Post List

Medicine posts

(Modify Search »)

  • November 30, 1999
  • 12:00 AM
  • 3,214 views

Nicotine and the Humphrey Bogart Gene

by Dirk Hanson in Addiction Inbox

You can lead a fish to water, but can you make it smoke?

... Read more »

Petzold AM, Balciunas D, Sivasubbu S, Clark KJ, Bedell VM, Westcot SE, Myers SR, Moulder GL, Thomas MJ, & Ekker SC. (2009) Nicotine response genetics in the zebrafish. Proceedings of the National Academy of Sciences of the United States of America, 106(44), 18662-7. PMID: 19858493  

  • November 30, 1999
  • 12:00 AM
  • 2,606 views

New GPCR structure: CXCR4 Chemokine Receptor (HIV and cancer target)

by Peter Nollert in Protein Crystallization Blog

Congratulations to Ray Stevens and team to determining and publishing the crystallographic structure of the CXCR4 Chemokine receptor in Science. The diffenent binding areas for the small molecule and peptide antagonist are nicely resolved and show extensive interactions with binding pocket residues in the 2.5 – 3.1 A crystal structures.... Read more »

Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC.... (2010) Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science (New York, N.Y.), 330(6007), 1066-71. PMID: 20929726  

  • November 30, 1999
  • 12:00 AM
  • 2,344 views

New GPCR structure: CXCR4 Chemokine Receptor (HIV and cancer target)

by Peter Nollert in Emerald BioStructures Blog

Congratulations to Ray Stevens and team to determining and publishing the crystallographic structure of the CXCR4 Chemokine receptor in Science. The diffenent binding areas for the small molecule and peptide antagonist are nicely resolved and show extensive interactions with binding pocket residues in the 2.5 – 3.1 A crystal structures... Read more »

Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC.... (2010) Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science (New York, N.Y.), 330(6007), 1066-71. PMID: 20929726  

  • November 30, 1999
  • 12:00 AM
  • 2,403 views

genetically engineered stem cell treatment, gen therapy for HIV virus infection, AIDS.

by B V Waghmare in HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets

Scientists have collected stem cells from patients own body , and engineered them , and induced in to them gens which expresses three RNA-based anti-HIV moieties as follows .
1.tat/rev short hairpin RNA,
2.TAR decoy,
3.CCR5 ribozyme.
Amongst these anti HIV moieties CCR5 ribozyme is capable of hampering production of CCR5 protein a essential protein which is responsible for HIV virus entry in to new host cell , there it can lower a viral load , in to patient and help anti retroviral drugs t........ Read more »

B V Waghmare. (2010) Information on genetically engineered stem cell treatment, gen therapy for HIV virus infection, AIDS. . bvwaghmare.blogspot.com. info:/

  • November 30, 1999
  • 12:00 AM
  • 2,409 views

Cellular Feast or Famine

by Sanford- Burnham in Beaker

Not all cholesterol is bad. Every cell requires it for growth – they either have to get cholesterol somewhere or they die. A sensor called sterol regulatory element-binding protein 2 (SREBP-2) monitors cellular cholesterol levels and responds to low levels by switching on genes that allow the cell to either 1) take up more from the bloodstream or 2) manufacture more from cholesterol building blocks inside the cell. Now researchers have uncovered a third cholesterol source also controlled b........ Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,910 views

HIV vaccine research: Protein which train B cells for production of antibodies against HIV which successfully neutralize HIV

by B V Waghmare in HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets

HIV virus rapidly undergoes mutation, which is main hurdle in developing vaccine against HIV.There is a region on HIV virus which shows less variations, called as Cd4 binding site ,therefore a protein which stimulate antibody formation against this region can be developed and used as a vaccine.
Researchers at Vaccine Research Center (VRC) and the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health have studied genes which code for such proteins which can........ Read more »

B V Waghmare. (2011) HIV vaccine development : Proteins which trains B Cells for production of antibodies which successfully neutralize HIV by binding with it . http://bvwaghmare.blogspot.com. info:/(DOI/arXiv/etc.)

  • November 30, 1999
  • 12:00 AM
  • 1,803 views

Using folate receptor alpha flurorescence imaging in ovarian cancer

by Sally Church in Pharma Strategy Blog

The idea behind this concept is that fluorescence technology can be used to help guide ovarian cancer surgery more effectively, since the tumors tend to be small and hard to see for surgeons performing the excision.... Read more »

van Dam, G., Themelis, G., Crane, L., Harlaar, N., Pleijhuis, R., Kelder, W., Sarantopoulos, A., de Jong, J., Arts, H., van der Zee, A.... (2011) Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results. Nature Medicine. DOI: 10.1038/nm.2472  

  • November 30, 1999
  • 12:00 AM
  • 2,300 views

Comparing Apples with Oranges: B&W

by Peter Nollert in Protein Crystallization Blog

Identifying individual amino acid residues within a GPCR and comparing these across different receptors is a routine task that’s helped by a widely accepted nomenclature system: that of Ballesteros and Weinstein.... Read more »

  • November 30, 1999
  • 12:00 AM
  • 2,601 views

Is this journal for real?

by Neurobonkers in Neurobonkers

This year 134 suspect new journals have appeared from the abyss, all published by the same clandestine company “Scientific & Academic Publishing, USA“... Read more »

Morrison, Heather. (2012) Scholarly Communication in Crisis. Freedom for scholarship in the internet age. Simon Fraser University School of Communication. info:/

  • November 30, 1999
  • 12:00 AM
  • 2,226 views

Many Vegetarians Consume Animal-Derived Products in Medicines

by United Academics in United Academics

What should vegetarians do when medicines contain animal products? The answer seems an easy one: to refuse them or to act according to their conscience. But what if the consumers are not appropriately informed about the medicine components, or the doctors not even know that it contains animal products?... Read more »

  • November 30, 1999
  • 12:00 AM
  • 2,317 views

Dizziness When Standing Up Linked to Greater Risk of Heart Failure: Research

by United Academics in United Academics

Many people feel suddenly dizzy when they stand up too quickly. This is caused by orthostatic hypotension, a rapid drop in blood pressure. Now a team of scientists at the University of North Carolina suggest that people with orthostatic hypotension might have a greater risk of developing heart failure.... Read more »

  • November 30, 1999
  • 12:00 AM
  • 2,348 views

The Aging Effects of the Sun Revealed on Trucker’s Face

by United Academics in United Academics

The man on the picture, William McElligott, spent 28 years of his life driving a delivery truck in Chicago. Only the left side of his face was exposed to the sun, with the result that it now looks much older than his right side. His case is a rare reminder of the aging effects of the sun, but also of the need to take precautions when working under certain conditions.... Read more »

Gordon, J., & Brieva, J. (2012) Unilateral Dermatoheliosis. New England Journal of Medicine, 366(16). DOI: 10.1056/NEJMicm1104059  

  • November 30, 1999
  • 12:00 AM
  • 1,877 views

Babies Are Healthier When There Is a Dog at Home: Research

by United Academics in United Academics

New research published in Pediatrics suggests that children living with a dog are significantly healthier than those living without it. The researchers followed up 397 Finnish children, asking their parents to fill in weekly questionnaires about their health until they were 1 year old. Scientists believe that this is so because dog contact helps the babies build up their immune system.... Read more »

Eija Bergroth, Sami Remes, Juha Pekkanen, Timo Kauppila, Gisela Büchele, & Leea Keski-Nisula. (2012) Respiratory Tract Illnesses During the First Year of Life: Effect of Dog and Cat Contacts. Pediatrics. info:/10.1542/peds.2011-2825

  • November 30, 1999
  • 12:00 AM
  • 1,569 views

A Holiday Without Helminths

by Michael Hsieh in Hsieh Lab Blog

What would a holiday without helminths, also known as parasitic worms, look like?... Read more »

Lustigman S, Prichard RK, Gazzinelli A, Grant WN, Boatin BA, McCarthy JS, & Basáñez MG. (2012) A research agenda for helminth diseases of humans: the problem of helminthiases. PLoS neglected tropical diseases, 6(4). PMID: 22545164  

  • November 30, 1999
  • 12:00 AM
  • 1,880 views

Fructose: friend or foe? Preliminary findings.

by Kismet in Biogerontology and Health

This discussion has been going on for quite some time and it is certainly not limited to the lay press and lay population. I have always been interested in double checking pop-sci claims, in this case the "evil fructose" meme.... Read more »

  • November 30, 1999
  • 12:00 AM
  • 2,178 views

I WILL FEAR NO EVIL: THE FIRST HEAD TRANSPLANT ON HUMAN

by Eugenio Maria Battaglia in Science to Grok

In 2008, doctor Sergio Canavero, an italian neurosurgeon based in Turin, IT, have awakened a 20 years old lady from a permanent post-traumatic vegetative state, by means of a bifocal extradural cortical electro-stimulation. Today, while Science still find it hard to explain consciousness and embodied cognition – the world-class neurosurgeon made a shock announcement: “I’m ready for the first head transplant on a man.”

In the manuscript published on Surgical Neurology I........ Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,533 views

Ibrutinib leads the race to CLL 17p deletion market

by Pieter Droppert in Biotech Strategy Blog

Earlier this month, Janssen/Pharmacyclics announced they had submitted a New Drug Application (NDA) for FDA approval of ibrutinib, an oral Bruton’s tyrosine kinase inhibitor (BTK) in chronic lymphocytic leukemia (CLL) for the treatment of patients with a deletion of the short arm of chromosome 17 (del17p).

The company have requested Priority review; approval later this year or in early 2014 is highly likely given that the agent also has Breakthrough designation status.

This is grea........ Read more »

Hartmut Döhner, M.D., Stephan Stilgenbauer, M.D., Axel Benner, M.Sc., Elke Leupolt, M.D., Alexander Kröber, M.D., Lars Bullinger, M.D., Konstanze Döhner, M.D., Martin Bentz, M.D., & Peter Lichter, Ph.D. (2000) Genomic Aberrations and Survival in Chronic Lymphocytic Leukemia. The New England Journal of Medicine, 1910-1916. info:/10.1056/NEJM200012283432602

  • November 30, 1999
  • 12:00 AM
  • 1,682 views

Electron-spin clue to solving general anesthesia mystery

by This Science is Crazy! in This Science Is Crazy!

New study on fruit flies suggests general anesthetics can affect electron-spin properties... Read more »

Turin Luca, Skoulakis Efthimios, & Horsfield Andrew. (2014) Electron spin changes during general anesthesia in Drosophila. PNAS, Early edition(N/A). DOI: 10.1073/pnas.1404387111  

  • November 30, 1999
  • 12:00 AM
  • 1,364 views

...How to Fix Science

by Viputheshwar Sitaraman in Draw Science

(Part 2/2) However, we can fix science. [Infographic]... Read more »

Alberts, B., Kirschner, M., Tilghman, S., & Varmus, H. (2014) Rescuing US biomedical research from its systemic flaws. Proceedings of the National Academy of Sciences, 111(16), 5773-5777. DOI: 10.1073/pnas.1404402111  

  • November 30, 1999
  • 12:00 AM
  • 905 views

PD-L1 expression associates with non-inactivated VHL ccRCC

by Joana Guedes in BHD Research Blog

The loss of the of the tumor suppressor gene VHL and the subsequent deregulation of VHL/HIF/VEGF signalling are known to play a role in development of clear cell renal cell carcinoma (ccRCC). Renal tumours associated with BHD syndrome are histologically diverse and include a percentage of ccRCC (Pavlovich et al., 2002). Anti-angiogenic therapies targeting the VHL/HIF/VEGF pathway have emerged in past years (Rini et al., 2006) but the development of resistance to these therapeutic agents is leadi........ Read more »

join us!

Do you write about peer-reviewed research in your blog? Use ResearchBlogging.org to make it easy for your readers — and others from around the world — to find your serious posts about academic research.

If you don't have a blog, you can still use our site to learn about fascinating developments in cutting-edge research from around the world.

Register Now

Research Blogging is powered by SMG Technology.

To learn more, visit seedmediagroup.com.