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  • July 31, 2014
  • 04:18 AM
  • 9 views

Dipeptidyl peptidase (DPP) IV and autism: supporting opioid-excess?

by Paul Whiteley in Questioning Answers

Serum levels of dipeptidyl peptidase (DPP) IV were found to be lower in children with autism compared to asymptomatic controls according to the study by Shahid Bashira & Laila AL-Ayadhi [1]. Based on analysis by ELISA, researchers concluded that "alterations in the plasma level of DPP IV play a role in the pathophysiology of autism".A sailor went to sea, sea, sea... @ Wikipedia Anyone who has followed the autism research scene for any length of time might have already heard ab........ Read more »

  • July 30, 2014
  • 04:00 PM
  • 5 views

SCIENCE IN THE NEWS: THE 2014 EBOLA OUTBREAK

by Emily Lawson in Antisense Science

If you’ve been watching the news recently, you’ll probably have seen reports on the Ebola outbreak in West Africa. Around 673 people in Guinea and Liberia have died so far (including one case of a Liberian government employee who died shortly after arriving at Lagos airport in Nigeria), making this the most deadly outbreak to date. So what exactly is Ebola, and why is it so deadly?

Ebola virus disease (EVD) has an incredibly high mortality rate – while the current outbreak h........ Read more »

Dixon MG, Schafer IJ, & EIS officer, CDC. (2014) Ebola viral disease outbreak - west Africa, 2014. MMWR. Morbidity and mortality weekly report, 63(25), 548-51. PMID: 24964881  

Gatherer, D. (2014) The 2014 Ebola virus disease outbreak in West Africa. Journal of General Virology, 95(Pt_8), 1619-1624. DOI: 10.1099/vir.0.067199-0  

  • July 30, 2014
  • 01:31 PM
  • 31 views

Suicide, it might be in the blood

by Gabriel in Lunatic Laboratories

I tried to kill myself, more than once in fact. It was a troubling time for me and as a former active duty Marine that might not be too surprising […]... Read more »

  • July 30, 2014
  • 11:24 AM
  • 20 views

Violent Death Rates Increased After Traumatic Brain Injury

by William Yates, M.D. in Brain Posts

Anecdotal reports have linked traumatic brain injury with later violent death including death by suicide.Few large epidemiological studies have been published on this association.However, a recent Swedish population study published in JAMA Psychiatry provides valuable insight into this issue.Seena Fazel and colleagues from the University of Oxford, University College London and the Karolinksa Institute examined a large database of over 200,000 patients with TBI.Cases of TBI were identified from ........ Read more »

  • July 30, 2014
  • 10:46 AM
  • 32 views

Influenza: How the Great War helped create the greatest pandemic the world has ever known | @GrrlScientist

by GrrlScientist in GrrlScientist

The Great War helped create the influenza pandemic of 1918, which eventually brought an early end to the Great War. Continue reading...... Read more »

  • July 30, 2014
  • 09:41 AM
  • 21 views

Video Tip of the Week: PhenDisco, “phenotype discoverer” for dbGap data

by Mary in OpenHelix

The dbGaP, database of Genotypes and Phenotypes, repository at NCBI collects information from research projects that link genotype and phenotype information and human variation, across many different types of studies, providing leads on variation that may be important to understand clinical issues. Some of the data is publicly available de-identified patient information, and some of the […]... Read more »

Doan Son, Lin Ko-Wei, Conway Mike, Ohno-Machado Lucila, Hsieh Alex, Feupe Stephanie Feudjio, Garland Asher, Ross Mindy K, Jiang Xiaoqian, & Farzaneh Seena. (2013) PhenDisco: phenotype discovery system for the database of genotypes and phenotypes. Journal of the American Medical Informatics Association : JAMIA. PMID: 23989082  

Tryka K. A., A. Sturcke, Y. Jin, Z. Y. Wang, L. Ziyabari, M. Lee, N. Popova, N. Sharopova, M. Kimura, & M. Feolo. (2013) NCBI's Database of Genotypes and Phenotypes: dbGaP. Nucleic Acids Research, 42(D1). DOI: http://dx.doi.org/10.1093/nar/gkt1211  

  • July 30, 2014
  • 08:10 AM
  • 92 views

Does Life Come In XXXS?

by Mark Lasbury in As Many Exceptions As Rules

Is there a minimum size for life? How would you measure it, cell volume or genome size? People do both. The current minimum example of life is Mycoplasma genitalium, at just 200 nm by 600 nm in well-fed cultures. M. genitalium also has the smallest known genome for a free-living organism (520 genes, we have about 27,000). Some organisms have fewer genes (137 or so) but are endosymbionts, so they can get away with trashing some of their DNA. New research shows that M. genitalium is a pathogenic o........ Read more »

Manhart LE. (2013) Mycoplasma genitalium: An emergent sexually transmitted disease?. Infectious disease clinics of North America, 27(4), 779-92. PMID: 24275270  

Gibson DG, Glass JI, Lartigue C, Noskov VN, Chuang RY, Algire MA, Benders GA, Montague MG, Ma L, Moodie MM.... (2010) Creation of a bacterial cell controlled by a chemically synthesized genome. Science (New York, N.Y.), 329(5987), 52-6. PMID: 20488990  

  • July 30, 2014
  • 04:52 AM
  • 25 views

Immunological effects from risperidone treatment in autism

by Paul Whiteley in Questioning Answers

The findings from Jai Eun Choi and colleagues [1] suggesting that use of the antipsychotic risperidone may impact on levels of certain cytokines - messenger cells of the immune system - in some cases of autism spectrum disorder (ASD) grabbed my attention recently. I've always been pretty interested in the complexity of the immune system when it comes to something like autism (see here) as well as the various examples of how many of the medications used to 'manage' aspects of autis........ Read more »

Choi JE, Widjaja F, Careaga M, Bent S, Ashwood P, & Hendren RL. (2014) Change in Plasma Cytokine Levels During Risperidone Treatment in Children with Autism. Journal of child and adolescent psychopharmacology. PMID: 24828014  

  • July 30, 2014
  • 12:05 AM
  • 18 views

The Devil Is In The Details…If You Can Get The Details Out

by Kyle Harris in Sports Medicine Research (SMR): In the Lab & In the Field

Over 75% of surveyed collegiate athletes, who believed they sustained a concussion in the past year, reported not seeking proper medical attention for that concussion. The most common reason athletes reported not seeking proper medical attention was not believing the concussion was severe enough to warrant stopping the activity to seek out a medical professional.... Read more »

  • July 29, 2014
  • 07:01 PM
  • 6 views

Gabapentin and pregabalin misuse

by DJMac in Recovery Review

  Gabapentin and pregabalin misuse are problems that are not going to go away. My post on gabapentin is one of the most-read on this site. While these are useful medicines, workers in drug treatment and support see patients regularly on gabapentin or pregabalin who have misused the drugs or who are misusing them. Guidance is [...]
The post Gabapentin and pregabalin misuse appeared first on Recovery Review.
... Read more »

  • July 29, 2014
  • 01:15 PM
  • 46 views

Can’t Handle the Stress? Blame your Brain

by Gabriel in Lunatic Laboratories

Do you rise to the occasion, or do you fold under the pressure? No matter which side of the fence you’re, you can thank [or blame] your brain. Some people […]... Read more »

  • July 29, 2014
  • 11:17 AM
  • 30 views

Treating Sleep Problems Following Traumatic Brain Injury

by William Yates, M.D. in Brain Posts

Sleep problems are common following traumatic brain injury (TBI).In a previous post, I reviewed a study of the risk factors for sleep disorders following TBI.The most severe TBI is a risk factor for hypersomnia. Anxiety and depression following TBI increase risk for insomnia complaints.Few large studies of treatment for sleep problems after TBI exist. However, a recent manuscript outlined the potential benefit of treatment of sleep disorders in a series of 12 subjects.Catherine Wiseman-Hake........ Read more »

  • July 29, 2014
  • 10:37 AM
  • 24 views

STING-associated autoinflammatory disease

by Aurelie in The Immuno Blog

A study published in the New England Journal of Medicine describes an autoinflammatory syndrome associated with mutations in the gene encoding STING. Dubbed SAVI, for STING-associated vasculopathy with onset in infancy, the disease is characterized by systemic inflammation, severe cutaneous … Continue reading →... Read more »

Liu, Y., Jesus, A., Marrero, B., Yang, D., Ramsey, S., Sanchez, G., Tenbrock, K., Wittkowski, H., Jones, O., Kuehn, H.... (2014) Activated STING in a Vascular and Pulmonary Syndrome. New England Journal of Medicine, 2147483647. DOI: 10.1056/NEJMoa1312625  

  • July 29, 2014
  • 04:04 AM
  • 37 views

Ketogenic diet and the valproate mouse model of autism

by Paul Whiteley in Questioning Answers

A brief entry today and yet another blog post that starts with a quote (sorry)... "The offspring exposed to VPA [valproic acid] prenatally demonstrated a significant decrease in the number of play initiations/attacks and this was reversed with the KD [ketogenic diet]".Gloucester Old Spot @ Wikipedia That finding reported in the paper by Ahn and colleagues [1] continues my interest in all-things related to prenatal VPA exposure and the reported effects on some offspring (........ Read more »

  • July 28, 2014
  • 07:55 PM
  • 49 views

Attention Deficit Hyperactivity Disorder & Eating Disorders: Is There a Link?

by Tetyana in Science of Eating Disorders


Attention deficit hyperactivity disorder (ADHD), characterized by inattention, hyperactivity, and impulsivity, is a common childhood disorder. ADHD can often persist into adolescence and adulthood. The prevalence of ADHD is thought to be between 6-7% among children and adolescents and ~5% among adults (Willcutt, 2012).
Increasingly, evidence from multiple studies has pointed to comorbidity between ADHD and eating disorders (EDs). For example, one study found that young females with ADHD we........ Read more »

  • July 28, 2014
  • 03:10 PM
  • 121 views

This Month In Blastocystis Research (JUL 2014)

by Christen Rune Stensvold in Blastocystis Parasite Blog

A new study from Colombia sees Blastocystis as a quasi-ubiquitous organism.... Read more »

  • July 28, 2014
  • 01:13 PM
  • 47 views

A New Hepatitis C Treatment offers Hope

by Gabriel in Lunatic Laboratories

Well this might seem weird, but today is world hepatitis day. I guess I should qualify weird with the fact that it’s only weird because no one really knows. What […]... Read more »

  • July 28, 2014
  • 09:14 AM
  • 50 views

Glasses-Free Computers

by Viputheshwar Sitaraman in Draw Science

Looking at computers with eyeglasses strains your eyes, so scientists are making computers that help your eyes out.... Read more »

Huang, F., Wetzstein, G., Barsky, B., & Raskar, R. (2014) Eyeglasses-free display. ACM Transactions on Graphics, 33(4), 1-12. DOI: 10.1145/2601097.2601122  

  • July 28, 2014
  • 04:24 AM
  • 80 views

Prenatal and neonatal blood mercury levels and autism

by Paul Whiteley in Questioning Answers

Acknowledging that some topics have the ability to furrow brows when it comes to autism research, mercury and autism is becoming something of a frequent talking point on this blog as a function of a whole slew of articles appearing in the peer-reviewed domain. If I were to [very tentatively] summarise the collected literature so far, it would be to say something like:Mosaic of mercury @ Wikipedia (i) there is quite a bit more research to be done on some sources of mercury being 'l........ Read more »

Yau VM, Green PG, Alaimo CP, Yoshida CK, Lutsky M, Windham GC, Delorenze G, Kharrazi M, Grether JK, & Croen LA. (2014) Prenatal and neonatal peripheral blood mercury levels and autism spectrum disorders. Environmental research, 294-303. PMID: 24981828  

  • July 26, 2014
  • 01:18 PM
  • 126 views

Save the Neurons: Fighting the Effects of Parkinsons

by Gabriel in Lunatic Laboratories

Possibly one of the most famous cases of parkinson’s is Michael J. Fox. More than just the “shakes” parkinson’s can cause a whole host of other problems mentally and physically […]... Read more »

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