Post List

Medicine posts

(Modify Search »)

  • November 30, 1999
  • 12:00 AM
  • 3,284 views

Nicotine and the Humphrey Bogart Gene

by Dirk Hanson in Addiction Inbox

You can lead a fish to water, but can you make it smoke?

... Read more »

Petzold AM, Balciunas D, Sivasubbu S, Clark KJ, Bedell VM, Westcot SE, Myers SR, Moulder GL, Thomas MJ, & Ekker SC. (2009) Nicotine response genetics in the zebrafish. Proceedings of the National Academy of Sciences of the United States of America, 106(44), 18662-7. PMID: 19858493  

  • November 30, 1999
  • 12:00 AM
  • 2,670 views

New GPCR structure: CXCR4 Chemokine Receptor (HIV and cancer target)

by Peter Nollert in Protein Crystallization Blog

Congratulations to Ray Stevens and team to determining and publishing the crystallographic structure of the CXCR4 Chemokine receptor in Science. The diffenent binding areas for the small molecule and peptide antagonist are nicely resolved and show extensive interactions with binding pocket residues in the 2.5 – 3.1 A crystal structures.... Read more »

Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC.... (2010) Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science (New York, N.Y.), 330(6007), 1066-71. PMID: 20929726  

  • November 30, 1999
  • 12:00 AM
  • 2,408 views

New GPCR structure: CXCR4 Chemokine Receptor (HIV and cancer target)

by Peter Nollert in Emerald BioStructures Blog

Congratulations to Ray Stevens and team to determining and publishing the crystallographic structure of the CXCR4 Chemokine receptor in Science. The diffenent binding areas for the small molecule and peptide antagonist are nicely resolved and show extensive interactions with binding pocket residues in the 2.5 – 3.1 A crystal structures... Read more »

Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC.... (2010) Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science (New York, N.Y.), 330(6007), 1066-71. PMID: 20929726  

  • November 30, 1999
  • 12:00 AM
  • 2,111 views

HIV vaccine research heading towards success,so near but so far, latest research and development towards developing HIV vaccine

by B V Waghmare in HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets

There are few cases observed where some people are tested HIV positive long ago but have not developed AIDS symptoms or the AIDS disease in their entire life and are called by researchers for finding out what is the key difference in them and the other peoples which is imparting capability for not developing HIV infection in to disease AIDS in such individuals.

Researchers have observed that there is a key difference in the genetic constitution of such peoples and they are termed as controlle........ Read more »

B V Waghmare. (2010) Information on HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets . www.bvwaghmare.blogspot.com. info:/DOI/arXiv/bvwaghmare

  • November 30, 1999
  • 12:00 AM
  • 2,061 views

Let’s Get Cellular: Meth Metabolism

by Dirk Hanson in Addiction Inbox

We know from the work of Nora Volkow and others that meth abusers have chronically low levels of dopamine D2 receptors in their brains. But what is going on in the rest of the body when methamphetamine addiction is running full force?... Read more »

Sun, L., Li, H., Seufferheld, M., Walters, K., Margam, V., Jannasch, A., Diaz, N., Riley, C., Sun, W., Li, Y.... (2011) Systems-Scale Analysis Reveals Pathways Involved in Cellular Response to Methamphetamine. PLoS ONE, 6(4). DOI: 10.1371/journal.pone.0018215  

  • November 30, 1999
  • 12:00 AM
  • 2,295 views

Let’s Get Cellular: Meth Metabolism

by Dirk Hanson in Addiction Inbox

We know from the work of Nora Volkow and others that meth abusers have chronically low levels of dopamine D2 receptors in their brains. But what is going on in the rest of the body when methamphetamine addiction is running full force?... Read more »

Sun, L., Li, H., Seufferheld, M., Walters, K., Margam, V., Jannasch, A., Diaz, N., Riley, C., Sun, W., Li, Y.... (2011) Systems-Scale Analysis Reveals Pathways Involved in Cellular Response to Methamphetamine. PLoS ONE, 6(4). DOI: 10.1371/journal.pone.0018215  

  • November 30, 1999
  • 12:00 AM
  • 1,957 views

HIV vaccine research: Protein which train B cells for production of antibodies against HIV which successfully neutralize HIV

by B V Waghmare in HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets

HIV virus rapidly undergoes mutation, which is main hurdle in developing vaccine against HIV.There is a region on HIV virus which shows less variations, called as Cd4 binding site ,therefore a protein which stimulate antibody formation against this region can be developed and used as a vaccine.
Researchers at Vaccine Research Center (VRC) and the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health have studied genes which code for such proteins which can........ Read more »

B V Waghmare. (2011) HIV vaccine development : Proteins which trains B Cells for production of antibodies which successfully neutralize HIV by binding with it . http://bvwaghmare.blogspot.com. info:/(DOI/arXiv/etc.)

  • November 30, 1999
  • 12:00 AM
  • 1,857 views

Using folate receptor alpha flurorescence imaging in ovarian cancer

by Sally Church in Pharma Strategy Blog

The idea behind this concept is that fluorescence technology can be used to help guide ovarian cancer surgery more effectively, since the tumors tend to be small and hard to see for surgeons performing the excision.... Read more »

van Dam, G., Themelis, G., Crane, L., Harlaar, N., Pleijhuis, R., Kelder, W., Sarantopoulos, A., de Jong, J., Arts, H., van der Zee, A.... (2011) Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results. Nature Medicine. DOI: 10.1038/nm.2472  

  • November 30, 1999
  • 12:00 AM
  • 2,359 views

Comparing Apples with Oranges: B&W

by Peter Nollert in Protein Crystallization Blog

Identifying individual amino acid residues within a GPCR and comparing these across different receptors is a routine task that’s helped by a widely accepted nomenclature system: that of Ballesteros and Weinstein.... Read more »

  • November 30, 1999
  • 12:00 AM
  • 2,676 views

Is this journal for real?

by Neurobonkers in Neurobonkers

This year 134 suspect new journals have appeared from the abyss, all published by the same clandestine company “Scientific & Academic Publishing, USA“... Read more »

Morrison, Heather. (2012) Scholarly Communication in Crisis. Freedom for scholarship in the internet age. Simon Fraser University School of Communication. info:/

  • November 30, 1999
  • 12:00 AM
  • 1,744 views

“Beware of Exercise” is a Sexy Headline

by nooffensebut in The Unsilenced Science

A new study that raised concerns about exercise should instead raise concerns about obesity.... Read more »

Claude Bouchard, Steven Blair, Timothy Church, Conrad Earnest, James Hagberg, Keijo Häkkinen, Nathan Jenkins, Laura Karavirta, William Kraus, Arthur Leon.... (2012) Adverse Metabolic Response to Regular Exercise: Is It a Rare or Common Occurrence?. PLOS One, 7(5). info:/10.1371/journal.pone.0037887

  • November 30, 1999
  • 12:00 AM
  • 1,924 views

Babies Are Healthier When There Is a Dog at Home: Research

by United Academics in United Academics

New research published in Pediatrics suggests that children living with a dog are significantly healthier than those living without it. The researchers followed up 397 Finnish children, asking their parents to fill in weekly questionnaires about their health until they were 1 year old. Scientists believe that this is so because dog contact helps the babies build up their immune system.... Read more »

Eija Bergroth, Sami Remes, Juha Pekkanen, Timo Kauppila, Gisela Büchele, & Leea Keski-Nisula. (2012) Respiratory Tract Illnesses During the First Year of Life: Effect of Dog and Cat Contacts. Pediatrics. info:/10.1542/peds.2011-2825

  • November 30, 1999
  • 12:00 AM
  • 1,408 views

Making sense of a small worm from big data

by Michael Hsieh in Hsieh Lab Blog

We recently published a gene expression microarray-based paper in PLOS Neglected Tropical Diseases. As a "reductionist", it was challenging for me to deal with the massive amount of data associated with the paper. ... Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,627 views

A Holiday Without Helminths

by Michael Hsieh in Hsieh Lab Blog

What would a holiday without helminths, also known as parasitic worms, look like?... Read more »

Lustigman S, Prichard RK, Gazzinelli A, Grant WN, Boatin BA, McCarthy JS, & Basáñez MG. (2012) A research agenda for helminth diseases of humans: the problem of helminthiases. PLoS neglected tropical diseases, 6(4). PMID: 22545164  

  • November 30, 1999
  • 12:00 AM
  • 1,926 views

Fructose: friend or foe? Preliminary findings.

by Kismet in Biogerontology and Health

This discussion has been going on for quite some time and it is certainly not limited to the lay press and lay population. I have always been interested in double checking pop-sci claims, in this case the "evil fructose" meme.... Read more »

  • November 30, 1999
  • 12:00 AM
  • 2,258 views

I WILL FEAR NO EVIL: THE FIRST HEAD TRANSPLANT ON HUMAN

by Eugenio Maria Battaglia in Science to Grok

In 2008, doctor Sergio Canavero, an italian neurosurgeon based in Turin, IT, have awakened a 20 years old lady from a permanent post-traumatic vegetative state, by means of a bifocal extradural cortical electro-stimulation. Today, while Science still find it hard to explain consciousness and embodied cognition – the world-class neurosurgeon made a shock announcement: “I’m ready for the first head transplant on a man.”

In the manuscript published on Surgical Neurology I........ Read more »

  • November 30, 1999
  • 12:00 AM
  • 2,332 views

Understanding PREDIMED and the Mediterranean diet: heart-healthy or hype?

by Kismet in Biogerontology and Health

I am going to discuss the failings of the PREDIMED study, real and imagined. I will do this in a Question & Answer style. Several questions are inspired by theheart.org and NEJM comments and even statements by the low fat "gurus", Essselstyn, Ornish, McDougall or Pritikin. It is no surprise they are up in arms after the study has been published. It threatens their livelihood.... Read more »

Estruch, R., Ros, E., Salas-Salvadó, J., Covas, M., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J.... (2013) Primary Prevention of Cardiovascular Disease with a Mediterranean Diet. New England Journal of Medicine, 368(14), 1279-1290. DOI: 10.1056/NEJMoa1200303  

  • November 30, 1999
  • 12:00 AM
  • 1,742 views

Electron-spin clue to solving general anesthesia mystery

by This Science is Crazy! in This Science Is Crazy!

New study on fruit flies suggests general anesthetics can affect electron-spin properties... Read more »

Turin Luca, Skoulakis Efthimios, & Horsfield Andrew. (2014) Electron spin changes during general anesthesia in Drosophila. PNAS, Early edition(N/A). DOI: 10.1073/pnas.1404387111  

  • November 30, 1999
  • 12:00 AM
  • 1,427 views

...How to Fix Science

by Viputheshwar Sitaraman in Draw Science

(Part 2/2) However, we can fix science. [Infographic]... Read more »

Alberts, B., Kirschner, M., Tilghman, S., & Varmus, H. (2014) Rescuing US biomedical research from its systemic flaws. Proceedings of the National Academy of Sciences, 111(16), 5773-5777. DOI: 10.1073/pnas.1404402111  

  • November 30, 1999
  • 12:00 AM
  • 948 views

PD-L1 expression associates with non-inactivated VHL ccRCC

by Joana Guedes in BHD Research Blog

The loss of the of the tumor suppressor gene VHL and the subsequent deregulation of VHL/HIF/VEGF signalling are known to play a role in development of clear cell renal cell carcinoma (ccRCC). Renal tumours associated with BHD syndrome are histologically diverse and include a percentage of ccRCC (Pavlovich et al., 2002). Anti-angiogenic therapies targeting the VHL/HIF/VEGF pathway have emerged in past years (Rini et al., 2006) but the development of resistance to these therapeutic agents is leadi........ Read more »

join us!

Do you write about peer-reviewed research in your blog? Use ResearchBlogging.org to make it easy for your readers — and others from around the world — to find your serious posts about academic research.

If you don't have a blog, you can still use our site to learn about fascinating developments in cutting-edge research from around the world.

Register Now

Research Blogging is powered by SRI Technology.

To learn more, visit http://selfregulationinstitute.org/.