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  • November 27, 2014
  • 04:55 AM
  • 5 views

FC is a technique that has no validity

by Paul Whiteley in Questioning Answers

FC, by the way, refers to Facilitated Communication, a controversial technique which as the name suggests relies on a facilitator to support "the hand or arm of a communicatively impaired individual while using a keyboard or other devices with the aim of helping the individual to point and thereby to communicate." The quote for the title of this post comes from the paper by Ralf Schlosser and colleagues [1] who following systematic review, found "unequivocal evidence for facilitator co........ Read more »

Schlosser RW, Balandin S, Hemsley B, Iacono T, Probst P, & von Tetzchner S. (2014) Facilitated Communication and Authorship: A Systematic Review. Augmentative and alternative communication (Baltimore, Md. : 1985), 1-10. PMID: 25384895  

  • November 26, 2014
  • 03:20 PM
  • 28 views

Need to turn off the pain? Well now we can!

by Gabriel in Lunatic Laboratories

My sister suffers from chronic pain issues. I’ve written several posts about how her autoimmune disease is a special brand of pain that you will thankfully (almost certainly) never have to feel. While great strides have been made in pain management, there are still relatively few options that do not carry the risk of being extremely addictive. Well thankfully there is some new research and it offers hope, not just for my sister, but for the millions of people suffering from chronic pain that ........ Read more »

Little JW, Ford A, Symons-Liguori AM, Chen Z, Janes K, Doyle T, Xie J, Luongo L, Tosh DK, Maione S.... (2014) Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states. Brain : a journal of neurology. PMID: 25414036  

  • November 26, 2014
  • 02:35 PM
  • 20 views

Tryptophan vs. The NFL Fan

by Mark Lasbury in The 'Scope

What is tryptophan, and is it indeed responsible for the snoring that follows Thanksgiving dinner? ... Read more »

  • November 26, 2014
  • 01:24 PM
  • 20 views

Chikungunya Virus nsP2 and the ER stress response

by thelonevirologist in Virology Tidbits

Chikungunya virus (CHIKV) is the causative agent of an arthropod (mosquito) transmitted disease which is characterised by a high fever, rash, joint pain, and arthritis which was reported in 1952 in Tanzania but has spread since to Europe, Asia, Oceania and more recently to America, including the Caribbean and North America.
Here the inhibition of the ER stress response by the viral nsP2 protein is discussed in the context of viral infection. ... Read more »

Krejbich-Trotot P, Gay B, Li-Pat-Yuen G, Hoarau JJ, Jaffar-Bandjee MC, Briant L, Gasque P, & Denizot M. (2011) Chikungunya triggers an autophagic process which promotes viral replication. Virology journal, 432. PMID: 21902836  

Frolov I, Akhrymuk M, Akhrymuk I, Atasheva S, & Frolova EI. (2012) Early events in alphavirus replication determine the outcome of infection. Journal of virology, 86(9), 5055-66. PMID: 22345447  

Rudd PA, Wilson J, Gardner J, Larcher T, Babarit C, Le TT, Anraku I, Kumagai Y, Loo YM, Gale M Jr.... (2012) Interferon response factors 3 and 7 protect against Chikungunya virus hemorrhagic fever and shock. Journal of virology, 86(18), 9888-98. PMID: 22761364  

Fros JJ, Liu WJ, Prow NA, Geertsema C, Ligtenberg M, Vanlandingham DL, Schnettler E, Vlak JM, Suhrbier A, Khromykh AA.... (2010) Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling. Journal of virology, 84(20), 10877-87. PMID: 20686047  

Fros JJ, Major LD, Scholte FE, Gardner J, van Hemert MJ, Suhrbier A, & Pijlman GP. (2014) Chikungunya virus nsP2-mediated host shut-off disables the unfolded protein response. The Journal of general virology. PMID: 25395592  

Rathore AP, Haystead T, Das PK, Merits A, Ng ML, & Vasudevan SG. (2014) Chikungunya virus nsP3 . Antiviral research, 7-16. PMID: 24388965  

  • November 26, 2014
  • 09:35 AM
  • 31 views

Illusion Makes People Speak with the Voice of Their Avatar

by Elizabeth Preston in Inkfish

Think you’re in control of your own body? A simple virtual-reality session could not only make you feel like an avatar’s body is your own, but make you speak more like the digital character. First there was the rubber-hand illusion, a classic experiment that showed syncing up someone’s touch perceptions with what they see happening […]The post Illusion Makes People Speak with the Voice of Their Avatar appeared first on Inkfish.... Read more »

  • November 26, 2014
  • 07:23 AM
  • 21 views

November 26, 2014

by Erin Campbell in HighMag Blog

 Patterns are soothing for left-brained folks like me, with the exception being those terrible patterned holiday sweaters that will come out of mothball-ridden closets soon (unsettling for everyone, really). Today’s images are from a paper describing a new micropatterning technique to look at plasma membrane proteins. The plasma membrane of a cell is riddled with many multi-protein complexes that facilitate communication and transport. These complexes provide a challenge to biologi........ Read more »

Lochte, S., Waichman, S., Beutel, O., You, C., & Piehler, J. (2014) Live cell micropatterning reveals the dynamics of signaling complexes at the plasma membrane. originally published in the Journal of Cell Biology, 207(3), 407-418. DOI: 10.1083/jcb.201406032  

  • November 26, 2014
  • 07:12 AM
  • 24 views

Thanksgiving week, light posting. One holiday genome (cranberries).

by Mary in OpenHelix

There’s nobody reading the blog this week each year, everyone is traveling or napping, at least in the US. So I’ll just bring a holiday genome I came across recently. Cranberries. This fruit is one of very few native North American fruits that are widely cultivated. I went looking to see if a genome paper […]... Read more »

  • November 26, 2014
  • 04:54 AM
  • 32 views

The gut microbiome in Down Syndrome

by Paul Whiteley in Questioning Answers

The recent preliminary findings from Elena Biagi and colleagues [1] (open-access) reporting on the constitution of the gut microbiome - the collected bacteria which reside in the deepest, darkest recesses of our gastrointestinal (GI) tract - in a small number of cases of Down's syndrome caught my eye recently.It's a funny feeling being taken under the wing of a dragonPerhaps a little bit unusually looking at the gut microbiome because of the link between premature ageing in Down's syndrome ........ Read more »

Biagi E, Candela M, Centanni M, Consolandi C, Rampelli S, Turroni S, Severgnini M, Peano C, Ghezzo A, Scurti M.... (2014) Gut Microbiome in Down Syndrome. PloS one, 9(11). PMID: 25386941  

  • November 25, 2014
  • 01:18 PM
  • 44 views

Oy. I worry about this with cell line studies a lot. Mis-IDed contaminated.

by Mary in OpenHelix

Via NCBI Announce mailing list: NCBI BioSample includes curated list of over 400 known misidentified and contaminated cell lines The NCBI BioSample database now includes a curated list of over 400 known misidentified and contaminated cell lines. Scientists should check this list before they start working with a new cell line to see if that cell line […]... Read more »

American Type Culture Collection Standards Development Organization Workgroup ASN-0002. (2010) Cell line misidentification: the beginning of the end. Nature Reviews Cancer, 10(6), 441-448. DOI: http://dx.doi.org/10.1038/nrc2852  

  • November 25, 2014
  • 08:00 AM
  • 45 views

As A Bird - It's No Turkey

by Mark Lasbury in As Many Exceptions As Rules

The turkey is an amazing bird, beyond it’s taste on Thanksgiving. It has some really funky structures on its head, like the caruncles, wattle and snood, but research shows that they are important in mate selection. The question is why they have been retained even though they are artificially bred nowadays. Maybe they are for more than just mate selection. And yes....turkeys can fly.... Read more »

  • November 25, 2014
  • 03:20 AM
  • 45 views

Serotonin - melatonin (and the in-betweeners) linked to autism

by Paul Whiteley in Questioning Answers

The paper by Pagan and colleagues [1] (open-access) looking at "serotonin, melatonin and the intermediate N-acetylserotonin (NAS) in a large cohort of patients with ASD [autism spectrum disorder] and their relatives" set the old grey-pink matter into action recently. Not only because I have some real interest in the starting material for these compounds - the aromatic amino acid known as tryptophan - but because this research group included some quite important analysis of the enz........ Read more »

Pagan C, Delorme R, Callebert J, Goubran-Botros H, Amsellem F, Drouot X, Boudebesse C, Le Dudal K, Ngo-Nguyen N, Laouamri H.... (2014) The serotonin-N-acetylserotonin-melatonin pathway as a biomarker for autism spectrum disorders. Translational psychiatry. PMID: 25386956  

  • November 24, 2014
  • 03:26 PM
  • 41 views

Hiding cells to prevent HIV transmission

by Gabriel in Lunatic Laboratories

The fight against HIV is ongoing and despite our rapid progression against the disease we still lack a cure or even adequate treatment for people infected. However, new research suggests that cloaking immune cells with antibodies that block T cell trafficking to the gut can substantially reduce the risk of viral transmission, at least in a non-human primate model of HIV infection. If it works out, this could help slow down the spread of HIV and give people a better shot at a normal life.... Read more »

  • November 24, 2014
  • 05:15 AM
  • 47 views

Helicobacter pylori and stem cells in the gastric crypt

by Artem Kaznatcheev in Evolutionary Games Group

Last Friday, the 4th Integrated Mathematical Oncology Workshop finished here at Moffitt. The event drew a variety of internal and external participants — you can see a blurry photo of many of them above — and was structured as a competition between four teams specializing in four different domains: Microbiome, Hepatitis C, Human papillomavirus, and […]... Read more »

Houghton, J., Stoicov, C., Nomura, S., Rogers, A.B., Carlson, J., Li, H., Cai, X., Fox, J.G., Goldenring, J.R., & Wang, T.C. (2004) Gastric cancer originating from bone marrow-derived cells. Science, 306(5701), 1568-71. PMID: 15567866  

  • November 24, 2014
  • 04:29 AM
  • 44 views

Finland, parental migration and offspring Asperger syndrome

by Paul Whiteley in Questioning Answers

A quote from the paper by Venla Lehti and colleagues [1] to start things off: "The study showed that children whose parents are both immigrants have a significantly lower likelihood of being diagnosed with Asperger's syndrome than those with two Finnish parents."Can I cook, or can't I?Based on an analysis of data derived from "the Finnish Hospital Discharge Register" and "the Finnish Medical Birth Register", researchers looked at the records of children with a diagnosis of Asperger syndrome (AS)........ Read more »

Lehti V, Cheslack-Postava K, Gissler M, Hinkka-Yli-Salomäki S, Brown AS, & Sourander A. (2014) Parental migration and Asperger's syndrome. European child . PMID: 25381114  

  • November 23, 2014
  • 02:09 PM
  • 75 views

Love, it’s in your genes

by Gabriel in Lunatic Laboratories

Most kids worry about passing tests, winning games, lost phones, fractured bones—and whether or not they will ever really fall in love. While the first few things are of relatively low value in the scientific pursuit, three Chinese researchers have focused on that last question. All in a bid to find out some of the more interesting questions about our genes: Why do some students stay single? What factors determine if a young adult falls in love?... Read more »

  • November 23, 2014
  • 10:52 AM
  • 41 views

Ampulex compressa: The Wasp That Turns Cockroaches Into Zombies

by beredim in Strange Animals

Jewel WaspBy Muhammad Mahdi Karim (Own work) [GFDL 1.2], via Wikimedia CommonsKingdom: AnimaliaPhylum: ArthropodaClass: InsectaOrder: HymenopteraSuborder: ApocritaSuperfamily: ApoideaFamily: AmpulicidaeGenus: AmpulexSpecies: Ampulex compressaCommon Name(s): Emerald cockroach wasp or jewel waspThe Emerald cockroach wasp is best known for its unusual parasitoid reproductive behavior, which among other includes stinging and injecting a cockroach with mind controlling toxins and using its ........ Read more »

  • November 22, 2014
  • 02:45 PM
  • 55 views

Mental Health- The invisible barrier for women’s care

by Gabriel in Lunatic Laboratories

A while back I wrote a post about mental health and jail sentences, it seems like no one takes mental health seriously and that leads to lack of care for the individual. Well a new study offers even more bad news on the mental health front. Women with symptoms of serious mental illness are significantly less likely to receive three routine cancer screenings – Pap tests, mammograms and clinical breast exams – than women in the general population, despite being at elevated risk for medical com........ Read more »

  • November 22, 2014
  • 10:32 AM
  • 62 views

Hammerhead Slug: World's Largest Flatworm

by beredim in Strange Animals

Bipalium kewenseNotice the distinctive hammer-like headBy Ajaykuyiloor (Own work) [CC-BY-SA-3.0], via Wikimedia CommonsKingdom: AnimaliaPhylum: PlatyhelminthesClass: TurbellariaOrder: TricladidaSuborder: ContinenticolaFamily: GeoplanidaeSubfamily: BipaliinaeGenus: BipaliumSpecies: Bipalium kewenseCommon Names: Hammerhead slug, Greenhouse PlanarianNicknamed as the "hammerhead slug" due to its half-moon shaped head, Bipalium kewense is not your ev........ Read more »

  • November 22, 2014
  • 09:10 AM
  • 87 views

Science Identifies The Catchiest Songs Ever – Did Your Favorite Make The List?

by Bill Sullivan in The 'Scope

Using science, researchers are studying what makes songs catchy as a way to understand learning and memory. Did your favorite song make the list? ... Read more »

  • November 21, 2014
  • 06:39 PM
  • 75 views

Dogtober = Canine science in October

by Cobb & Hecht in Do You Believe In Dog?

What a BOOMING month for dogs and science October was! We've captured the links to all the latest blogs, research and news that caught out attention throughout Dog-tober.Thanks to Storify (click here if the you can't see the collection of links below) you can make sure you didn't miss out too.[View the story "Do You Believe in Dog? [01-31 October 2014]" on Storify] Further reading:Bradshaw J.W.S. & Nicola J. Rooney (2014). Why do adult dogs ‘play’?, Behavioural Processes, DOI: http:/........ Read more »

Bozkurt Alper, Barbara Sherman, Rita Brugarolas, Sean Mealin, John Majikes, Pu Yang, & Robert Loftin. (2014) Towards Cyber-Enhanced Working Dogs for Search and Rescue. IEEE Intelligent Systems, 1-1. DOI: http://dx.doi.org/10.1109/mis.2014.77  

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