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  • February 11, 2017
  • 04:43 AM
  • 386 views

Pregnancy exposure to SSRIs and offspring autism risk: debate continues

by Paul Whiteley in Questioning Answers

"It remains unclear whether the association between first trimester SSRI [selective serotonin reuptake inhibitor] exposure and child autism that was present in the case-control studies even after adjustment for MMI [maternal mental illness] is a true association or a product of residual confounding."So said the results of the systematic review and meta-analysis undertaken by Hilary Brown and colleagues [1] looking at a potentially important association between pregnancy use of a class ........ Read more »

  • February 10, 2017
  • 12:15 PM
  • 352 views

Scientific reliability and the role of theory

by Multiple Authors in EPPI-Centre blog

The replication crisis, publication bias, p-hacking, harking, bad incentives, undesirable pressures and probably other factors all contribute to diminish the trustworthiness of published research, with obvious implications for research synthesis. Sergio Graziosi asks whether demanding simple theoretical clarity might be part of the solution.
... Read more »

Kerr NL. (1998) HARKing: hypothesizing after the results are known. Personality and social psychology review : an official journal of the Society for Personality and Social Psychology, Inc, 2(3), 196-217. PMID: 15647155  

Head ML, Holman L, Lanfear R, Kahn AT, & Jennions MD. (2015) The extent and consequences of p-hacking in science. PLoS biology, 13(3). PMID: 25768323  

Munafò, M., Nosek, B., Bishop, D., Button, K., Chambers, C., Percie du Sert, N., Simonsohn, U., Wagenmakers, E., Ware, J., & Ioannidis, J. (2017) A manifesto for reproducible science. Nature Human Behaviour, 1(1), 21. DOI: 10.1038/s41562-016-0021  

  • February 10, 2017
  • 07:19 AM
  • 330 views

BHD in patients undergoing chest CT and characteristics of BHD in Korea.

by Joana Guedes in BHD Research Blog

To date, there have been no prospective studies attempting to diagnose BHD syndrome or literature reviews on BHD in Korea. Park et al. (2017) address this in their new study that aims to detect BHD prospectively in patients undergoing chest computed tomography (CT) scans and to classify the characteristics of BHD in Korea.... Read more »

  • February 10, 2017
  • 03:27 AM
  • 338 views

A few-foods diet for ADHD: a systematic review of meta-analyses of double-blind, placebo-controlled trials

by Paul Whiteley in Questioning Answers

"... the effect sizes of a few-foods diet are medium to large, justifying implementation of a diagnostic FFD [few-foods diet] in subgroups of children with ADHD [attention-deficit hyperactivity disorder], thus offering innovative treatment opportunities for ADHD."So said the "Systematic Review of Meta-Analyses of Double-Blind Placebo-Controlled Trials" published by Lidy Pelsser and colleagues [1] (open-access available here) looking at various dietary interventions that have ........ Read more »

  • February 9, 2017
  • 03:01 AM
  • 339 views

On dietary and nutritional therapies for ME/CFS

by Paul Whiteley in Questioning Answers

ME/CFS in case you don't already know refers to Myalgic Encephalomyelitis / Chronic Fatigue Syndrome and, according to the findings reported by Nadia Campagnolo and colleagues [1], is in need of quite a bit more scientific investigation when it comes to the application of dietary changes and nutritional supplements to potentially alter the course of the condition(s).Surveying the peer-reviewed literature "from 1994 to May 2016" the authors looked for peer-reviewed studies where "CFS/ME........ Read more »

Campagnolo N, Johnston S, Collatz A, Staines D, & Marshall-Gradisnik S. (2017) Dietary and nutrition interventions for the therapeutic treatment of chronic fatigue syndrome/myalgic encephalomyelitis: a systematic review. Journal of human nutrition and dietetics : the official journal of the British Dietetic Association. PMID: 28111818  

  • February 8, 2017
  • 04:33 AM
  • 376 views

On atopic disease and ADHD: 'strong evidence' for an association

by Paul Whiteley in Questioning Answers

"This current systematic review provides strong evidence that ADHD [attention-deficit hyperactivity disorder] is associated with atopic diseases and that individuals have a 30% to 50% greater chance of developing ADHD compared to controls."So said the results of the systematic review and meta-analysis published by Jurjen van der Schans and colleagues [1] looking at the collected peer-reviewed science literature on how conditions such as asthma, eczema and rhinitis might increase t........ Read more »

  • February 8, 2017
  • 04:30 AM
  • 334 views

Physical Activity Within 7 Days May Lead to Better Long-Term Outcomes After a Concussion

by Jane McDevitt in Sports Medicine Research (SMR): In the Lab & In the Field

Among children and adolescents with acute concussion, participation in physical activity within 7 days of acute injury compared with no physical activity was associated with lower risk of persistent postconcussion symptoms at 28 days post injury.... Read more »

  • February 7, 2017
  • 04:35 AM
  • 416 views

Psychiatric disorders among male juvenile detainees in South Korea

by Paul Whiteley in Questioning Answers

"Juvenile detainees evidence high rates of psychiatric disorders and comorbidities. Assessment of and intervention in psychiatric disorders, especially alcohol use disorder and comorbid alcohol use disorder with disruptive behavior disorders, may help prevent further offenses."So concluded Johanna Inhyang Kim and colleagues [1] (open-access) following their investigation into the prevalence of DSM-IV psychiatric criteria in a sample of 173 male juvenile detainees aged between 15-19 years ol........ Read more »

  • February 6, 2017
  • 04:41 AM
  • 365 views

Natural course of "chronic disabling fatigue" in adolescents

by Paul Whiteley in Questioning Answers

"We use the term 'chronic disabling fatigue' (CDF) because CFS/ME [chronic fatigue syndrome / myalgic encephalomyelitis] was not verified by clinical diagnosis."That was one of the important details included in the findings reported by Tom Norris and colleagues [1] (open-access) who "aimed to describe the epidemiology and natural course of CFS/ME in adolescents aged 13–18 years." Relying on data derived from The Avon Longitudinal Study of Parents and Children (ALSPAC) (so........ Read more »

Norris T, Collin SM, Tilling K, Nuevo R, Stansfeld SA, Sterne JA, Heron J, & Crawley E. (2017) Natural course of chronic fatigue syndrome/myalgic encephalomyelitis in adolescents. Archives of disease in childhood. PMID: 28104625  

  • February 4, 2017
  • 04:27 AM
  • 405 views

ADHD, obesity and bariatric surgery?

by Paul Whiteley in Questioning Answers

"The findings suggest that a considerable number of patients before and after bariatric surgery screened positive for ADHD [attention-deficit hyperactivity disorder]. It can be hypothesized that some core ADHD symptoms improve after surgery."Bariatric surgery, where several surgical options are available to aid weight loss in those who present with 'dangerous' obesity, was the topic of the paper by Nielsen and colleagues [1] (open-access available here) who set out to compare "pre- and........ Read more »

  • February 3, 2017
  • 11:22 AM
  • 212 views

Brain Shape and Personality Type

by William Yates, M.D. in Brain Posts

Personality has often been conceptualized a a human feature shaped largely by nurture and environment.Unlike major neuroscience medicine disorders, personality features have been considered less influenced by brain structure and genetic influences.A recent brain structure (morphology) study puts these assumptions at risk.Roberta Riccelli along with colleagues in Italy and Florida State University studied brain structural features across 507 participants in the Human Connectome Project.All subjec........ Read more »

  • February 3, 2017
  • 03:03 AM
  • 426 views

"Schizophrenia confers a high endogenous risk for diabetes"

by Paul Whiteley in Questioning Answers

"Schizophrenia confers a high endogenous risk for diabetes, and the risk is further increased by both first-generation and second-generation antipsychotics."So concluded Anto Rajkumar and colleagues [1] who relied on participant data in the thousands derived from several of those very helpful Scandinavian population registries (this time in Denmark) to add some further science to the idea that psychiatric diagnoses like schizophrenia seem to carry an elevated risk for all-manner of somatic ........ Read more »

  • February 2, 2017
  • 03:25 AM
  • 646 views

Hyperuricemia present in both medicated and unmedicated kids with autism

by Paul Whiteley in Questioning Answers

I was intrigued to read the findings reported by Natchaya Vanwong and colleagues [1] talking about the presence of hyperuricemia - an excess of uric acid in the blood - in their cohort of children and young adults diagnosed with an autism spectrum disorder (ASD). Intrigued not only because the authors discuss how the use of the atypical antipsychotic risperidone might *correlate* with elevations of uric acid but also how: "Hyperuricemia was present in 44.70% of risperidone-naïve patients w........ Read more »

  • February 1, 2017
  • 04:30 AM
  • 654 views

Overtrained Athletes Have Abnormal Biochemical Response to Exercise

by Nicole Cattano in Sports Medicine Research (SMR): In the Lab & In the Field

Overtrained athletes have abnormal inflammatory and anabolic responses to exercise, indicating that their body is not responding to exercise the way that it should.... Read more »

  • February 1, 2017
  • 03:21 AM
  • 644 views

Autism and a 'clear' reduction of behavioural severity in cases diagnosed

by Paul Whiteley in Questioning Answers

"This study provides the first clear evidence of a reduction over time in the behavioral severity of individuals diagnosed with Autistic Disorder during a period of stability in diagnostic criteria."So said the study findings reported by Andrew Whitehouse and colleagues [1] (a man not afraid to make waves when it comes to thinking about autism or about approaches to intervention) looking at "whether there were changes over time in the qualitative and quantitative phenotype of individuals wh........ Read more »

Whitehouse AJ, Cooper MN, Bebbington K, Alvares G, Lin A, Wray J, & Glasson EJ. (2017) Evidence of a reduction over time in the behavioral severity of autistic disorder diagnoses. Autism research : official journal of the International Society for Autism Research. PMID: 28102641  

  • January 31, 2017
  • 03:18 AM
  • 600 views

S100B protein and autism continued

by Paul Whiteley in Questioning Answers

"Our findings showing an increase in peripheral concentrations of S100B and TNF-α provide limited support to the hypothesis about the roles of altered immune function and S100B in autism spectrum disorder (ASD)."So said the findings reported by Selin Aktan Guloksuz and colleagues [1] (open-access available here) continuing some discussions a few years back on a possible role for S100B in relation to at least some autism (see here).S100B - S100 calcium-binding protein B - is a compound invo........ Read more »

Guloksuz SA, Abali O, Aktas Cetin E, Bilgic Gazioglu S, Deniz G, Yildirim A, Kawikova I, Guloksuz S, & Leckman JF. (2017) Elevated plasma concentrations of S100 calcium-binding protein B and tumor necrosis factor alpha in children with autism spectrum disorders. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). PMID: 28099628  

  • January 30, 2017
  • 03:08 AM
  • 671 views

High frequency of (self-reported) ADHD symptoms in eating disorders

by Paul Whiteley in Questioning Answers

"There is a high frequency of ADHD [attention-deficit hyperactivity disorder] symptoms in patients with binge eating/purging eating disorders that motivates further studies."That was the conclusion reached in the study by Nils Erik Svedlund and colleagues [1] (open-access) who, among other things, set out to "explore the prevalence and types of self-reported ADHD symptoms in a large, unselected group of ED [eating disorder] patients assessed in a specialized ED clinic." ........ Read more »

  • January 28, 2017
  • 04:26 PM
  • 658 views

RCT of traditional running shoes vs minimalist running shoes

by Craig Payne in Running Research Junkie

RCT of traditional running shoes vs minimalist running shoes... Read more »

  • January 28, 2017
  • 04:15 AM
  • 644 views

"Should gluten-free foods be available on prescription?"

by Paul Whiteley in Questioning Answers

Continuing the theme of blogging outside of the core material typically included on this site, I couldn't resist a mention of the 'head-to-head' debate talked about in the article by Matthew Kurien and colleagues [1] published in the British Medical Journal (BMJ).As per the title of this post, the name of the game was gluten-free products being available on prescription here in Blighty, and in particular, the prescribing of gluten-free products to patients diagnosed with coeliac disease. Th........ Read more »

Kurien M, Sleet S, Sanders DS, & Cave J. (2017) Should gluten-free foods be available on prescription?. BMJ (Clinical research ed.). PMID: 28073799  

  • January 27, 2017
  • 05:13 AM
  • 563 views

TSC1 expression is affected by VHL alterations and HIF-1α production in clear-cell RCC

by Joana Guedes in BHD Research Blog

VHL genetic alterations do not affect the production of HIF-α in clear-cell renal cell carcinoma (ccRCC). However, their effects on tuberous sclerosis proteins (TSC1/2) and heat shock protein 90 (Hsp90) expression are currently unknown. In a recent study, Damjanovic et al. (2016) evaluated the impact of VHL genetic alterations and HIF-α production on the expression of TSC proteins and Hsp90 in 47 sporadic ccRCCs and corresponding normal tissues.... Read more »

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