated with ASD [autism spectrum disorder]."That was one of the results reported by Stephen Schultz & Georgianna Gould  (open-access available here) as part of their survey of the US "National Database for Autism Research (NDAR) of the National Institute of Mental Health (NIMH)" looking at "whether ASD is associated with acetaminophen use." Acetaminophen by the way, is another name for paracetamol, the over-the-counter ........ Read more »
Schultz ST, & Gould GG. (2016) Acetaminophen Use for Fever in Children Associated with Autism Spectrum Disorder. Autism-open access, 6(2). PMID: 27695658
'The times they are a changin'' said a Nobel prize winner and that's also a sentiment that seems true when it comes to chronic fatigue syndrome / myalgic encephalomyeltis (CFS/ME) too (see here for example).Anyone who has followed the tos-and-fros of the PACE trial - the one that suggested that CBT (cognitive behavioural therapy) and GET (graded exercise therapy) might provide some significant relief of symptoms associated with CFS/ME - will probably have heard the ........ Read more »
Geraghty KJ, & Esmail A. (2016) Chronic fatigue syndrome: is the biopsychosocial model responsible for patient dissatisfaction and harm?. The British journal of general practice : the journal of the Royal College of General Practitioners, 66(649), 437-8. PMID: 27481982
Bladder cancer is the seventh most common cancer in males worldwide. Every year, about 20,000 people in Japan are diagnosed with bladder cancer, of whom around 8,000--mostly men--succumb to the disease. Bladder cancers can be grouped into two types: non-muscle-invasive cancers, which have a five-year survival rate of 90 percent, and muscle-invasive cancers, which have poor prognoses.
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Matsumoto, R., Tsuda, M., Yoshida, K., Tanino, M., Kimura, T., Nishihara, H., Abe, T., Shinohara, N., Nonomura, K., & Tanaka, S. (2016) Aldo-keto reductase 1C1 induced by interleukin-1β mediates the invasive potential and drug resistance of metastatic bladder cancer cells. Scientific Reports, 34625. DOI: 10.1038/srep34625
Meta-analyses eh? You spend ages waiting for one and two come along in quick succession. Well today I'm posting about yet another meta-analysis of the peer-reviewed scientific literature suggesting that "excessive maternal BMI [body mass index] is associated with an increased ASD [autism spectrum disorder] risk in offspring." The review by Ying Wang et al follows hot on the heels of the meta-analysis by Li and colleagues  (see here for my take) but further looked a........ Read more »
Wang, Y., Tang, S., Xu, S., Weng, S., & Liu, Z. (2016) Maternal Body Mass Index and Risk of Autism Spectrum Disorders in Offspring: A Meta-analysis. Scientific Reports, 34248. DOI: 10.1038/srep34248
Although it has already been known for some time that the brain does not remain rigid in its structure even in adulthood, scientists have recently made a surprising discovery. The brain is not only able to adapt to changing conditions in long-term processes, but it can do this every month.
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Barth, C., Steele, C., Mueller, K., Rekkas, V., Arélin, K., Pampel, A., Burmann, I., Kratzsch, J., Villringer, A., & Sacher, J. (2016) In-vivo Dynamics of the Human Hippocampus across the Menstrual Cycle. Scientific Reports, 32833. DOI: 10.1038/srep32833
Tauopathies are a group of neurodegenerative disorders, including Alzheimer's disease that are characterized by the deposition of aggregates of the tau protein inside brain cells. A new study reveals that the cutting of tau by an enzyme called caspase-2 may play a critical role in the disordered brain circuit function that occurs in these diseases.
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Zhao, X., Kotilinek, L., Smith, B., Hlynialuk, C., Zahs, K., Ramsden, M., Cleary, J., & Ashe, K. (2016) Caspase-2 cleavage of tau reversibly impairs memory. Nature Medicine. DOI: 10.1038/nm.4199
I'm not gonna dwell too much on the findings reported by Lee and colleagues  talking about how "toddlers who suffer from AD [atopic dermatitis] at the age younger than 3 years are at a higher risk of developing ADHD [attention-deficit hyperactivity disorder] and ASD [autism spectrum disorder] during later childhood" because science already seems to understand that there may be an important connection between early allergic disease and later offspring behavioural/........ Read more »
Lee CY, Chen MH, Jeng MJ, Hsu JW, Tsai SJ, Bai YM, Hung GY, Yen HJ, Chen TJ, & Su TP. (2016) Longitudinal association between early atopic dermatitis and subsequent attention-deficit or autistic disorder: A population-based case-control study. Medicine, 95(39). PMID: 27684861
High cholesterol might harm more than our cardiovascular systems. New research using animal models suggests that high cholesterol levels trigger mitochondrial oxidative stress on cartilage cells, causing them to die, and ultimately leading to the development of osteoarthritis.
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Farnaghi, S., Prasadam, I., Cai, G., Friis, T., Du, Z., Crawford, R., Mao, X., & Xiao, Y. (2016) Protective effects of mitochondria-targeted antioxidants and statins on cholesterol-induced osteoarthritis. The FASEB Journal. DOI: 10.1096/fj.201600600R
Neuroscience medicine clinicians encounter patients every day who have both a mental and substance use disorder.This co-occurrence, or comorbidity, complicates diagnosis, treatment and outcome.The exact mechanism for this comorbidity issue is unclear.A recent study out of Washington University in St. Louis and King's College London provides some insight into this comorbidity issue.They examined participants in the Study of Addiction: Genetics and Environment (SAGE). These subjects provided genet........ Read more »
Carey CE, Agrawal A, Bucholz KK, Hartz SM, Lynskey MT, Nelson EC, Bierut LJ, & Bogdan R. (2016) Associations between Polygenic Risk for Psychiatric Disorders and Substance Involvement. Frontiers in genetics, 149. PMID: 27574527
Forgetting Earth Dementia. Few words inspire greater fear in those of us who value (quasi-?) independent thought. The term ‘dementia’ encompasses various brain disorders that all share some scary traits: general decline in cognitive function, decreased ability to speak, and in later stages, being unable to take care of oneself. Unfortunately, as human lifespan increases […]... Read more »
Killin LO, Starr JM, Shiue IJ, & Russ TC. (2016) Environmental risk factors for dementia: a systematic review. BMC geriatrics, 16(1), 175. PMID: 27729011
Parihar VK, Allen BD, Caressi C, Kwok S, Chu E, Tran KK, Chmielewski NN, Giedzinski E, Acharya MM, Britten RA.... (2016) Cosmic radiation exposure and persistent cognitive dysfunction. Scientific reports, 34774. PMID: 27721383
'Thick and fast' is probably the best way that I can describe the flurry of peer-reviewed scientific papers recently appearing (see here and see here for examples) talking about how chronic fatigue syndrome (CFS) (also linked to the diagnosis of myalgic encephalomyelitis, ME) might have some important biological processes attached to it.Now we can add the findings reported by Federica Ciregia and colleagues  (open-access) to the list and their observations that "the identification of bio........ Read more »
Ciregia F, Kollipara L, Giusti L, Zahedi RP, Giacomelli C, Mazzoni MR, Giannaccini G, Scarpellini P, Urbani A, Sickmann A.... (2016) Bottom-up proteomics suggests an association between differential expression of mitochondrial proteins and chronic fatigue syndrome. Translational psychiatry, 6(9). PMID: 27676445
Today I'm once again blogging about peer-reviewed research suggesting that when it comes to the long-term effects of attention-deficit/hyperactivity disorder (ADHD) on a person, there is some pretty solid evidence that addressing symptoms early could "potentially avert a wide range of future adverse outcomes."The paper making such a conclusion is the one from Holly Erskine and colleagues  who conducted a systematic review and meta-analysis pertinent to this topic; also taking into accoun........ Read more »
Erskine HE, Norman RE, Ferrari AJ, Chan GC, Copeland WE, Whiteford HA, & Scott JG. (2016) Long-Term Outcomes of Attention-Deficit/Hyperactivity Disorder and Conduct Disorder: A Systematic Review and Meta-Analysis. Journal of the American Academy of Child and Adolescent Psychiatry, 55(10), 841-50. PMID: 27663939
Vitamins A and C aren't just good for your health, they affect your DNA too. Researchers have discovered how vitamins A and C act to modify the epigenetic 'memory' held by cells; insight which is significant for regenerative medicine and our ability to reprogramme cells from one identity to another.
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Hore, T., von Meyenn, F., Ravichandran, M., Bachman, M., Ficz, G., Oxley, D., Santos, F., Balasubramanian, S., Jurkowski, T., & Reik, W. (2016) Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms. Proceedings of the National Academy of Sciences, 201608679. DOI: 10.1073/pnas.1608679113
"At 13 years, adolescents who had received a diagnosis of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) who were attending specialist CFS/ME services were more than two times more likely to be obese than adolescents in the general population."At first reading, I wasn't particularly surprised by the findings reported by Norris and colleagues  (open-access) drawing on data partly derived from everyone's favourite UK longitudinal birth cohort: ALSPAC (Avon Longitudinal Study of Par........ Read more »
Norris T, Hawton K, Hamilton-Shield J, & Crawley E. (2016) Obesity in adolescents with chronic fatigue syndrome: an observational study. Archives of disease in childhood. PMID: 27655658
"TKD [Taekwondo] training can help children with ASD [autism spectrum disorder] improve their balance."Go on."Our findings suggest that TKD can be a fun, feasible, and effective therapeutic option for balance improvement of children with ASD."So said the results of the study by Yumi Kim  (open-access) looking at whether the Korean martial art might be able to help with aspects of some of the very important movement issues that can be associated with a diagnosis of autism.B........ Read more »
Kim Y, Todd T, Fujii T, Lim JC, Vrongistinos K, & Jung T. (2016) Effects of Taekwondo intervention on balance in children with autism spectrum disorder. Journal of exercise rehabilitation, 12(4), 314-9. PMID: 27656628
Increasingly powerful computers using ever-more sophisticated programs are challenging human supremacy in areas as diverse as playing chess and making emotionally compelling music. But can digital diagnosticians match, or even outperform, human physicians? The answer, according to a new study, is "not quite."
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Semigran, H., Levine, D., Nundy, S., & Mehrotra, A. (2016) Comparison of Physician and Computer Diagnostic Accuracy. JAMA Internal Medicine. DOI: 10.1001/jamainternmed.2016.6001
Memory impairment is a key symptom of Alzheimer's dementia common to patients with the condition.However, additional cognitive and behavioral symptoms vary between patients with a clinical and pathological diagnosis of Alzheimer's disease.A key area of research is focused on understanding factors that contribute to symptom variability in Alzheimer's disease.A team of researchers from Singapore and Harvard Medical School recently published an important study on this topic.They analyzed structural........ Read more »
Zhang X, Mormino EC, Sun N, Sperling RA, Sabuncu MR, Yeo BT, & Alzheimer’s Disease Neuroimaging Initiative. (2016) Bayesian model reveals latent atrophy factors with dissociable cognitive trajectories in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID: 27702899
Having recently mentioned the BBC headline that makes up the title of this entry in a related post (see here) I'm pleased to be finally able to bring the paper by Daniel Mackay and colleagues  (open-access) to your attention.Observing that in Scotland at least, "that season of conception is strikingly associated with the subsequent risk of special educational needs in the offspring" there are various potential implications to come from such data covering both learning (intellectual) disabilit........ Read more »
Mackay DF, Smith GC, Cooper SA, Wood R, King A, Clark DN, & Pell JP. (2016) Month of Conception and Learning Disabilities: A Record-Linkage Study of 801,592 Children. American journal of epidemiology. PMID: 27651381
"Hypertension in pregnancy was associated with ASD [autism spectrum disorder] in this population even after controlling for known confounders."So said the findings reported by Eileen Curran and colleagues  who, once again (see here), relied on "data from the Millennium Cohort Study" to produce some potentially important information about how adverse pregnancy conditions may/may not impact on offspring behaviour and development.Hypertension (a.k.a high blood pressure) during pre........ Read more »
Eileen A. Curran, Ali S. Khashan, Gerard W. O’Keeffe, & Louise C. Kenny. (2016) 35 Hypertension in pregnancy and autism spectrum disorder in a British cohort. regnancy Hypertension: An International Journal of Women's Cardiovascular Health., 153. info:/
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