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  • September 4, 2015
  • 02:28 PM
  • 14 views

Common antidepressant may change brain

by Dr. Jekyll in Lunatic Laboratories

A commonly prescribed antidepressant may alter brain structures in depressed and non-depressed individuals in very different ways, according to new research. The study – conducted in nonhuman primates with brain structures and functions similar to those of humans – found that the antidepressant sertraline, a selective serotonin reuptake inhibitor (SSRI) marketed as Zoloft, significantly increased the volume of one brain region in depressed subjects but decreased the volume of two brain areas........ Read more »

Willard, S., Uberseder, B., Clark, A., Daunais, J., Johnston, W., Neely, D., Massey, A., Williamson, J., Kraft, R., Bourland, J.... (2015) Long term sertraline effects on neural structures in depressed and nondepressed adult female nonhuman primates. Neuropharmacology, 369-378. DOI: 10.1016/j.neuropharm.2015.06.011  

  • September 4, 2015
  • 06:08 AM
  • 21 views

Everolimus for the treatment of lymphangioleiomyomatosis

by Danielle Stevenson in BHD Research Blog

mTOR is dysregulated in a range of tumour types and can be targeted with mTOR inhibitor treatments such as everolimus and sirolimus. Tuberous sclerosis complex (TSC) and sporadic lymphangioleiomyamatosis (LAM) result from mutations in TSC1 or TSC2 that disrupt mTOR signalling (Carsillo et al., 2000, Glasgow et al., 2010). The associated aberrant cell growth, survival and movement results in the formation of slow growing tumours in various tissues and pulmonary cyst formation with loss of pulmona........ Read more »

Goldberg HJ, Harari S, Cottin V, Rosas IO, Peters E, Biswal S, Cheng Y, Khindri S, Kovarik JM, Ma S.... (2015) Everolimus for the treatment of lymphangioleiomyomatosis: a phase II study. The European respiratory journal, 46(3), 783-94. PMID: 26113676  

  • September 4, 2015
  • 05:00 AM
  • 25 views

Brain glutathione and "ASD in intellectually able adult men"

by Paul Whiteley in Questioning Answers

A quote to start:"[1H]MRS [proton magnetic resonance spectroscopy] measures of cortical and subcortical GSH [glutathione] are not a biomarker for ASD [autism spectrum disorder] in intellectually able adult men."So said the study published by Alice Durieux and colleagues [1] (open-access available here) based on the measurement of "GSH concentrations in the basal ganglia (BG) and the dorsomedial prefrontal cortex of 21 normally intelligent adult males with ASD and 29........ Read more »

Durieux AM, Horder J, Mendez MA, Egerton A, Williams SC, Wilson CE, Spain D, Murphy C, Robertson D, Barker GJ.... (2015) Cortical and subcortical glutathione levels in adults with autism spectrum disorder. Autism research : official journal of the International Society for Autism Research. PMID: 26290215  

  • September 3, 2015
  • 05:38 PM
  • 18 views

Wild Blueberry Polyphenols May Help Fight Periodontal Disease

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Daniel Grenier, Ph.D. Professeur titulaire Oral Ecology Research Group, Faculty of Dentistry, and  Institute of Nutrition and Functional Foods, Université Laval Quebec City, QC, Canada Medical Research: What is the background for this study? Dr. Grenier: Periodontal … Continue reading →
The post Wild Blueberry Polyphenols May Help Fight Periodontal Disease appeared first on MedicalResearch.com Medical Research Studies with Interviews and News.
... Read more »

Daniel Grenier, Ph.D. (2015) Wild Blueberry Polyphenols May Help Fight Periodontal Disease . MedicalResearch.com. info:/

  • September 3, 2015
  • 04:16 PM
  • 19 views

Microscopic Regression in Thin Melanoma May Be Good Prognostic Sign

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Simone Ribero,  M.D., Ph.D.  University of Turin Department of Medical Sciences Turin Italy and King’s College London Department of Twin Research and Genetic Epidemiology St Thomas’ campus London, UK Medical Research: What is the background for this study? … Continue reading →
The post Microscopic Regression in Thin Melanoma May Be Good Prognostic Sign appeared first on MedicalResearch.com Medical Research Studies with Interviews and News.
... Read more »

Simone Ribero, M.D., Ph.D. (2015) Microscopic Regression in Thin Melanoma May Be Good Prognostic Sign. MedicalResearch.com. info:/

  • September 3, 2015
  • 02:23 PM
  • 33 views

Neurons In Brain Most Affected by Alcohol Identified

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Dr. Jun Wang MD PhD, Assistant Professor Department of Neuroscience and Experimental Therapeutics Interdisciplinary Program in Neuroscience Texas A&M College of Medicine Medical Research: What is the background for this study? Dr. Wang: Alcohol use disorder is … Continue reading →
The post Neurons In Brain Most Affected by Alcohol Identified appeared first on MedicalResearch.com Medical Research Studies with Interviews and News.
... Read more »

Dr. Jun Wang MD PhD, Assistant Professor. (2015) Neurons In Brain Most Affected by Alcohol Identified. MedicalResearch.com. info:/

  • September 3, 2015
  • 02:08 PM
  • 15 views

Protein Keratin Promotes Cancer Growth and Chemotherapy Resistance

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Kenneth R. Shroyer, MD, PhD The Marvin Kuschner Professor and Chair Department of Pathology Stony Brook Medicine Stony Brook, NY     Medical Research: What is the background for this study? What are the main findings? Dr. … Continue reading →
The post Protein Keratin Promotes Cancer Growth and Chemotherapy Resistance appeared first on MedicalResearch.com Medical Research Studies with Interviews and News.
... Read more »

Kenneth R. Shroyer, MD, PhD. (2015) Protein Keratin Promotes Cancer Growth and Chemotherapy Resistance. MedicalResearch.com. info:/

  • September 3, 2015
  • 02:06 PM
  • 35 views

Do antipsychotic medications affect cortical thinning?

by Dr. Jekyll in Lunatic Laboratories

People diagnosed with schizophrenia critically rely upon treatment with antipsychotic medications to manage their symptoms and help them function at home and in the workplace. But despite their benefits, antipsychotic medications might also have some negative effects on brain structure or function when taken for long periods of time.... Read more »

  • September 3, 2015
  • 01:52 PM
  • 19 views

Melatonin Did Not Improve Fatigue in Cancer Patients

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Charlotte Lund Rasmussen Research Unit, Department of Palliative Medicine Bispebjerg Hospital, Copenhagen, Denmark Medical Research: What is the background for this study? What are the main findings? Response: We see that patients with advanced cancer often suffer … Continue reading →
The post Melatonin Did Not Improve Fatigue in Cancer Patients appeared first on MedicalResearch.com Medical Research Studies with Interviews and News.
... Read more »

Charlotte Lund Rasmussen. (2015) Melatonin Did Not Improve Fatigue in Cancer Patients. MedicalResearch.com. info:/

  • September 3, 2015
  • 12:04 PM
  • 17 views

Telemedicine May Help Patients Adopt Healthy Lifestyle and Manage Chronic Diseases

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Dr. Rashid Bashshur PhD Director of Telemedicine University of Michigan Health System Emeritus Professor of Health Management and Policy University of Michigan, School of Public Health  Medical Research: What is the background for this study? What are … Continue reading →
The post Telemedicine May Help Patients Adopt Healthy Lifestyle and Manage Chronic Diseases appeared first on MedicalResearch.com Medical Research Studies with Interviews and New........ Read more »

Dr. Rashid Bashshur PhD. (2015) Telemedicine May Help Patients Adopt Healthy Lifestyle and Manage Chronic Diseases. MedicalResearch.com. info:/

  • September 3, 2015
  • 11:20 AM
  • 21 views

Healthy Diet Not Cure-All For Depression

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Dr. Mila Kingsbury PhD Senior Research Associate at Department of Epidemiology and Community Medicine University of Ottawa   Medical Research: What is the background for this study? Dr. Kingsbury: Eating a healthy diet, including enough fruits and … Continue reading →
The post Healthy Diet Not Cure-All For Depression appeared first on MedicalResearch.com Medical Research Studies with Interviews and News.
... Read more »

Dr. Mila Kingsbury PhD. (2015) Healthy Diet Not Cure-All For Depression. MedicalResearch.com. info:/

  • September 3, 2015
  • 04:34 AM
  • 43 views

What will happen to my child when I'm gone?

by Paul Whiteley in Questioning Answers

From time to time I cover some uncomfortable topics on this blog as a function of what hand the autism research cards deal. Today is another one of those times as I bring to your attention the paper by Cathy Cox and colleagues [1] and their analysis of death concerns and psychological wellbeing in mothers of children diagnosed with an autism spectrum disorder (ASD).What they observed based on completion of a "fear of death scale" and "measures of death-thought accessibility, positive and negativ........ Read more »

  • September 2, 2015
  • 03:23 PM
  • 18 views

“Happy Meal” Law Would Decrease Fat, Sugar, Salt and Calories in Kids’ Meals

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Brian D. Elbel, PhD, MPH Associate professor, Departments of Population Health, Division of Health and Behavior and Medicine, Division of General Internal Medicine Marie Bragg, PhD Assistant professorDepartment of Population Health Jonathan Cantor, MS Department of Population … Continue reading →
The post “Happy Meal” Law Would Decrease Fat, Sugar, Salt and Calories in Kids’ Meals appeared first on MedicalResearch.com Medical Rese........ Read more »

MedicalResearch.com Interview. (2015) "Happy Meal" Law Would Decrease Fat, Sugar, Salt and Calories in Kids' Meals. MedicalResearch.com. info:/

  • September 2, 2015
  • 01:00 PM
  • 16 views

Poor Patients Receiving Care Through Ryan White Programs Achieve Better HIV Control

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Dr. John Weiser MD MPH Medical epidemiologist Division of HIV/AIDS Prevention CDC  Medical Research: What is the background for this study? What are the main findings? Dr. Weiser: Ryan White was an Indiana teenager diagnosed with AIDS … Continue reading →
The post Poor Patients Receiving Care Through Ryan White Programs Achieve Better HIV Control appeared first on MedicalResearch.com Medical Research Studies with Interviews and News.
... Read more »

Dr. John Weiser MD MPH. (2015) Poor Patients Receiving Care Through Ryan White Programs Achieve Better HIV Control. MedicalResearch.com. info:/

  • September 2, 2015
  • 12:48 PM
  • 45 views

Managing Fatigue in Match-Play Tennis

by William Yates, M.D. in Brain Posts

The 2015 U.S. Tennis Open is in full swing and I ran into an interesting recent manuscript summarizing fatigue in tennis.Fatigue has multiple elements including changes in muscle performance, blood markers of lactic acid and other compounds as well as brain central perception factors.Long multi-set matches can last four or five hours. Obviously, at the end of this type of exertion, players have had to adjust to effects of significant fatigue.Reid and Duffield review the key elements of fatigue i........ Read more »

Reid M, & Duffield R. (2014) The development of fatigue during match-play tennis. British journal of sports medicine. PMID: 24668384  

  • September 2, 2015
  • 12:20 PM
  • 14 views

Distance From Hospital Linked To Worse 30-Day Cardiac Surgery Outcomes

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Dr. Ansar Hassan MD PhD Department of Cardiac Surgery New Brunswick Heart Centre Saint John Regional Hospital Saint John, New Brunswick Medical Research: What is the background for this study? What are the main findings? Dr. Hassan: … Continue reading →
The post Distance From Hospital Linked To Worse 30-Day Cardiac Surgery Outcomes appeared first on MedicalResearch.com Medical Research Studies with Interviews and News.
... Read more »

MedicalResearch.com Interview with:, & Dr. Ansar Hassan MD PhD. (2015) Distance From Hospital Linked To Worse 30-Day Cardiac Surgery Outcomes. MedicalResearch.com. info:/

  • September 2, 2015
  • 09:50 AM
  • 5 views

Gene Variant May Explain Why Some Children Respond More Aggressively To Stress

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Beate W. Hygen PhD Student Department of Psychology Norwegian University of Science and Technology Social Science Medical Research: What is the background for this study? Response: The study is part of the Trondheim Early Secure Study (TESS) conducted … Continue reading →
The post Gene Variant May Explain Why Some Children Respond More Aggressively To Stress appeared first on MedicalResearch.com Medical Research Studies with Interviews and News.
... Read more »

MedicalResearch.com Interview with:, & Sameek Roychowdhury, MD, PhD. (2015) Gene Variant May Explain Why Some Children Respond More Aggressively To Stress. MedicalResearch.com. info:/

  • September 2, 2015
  • 09:30 AM
  • 4 views

Cancer Driver Log Facilitates Precision Medicine, Linking Providers With Genetic Data Bank

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Sameek Roychowdhury, MD, PhD Assistant Professor, Internal Medicine, College of Medicine Assistant Professor, Department of Pharmacology College of Pharmacy Department of Internal Medicine Division of Medical Oncology Wexner Medical Center The Ohio State University Medical Research: What … Continue reading →
The post Cancer Driver Log Facilitates Precision Medicine, Linking Providers With Genetic Data Bank appeared first on MedicalResearch.com Medi........ Read more »

Sameek Roychowdhury, MD, PhD. (2015) Cancer Driver Log Facilitates Precision Medicine, Linking Providers With Genetic Data Bank . MedicalResearch.com. info:/

  • September 2, 2015
  • 08:15 AM
  • 45 views

Don’t Disrespect The Dizygotic

by Mark Lasbury in As Many Exceptions As Rules

Spies try to look boring, but in reality they are much more interesting than the average Joe. So it is with dizygotic twins; monozygotic twins (“identical”) get all the glory, but they’re just a split egg, any female can do it. But dizygotic twins – certain families have more, Nigerian women have more, older women have more, taller women and overweight women have more. Now there’s something that looks boring but must be interesting.... Read more »

Simpson, C., Robertson, D., Al-Musawi, S., Heath, D., McNatty, K., Ritter, L., Mottershead, D., Gilchrist, R., Harrison, C., & Stanton, P. (2014) Aberrant GDF9 Expression and Activation Are Associated With Common Human Ovarian Disorders. The Journal of Clinical Endocrinology , 99(4). DOI: 10.1210/jc.2013-3949  

Palmer, J., Zhao, Z., Hoekstra, C., Hayward, N., Webb, P., Whiteman, D., Martin, N., Boomsma, D., Duffy, D., & Montgomery, G. (2006) Novel Variants in Growth Differentiation Factor 9 in Mothers of Dizygotic Twins. The Journal of Clinical Endocrinology , 91(11), 4713-4716. DOI: 10.1210/jc.2006-0970  

Hoekstra, C., Willemsen, G., van Beijsterveldt, C., Lambalk, C., Montgomery, G., & Boomsma, D. (2010) Body composition, smoking, and spontaneous dizygotic twinning. Fertility and Sterility, 93(3), 885-893. DOI: 10.1016/j.fertnstert.2008.10.012  

Groeneveld, E., Lambers, M., Stakelbeek, M., Mooij, T., van den Belt-Dusebout, A., Heymans, M., Schats, R., Hompes, P., Hoek, A., Burger, C.... (2012) Factors associated with dizygotic twinning after IVF treatment with double embryo transfer. Human Reproduction, 27(10), 2966-2970. DOI: 10.1093/humrep/des258  

  • September 2, 2015
  • 07:31 AM
  • 5 views

Serious Injuries Rise As Older Age Groups Takes Up Cycling

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Benjamin N. Breyer MD, MAS, FACS Associate Professor in Residence Department of Urology University of California, San Francisco Chief of Urology, San Francisco General Hospital Director, UCSF Male Genitourinary Reconstruction and Trauma Surgery Fellowship   Medical Research: What … Continue reading →
The post Serious Injuries Rise As Older Age Groups Takes Up Cycling appeared first on MedicalResearch.com Medical Research Studies with Intervie........ Read more »

MedicalResearch.com Interview with:, & Benjamin N. Breyer MD, MAS, FACS. (2015) Serious Injuries Rise As Older Age Group Takes Up Cycling. MedicalResearch.com. info:/

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