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  • April 24, 2014
  • 04:48 AM
  • 21 views

What You Need To Know About The New Ebola Outbreak

by Rebekah Morrow in United Academics

Recent outbreaks of Ebola virus in Guinea have made international news. Ebola virus was first identified in 1976 in the region that is now the Democratic Republic of the Congo in central Africa. The virus was named after the river near where it was found. Since 1976, there have been multiple outbreaks in central Africa, but this year is the first time that an outbreak has occurred as far west as Guinea and Sierra Leone.... Read more »

Groseth, A., Feldmann, H., & Strong, J. (2007) The ecology of Ebola virus. Trends in Microbiology, 15(9), 408-416. DOI: 10.1016/j.tim.2007.08.001  

Pettitt, J., Zeitlin, L., Kim, D., Working, C., Johnson, J., Bohorov, O., Bratcher, B., Hiatt, E., Hume, S., Johnson, A.... (2013) Therapeutic Intervention of Ebola Virus Infection in Rhesus Macaques with the MB-003 Monoclonal Antibody Cocktail. Science Translational Medicine, 5(199), 199-199. DOI: 10.1126/scitranslmed.3006608  

  • April 24, 2014
  • 04:35 AM
  • 22 views

As if you needed telling...

by Paul Whiteley in Questioning Answers

"GI [gastrointestinal] dysfunction was prevalent in this cohort of children with ASD [autism spectrum disorders], observations consistent with the reports of parents and other clinicians". That was one of the conclusions reached by Victor Kang and colleagues [1] in their study looking at GI issues in cases of autism.Of course we've been here before... many times in fact, as autism research delivers more evidence that bowel issues are quite frequently over-represented in cases of autism........ Read more »

Kang V, Wagner GC, & Ming X. (2014) Gastrointestinal Dysfunction in Children With Autism Spectrum Disorders. Autism research : official journal of the International Society for Autism Research. PMID: 24753336  

  • April 24, 2014
  • 12:29 AM
  • 21 views

Effect of Pose/Chi type running instruction on running economy

by Craig Payne in Running Research Junkie

Effect of Pose/Chi type running instruction on running economy... Read more »

Craighead D, Lehecka N, & King DL. (2014) A novel running mechanic's class changes kinematics but not running economy. Journal of strength and conditioning research / National Strength . PMID: 24736769  

  • April 23, 2014
  • 08:25 AM
  • 28 views

Chili Peppers Run Hot And Cold

by Mark Lasbury in As Many Exceptions As Rules

Hot peppers are hot because their capsaicin binds to the TRPV1 heat sensing ion channel. Agonists of TRPV1 can lead to a hypothermia, while antagonists result in a hyperthermia. Normally these would be poor outcomes, but there are particular instances that new researchs are showing to be beneficial. Brown adipose tissue is promoted by TRPV1 agonists, and studies are showing that capsaicin can hinder formation of white adipose tissue. Likewise, agonists of TRPV1 can induce a protective hypothermi........ Read more »

Yoneshiro T, Aita S, Matsushita M, Kayahara T, Kameya T, Kawai Y, Iwanaga T, & Saito M. (2013) Recruited brown adipose tissue as an antiobesity agent in humans. The Journal of clinical investigation, 123(8), 3404-8. PMID: 23867622  

Feng Z, Hai-Ning Y, Xiao-Man C, Zun-Chen W, Sheng-Rong S, & Das UN. (2014) Effect of yellow capsicum extract on proliferation and differentiation of 3T3-L1 preadipocytes. Nutrition (Burbank, Los Angeles County, Calif.), 30(3), 319-25. PMID: 24296036  

Muzzi M, Felici R, Cavone L, Gerace E, Minassi A, Appendino G, Moroni F, & Chiarugi A. (2012) Ischemic neuroprotection by TRPV1 receptor-induced hypothermia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 32(6), 978-82. PMID: 22434066  

  • April 23, 2014
  • 07:00 AM
  • 29 views

How ginseng works against flu

by Patricia Pedro in United Academics

Not that long ago, I heard about ginseng in my Plants’ Diversity class, but it was not given that much relevance. Soon after that, ginseng teas and supplements and a panoply of ginseng-made products appeared in the market. Then I finally realized I may not have given ginseng the importance it deserves.... Read more »

Lee JS, Hwang HS, Ko EJ, Lee YN, Kwon YM, Kim MC, & Kang SM. (2014) Immunomodulatory activity of red ginseng against influenza A virus infection. Nutrients, 6(2), 517-29. PMID: 24473234  

  • April 23, 2014
  • 04:25 AM
  • 33 views

Phenylalanine and schizophrenia: new directions for intervention?

by Paul Whiteley in Questioning Answers

As regular readers might already have noticed, amino acids are a bit of a obsession of mine on this blog. Out of all of them - and there are quite a few - I'm particularly interested in the aromatic amino acids and the their various connections to health and wellbeing. I've talked at length about some of the proposed connections made between amino acids such as tryptophan, tyrosine and phenylalanine to all manner of conditions but specifically with the autism spectrum in mind (see here).The conv........ Read more »

Olaoluwa Okusaga, Olesja Muravitskaja, Dietmar Fuchs, Ayesha Ashraf, Sarah Hinman, Ina Giegling, Annette M. Hartmann, Bettina Konte, Marion Friedl, Jason Schiffman.... (2014) Elevated Levels of Plasma Phenylalanine in Schizophrenia: A Guanosine Triphosphate Cyclohydrolase-1 Metabolic Pathway Abnormality?. PLoS ONE. DOI: 10.1371/journal.pone.0085945  

  • April 22, 2014
  • 02:56 PM
  • 32 views

Polar Opposites? The Social Construction of Bulimia and Anorexia Nervosa

by Andrea in Science of Eating Disorders


Some might argue that bulimia nervosa is more “hidden” than anorexia nervosa — it is not always obvious that someone is suffering from bulimia (though, I would argue, it is not always obvious that someone is suffering from any eating disorder). Even when it is “discovered,” BN is often placed in opposition with AN — as if the two were polar opposites.
Indeed, attempts to define a phenotype (a set of observable traits or characteristics) for AN and BN tend to oppose the ........ Read more »

  • April 22, 2014
  • 10:21 AM
  • 47 views

Religious Belief Linked to Brain Cortex Thickness

by William Yates, M.D. in Brain Posts

In a previous post, I reviewed a longitudinal study of religious belief and major depression.This study by Lisa Miller and colleagues found a reduced risk of depression in subjects who rated religious belief or spirituality as an important factor in their lives.Reduction in depression risk with religiosity/spirituality was largest (90% smaller risk) in those with a family history of depression.This correlation may not be causal and may be explained by some common third factor between religion an........ Read more »

  • April 21, 2014
  • 03:00 PM
  • 41 views

EASTER CHOCOLATE CRAVINGS: THE POWER OF POLYPHENOLS

by Alex Giffen in Antisense Science

The health benefits of chocolate explained this Easter... Read more »

Katz, D., Doughty, K., & Ali, A. (2011) Cocoa and Chocolate in Human Health and Disease. Antioxidants , 15(10), 2779-2811. DOI: 10.1089/ars.2010.3697  

Franco R, Oñatibia-Astibia A, & Martínez-Pinilla E. (2013) Health benefits of methylxanthines in cacao and chocolate. Nutrients, 5(10), 4159-73. PMID: 24145871  

Selmi C, Cocchi CA, Lanfredini M, Keen CL, & Gershwin ME. (2008) Chocolate at heart: the anti-inflammatory impact of cocoa flavanols. Molecular nutrition , 52(11), 1340-8. PMID: 18991246  

Ellam S, & Williamson G. (2013) Cocoa and human health. Annual review of nutrition, 105-28. PMID: 23642199  

  • April 21, 2014
  • 05:15 AM
  • 45 views

Lathosterolosis, cholesterol and autism?

by Paul Whiteley in Questioning Answers

Although intrigued by the findings reported by Pier Luigi Calvo and colleagues [1] describing a "unique case" potentially linking liver functions and cognitive functions with a hat-tip to the presentation of autistic behaviours, I'll readily admit that I am way out of my comfort and competence zones when discussing this paper so please be ready with that pinch of salt.How do you like your eggs in the morning? @ Wikipedia As per what the paper and accompanying press release (see he........ Read more »

Calvo, P., Brunati, A., Spada, M., Romagnoli, R., Corso, G., Parenti, G., Rossi, M., Baldi, M., Carbonaro, G., David, E.... (2014) Liver Transplantation in Defects of Cholesterol Biosynthesis: The Case of Lathosterolosis. American Journal of Transplantation. DOI: 10.1111/ajt.12645  

  • April 20, 2014
  • 03:34 PM
  • 102 views

420: How Marijuana Messes With the Brain

by Alexis Delanoir in How to Paint Your Panda

Cannabis use has previously been associated with cognitive impairment, and Smith et al. (2013) showed that heavy marijuana use was associated with poor working memory and brain abnormalities. Now, Gilman et al. (2014) propose that even casual use of marijuana is associated with such negative effects. Is this an issue of correlation/causation, of funding bias, or are the world's weed smokers really in neurological danger? In this post, in celebration of 4/20, I provide context for the recent........ Read more »

Meier, M., Caspi, A., Ambler, A., Harrington, H., Houts, R., Keefe, R., McDonald, K., Ward, A., Poulton, R., & Moffitt, T. (2012) Persistent cannabis users show neuropsychological decline from childhood to midlife. Proceedings of the National Academy of Sciences, 109(40). DOI: 10.1073/pnas.1206820109  

  • April 20, 2014
  • 06:03 AM
  • 159 views

The Mystery of “Quantum Resonance Spectroscopy”

by Neuroskeptic in Neuroskeptic_Discover

Can quantum physics help to diagnose schizophrenia and depression? A paper just published in the Journal of Nervous and Mental Disease claims that a technique called ‘quantum resonance spectroscopy’ (QRS) can accurately diagnose various mental health problems. But is it quantum wizardry or magic quackery? According to the authors of the new paper, Zhang et […]The post The Mystery of “Quantum Resonance Spectroscopy” appeared first on Neuroskeptic.... Read more »

Zhang Y, Liu F, Shi J, Yue X, Zhang H, Du X, Sun L, & Yuan J. (2014) Exploratory quantum resonance spectrometer as a discriminator for psychiatric affective disorders. The Journal of nervous and mental disease, 202(4), 287-91. PMID: 24647211  

  • April 19, 2014
  • 07:34 AM
  • 133 views

Typing Method for Cryptosporidium Meleagridis

by Christen Rune Stensvold in Christen Rune Stensvold

You can read about the development and use of a highly applicable typing method for C. meleagridis isolates in a newly published paper in Journal of Clinical Microbiology.... Read more »

  • April 19, 2014
  • 07:34 AM
  • 155 views

Typing Method for Cryptosporidium Meleagridis

by Christen Rune Stensvold in Blastocystis Parasite Blog

You can read about the development and use of a highly applicable typing method for C. meleagridis isolates in a newly published paper in Journal of Clinical Microbiology.... Read more »

  • April 19, 2014
  • 05:34 AM
  • 60 views

Dump fossil fuels for the health of our hearts

by Andy Extance in Simple Climate

Cleaning up air pollution will provide immediate health gains as well as longer-term climate benefits, highlights New York University's George Thurston... Read more »

Thurston, G. (2013) Mitigation policy: Health co-benefits. Nature Climate Change, 3(10), 863-864. DOI: 10.1038/nclimate2013  

Rice, M., Thurston, G., Balmes, J., & Pinkerton, K. (2014) Climate Change. A Global Threat to Cardiopulmonary Health. American Journal of Respiratory and Critical Care Medicine, 189(5), 512-519. DOI: 10.1164/rccm.201310-1924PP  

  • April 19, 2014
  • 12:46 AM
  • 61 views

Energy Expenditure (Calories Burned) in Anorexia Nervosa Patients

by Tetyana in Science of Eating Disorders


How many calories do patients with anorexia nervosa need to eat to gain a kilo (2.2 lbs)? It seems like a simple question and one that we should have figured out a long time ago, given the importance (err, necessity) of refeeding and weight restoration in recovery from anorexia nervosa.
Unfortunately, research in this area has often led to contradictory results (see Salisbury et al., 1995 and de Zwaan et al., 2002 for reviews). Fortunately, a paper by Stephan Zipfel and colleagues (2013,........ Read more »

Zipfel S, Mack I, Baur LA, Hebebrand J, Touyz S, Herzog W, Abraham S, Davies PS, & Russell J. (2013) Impact of exercise on energy metabolism in anorexia nervosa. Journal of Eating Disorders, 1(1), 37. PMID: 24499685  

  • April 18, 2014
  • 07:02 AM
  • 72 views

Hey, trial lawyers! The FDA is watching you!

by Doug Keene in The Jury Room

And they want you to stop abusing their Adverse Event Reporting System (FAERS). We’ve worked a number of cases recently where FDA warnings were used as evidence at trial and were very interested to see this article in the American Journal of Gastroenterology. And the answer to the skeptic’s question is “no”. No, we don’t […]

Related posts:
Should you ask your overweight female client to diet before trial?
Black? On trial in Florida? You don’t want an all-white jury!
Predic........ Read more »

Racine A, Cuerq A, Bijon A, Ricordeau P, Weill A, Allemand H, Chosidow O, Boutron-Ruault MC, & Carbonnel F. (2014) Isotretinoin and risk of inflammatory bowel disease: a French nationwide study. The American Journal of Gastroenterology, 109(4), 563-9. PMID: 24535094  

  • April 17, 2014
  • 07:49 AM
  • 99 views

Cannabis use and structural changes in the brain

by Robb Hollis in Antisense Science

“One or two spliffs a week could mess up your brain” – Metro, 16 April 2014

Spark your interest? This headline caught the eyes of the Antisense team, so we chased down the original article in the Journal of Neuroscience and took a closer look!

Cannabis is the most commonly used illegal drug in the US, and the ‘casual use’ culture surrounding marijuana is a subject of great debate and controversy, with arguments for drug legalisation making their way into our ........ Read more »

  • April 17, 2014
  • 04:31 AM
  • 55 views

Mitochondrial dysfunction as a neurobiological subtype of autism

by Paul Whiteley in Questioning Answers

The paper by Suzanne Goh and colleagues [1] reporting on "a possible neurobiological subtype of mitochondrial dysfunction in ASD [autism spectrum disorder]" is a worthy addition to the research roll call which has graced this blog down the years. Based on the analysis of brain lactate levels - a potential marker of mitochondrial dysfunction - via the analysis of lactate doublets on brain magnetic resonance spectroscopic imaging (MRSI), authors picked up a significantly higher rate of l........ Read more »

  • April 16, 2014
  • 02:00 PM
  • 37 views

Glucosidase I: Could targeting N-linked glycosylation of proteins help us fight viral infection?

by Amy Swanston in Antisense Science

Viruses are sneaky. As you probably already know from your last bout with the common cold or the flu, for most viral infections doctors will simply prescribe plenty of water and bed rest. But what if we could stop the virus from replicating, or block it from entering the host cells in the first place?
Recent research on two siblings with a rare mutation in a key glycosylation enzyme (alpha-glucosidase I) sparked our interest as these children were found to be resistant to a number of bacteria........ Read more »

Sadat, M., Moir, S., Chun, T., Lusso, P., Kaplan, G., Wolfe, L., Memoli, M., He, M., Vega, H., Kim, L.... (2014) Glycosylation, Hypogammaglobulinemia, and Resistance to Viral Infections. New England Journal of Medicine, 2147483647. DOI: 10.1056/NEJMoa1302846  

Herscovics, A. (1999) Importance of glycosidases in mammalian glycoprotein biosynthesis. Biochimica et Biophysica Acta (BBA) - General Subjects, 1473(1), 96-107. DOI: 10.1016/S0304-4165(99)00171-3  

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