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  • July 5, 2015
  • 01:50 PM
  • 7 views

Discovery points to a new path toward a universal flu vaccine

by Dr. Jekyll in Lunatic Laboratories

Flu vaccines can be something of a shot in the dark. Not only must they be given yearly, there’s no guarantee the strains against which they protect will be the ones circulating once the season arrives. New research by Rockefeller University scientists suggests it may be possible to harness a previously unknown mechanism within the immune system to create more effective and efficient vaccines against this ever-mutating virus.... Read more »

Wang, T., Maamary, J., Tan, G., Bournazos, S., Davis, C., Krammer, F., Schlesinger, S., Palese, P., Ahmed, R., & Ravetch, J. (2015) Anti-HA Glycoforms Drive B Cell Affinity Selection and Determine Influenza Vaccine Efficacy. Cell, 162(1), 160-169. DOI: 10.1016/j.cell.2015.06.026  

  • July 4, 2015
  • 02:50 PM
  • 27 views

Evidence of Value of Orphan Drugs Inconsistent

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Igho Onakpoya MD MSc Clarendon Scholar University of Oxford Centre for Evidence-Based Medicine Nuffield Department of Primary Care Health Sciences Oxford UK MedicalResearch: What is the background for this study? What are the main findings? Dr. Onakpoya: Several … Continue reading →
The post Evidence of Value of Orphan Drugs Inconsistent appeared first on MedicalResearch.com Medical Research Interviews and News.
... Read more »

Igho Onakpoya MD MSc, & Clarendon Scholar. (2015) Evidence of Value of Orphan Drugs Inconsistent. medicalresearch.com. info:/

  • July 4, 2015
  • 02:26 PM
  • 30 views

Long-term memories are maintained by prion-like proteins

by Dr. Jekyll in Lunatic Laboratories

Research from Columbia University Medical Center (CUMC) has uncovered further evidence of a system in the brain that persistently maintains memories for long periods of time. And paradoxically, it works in the same way as mechanisms that cause mad cow disease, kuru, and other degenerative brain diseases.... Read more »

Fioriti, L., Myers, C., Huang, Y., Li, X., Stephan, J., Trifilieff, P., Colnaghi, L., Kosmidis, S., Drisaldi, B., Pavlopoulos, E.... (2015) The Persistence of Hippocampal-Based Memory Requires Protein Synthesis Mediated by the Prion-like Protein CPEB3. Neuron, 86(6), 1433-1448. DOI: 10.1016/j.neuron.2015.05.021  

Drisaldi, B., Colnaghi, L., Fioriti, L., Rao, N., Myers, C., Snyder, A., Metzger, D., Tarasoff, J., Konstantinov, E., Fraser, P.... (2015) SUMOylation Is an Inhibitory Constraint that Regulates the Prion-like Aggregation and Activity of CPEB3. Cell Reports, 11(11), 1694-1702. DOI: 10.1016/j.celrep.2015.04.061  

Stephan, J., Fioriti, L., Lamba, N., Colnaghi, L., Karl, K., Derkatch, I., & Kandel, E. (2015) The CPEB3 Protein Is a Functional Prion that Interacts with the Actin Cytoskeleton. Cell Reports, 11(11), 1772-1785. DOI: 10.1016/j.celrep.2015.04.060  

  • July 4, 2015
  • 05:19 AM
  • 31 views

A viral 'cause' of obesity?

by Paul Whiteley in Questioning Answers

I must thank Leah Hardy (@LeahFHardy) for bringing to my attention the paper by Qinglong Shang and colleagues [1] (open-access available here) reporting that: "Ad36 [Human adenovirus 36] infection is associated with an increased risk of obesity development."Based on a meta-analysis of the available research literature examining whether Ad-36 - "a nonenveloped icosahedral virus comprised of double-stranded DNA and is one of 56 serotypes in 7 subgroups of human adenoviruses" - might........ Read more »

  • July 3, 2015
  • 04:37 PM
  • 48 views

REM sleep critical for young brain development; medication interferes

by Dr. Jekyll in Lunatic Laboratories

Rapid eye movement or REM sleep actively converts waking experiences into lasting memories and abilities in young brains reports a new study. The finding broadens the understanding of children’s sleep needs and calls into question the increasing use of REM-disrupting medications such as stimulants and antidepressants.

... Read more »

Michelle C. Dumoulin Bridi, Sara J. Aton, Julie Seibt, Leslie Renouard, Tammi Coleman1, & Marcos G. Frank. (2015) Rapid eye movement sleep promotes cortical plasticity in the developing brain. Science Advances. info:/10.1126/sciadv.1500105

  • July 3, 2015
  • 04:05 PM
  • 36 views

Novel DNA repair mechanism brings new horizons

by Dr. Jekyll in Lunatic Laboratories

The DNA molecule is chemically unstable giving rise to DNA lesions of different nature. That is why DNA damage detection, signaling and repair, collectively known as the DNA damage response, are needed. A group of researchers discovered a new mechanism of DNA repair, which opens up new perspectives for the treatment and prevention of neurodegenerative diseases.... Read more »

Nikolay A. Pestov, Nadezhda S. Gerasimova, Olga I. Kulaeva, & Vasily M. Studitsky. (2015) Structure of transcribed chromatin is a sensor of DNA damage. Science Advances. info:/10.1126/sciadv.1500021

  • July 3, 2015
  • 11:45 AM
  • 25 views

Warming Climate May Not Reduce Winter Mortality

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Prof. Patrick L Kinney Ph.D. Professor of Environmental Health Sciences and Director, Columbia Climate and Health Program Mailman School of Public Health Columbia University, New York, NY Medical Research: What is the background for this study? Dr. Kinney: … Continue reading →
The post Warming Climate May Not Reduce Winter Mortality appeared first on MedicalResearch.com Medical Research Interviews and News.
... Read more »

Prof. Patrick L Kinney Ph.D., & Professor of Environmental Health Sciences. (2015) Warming Climate May Not Reduce Winter Mortality. MedicalResearch.com. info:/

  • July 3, 2015
  • 09:13 AM
  • 27 views

Diabetes Medication Reduced Weight and Improved Metabolic Parameters in Obese Patients

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Dr. F. Xavier Pi–Sunyer MD Division of Endocrinology and Obesity Research Center Columbia University, New York Medical Research: What is the background for this study? What are the main findings? Dr. Pi-Sunye: In a large randomized trial, … Continue reading →
The post Diabetes Medication Reduced Weight and Improved Metabolic Parameters in Obese Patients appeared first on MedicalResearch.com Medical Research Interviews and News.
... Read more »

Dr. F. Xavier Pi-Sunyer MD, & Division of Endocrinology and Obesity Research Center. (2015) Diabetes Medication Reduced Weight and Improved Metabolic Parameters in Obese Patients. MedicalResearch.com. info:/

  • July 3, 2015
  • 08:54 AM
  • 21 views

Low Testosterone Linked To Obesity and Depression In Men

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Michael S. Irwig MD Division of Endocrinology Medical Faculty Associates George Washington University Medical Research: What is the background for this study? What are the main findings? Response: Many factors are associated with lower testosterone levels and … Continue reading →
The post Low Testosterone Linked To Obesity and Depression In Men appeared first on MedicalResearch.com Medical Research Interviews and News.
... Read more »

Michael S. Irwig MD Division of Endocrinology Medical Faculty Associates. (2015) Low Testosterone Linked To Obesity and Depression In Men. MedicalResearch.com. info:/

  • July 3, 2015
  • 06:06 AM
  • 47 views

A new tissue-specific FLCN-deficient mouse model of renal tumourigenesis

by Danielle Stevenson in BHD Research Blog

Animal models can be useful for understanding disease pathology and as preclinical models for drug testing. As BHD patients develop renal cell carcinomas (RCCs) of varied histologies, associated with a loss of FLCN, BHD animal models could be used to study of a wide range of renal cancer subtypes. Current BHD mouse models include kidney-specific Flcn-knockouts (Chen et al., 2008, Baba et al., 2008) and ubiquitous knockouts (Hasumi et al., 2009, Hartman et al., 2009, Hudon et al., 2010). The form........ Read more »

Chen J, Huang D, Rubera I, Futami K, Wang P, Zickert P, Khoo SK, Dykema K, Zhao P, Petillo D.... (2015) Disruption of tubular Flcn expression as a mouse model for renal tumor induction. Kidney international. PMID: 26083655  

  • July 3, 2015
  • 06:02 AM
  • 69 views

5 Tips For Better Sleep

by Elisabeth Buhl Thubron in United Academics

Adding some ‘worry time’ to your day could work better than pills.... Read more »

  • July 3, 2015
  • 04:56 AM
  • 42 views

Vitamin D metabolic gene variants and risk for autism

by Paul Whiteley in Questioning Answers

I was really rather happy to see the "preliminary evidence" reported by Rebecca Schmidt and colleagues [1] when it came to examining whether selected vitamin D metabolic gene variants might show linkage to autism spectrum disorder (ASD) based on data derived from the CHARGE initiative.For quite a while now I've discussed the various peer-reviewed science on the topic of vitamin D deficiency / insufficiency with autism in mind on this blog (see here and see here for example). Specifically, h........ Read more »

Schmidt RJ, Hansen RL, Hartiala J, Allayee H, Sconberg JL, Schmidt LC, Volk HE, & Tassone F. (2015) Selected vitamin D metabolic gene variants and risk for autism spectrum disorder in the CHARGE Study. Early human development, 91(8), 483-489. PMID: 26073892  

  • July 2, 2015
  • 06:50 PM
  • 43 views

You are here: Home › Injury › Foot Strike Pattern and Injury Rates Foot Strike Pattern and Injury Rates

by Craig Payne in Running Research Junkie

You are here: Home › Injury › Foot Strike Pattern and Injury Rates
Foot Strike Pattern and Injury Rates... Read more »

  • July 2, 2015
  • 02:54 PM
  • 22 views

Study Compares Two Surgical Techniques To Relieve Migraine Headaches

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Dr. Bahman Guyuron MD Cleveland and Lyndhurst, Ohio From the Department of Plastic Surgery, University Hospital Case Medical Center; and the American Migraine Center Medical Research: What is the background for this study? Dr. Guyuron: Through several … Continue reading →
The post Study Compares Two Surgical Techniques To Relieve Migraine Headaches appeared first on MedicalResearch.com Medical Research Interviews and News.
... Read more »

Dr. Bahman Guyuron MD, & Cleveland and Lyndhurst. (2015) Study Compares Two Surgical Techniques To Relieve Migraine Headaches. MedicalResearch.com. info:/

  • July 2, 2015
  • 02:18 PM
  • 21 views

Biomarker Predicts Bladder Cancer Response To Treatment

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Chao Cheng, Ph.D. Assistant Professor Department of Genetics Institute for Quantitative Biomedical Sciences Geisel School of Medicine at Dartmouth Hanover NH, 03755 Medical Research: What is the background for this study? Dr. Cheng: Bladder cancer is a … Continue reading →
The post Biomarker Predicts Bladder Cancer Response To Treatment appeared first on MedicalResearch.com Medical Research Interviews and News.
... Read more »

Chao Cheng, Ph.D., & Assistant Professor. (2015) Biomarker Predicts Bladder Cancer Response To Treatment. MedicalResearch.com. info:/

  • July 2, 2015
  • 11:57 AM
  • 40 views

Digesting bread and pasta can release biologically active molecules

by Dr. Jekyll in Lunatic Laboratories

Biologically active molecules released by digesting bread and pasta can survive digestion and potentially pass through the gut lining, suggests new research. The study reveals the molecules released when real samples of bread and pasta are digested, providing new information for research into gluten sensitivity.... Read more »

  • July 2, 2015
  • 06:34 AM
  • 4 views

Tubal Ligation May Limit Spread Of Endometrial Cancer

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Ashley S. Felix, PhD Bethesda, MD MedicalResearch: What is the background for this study? What are the main findings? Dr. Felix: Endometrial cancer prognosis is strongly affected by disease stage, or the extent of spread from the … Continue reading →
The post Tubal Ligation May Limit Spread Of Endometrial Cancer appeared first on MedicalResearch.com Medical Research Interviews and News.
... Read more »

Ashley S. Felix, PhD, & Bethesda, MD. (2015) Tubal Ligation May Limit Spread Of Endometrial Cancer. MedicalResearch.com. info:/

  • July 2, 2015
  • 06:25 AM
  • 4 views

New Rapid Test For Ebola May Be Useful In High-Risk Populations

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Jana Broadhurst, MD, PhD Stanford University Nira R Pollock MD PhD Boston Children’s Hospital, Boston, MA Medical Research: What is the background for this study? What are the main findings? Response: At present, diagnosis of Ebola virus … Continue reading →
The post New Rapid Test For Ebola May Be Useful In High-Risk Populations appeared first on MedicalResearch.com Medical Research Interviews and News.
... Read more »

Jana Broadhurst, MD, PhD, University of California, San Francisco, Nira R Pollock MD PhD, & Boston Children's Hospital, Boston, MA. (2015) New Rapid Test For Ebola May Be Useful In High-Risk Populations. MedicalResearch.com. info:/

  • July 2, 2015
  • 02:34 AM
  • 49 views

Acute bipolar depression and immune alterations

by Paul Whiteley in Questioning Answers

"Individuals with acute bipolar depression show immune alterations. Some of the alterations are similar to those found in acute mania."That was the bottom line reported by Faith Dickerson and colleagues [1] following their analysis of blood samples provided by "82 individuals with acute bipolar depression, 147 with acute mania, and 280 controls." Looking for the presence of various antibodies to "human herpesviruses, gliadin, Toxoplasma gondii, and endogenous retroviruses as well as for C-reacti........ Read more »

Dickerson F, Katsafanas E, Schweinfurth LA, Savage CL, Stallings C, Origoni A, Khushalani S, Lillehoj E, & Yolken R. (2015) Immune alterations in acute bipolar depression. Acta psychiatrica Scandinavica. PMID: 26061032  

  • July 1, 2015
  • 11:59 PM
  • 46 views

Comparison of running injuries between shod and barefoot

by Craig Payne in Running Research Junkie

Comparison of running injuries between shod and barefoot ... Read more »

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