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  • November 30, 1999
  • 12:00 AM

Female snails in Australia are just happy to see you

by Miriam Goldstein in Deep Sea News

In which a distraught marine snail seeks advice about a penis sprouting from the right side of her head.... Read more »

  • November 30, 1999
  • 12:00 AM

So, is Darwinian Natural Selection Optimal?

by Croor Singh in Learning to be Terse

Game-theoretic approaches to study whether multiple strategies are possible in the same environment.... Read more »

Daniel S. Falster, & Mark Westoby. (2003) Plant height and evolutionary games. Trends in Ecology , 18(7), 337-343. DOI: 10.1016/S0169-5347(03)00061-2  

  • November 30, 1999
  • 12:00 AM

Diversity: It Matters! (for plants & algae)

by jebyrnes in I'm a chordata, urochordata!

Geological time has witnessed 5 extinction crises. Now we're in the middle of the 6th - this time driven by man. What's unprecedented, however, is the rate we are driving species extinct. For many taxa, it's faster than we've seen in geological time (see here for discussion).

So? Will vast reductions in the diversity of species on earth matter? I mean, heck, maybe we only need two or three of each taxa, and we’re all good. Or maybe not…

This question has ........ Read more »

Cardinale, B., Matulich, K., Hooper, D., Byrnes, J., Duffy, E., Gamfeldt, L., Balvanera, P., O'Connor, M., & Gonzalez, A. (2011) The functional role of producer diversity in ecosystems. American Journal of Botany, 98(3), 572-592. DOI: 10.3732/ajb.1000364  

  • November 30, 1999
  • 12:00 AM

Dance Macabre: Will 14th Century Remains Reveal the Pandemic Secrets of the Black Death?

by Sara Klink in Promega Connections

Another group of researchers decided to further analyze the causative agent of the Black Plague by enriching for and sequencing one of the extrachromasomal plasmids present in the bacterial genome: the 9.6kb virulence-associated pPCP1 plasmid.

The recently published research in the Proceedings of the National Association of Science USA chose to use samples from East Smithfield (ES) cemetery in London, England, a burial ground that was established during the medieval Black Death pandemic of 13........ Read more »

Schuenemann VJ, Bos K, Dewitte S, Schmedes S, Jamieson J, Mittnik A, Forrest S, Coombes BK, Wood JW, Earn DJ.... (2011) From the Cover: Targeted enrichment of ancient pathogens yielding the pPCP1 plasmid of Yersinia pestis from victims of the Black Death. Proceedings of the National Academy of Sciences of the United States of America, 108(38). PMID: 21876176  

  • November 30, 1999
  • 12:00 AM

Using folate receptor alpha flurorescence imaging in ovarian cancer

by Sally Church in Pharma Strategy Blog

The idea behind this concept is that fluorescence technology can be used to help guide ovarian cancer surgery more effectively, since the tumors tend to be small and hard to see for surgeons performing the excision.... Read more »

van Dam, G., Themelis, G., Crane, L., Harlaar, N., Pleijhuis, R., Kelder, W., Sarantopoulos, A., de Jong, J., Arts, H., van der Zee, A.... (2011) Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results. Nature Medicine. DOI: 10.1038/nm.2472  

  • November 30, 1999
  • 12:00 AM


by xxx in Anole Annals

xxx... Read more »

Kirsten E. Nicholson and Paul M. Richards. (2011) Home-range size and overlap within an introduced population of the Cuban Knight Anole, Anolis equestris (Squamata: Iguanidae). Phyllomedusa, 10(1), 65-73. info:/

  • November 30, 1999
  • 12:00 AM

“Survival of the funkiest”, or how to evolve a hit song?

by Michael Czaplinski in Inside the Black Box

Evolving "loops", which are short musical pieces become more attractive under selective pressure from listeners. Some interesting phenomena occur!... Read more »

Robert M. MacCallum, Matthias Mauch, Austin Burt, & Armand M. Leroi. (2012) Evolution of Music by Public Choice. PNAS. DOI: 10.1073/pnas.1203182109  

  • November 30, 1999
  • 12:00 AM

Methylomes in Lethal Prostate Cancer Support Personalized Medicine

by Nicole Kelesoglu in E3 Engaging Epigenetics Experts

Description of new Science Translational Medicine pub out of Johns Hopkins. Epigenetic profiling of metastatic prostate cancer reveals that epigenetic biomarkers are worth the search.... Read more »

  • November 30, 1999
  • 12:00 AM

Tadpoles see through their asses

by Papes in Sick Papes

A compelling example of the brain’s dynamic ballsiness (i.e., the ability of neural circuits to learn to detect unfamiliar sensory stimuli), is described in a recent exercise in sickness by the duo of Blackiston and Levin. ... Read more »

  • November 30, 1999
  • 12:00 AM

Tet1 Enzyme Based Enrichment Method for Methylome Sequencing: TamC-Seq

by Nicole Kelesoglu in E3 Engaging Epigenetics Experts

Summary of a recent Nature paper that details a new inexpensive, enzyme based enrichment method for methylome sequencing. ... Read more »

Zhang L, Szulwach KE, Hon GC, Song CX, Park B, Yu M, Lu X, Dai Q, Wang X, Street CR.... (2013) Tet-mediated covalent labelling of 5-methylcytosine for its genome-wide detection and sequencing. Nature communications, 1517. PMID: 23443545  

  • November 30, 1999
  • 12:00 AM

Dealing with a Stealthy Protein Sample Killer: Shipping on Dry Ice

by Dave Dilyx in Protein Solubility Blog

what could have (actually: should have) been done decades ago, this team of academic and industrial scientists convincingly demonstrate that "...exposure of the solutions to CO2 cause[s] the formation of carbonic acid, resulting in protein damage from the pH drop." In a series of experiments they rule out the type of storage vial, container material of body, cap and seal (borosilicate glass, polyethylene, polypropylene, melamine formaldeyde, phenol formaldehyde, polyethylene terephthal........ Read more »

Murphy BM, Swarts S, Mueller BM, van der Geer P, Manning MC, & Fitchmun MI. (2013) Protein instability following transport or storage on dry ice. Nature methods, 10(4), 278-9. PMID: 23538862  

  • November 30, 1999
  • 12:00 AM

Spiders as catalysts for ecosystem development

by Chris Buddle in Arthropod Ecology

In this post, the role of spiders in the development of ecosystems is discussed, especially in light of their ability to colonize habitats rapidly. ... Read more »

  • November 30, 1999
  • 12:00 AM

2014: The Year in Science

by Viputheshwar Sitaraman in Draw Science

The year in review: innovative discoveries and progress in all different fields of science. [Infographic]... Read more »

Qiu, X., Wong, G., Audet, J., Bello, A., Fernando, L., Alimonti, J., Fausther-Bovendo, H., Wei, H., Aviles, J., Hiatt, E.... (2014) Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp. Nature, 514(7520), 47-53. DOI: 10.1038/nature13777  

Obokata, H., Wakayama, T., Sasai, Y., Kojima, K., Vacanti, M., Niwa, H., Yamato, M., & Vacanti, C. (2014) Stimulus-triggered fate conversion of somatic cells into pluripotency. Nature, 505(7485), 641-647. DOI: 10.1038/nature12968  

Quintana, E., Barclay, T., Raymond, S., Rowe, J., Bolmont, E., Caldwell, D., Howell, S., Kane, S., Huber, D., Crepp, J.... (2014) An Earth-Sized Planet in the Habitable Zone of a Cool Star. Science, 344(6181), 277-280. DOI: 10.1126/science.1249403  

A.K. Geim, & K. S. Novoselov. (2010) The rise and rise of graphene. Nature Nanotechnology, 5(11), 755-755. DOI: 10.1038/nnano.2010.224  

  • November 30, 1999
  • 12:00 AM

Robotic researcher to the rescue

by kylius wilkins in It Ain't Magic

Masaki Watabe talks about automated robotic researchers, future robot rule, and scientific philosophy.... Read more »

Watabe, M., Arjunan, S., Fukushima, S., Iwamoto, K., Kozuka, J., Matsuoka, S., Shindo, Y., Ueda, M., & Takahashi, K. (2015) A Computational Framework for Bioimaging Simulation. PLOS ONE, 10(7). DOI: 10.1371/journal.pone.0130089  

  • November 30, 1999
  • 12:00 AM

Impairment of neurogenesis in ZIKV infected neuronal cells: strain specific ? Asian/American v. African strains

by thelonevirologist in Virology Tidbits

During the current Zika Virus (ZIKV) outbreaks in the Americas, an increased number of cognitive malformations including but not limited to microcephaly in foetuses and neonates of mothers who had been infected with ZIKV during pregnancy, lead to the conclusion that ZIKV might be neuroteratogenic, a hypothesis that has been supported by findings that various ZIKV strains –including isolates from Asia such ZIKV SZ 01, ZIKV FSS13025 and H/PF/2013 as well as isolates from the Americas such a........ Read more »

Li H, Saucedo-Cuevas L, Shresta S, & Gleeson JG. (2016) The Neurobiology of Zika Virus. Neuron, 92(5), 949-958. PMID: 27930910  

van den Pol AN, Mao G, Yang Y, Ornaghi S, & Davis JN. (2017) Zika virus targeting in the developing brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. PMID: 28123079  

Li H, Saucedo-Cuevas L, Regla-Nava JA, Chai G, Sheets N, Tang W, Terskikh AV, Shresta S, & Gleeson JG. (2016) Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation. Cell stem cell, 19(5), 593-598. PMID: 27545505  

Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, Yao B, Shin J, Zhang F, Lee EM.... (2016) Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell stem cell, 18(5), 587-90. PMID: 26952870  

Garcez PP, Nascimento JM, de Vasconcelos JM, Madeiro da Costa R, Delvecchio R, Trindade P, Loiola EC, Higa LM, Cassoli JS, Vitória G.... (2017) Zika virus disrupts molecular fingerprinting of human neurospheres. Scientific reports, 40780. PMID: 28112162  

Gabriel, E., Ramani, A., Karow, U., Gottardo, M., Natarajan, K., Gooi, L., Goranci-Buzhala, G., Krut, O., Peters, F., Nikolic, M.... (2017) Recent Zika Virus Isolates Induce Premature Differentiation of Neural Progenitors in Human Brain Organoids. Cell Stem Cell. DOI: 10.1016/j.stem.2016.12.005  

Gromley A, Jurczyk A, Sillibourne J, Halilovic E, Mogensen M, Groisman I, Blomberg M, & Doxsey S. (2003) A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase. The Journal of cell biology, 161(3), 535-45. PMID: 12732615  

Meitinger F, Anzola JV, Kaulich M, Richardson A, Stender JD, Benner C, Glass CK, Dowdy SF, Desai A, Shiau AK.... (2016) 53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration. The Journal of cell biology, 214(2), 155-66. PMID: 27432897  

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