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  • September 22, 2014
  • 02:17 PM
  • 23 views

Autism and the Low Iron Connection

by Gabriel in Lunatic Laboratories

The topic of autism is a charged one. Maybe it’s because it isn’t a simple diagnosis; there are many roads to autism. Most of them are probably genetic, some of them are likely environmental, and none of them are related to vaccination (sorry to burst your bubble anti vax people, it’s called science). Some new research shows another possible (environmental) cause. The new study shows that mothers of children with autism are significantly less likely to report taking iron supplements before........ Read more »

Rebecca J. Schmidt et al. (2014) Maternal intake of supplemental iron and risk for autism spectrum disorders. American Journal of Epidemiology. info:/

  • September 22, 2014
  • 09:00 AM
  • 29 views

Creating The Master Breed

by Mark E. Lasbury in The 'Scope

The German nationalistic sentiment before and during World War II led to some bizarre selective breeding experiments. Two brothers, Heinz and Luke Heck tried to resurrect extinct large animals that once roamed the European forests, and they also tried to breed the perfect German hunting dog – a purely German hunting dog, of course. Whether a good idea or not, the Jadgterrier is one of the few truly healthy pure bred dogs.... Read more »

Zeyland J, Wolko L, Bocianowski J, Szalata M, Słomski R, Dzieduszycki AM, Ryba M, Przystałowska H, & Lipiński D. (2013) Complete mitochondrial genome of wild aurochs (Bos primigenius) reconstructed from ancient DNA. Polish journal of veterinary sciences, 16(2), 265-73. PMID: 23971194  

  • September 22, 2014
  • 03:32 AM
  • 39 views

Omega-3 fatty acids and ADHD

by Paul Whiteley in Questioning Answers

With a title like that, this post could turn out to be quite a long winded blog entry. As it happens, I'm not going to subject you, dear reader, to such a literary onslaught but rather focus my attention on the paper by Elizabeth Hawkey & Joel Nigg [1] who undertook two meta-analyses and concluded that: "Omega-3 levels are reduced in children with ADHD [attention-deficit hyperactivity disorder]" and "Dietary supplementation appears to create modest improvements in symptoms"."Maybe the 80s wi........ Read more »

  • September 21, 2014
  • 07:21 AM
  • 58 views

Warning: This Post Will Change Your Brain

by Neuroskeptic in Neuroskeptic_Discover

Last week I gave a talk in Brazil called Why Is It So Hard To Think About The Brain?, Well, no sooner have I returned than a story appeared that illustrates my point all too well. A neuroscience paper made headlines around the world on Friday. Here’s Time‘s take: One Dose of Antidepressant Changes the […]The post Warning: This Post Will Change Your Brain appeared first on Neuroskeptic.... Read more »

Schaefer, A., Burmann, I., Regenthal, R., Arélin, K., Barth, C., Pampel, A., Villringer, A., Margulies, D., & Sacher, J. (2014) Serotonergic Modulation of Intrinsic Functional Connectivity. Current Biology. DOI: 10.1016/j.cub.2014.08.024  

  • September 20, 2014
  • 03:43 PM
  • 62 views

Lengthen Telomeres and Turn Back Aging

by Gabriel in Lunatic Laboratories

Want to live longer and healthier? Of course you do, well science may just have the answer! Scientists have discovered an on-and-off "switch" in cells that may hold the key to healthy aging. This switch points to a way to encourage healthy cells to keep dividing and generating, for example, new lung or liver tissue, even in old age. Getting cells to divide might not be that hard (or even very useful), but that isn't all, it gets better!... Read more »

  • September 20, 2014
  • 10:15 AM
  • 49 views

Autumn Leaves: More Than Just Pretty Colors

by Kelly Hallstrom in The 'Scope

Why do the leaves change color in the fall? It might not be for the reason you think...... Read more »

Schaefer HM, & Rolshausen G. (2006) Plants on red alert: do insects pay attention?. BioEssays : news and reviews in molecular, cellular and developmental biology, 28(1), 65-71. PMID: 16369938  

  • September 20, 2014
  • 04:51 AM
  • 60 views

Antibiotics and risk of pediatric Crohn's disease

by Paul Whiteley in Questioning Answers

I couldn't let the meta-analysis from Ryan Ungaro and colleagues [1] pass without a brief mention. Concluding that: "Exposure to antibiotics appears to increase the odds of being newly diagnosed with CD [Crohn's disease] but not UC [ulcerative colitis]" and further: "This risk is most marked in children diagnosed with CD", the implications from this and other findings in this area may be far-reaching.I've talked before on this blog about antibiotic exposure and risk of inflam........ Read more »

Ungaro R, Bernstein CN, Gearry R, Hviid A, Kolho KL, Kronman MP, Shaw S, Van Kruiningen H, Colombel JF, & Atreja A. (2014) Antibiotics Associated With Increased Risk of New-Onset Crohn's Disease But Not Ulcerative Colitis: A Meta-Analysis. The American journal of gastroenterology. PMID: 25223575  

  • September 19, 2014
  • 07:28 PM
  • 56 views

Nanosponges Clean up Antibody-mediated Autoimmune Disease

by Gabriel in Lunatic Laboratories

What does lupus, rheumatoid arthritis, type I diabetes, multiple sclerosis, and rheumatic heart disease have in common? All of these (and many other) apparently unrelated disorders are caused by autoimmunity, in which the immune system produces antibodies that attack normal, healthy cells and tissues. Currently considered incurable, these autoimmune diseases can be managed, but to varying degrees and not without serious side effects. Moreover, autoimmune diseases include a wide range of dysfunct........ Read more »

Copp JA, Fang RH, Luk BT, Hu CM, Gao W, Zhang K, & Zhang L. (2014) Clearance of pathological antibodies using biomimetic nanoparticles. Proceedings of the National Academy of Sciences of the United States of America, 111(37), 13481-6. PMID: 25197051  

  • September 19, 2014
  • 06:25 PM
  • 54 views

Estimating how much we don't know

by Iddo Friedberg in Byte Size Biology

Most of our understanding of what genes do comes from computational predictions, rather than actual experiments. For almost any given gene that is sequenced, its function is determined by putting its sequence through one or more function annotation algorithms. Computational annotation is cheaper and more feasible than cloning, translating, and assaying the gene product (typically a protein) to find out exactly what it does. Experiments can be long, expensive and, in many cases, impossible to pe........ Read more »

  • September 19, 2014
  • 01:21 PM
  • 71 views

New test for Diagnosing Alzheimer’s Early

by Gabriel in Lunatic Laboratories

Alzheimer’s diagnosis is important, like the famous slogan “with a stroke, time lost is brain lost,” detecting alzheimer’s is important in order to stave off cognitive decline. A just like a stroke time lost is brain lost. Unfortunately early diagnosis has been hard to come by, but now researchers say a simple test that combines thinking and movement can help to detect heightened risk for developing Alzheimer’s disease in a person. The best part, they say this will work even before the........ Read more »

  • September 19, 2014
  • 05:06 AM
  • 59 views

Air travel may cause pneumothorax in BHD patients

by Lizzie Perdeaux in BHD Research Blog

One concern many BHD patients have is whether it is safe to take commercial flights, or whether this would increase the chances of a pneumothorax. A recently published study, by Professor Pieter Postmus and his team at the VU Medical … Continue reading →... Read more »

Postmus PE, Johannesma PC, Menko FH, & Paul MA. (2014) In-Flight Pneumothorax: Diagnosis May Be Missed because of Symptom Delay. American journal of respiratory and critical care medicine, 190(6), 704-5. PMID: 25221882  

  • September 19, 2014
  • 04:08 AM
  • 68 views

Increasing parental age and autism severity?

by Paul Whiteley in Questioning Answers

An interesting paper by David Geier and colleagues [1] (open-access here) caught my eye recently, concluding that there was a lack of support for the suggestion that: "increasing parental age was associated with increasing autism spectrum disorder phenotypic severity"."the snozzberries taste like snozzberries".Before progressing through the paper and its possible implications, the eagle-eyed out there might have already spotted the name Dr Brian Hooker on the authorship list of the Geier paper. ........ Read more »

  • September 18, 2014
  • 11:45 PM
  • 62 views

Experimental and comparative oncology: zebrafish, dogs, elephants

by Artem Kaznatcheev in Evolutionary Games Group

One of the exciting things about mathematical oncology is that thinking about cancer often forces me to leave my comfortable arm-chair and look at some actually data. No matter how much I advocate for the merits of heuristic modeling, when it comes to cancer, data-agnostic models take second stage to data-rich modeling. This close relationship […]... Read more »

Gallaher, J., & Anderson, A.R. (2013) Evolution of intratumoral phenotypic heterogeneity: the role of trait inheritance. Interface Focus, 3(4), 20130016. arXiv: 1305.0524v1

  • September 18, 2014
  • 03:44 PM
  • 92 views

MERS-CoV vaccine

by thelonevirologist in Virology Tidbits

MERS-CoV is the causative agent of a severe and fatal respiratory illness in humans with no known effective antiviral therapy or vaccine. Although MERS-CoV infections have been reported from countries outside the Arabian peninsula, local transmission with the exception of family cluster of three cases in Tunisia (with the index case being infected in the KSA) has been limited to the Kingdom of Saudi Arabia, the Kingdom of Jordan, Qatar, Oman, and the United Arab Emirates. Recent developments on ........ Read more »

Corman VM, Jores J, Meyer B, Younan M, Liljander A, Said MY, Gluecks I, Lattwein E, Bosch BJ, Drexler JF.... (2014) Antibodies against MERS coronavirus in dromedary camels, Kenya, 1992-2013. Emerging infectious diseases, 20(8), 1319-22. PMID: 25075637  

Yang L, Wu Z, Ren X, Yang F, Zhang J, He G, Dong J, Sun L, Zhu Y, Zhang S.... (2014) MERS-related betacoronavirus in Vespertilio superans bats, China. Emerging infectious diseases, 20(7), 1260-2. PMID: 24960574  

  • September 18, 2014
  • 12:58 PM
  • 84 views

Is Stress Eating Away at You? No, Literally…

by Gabriel in Lunatic Laboratories

Ever wonder why, when people are too stressed, they are often grouchy, grumpy, nasty, distracted or forgetful? It may not be something you’ve done, in fact it turns out stress is literally tearing apart the brain. By this I mean that researchers have just highlighted a fundamental synaptic mechanism that explains the relationship between chronic stress and the loss of social skills and cognitive impairment. When triggered by stress, an enzyme attacks a synaptic regulatory molecule in the brain........ Read more »

van der Kooij, M., Fantin, M., Rejmak, E., Grosse, J., Zanoletti, O., Fournier, C., Ganguly, K., Kalita, K., Kaczmarek, L., & Sandi, C. (2014) Role for MMP-9 in stress-induced downregulation of nectin-3 in hippocampal CA1 and associated behavioural alterations. Nature Communications, 4995. DOI: 10.1038/ncomms5995  

  • September 18, 2014
  • 08:00 AM
  • 94 views

Pythons and the Land - The Bangladesh Python Project Part IV --Guest Post--

by David Steen in Living Alongside Wildlife

By Jon Hakim

Make sure to start at Part I.

“Snake call!  It's the python.  Are you up?  We got a call for the python.”









The words were almost the same, but I woke up to see that
Caesar's face held a grimace.  The
call he feared had come. 






Let's back up to the night before.



In the last post I left you in a moment of triumph.  Kanai had led four of us right to our
target species... Read more »

Rahman, Shahriar Caesar, & et al. (2013) Monsoon does matter: annual activity patterns in a snake assemblage from Bangladesh. The Herpetological Journal, 203-208. info:/

  • September 18, 2014
  • 04:50 AM
  • 105 views

Anxiety and sensory over-responsivity linked to gut issues in autism

by Paul Whiteley in Questioning Answers

"The name's Lonnegan! Doyle Lonnegan!"Consider this micropost an extension of some previous discussions on this blog about how gastrointestinal (GI) issues present in cases of autism might show some connection to the presence of anxiety and sensory issues (see here). Today I'm discussing further research by Micah Mazurek and colleagues [1] which follows a previous publication by this author [2] on this topic.In the latest paper, Dr Mazurek and colleagues describe the course of abdominal pain in ........ Read more »

  • September 17, 2014
  • 02:49 PM
  • 59 views

September 17, 2014

by Erin Campbell in HighMag Blog

All good things must end—even the focal adhesions that are so key to cell migration. Today’s notable image is the first live cell visualization of ECM degradation at focal adhesions, in a recent paper that reports the link between CLASPs, exocytosis, and focal adhesion turnover. Cell migration depends on the precisely-timed formation of focal adhesions (FAs) that link the crawling cell to the extracellular matrix (ECM). FAs serve as anchor points for the crawling cell, yet must later di........ Read more »

  • September 17, 2014
  • 01:24 PM
  • 69 views

Biofilms: Using Bacteria for new Designer Nanomaterials

by Gabriel in Lunatic Laboratories

For most people biofilms conjure up images of slippery stones in a streambed and dirty drains. While there are plenty of "bad" biofilms around – they are even the same stuff that causes pesky dental plaque and a host of other more serious medical problems – a team of researchers sees biofilms as a robust new platform for designer nanomaterials that could clean up polluted rivers, manufacture pharmaceutical products, fabricate new textiles, and more.... Read more »

Peter Q. Nguyen,, Zsofia Botyanszki,, Pei Kun R. Tay,, & Neel S. Joshi. (2014) Programmable biofilm-based materials from engineered curli nanofibres. Nature Communications. info:/10.1038/ncomms5945

  • September 17, 2014
  • 12:48 PM
  • 66 views

Live Fast, Die Young: Evolutionary Outcomes of an Asteroid Impact

by Melissa Chernick in Science Storiented

A new semester has started and with it an influx of new students into the lab has begun. Busy has become my middle name. So when I was looking around for a paper to write about I wanted something different and cool. Not exactly hard to find in science. The asteroid known as 2012 DA14 will narrowly miss Earth this Friday, the closest known asteroid flyby on record. And by close we’re talking within the orbits of many communications satellites. This got me thinking about and looking for recent p........ Read more »

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