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  • December 22, 2016
  • 04:30 AM
  • 360 views

More Is Better: Exercise Therapy for the Ankle

by Kyle Kosik in Sports Medicine Research (SMR): In the Lab & In the Field

Exercise therapy and external supports reduce the chance of an ankle sprain; increasing the volume of exercise further reduces the odds.... Read more »

  • December 22, 2016
  • 03:31 AM
  • 393 views

Psychosis (sometimes) as an immune disorder?

by Paul Whiteley in Questioning Answers

"Some psychosis cases an 'immune disorder'" went the BBC headline with reference to the paper by Belinda Lennox and colleagues [1] talking about the detection of antibodies against the N-methyl-D-aspartate receptor (NMDAR) in cases of first-episode psychosis (FEP).Although by no means a universal phenomenon, researchers reported that 3% of their 228 participants diagnosed with FEP who provided a blood sample showed the presence of NMDAR antibodies compared with none of the healthy controls ........ Read more »

  • December 21, 2016
  • 06:02 AM
  • 429 views

"New form of autism found"

by Paul Whiteley in Questioning Answers

"New form of autism found" went one of the headlines reporting on the paper by Dora C. Tărlungeanu and colleagues [1] and findings that "elucidate a neurological syndrome defined by SLC7A5 mutations and support an essential role for the BCAA [branched-chain amino acids] in human brain function." This work continues a rather important research story talking about how one 'type' of autism might have some important roots in relation to the branched-chain amino acids and their m........ Read more »

Tărlungeanu, D., Deliu, E., Dotter, C., Kara, M., Janiesch, P., Scalise, M., Galluccio, M., Tesulov, M., Morelli, E., Sonmez, F.... (2016) Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder. Cell, 167(6), 1481-2147483647. DOI: 10.1016/j.cell.2016.11.013  

  • December 21, 2016
  • 04:30 AM
  • 350 views

Colder May Not Be Cool for Recovery

by Nicole Cattano in Sports Medicine Research (SMR): In the Lab & In the Field

After exercise, cold water immersion at 15°C may offer some improvements in recovery based on performance of a jump task and possibly markers of muscle damage. A colder temperature may not be as effective as cool water, so controlling the treatment parameters based on evidence is important.... Read more »

Vieira, A., Siqueira, A., Ferreira-Junior, J., do Carmo, J., Durigan, J., Blazevich, A., & Bottaro, M. (2016) The Effect of Water Temperature during Cold-Water Immersion on Recovery from Exercise-Induced Muscle Damage. International Journal of Sports Medicine, 37(12), 937-943. DOI: 10.1055/s-0042-111438  

  • December 20, 2016
  • 04:33 AM
  • 417 views

Generation R does gestational vitamin D levels and autistic traits

by Paul Whiteley in Questioning Answers

"Gestational vitamin D deficiency was associated with autism-related traits in a large population-based sample. Because gestational vitamin D deficiency is readily preventable with safe, cheap and accessible supplements, this candidate risk factor warrants closer scrutiny."So said the findings reported by Vinkhuyzen and colleagues [1] (open-access) reporting on data derived from "the Generation R Study, a population-based prospective cohort from fetal life onward, based in Rotterdam, The Netherl........ Read more »

Vinkhuyzen AA, Eyles DW, Burne TH, Blanken LM, Kruithof CJ, Verhulst F, Jaddoe VW, Tiemeier H, & McGrath JJ. (2016) Gestational vitamin D deficiency and autism-related traits: the Generation R Study. Molecular psychiatry. PMID: 27895322  

  • December 20, 2016
  • 04:30 AM
  • 352 views

Is High School Specialization Needed to Participate at the Division I Level?

by Adam Lake in Sports Medicine Research (SMR): In the Lab & In the Field

The majority of athletes participating in NCAA Division I sports reported that they were not highly specialized in that sport during high school.... Read more »

Post, E., Thein-Nissenbaum, J., Stiffler, M., Brooks, M., Bell, D., Sanfilippo, J., Trigsted, S., Heiderscheit, B., & McGuine, T. (2016) High School Sport Specialization Patterns of Current Division I Athletes. Sports Health: A Multidisciplinary Approach. DOI: 10.1177/1941738116675455  

  • December 19, 2016
  • 03:19 AM
  • 415 views

Gut barrier integrity meets blood-brain barrier integrity with autism in mind

by Paul Whiteley in Questioning Answers

"In the ASD [autism spectrum disorder] brain, there is an altered expression of genes associated with BBB [blood-brain barrier] integrity coupled with increased neuroinflammation and possibly impaired gut barrier integrity."Although pretty enthused to see research linking names like Anna Sapone, Tim Buie and Alessio Fasano in the recent paper published by Maria Fiorentino and colleagues [1] (open-access), I was slightly less impressed with the use of the term 'the ASD brain' ........ Read more »

Fiorentino, M., Sapone, A., Senger, S., Camhi, S., Kadzielski, S., Buie, T., Kelly, D., Cascella, N., & Fasano, A. (2016) Blood–brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders. Molecular Autism, 7(1). DOI: 10.1186/s13229-016-0110-z  

  • December 18, 2016
  • 12:41 AM
  • 324 views

On the Interpretation of Neuroscientific Findings

by Justin A. Sattin in The Ghost of Charcot

A review of classic "split brain" research and critique of a new paper regarding "functional" splits in brain function.... Read more »

Sasai, S., Boly, M., Mensen, A., & Tononi, G. (2016) Functional split brain in a driving/listening paradigm. Proceedings of the National Academy of Sciences, 113(50), 14444-14449. DOI: 10.1073/pnas.1613200113  

  • December 17, 2016
  • 05:51 AM
  • 353 views

Pregnancy influenza infection not linked to offspring autism

by Paul Whiteley in Questioning Answers

"There was no association between maternal influenza [flu] infection anytime during pregnancy and increased ASD [autism spectrum disorder] risk."So said the findings reported by Ousseny Zerbo and colleagues [1] continuing a research theme from this author (see here for example) looking at how various infections 'encountered' during critical periods of pregnancy may / may not impact on offspring autism risk. This time around the focus was on viral infections and in partic........ Read more »

  • December 16, 2016
  • 05:25 AM
  • 341 views

Patient participation in clinical trials

by Joana Guedes in BHD Research Blog

Clinical trials are crucial to help doctors and scientists understand how to safely treat a particular condition, to evaluate new treatments and to test drug safety and efficacy. They have an important role in every step of managing a condition with different clinical trials helping with prevention, diagnosis, treatments and follow-up support.... Read more »

  • December 16, 2016
  • 04:30 AM
  • 307 views

Frequency and Location of Head Impacts in Division 1 Men’s Lacrosse Players

by Patricia Kelshaw, MS, LAT, ATC in Sports Medicine Research (SMR): In the Lab & In the Field

Player position and session type such as practice or game are the main factors that influence head impact frequencies and magnitudes for lacrosse athletes.... Read more »

  • December 16, 2016
  • 03:16 AM
  • 351 views

Non-febrile seizures in children with autism vs unaffected siblings

by Paul Whiteley in Questioning Answers

"Children with idiopathic ASD [autism spectrum disorder] are significantly more likely to have non-febrile seizures than their unaffected siblings, suggesting that non-febrile seizures may be ASD-specific."So said the findings from Lena McCue and colleagues [1] (open-access) continuing a research theme looking at one of the important 'comorbidities' that seems to be over-represented when it comes to a diagnosis of autism (see here). Idiopathic autism or ASD refers to autism as the........ Read more »

  • December 15, 2016
  • 04:30 AM
  • 325 views

Cortisol and Testosterone Levels Following Exhaustive Endurance Exercise: How Much Recovery Do Athletes Really Need?

by Jennifer Fields in Sports Medicine Research (SMR): In the Lab & In the Field

Following high-intensity endurance exercise, recovery may require 48-72 hours for cortisol and testosterone to return back to resting levels. ... Read more »

Anderson, T., Lane, A., & Hackney, A. (2016) Cortisol and testosterone dynamics following exhaustive endurance exercise. European Journal of Applied Physiology, 116(8), 1503-1509. DOI: 10.1007/s00421-016-3406-y  

  • December 15, 2016
  • 02:59 AM
  • 410 views

ADHD, not autism, might count when it comes to 'comorbid psychiatric symptomatology'

by Paul Whiteley in Questioning Answers

A quote to begin this fairly brief post: "Our study concluded that higher levels of ADHD [attention-deficit hyperactivity disorder] severity-not ASD [autism spectrum disorder] severity-were associated with a higher prevalence of comorbid psychiatric symptomatology in school-age children with ASD. These findings may encourage clinicians to thoroughly assess ADHD symptomatology in ASD children to better inform treatment planning."That was the research bottom line reported by Ro........ Read more »

  • December 14, 2016
  • 04:30 AM
  • 319 views

Identifying Athletes at Risk for Chronic Ankle Instability

by Matt Prebble in Sports Medicine Research (SMR): In the Lab & In the Field

The jump-landing protocol was able to distinguish between healthy, ‘coper’, and unstable ankles. This protocol may be useful for identifying athletes at increased risk for injury, and as a return to play indicator following rehabilitation.... Read more »

  • December 14, 2016
  • 03:07 AM
  • 381 views

Urinary metabolomics in autism turns up tryptophan (again)

by Paul Whiteley in Questioning Answers

"The tryptophan metabolic pathway collectively displays the largest perturbations in ASD [autism spectrum disorder]."So said the findings reported by Federica Gevi and colleagues [1] (open-access) who provide yet more 'metabolomic' data when it comes to autism to add to the already quite voluminous peer-reviewed matter on this topic (see here for example).Just in case you aren't analytical chemistry-saavy, metabolomics is basically the study of the various chemical fingerprints that th........ Read more »

  • December 13, 2016
  • 04:30 AM
  • 323 views

Can Using a Whole Body Vibration Warm-up Give Athletes Quicker Feet?

by Stuart McCrory in Sports Medicine Research (SMR): In the Lab & In the Field

Whole-body vibration improves performance on quick feet test when compared to a traditional warm-up.... Read more »

Donahue RB, Vingren JL, Duplanty AA, Levitt DE, Luk HY, & Kraemer WJ. (2016) Acute Effect of Whole-Body Vibration Warm-up on Footspeed Quickness. Journal of strength and conditioning research, 30(8), 2286-91. PMID: 27328378  

  • December 13, 2016
  • 04:25 AM
  • 372 views

'My child is not talking'. Online concerns and internet-based screening for autism?

by Paul Whiteley in Questioning Answers

"Online communities are used as platforms by parents to verify developmental and health concerns related to their child."That was the starting point for the study results reported by Ben-Sasson & Yom-Tov [1] (open-access available here) who approached an increasingly important issue related to how the Internet and social media in particular, is fast becoming one of the 'go-to' options when it comes to parental concerns about their child's development and the question: could it be autism........ Read more »

  • December 12, 2016
  • 04:37 AM
  • 355 views

Maternal immune activation (MIA) and Old World monkeys

by Paul Whiteley in Questioning Answers

Old World monkeys detailed in the title of this post, specifically refers to a type of animal called a rhesus macaque who were the 'participants' of choice as detailed in a recent study by Destanie Rose and colleagues [1] looking at a concept called maternal immune activation (MIA).Those who followed this blog down the years will no doubt have seen me discuss MIA before in the context of autism and/or schizophrenia (see here for example). The basic theory is that whilst in-utero a........ Read more »

  • December 12, 2016
  • 04:30 AM
  • 326 views

Substance Use by Gender and Race Among Teenage Athletes

by Jessica Pope in Sports Medicine Research (SMR): In the Lab & In the Field

While general substance use patterns are seen in adolescent athletes, some gender and racial/ethnic groups are at more risk than others. Prevention and educational programs should be designed with this in mind.... Read more »

Parent, M., Bradstreet, T., Piper, M., Brace, T., & Parkman, T. (2016) Racial Disparities in Substance Use by Sport Participation Among High School Students. Journal of Studies on Alcohol and Drugs, 77(6), 980-985. DOI: 10.15288/jsad.2016.77.980  

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